+

WO2001096398A3 - Uncoupling proteins as targets for the treatment of heart failure - Google Patents

Uncoupling proteins as targets for the treatment of heart failure Download PDF

Info

Publication number
WO2001096398A3
WO2001096398A3 PCT/US2001/019230 US0119230W WO0196398A3 WO 2001096398 A3 WO2001096398 A3 WO 2001096398A3 US 0119230 W US0119230 W US 0119230W WO 0196398 A3 WO0196398 A3 WO 0196398A3
Authority
WO
WIPO (PCT)
Prior art keywords
heart failure
treatment
targets
uncoupling proteins
present
Prior art date
Application number
PCT/US2001/019230
Other languages
French (fr)
Other versions
WO2001096398A2 (en
Inventor
Charles J Homcy
Original Assignee
Cor Therapeutics Inc
Charles J Homcy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cor Therapeutics Inc, Charles J Homcy filed Critical Cor Therapeutics Inc
Priority to AU2001268461A priority Critical patent/AU2001268461A1/en
Publication of WO2001096398A2 publication Critical patent/WO2001096398A2/en
Publication of WO2001096398A3 publication Critical patent/WO2001096398A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides methods of identifying an agent effective for the treatment of heart failure by modulating the expression or activity of uncoupling proteins (UCP). The present invention also provides compositions and methods for treating heart failure.
PCT/US2001/019230 2000-06-15 2001-06-15 Uncoupling proteins as targets for the treatment of heart failure WO2001096398A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001268461A AU2001268461A1 (en) 2000-06-15 2001-06-15 Uncoupling proteins as targets for the treatment of heart failure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21153600P 2000-06-15 2000-06-15
US60/211,536 2000-06-15

Publications (2)

Publication Number Publication Date
WO2001096398A2 WO2001096398A2 (en) 2001-12-20
WO2001096398A3 true WO2001096398A3 (en) 2002-05-16

Family

ID=22787332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019230 WO2001096398A2 (en) 2000-06-15 2001-06-15 Uncoupling proteins as targets for the treatment of heart failure

Country Status (2)

Country Link
AU (1) AU2001268461A1 (en)
WO (1) WO2001096398A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221413B2 (en) 2009-12-23 2019-03-05 Curna, Inc. Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050894A2 (en) * 2002-11-27 2004-06-17 Artesian Therapeutics, Inc. Heart failure gene determination and therapeutic screening
US10047395B2 (en) * 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045313A1 (en) * 1997-04-04 1998-10-15 Amylin Pharmaceuticals, Inc. Novel uncoupling protein and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045313A1 (en) * 1997-04-04 1998-10-15 Amylin Pharmaceuticals, Inc. Novel uncoupling protein and methods of use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GENG Y-J ET AL: "APOPTOSIS OF CARDIAC MYOCYTES IN GSALPHA TRANSGENIC MICE", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 84, no. 1, 8 January 1999 (1999-01-08), pages 34 - 42, XP001007327, ISSN: 0009-7330 *
KELLY LINDA J ET AL: "Peroxisome proliferator-activated receptors gamma and alpha mediated in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression.", ENDOCRINOLOGY, vol. 139, no. 12, December 1998 (1998-12-01), pages 4920 - 4927, XP002182349, ISSN: 0013-7227 *
SILVA J ENRIQUE ET AL: "Regulation of the uncoupling protein gene expression.", EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 136, no. 3, 1997, pages 251 - 264, XP000918584, ISSN: 0804-4643 *
VAN DER LEE KARIN A J M ET AL: "Effects of fatty acids on uncoupling protein-2 expression in the rat heart.", FASEB JOURNAL, vol. 14, no. 3, March 2000 (2000-03-01), pages 495 - 502, XP002182350, ISSN: 0892-6638 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221413B2 (en) 2009-12-23 2019-03-05 Curna, Inc. Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2

Also Published As

Publication number Publication date
AU2001268461A1 (en) 2001-12-24
WO2001096398A2 (en) 2001-12-20

Similar Documents

Publication Publication Date Title
WO1999043651A3 (en) Inhibitors of phospholipase enzymes
WO2003073999A3 (en) Pini-modulating compounds and methods of use thereof
IL189629A0 (en) Compositions containing human ctla-4 antibodies
IL183953A0 (en) Method of reducing oxidant induced damage of a food product, a pharmaceutical, or stored blood
WO2003074550A3 (en) Pin1-modulating compounds and methods of use thereof
ATE238307T1 (en) SUBSTITUTED PORPHYRINS
WO2001044247A3 (en) Agents and methods for the treatment of proliferative diseases
HK1064950A1 (en) Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
ZA971183B (en) Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants.
WO2002091858A8 (en) Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
TW200640944A (en) VGF polypeptides and methods of treating VGF-related disorders
WO2003010291A3 (en) Treatment of immune disorders and b cell disorders
EP0861663A3 (en) Osteoclastgenic inhibitory agent comprising interleukin-18
EP1254260A4 (en) Methods for diagnosing and treating heart disease
IL143516A0 (en) COMPOUNDS AND METHODS FOR MODULATING ACTIVATION OF NF-k-B
WO2004091436A3 (en) Methods and compositions for treating ocular disease
WO2000040232A3 (en) Bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
MXPA02000680A (en) Vgf polypeptides and methods of treating vgf-related disorders.
WO2002041831A3 (en) Inositol derivatives for increasing chloride secretion and inhibiting inflammation
WO2001096398A3 (en) Uncoupling proteins as targets for the treatment of heart failure
WO2002062205A3 (en) Methods for diagnosing and treating heart disease
WO2003087840A3 (en) Protein involved in cancer
WO2003017817A3 (en) Diagnosis, prevention and treatment of cancer
WO2001044235A3 (en) Agents and methods for the treatment of proliferative diseases
WO2003028536A3 (en) Methods for diagnosing and treating heart disease

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载