WO2001079427A3 - Nouveau polypeptide, canal ionique humain 9 pour le chlore, et polynucleotide codant pour ce polypeptide - Google Patents
Nouveau polypeptide, canal ionique humain 9 pour le chlore, et polynucleotide codant pour ce polypeptide Download PDFInfo
- Publication number
- WO2001079427A3 WO2001079427A3 PCT/CN2001/000376 CN0100376W WO0179427A3 WO 2001079427 A3 WO2001079427 A3 WO 2001079427A3 CN 0100376 W CN0100376 W CN 0100376W WO 0179427 A3 WO0179427 A3 WO 0179427A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptide
- chlorine
- polynucleotide encoding
- ion channel
- discloses
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 title abstract 3
- 102000004310 Ion Channels Human genes 0.000 title abstract 3
- 229910052801 chlorine Inorganic materials 0.000 title abstract 3
- 239000000460 chlorine Substances 0.000 title abstract 3
- 102000040430 polynucleotide Human genes 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 3
- 239000002157 polynucleotide Substances 0.000 title abstract 3
- 206010012559 Developmental delay Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne un nouveau polypeptide, un canal ionique humain 9 pour le chlore, et un polynucléotide codant pour ce polypeptide ainsi qu'un procédé d'obtention de ce polypeptide par des techniques recombinantes d'ADN. L'invention concerne en outre les applications de ce polypeptide dans le traitement de maladies, notamment de la paramyotonie, des tumeurs malignes, de l'hémopathie, des troubles du développement, de l'infection par VIH, de maladies immunitaires et de diverses inflammations. L'invention concerne aussi l'antagoniste agissant contre le polypeptide et son action thérapeutique ainsi que les applications de ce polynucléotide codant pour le canal ionique humain 9 pour le chlore.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU56055/01A AU5605501A (en) | 2000-03-22 | 2001-03-19 | A novel polypeptide, a human ion channel 9 for chlorine and the polynucleotide encoding the polypeptide |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00115062A CN1314411A (zh) | 2000-03-22 | 2000-03-22 | 一种新的多肽——人氯离子通道蛋白9和编码这种多肽的多核苷酸 |
| CN00115062.6 | 2000-03-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2001079427A2 WO2001079427A2 (fr) | 2001-10-25 |
| WO2001079427A3 true WO2001079427A3 (fr) | 2002-01-24 |
Family
ID=4584533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2001/000376 WO2001079427A2 (fr) | 2000-03-22 | 2001-03-19 | Nouveau polypeptide, canal ionique humain 9 pour le chlore, et polynucleotide codant pour ce polypeptide |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1314411A (fr) |
| AU (1) | AU5605501A (fr) |
| WO (1) | WO2001079427A2 (fr) |
-
2000
- 2000-03-22 CN CN00115062A patent/CN1314411A/zh active Pending
-
2001
- 2001-03-19 AU AU56055/01A patent/AU5605501A/en not_active Abandoned
- 2001-03-19 WO PCT/CN2001/000376 patent/WO2001079427A2/fr active Application Filing
Non-Patent Citations (4)
| Title |
|---|
| BRANDT S. AND JENTSCH T.J.: "CLC-6 and CLC-7 are two novel broadly expressed members of the CLC chloride channel family", FEBS LETT., vol. 377, no. 1, 1995, pages 15 - 20 * |
| CLAVERIE J.M. AND MAKALOWSKI W.: "Alu alert", NATURE, vol. 371, no. 6500, 1994, pages 752 * |
| LAMB F.S. ET AL.: "Expression of CLCN voltage-gated chloride channel genes in human blood vessels", J. MOL. CELL. CARDIOL., vol. 31, no. 3, 1999, pages 657 - 666 * |
| THIEMANN A. ET AL.: "A chloride channel widely expressed in epithelial and non-epithelial cells", NATURE, vol. 356, no. 6364, 1992, pages 57 - 60 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001079427A2 (fr) | 2001-10-25 |
| CN1314411A (zh) | 2001-09-26 |
| AU5605501A (en) | 2001-10-30 |
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