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WO2001090759A3 - Methode de diagnostic - Google Patents

Methode de diagnostic Download PDF

Info

Publication number
WO2001090759A3
WO2001090759A3 PCT/GB2001/002298 GB0102298W WO0190759A3 WO 2001090759 A3 WO2001090759 A3 WO 2001090759A3 GB 0102298 W GB0102298 W GB 0102298W WO 0190759 A3 WO0190759 A3 WO 0190759A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyperinsulinism
infancy
diagnostic method
atp channels
detecting altered
Prior art date
Application number
PCT/GB2001/002298
Other languages
English (en)
Other versions
WO2001090759A2 (fr
Inventor
Albert Aynsley-Green
Keith Lindley
Kevin Docherty
Mark Dunne
Roger Frank Lever James
Wendy Macfarlane
Original Assignee
Univ Aberdeen
Univ Sheffield
Univ Leicester
Univ London
Aynsley Green Albert
Keith Lindley
Kevin Docherty
Mark Dunne
Lever James R F
Wendy Macfarlane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Aberdeen, Univ Sheffield, Univ Leicester, Univ London, Aynsley Green Albert, Keith Lindley, Kevin Docherty, Mark Dunne, Lever James R F, Wendy Macfarlane filed Critical Univ Aberdeen
Priority to AU2001258611A priority Critical patent/AU2001258611A1/en
Publication of WO2001090759A2 publication Critical patent/WO2001090759A2/fr
Publication of WO2001090759A3 publication Critical patent/WO2001090759A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une méthode de diagnostic de la cause de l'hyperinsulinisme du nourrisson consistant à analyser un tissu afin de détecter des défauts dans la régulation des canaux KATP, ainsi qu'une méthode destinée à son traitement.
PCT/GB2001/002298 2000-05-23 2001-05-23 Methode de diagnostic WO2001090759A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001258611A AU2001258611A1 (en) 2000-05-23 2001-05-23 Method of diagnosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0012501.3 2000-05-23
GBGB0012501.3A GB0012501D0 (en) 2000-05-23 2000-05-23 A method of diagnosis

Publications (2)

Publication Number Publication Date
WO2001090759A2 WO2001090759A2 (fr) 2001-11-29
WO2001090759A3 true WO2001090759A3 (fr) 2002-03-28

Family

ID=9892190

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/002298 WO2001090759A2 (fr) 2000-05-23 2001-05-23 Methode de diagnostic

Country Status (3)

Country Link
AU (1) AU2001258611A1 (fr)
GB (1) GB0012501D0 (fr)
WO (1) WO2001090759A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011759A1 (fr) * 1997-09-04 1999-03-11 University Of Aberdeen LIGNEE DE CELLULES β SENSIBLE AU GLUCOSE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011759A1 (fr) * 1997-09-04 1999-03-11 University Of Aberdeen LIGNEE DE CELLULES β SENSIBLE AU GLUCOSE

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KANE C. ET AL.: "Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic xypoglycemia of infancy", NATURE MEDICINE, vol. 2, no. 12, 1996, pages 1344 - 1347, XP002181911 *
MACFARLANE WENDY M ET AL: "Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 48, 26 November 1999 (1999-11-26), pages 34059 - 34066, XP002181910, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
GB0012501D0 (en) 2000-07-12
AU2001258611A1 (en) 2001-12-03
WO2001090759A2 (fr) 2001-11-29

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