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WO2001098339A3 - Compositions and methods for the therapy and diagnosis of breast cancer - Google Patents

Compositions and methods for the therapy and diagnosis of breast cancer Download PDF

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Publication number
WO2001098339A3
WO2001098339A3 PCT/US2001/019032 US0119032W WO0198339A3 WO 2001098339 A3 WO2001098339 A3 WO 2001098339A3 US 0119032 W US0119032 W US 0119032W WO 0198339 A3 WO0198339 A3 WO 0198339A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
diagnosis
breast cancer
therapy
polypeptides
Prior art date
Application number
PCT/US2001/019032
Other languages
French (fr)
Other versions
WO2001098339A2 (en
Inventor
Steven G Reed
Jiangchun Xu
Davin C Dillon
Marc W Retter
Susan L Harlocker
Original Assignee
Corixa Corp
Steven G Reed
Jiangchun Xu
Davin C Dillon
Marc W Retter
Susan L Harlocker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/602,877 external-priority patent/US6432707B1/en
Application filed by Corixa Corp, Steven G Reed, Jiangchun Xu, Davin C Dillon, Marc W Retter, Susan L Harlocker filed Critical Corixa Corp
Priority to AU2001280443A priority Critical patent/AU2001280443A1/en
Publication of WO2001098339A2 publication Critical patent/WO2001098339A2/en
Publication of WO2001098339A3 publication Critical patent/WO2001098339A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
PCT/US2001/019032 2000-06-22 2001-06-12 Compositions and methods for the therapy and diagnosis of breast cancer WO2001098339A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001280443A AU2001280443A1 (en) 2000-06-22 2001-06-12 Compositions and methods for the therapy and diagnosis of breast cancer

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09/602,877 US6432707B1 (en) 1997-12-24 2000-06-22 Compositions and methods for the therapy and diagnosis of breast cancer
US09/602,877 2000-06-22
US68750700A 2000-10-12 2000-10-12
US09/687,507 2000-10-12
US77838101A 2001-02-06 2001-02-06
US09/778,381 2001-02-06

Publications (2)

Publication Number Publication Date
WO2001098339A2 WO2001098339A2 (en) 2001-12-27
WO2001098339A3 true WO2001098339A3 (en) 2003-07-31

Family

ID=27416864

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019032 WO2001098339A2 (en) 2000-06-22 2001-06-12 Compositions and methods for the therapy and diagnosis of breast cancer

Country Status (2)

Country Link
AU (1) AU2001280443A1 (en)
WO (1) WO2001098339A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001035811A2 (en) * 1999-11-16 2001-05-25 Eos Biotechnology, Inc. Methods of diagnosing and determining prognosis of breast cancer
EP2275549A1 (en) * 2000-06-23 2011-01-19 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CN100354302C (en) * 2005-01-18 2007-12-12 北京大学 SIP gene and its coded protein and uses
CN100357320C (en) * 2005-01-18 2007-12-26 北京大学 ZIBC gene and its coded protein and uses

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018945A1 (en) * 1996-10-31 1998-05-07 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
WO1998021331A1 (en) * 1996-11-12 1998-05-22 Incyte Pharmaceuticals, Inc. Human breast tumor-specific proteins
WO1998033915A1 (en) * 1997-02-03 1998-08-06 Human Genome Sciences, Inc. Breast cancer specific gene 1
WO1999033869A2 (en) * 1997-12-24 1999-07-08 Corixa Corporation Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
WO2001075171A2 (en) * 2000-04-03 2001-10-11 Corixa Corporation Methods, compositions and kits for the detection and monitoring of breast cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018945A1 (en) * 1996-10-31 1998-05-07 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
WO1998021331A1 (en) * 1996-11-12 1998-05-22 Incyte Pharmaceuticals, Inc. Human breast tumor-specific proteins
WO1998033915A1 (en) * 1997-02-03 1998-08-06 Human Genome Sciences, Inc. Breast cancer specific gene 1
WO1999033869A2 (en) * 1997-12-24 1999-07-08 Corixa Corporation Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
WO2001075171A2 (en) * 2000-04-03 2001-10-11 Corixa Corporation Methods, compositions and kits for the detection and monitoring of breast cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DIATCHENKO L ET AL: "SUPPRESSION SUBTRACTIVE HYBRIDIZATION: A METHOD FOR GENERATING DIFFERENTIALLY REGULATED OR TISSUE-SPECIFIC CDNA PROBES AND LIBRARIES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 June 1996 (1996-06-01), pages 6025 - 6030, XP002911922, ISSN: 0027-8424 *
JIANG Y ET AL: "DISCOVERY OF DIFFERENTIALLY EXPRESSED GENES IN HUMAN BREAST CANCER USING SUBTRACTED CDNA LIBRARIES AND CDNA MICROARRAYS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 14, no. 21, 2002, pages 2270 - 2282, XP001075060, ISSN: 0950-9232 *
MARTIN K J ET AL: "A HYBRIDIZATION ARRAY ASSAY USING DIFFERENTIAL DISPLAY-IDENTIFIED MARKERS FOR EARLY DETECTION AND STAGING OF BREAST CANCER", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 40, 10 April 1999 (1999-04-10), pages 319, XP001026342, ISSN: 0197-016X *
XU ET AL: "Identification of differentially expressed genes in human breast tumor using substraction and microarray", CHEMICAL ABSTRACTS + INDEXES, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 40, March 1999 (1999-03-01), pages 319, XP002160220, ISSN: 0009-2258 *

Also Published As

Publication number Publication date
WO2001098339A2 (en) 2001-12-27
AU2001280443A1 (en) 2002-01-02

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