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WO2001064198A3 - Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives - Google Patents

Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives Download PDF

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Publication number
WO2001064198A3
WO2001064198A3 PCT/EP2001/002167 EP0102167W WO0164198A3 WO 2001064198 A3 WO2001064198 A3 WO 2001064198A3 EP 0102167 W EP0102167 W EP 0102167W WO 0164198 A3 WO0164198 A3 WO 0164198A3
Authority
WO
WIPO (PCT)
Prior art keywords
transferase inhibitor
protein transferase
farnesyl protein
podophyllotoxin derivatives
inhibitor combinations
Prior art date
Application number
PCT/EP2001/002167
Other languages
French (fr)
Other versions
WO2001064198A2 (en
Inventor
Mary Ellen Margaret Rybak
Original Assignee
Janssen Pharmaceutica Nv
Mary Ellen Margaret Rybak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Mary Ellen Margaret Rybak filed Critical Janssen Pharmaceutica Nv
Priority to EP01913838A priority Critical patent/EP1267871A2/en
Priority to AU2001239275A priority patent/AU2001239275A1/en
Priority to JP2001563095A priority patent/JP2003525238A/en
Priority to CA002397256A priority patent/CA2397256A1/en
Publication of WO2001064198A2 publication Critical patent/WO2001064198A2/en
Publication of WO2001064198A3 publication Critical patent/WO2001064198A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is concerned with combinations of a farnesyl transferase inhibitor and an anti-tumor podophyllotoxin derivative for inhibiting the growth of tumor cells and useful in the treatment of cancer.
PCT/EP2001/002167 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives WO2001064198A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01913838A EP1267871A2 (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
AU2001239275A AU2001239275A1 (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
JP2001563095A JP2003525238A (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with antitumor podophyllotoxin derivatives
CA002397256A CA2397256A1 (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00200695 2000-02-29
EP00200695.5 2000-02-29

Publications (2)

Publication Number Publication Date
WO2001064198A2 WO2001064198A2 (en) 2001-09-07
WO2001064198A3 true WO2001064198A3 (en) 2002-03-21

Family

ID=8171114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/002167 WO2001064198A2 (en) 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives

Country Status (5)

Country Link
EP (1) EP1267871A2 (en)
JP (1) JP2003525238A (en)
AU (1) AU2001239275A1 (en)
CA (1) CA2397256A1 (en)
WO (1) WO2001064198A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080113028A1 (en) 2004-09-22 2008-05-15 Kazuhisa Shimizu Novel Block Copolymer, Micelle Preparation, And Anticancer Agent Containing The Same As Active Ingredient
CA2634598A1 (en) 2005-12-23 2007-07-05 Link Medicine Corporation Treatment of synucleinopathies
WO2007111211A1 (en) 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
EP2019122A4 (en) * 2006-05-18 2009-07-01 Nippon Kayaku Kk Polymer conjugate of podophyllotoxin
JP5503872B2 (en) 2006-11-06 2014-05-28 日本化薬株式会社 Polymer derivatives of nucleic acid antimetabolites
EP2090607B1 (en) 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
WO2009136572A1 (en) 2008-05-08 2009-11-12 日本化薬株式会社 Polymer conjugate of folic acid or folic acid derivative
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
WO2012067138A1 (en) 2010-11-17 2012-05-24 日本化薬株式会社 Novel polymer derivative of cytidine metabolism antagonist
RU2623426C2 (en) 2011-09-11 2017-06-26 Ниппон Каяку Кабусики Кайся Method of obtaining a block copolymer
PE20150778A1 (en) 2012-10-16 2015-05-23 Janssen Pharmaceutica Nv ROR-GAMMA-T METHYLENE-LINKED QUINOLINYL MODULATORS
CA2888480C (en) 2012-10-16 2021-03-16 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of ror.gamma.t
EP2909193B1 (en) 2012-10-16 2017-04-19 Janssen Pharmaceutica NV Phenyl linked quinolinyl modulators of ror-gamma-t
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
JP6608358B2 (en) 2013-10-15 2019-11-20 ヤンセン ファーマシューティカ エヌ．ベー． RoRyT quinolinyl modulator
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
CA2926339A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of roryt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016443A1 (en) * 1995-10-31 1997-05-09 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 2-quinolone derivatives
WO1997021701A1 (en) * 1995-12-08 1997-06-19 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives
WO1998040383A1 (en) * 1997-03-10 1998-09-17 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with n- or c-linked imidazoles
WO1998049157A1 (en) * 1997-04-25 1998-11-05 Janssen Pharmaceutica N.V. Farnesyltransferase inhibiting quinazolinones
WO1999032114A1 (en) * 1997-12-22 1999-07-01 Schering Corporation Combination of benzocycloheptapyridine compounds and antineoplastic drugs for treating proliferative diseases
WO1999065494A1 (en) * 1998-06-15 1999-12-23 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000001382A1 (en) * 1998-07-02 2000-01-13 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000039082A2 (en) * 1998-12-23 2000-07-06 Janssen Pharmaceutica N.V. 1,2-annelated quinoline derivatives

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016443A1 (en) * 1995-10-31 1997-05-09 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 2-quinolone derivatives
WO1997021701A1 (en) * 1995-12-08 1997-06-19 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives
WO1998040383A1 (en) * 1997-03-10 1998-09-17 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with n- or c-linked imidazoles
WO1998049157A1 (en) * 1997-04-25 1998-11-05 Janssen Pharmaceutica N.V. Farnesyltransferase inhibiting quinazolinones
WO1999032114A1 (en) * 1997-12-22 1999-07-01 Schering Corporation Combination of benzocycloheptapyridine compounds and antineoplastic drugs for treating proliferative diseases
WO1999065494A1 (en) * 1998-06-15 1999-12-23 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000001382A1 (en) * 1998-07-02 2000-01-13 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000039082A2 (en) * 1998-12-23 2000-07-06 Janssen Pharmaceutica N.V. 1,2-annelated quinoline derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHELLENS J H M ET AL: "PHASE I AND PHARMACOLOGIC STUDY WITH THE NOVEL FARNESYLTRANSFERASE INHIBITOR (FTI) R15777", SHIPBUILDING AND SHIPPING RECORD, IP INDUSTRIAL PRESS LTD. LONDON, GB, vol. 40, March 1999 (1999-03-01), pages 724, XP000952727 *

Also Published As

Publication number Publication date
JP2003525238A (en) 2003-08-26
EP1267871A2 (en) 2003-01-02
CA2397256A1 (en) 2001-09-07
AU2001239275A1 (en) 2001-09-12
WO2001064198A2 (en) 2001-09-07

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