WO1992005278A3 - Procede de determination de l'expression differentielle de arn pour la proteine precurseur de l'amyloide - Google Patents
Procede de determination de l'expression differentielle de arn pour la proteine precurseur de l'amyloide Download PDFInfo
- Publication number
- WO1992005278A3 WO1992005278A3 PCT/EP1991/001772 EP9101772W WO9205278A3 WO 1992005278 A3 WO1992005278 A3 WO 1992005278A3 EP 9101772 W EP9101772 W EP 9101772W WO 9205278 A3 WO9205278 A3 WO 9205278A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- app
- precursor protein
- mrna
- amyloid precursor
- determination
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 title abstract 2
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 title abstract 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 title abstract 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 2
- 108020004999 messenger RNA Proteins 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention se rapporte à un procédé de détermination qualitative et quantitative de l'expression des différents ARNs messagers pour la protéine humaine précurseur de l'amyloïde (APP) dans les tissus biologiques humains, cette méthodologie pouvant être utilisée pour effectuer un contrôle diagnostique de la maladie d'Alzheimer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT04169190A IT1243515B (it) | 1990-09-17 | 1990-09-17 | Metodo per la determinazione della espressione differenziale degli rna messangers per la proteina precursore dell'amiloide (amyloid precursor protein, app) |
| IT41691A/90 | 1990-09-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1992005278A2 WO1992005278A2 (fr) | 1992-04-02 |
| WO1992005278A3 true WO1992005278A3 (fr) | 1992-05-14 |
Family
ID=11253064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1991/001772 WO1992005278A2 (fr) | 1990-09-17 | 1991-09-17 | Procede de determination de l'expression differentielle de arn pour la proteine precurseur de l'amyloide |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN1062925A (fr) |
| AU (1) | AU8492591A (fr) |
| IT (1) | IT1243515B (fr) |
| WO (1) | WO1992005278A2 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| NZ242955A (en) * | 1991-06-13 | 1995-01-27 | Ici Plc | Dna containing gene sequences corresponding to sequences causing alzheimers disease, detection, recombinant yeast with such code |
| CA2129787A1 (fr) * | 1993-08-27 | 1995-02-28 | Russell G. Higuchi | Surveillance de plusieurs reactions d'amplification simultanement et analyse de ces reactions simultanement |
| CN103884698B (zh) | 2004-06-07 | 2017-04-12 | 先锋生物科技股份有限公司 | 用于微流体器件的光学透镜系统和方法 |
| US7874026B2 (en) | 2007-08-24 | 2011-01-25 | Double Space Bed Systems, Inc. | System and method for raising and lowering a bed |
| CN105717182B (zh) * | 2016-03-10 | 2018-05-11 | 中南大学 | 一种用于同步检测淀粉样多肽单体和聚集体的生物传感器及其构建方法和应用 |
-
1990
- 1990-09-17 IT IT04169190A patent/IT1243515B/it active IP Right Grant
-
1991
- 1991-09-17 AU AU84925/91A patent/AU8492591A/en not_active Abandoned
- 1991-09-17 CN CN91109788A patent/CN1062925A/zh active Pending
- 1991-09-17 WO PCT/EP1991/001772 patent/WO1992005278A2/fr active Application Filing
Non-Patent Citations (8)
| Title |
|---|
| Biochemical and Biophysical Research Communications, vol. 157, no. 2, 15 December 1988, S. TANAKA et al.: "Three types anyloid protein precursor mRNA in human brain: their differential expression in Alzheimer's disease", pages 472-479, see whole article * |
| Biochemical and Biophysical Research Communications, vol. 166, no. 3, 14 February 1990, J. KANG et al.: "Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4695 mRNA is predominantly produced in rat and human brain", pages 1192-1200, see whole article * |
| Biochemical and Biophysical Research Communications, vol. 171, no. 1, 31 August 1990, K. YOSHIKAWA et al.: "Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells", pages 204-209, see whole article * |
| Cellular and Molecular Neurobiology, vol. 10, no. 4, December 1990, R.J. DONNELLY et al.: "Interleukin-1 stimulates the beta-amyloid precursor protein promoter", pages 485-496, see summary * |
| FEBS Letters, vol. 241, no. 1,2, December 1988, L. AUTILIO-GAMBETTI et al.: "The amyloid precursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types", pages 94-98, see whole article * |
| Proceedings of the National Academy of Science of USA, vol. 86, October 1989, D. GOLDGABER et al.: "Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells", pages 7606-7610, see whole article (cited in the application) * |
| Proceedings of the National Academy of Sciences of USA, vol. 88, January 1991, M.J. ADLER et al.: "Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts", pages 16-20, see whole article * |
| Science, vol. 241, no. 4869, 26 August 1988, M.R. PALMERT et al.: "Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease", pages 1080-1804, see whole article * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU8492591A (en) | 1992-04-15 |
| IT9041691A0 (it) | 1990-09-17 |
| IT9041691A1 (it) | 1992-03-17 |
| WO1992005278A2 (fr) | 1992-04-02 |
| CN1062925A (zh) | 1992-07-22 |
| IT1243515B (it) | 1994-06-16 |
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