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WO2001096398A3 - Proteines bruleuses de graisses excedentaires utilisees comme cibles dans le traitement de l'insuffisance cardiaque - Google Patents

Proteines bruleuses de graisses excedentaires utilisees comme cibles dans le traitement de l'insuffisance cardiaque Download PDF

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Publication number
WO2001096398A3
WO2001096398A3 PCT/US2001/019230 US0119230W WO0196398A3 WO 2001096398 A3 WO2001096398 A3 WO 2001096398A3 US 0119230 W US0119230 W US 0119230W WO 0196398 A3 WO0196398 A3 WO 0196398A3
Authority
WO
WIPO (PCT)
Prior art keywords
heart failure
treatment
targets
uncoupling proteins
present
Prior art date
Application number
PCT/US2001/019230
Other languages
English (en)
Other versions
WO2001096398A2 (fr
Inventor
Charles J Homcy
Original Assignee
Cor Therapeutics Inc
Charles J Homcy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cor Therapeutics Inc, Charles J Homcy filed Critical Cor Therapeutics Inc
Priority to AU2001268461A priority Critical patent/AU2001268461A1/en
Publication of WO2001096398A2 publication Critical patent/WO2001096398A2/fr
Publication of WO2001096398A3 publication Critical patent/WO2001096398A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention porte sur des procédés d'identification d'un agent efficace dans le traitement de l'insuffisance cardiaque et de modulation de l'expression ou de l'activité de la protéine brûleuse de graisses excédentaires. Cette invention porte également sur des compositions et des procédés de traitement de l'insuffisance cardiaque.
PCT/US2001/019230 2000-06-15 2001-06-15 Proteines bruleuses de graisses excedentaires utilisees comme cibles dans le traitement de l'insuffisance cardiaque WO2001096398A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001268461A AU2001268461A1 (en) 2000-06-15 2001-06-15 Uncoupling proteins as targets for the treatment of heart failure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21153600P 2000-06-15 2000-06-15
US60/211,536 2000-06-15

Publications (2)

Publication Number Publication Date
WO2001096398A2 WO2001096398A2 (fr) 2001-12-20
WO2001096398A3 true WO2001096398A3 (fr) 2002-05-16

Family

ID=22787332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019230 WO2001096398A2 (fr) 2000-06-15 2001-06-15 Proteines bruleuses de graisses excedentaires utilisees comme cibles dans le traitement de l'insuffisance cardiaque

Country Status (2)

Country Link
AU (1) AU2001268461A1 (fr)
WO (1) WO2001096398A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221413B2 (en) 2009-12-23 2019-03-05 Curna, Inc. Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050894A2 (fr) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. Detection des genes lies a l'insuffisance cardiaque et dosage therapeutique
US10047395B2 (en) * 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045313A1 (fr) * 1997-04-04 1998-10-15 Amylin Pharmaceuticals, Inc. Proteine decouplante et procedes d'utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045313A1 (fr) * 1997-04-04 1998-10-15 Amylin Pharmaceuticals, Inc. Proteine decouplante et procedes d'utilisation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GENG Y-J ET AL: "APOPTOSIS OF CARDIAC MYOCYTES IN GSALPHA TRANSGENIC MICE", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 84, no. 1, 8 January 1999 (1999-01-08), pages 34 - 42, XP001007327, ISSN: 0009-7330 *
KELLY LINDA J ET AL: "Peroxisome proliferator-activated receptors gamma and alpha mediated in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression.", ENDOCRINOLOGY, vol. 139, no. 12, December 1998 (1998-12-01), pages 4920 - 4927, XP002182349, ISSN: 0013-7227 *
SILVA J ENRIQUE ET AL: "Regulation of the uncoupling protein gene expression.", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 136, no. 3, 1997, pages 251 - 264, XP000918584, ISSN: 0804-4643 *
VAN DER LEE KARIN A J M ET AL: "Effects of fatty acids on uncoupling protein-2 expression in the rat heart.", FASEB JOURNAL, vol. 14, no. 3, March 2000 (2000-03-01), pages 495 - 502, XP002182350, ISSN: 0892-6638 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221413B2 (en) 2009-12-23 2019-03-05 Curna, Inc. Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2

Also Published As

Publication number Publication date
AU2001268461A1 (en) 2001-12-24
WO2001096398A2 (fr) 2001-12-20

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