AU2001239275A1 - Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives - Google Patents

Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives

Info

Publication number: AU2001239275A1
Authority: AU; Australia
Prior art keywords: protein transferase; transferase inhibitor; farnesyl protein; podophyllotoxin derivatives; inhibitor combinations
Prior art date: 2000-02-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001239275A

Inventor

Mary Ellen Margaret Rybak

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-29

Filing date

2001-02-26

Publication date

2001-09-12

2001-02-26 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2001-09-12 Publication of AU2001239275A1 publication Critical patent/AU2001239275A1/en

Status Abandoned legal-status Critical Current

Links

230000000259 anti-tumor effect Effects 0.000 title 1
229940045696 antineoplastic drug podophyllotoxin derivative Drugs 0.000 title 1
YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical class COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 title 1
239000003600 podophyllotoxin derivative Substances 0.000 title 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AU2001239275A 2000-02-29 2001-02-26 Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives Abandoned AU2001239275A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP00200695		2000-02-29
EP00200695		2000-02-29
PCT/EP2001/002167 WO2001064198A2 (en)	2000-02-29	2001-02-26	Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives

Publications (1)

Publication Number	Publication Date
AU2001239275A1 true AU2001239275A1 (en)	2001-09-12

Family

ID=8171114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001239275A Abandoned AU2001239275A1 (en)	2000-02-29	2001-02-26	Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives

Country Status (5)

Country	Link
EP (1)	EP1267871A2 (en)
JP (1)	JP2003525238A (en)
AU (1)	AU2001239275A1 (en)
CA (1)	CA2397256A1 (en)
WO (1)	WO2001064198A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1792927T3 (en)	2004-09-22	2013-06-10	Nippon Kayaku Kk	New block copolymer, micelle preparation and anticancer agent containing the same as active ingredient
JP2009521470A (en)	2005-12-23	2009-06-04	リンクメディシンコーポレイション	Treatment of synuclein disorder
KR20080106254A (en)	2006-03-28	2008-12-04	니폰 가야꾸 가부시끼가이샤	Polymeric conjugates of taxanes
WO2007135910A1 (en) *	2006-05-18	2007-11-29	Nippon Kayaku Kabushiki Kaisha	Polymer conjugate of podophyllotoxin
JP5503872B2 (en)	2006-11-06	2014-05-28	日本化薬株式会社	Polymer derivatives of nucleic acid antimetabolites
JP5548365B2 (en)	2006-11-08	2014-07-16	日本化薬株式会社	Polymer derivatives of nucleic acid antimetabolites
US8703878B2 (en)	2007-09-28	2014-04-22	Nippon Kayaku Kabushiki Kaisha	High-molecular weight conjugate of steroids
CN101977631A (en)	2008-03-18	2011-02-16	日本化药株式会社	Polymer conjugate of physiologically active substance
JP5366940B2 (en)	2008-05-08	2013-12-11	日本化薬株式会社	Polymer conjugate of folic acid or folic acid derivative
US8808749B2 (en)	2009-05-15	2014-08-19	Nippon Kayaku Kabushiki Kaisha	Polymer conjugate of bioactive substance having hydroxy group
TW201304805A (en)	2010-11-17	2013-02-01	Nippon Kayaku Kk	Novel polymer derivative of cytidine metabolism antagonist
WO2013035641A1 (en)	2011-09-11	2013-03-14	日本化薬株式会社	Method for manufacturing block copolymer
MY189505A (en)	2012-10-16	2022-02-16	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of roryt
CA2888485C (en)	2012-10-16	2021-01-26	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of ror.gamma.t
CN104884448A (en)	2012-10-16	2015-09-02	詹森药业有限公司	Heteroaryl linked quinolinyl modulators of roryt
US9346782B2 (en)	2013-10-15	2016-05-24	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9624225B2 (en)	2013-10-15	2017-04-18	Janssen Pharmaceutica Nv	Quinolinyl modulators of RORγt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW349948B (en) *	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
KR100272676B1 (en) *	1995-12-08	2000-11-15	디르크 반테	Farnesyl protein transferase inhibiting (imidazol-5-yl) methyl-2-quinolinone derivatives
TW591030B (en) *	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
CA2288140C (en) *	1997-04-25	2007-04-03	Janssen Pharmaceutica N.V.	Farnesyltransferase inhibiting quinazolinones
ES2255196T3 (en) *	1997-12-22	2006-06-16	Schering Corporation	COMBINATION OF BENZOCICLOHEPTAPIRIDINA COMPOUNDS AND ANTINEOPLASIC PHARMACOS FOR THE TREATMENT OF PROLIFERATIVE DISEASES.
WO1999065494A1 (en) *	1998-06-15	1999-12-23	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
WO2000001382A1 (en) *	1998-07-02	2000-01-13	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
SI1140935T1 (en) *	1998-12-23	2003-10-31	Janssen Pharmaceutica N.V.	1,2-annelated quinoline derivatives

2001
- 2001-02-26 JP JP2001563095A patent/JP2003525238A/en not_active Withdrawn
- 2001-02-26 AU AU2001239275A patent/AU2001239275A1/en not_active Abandoned
- 2001-02-26 WO PCT/EP2001/002167 patent/WO2001064198A2/en not_active Application Discontinuation
- 2001-02-26 CA CA002397256A patent/CA2397256A1/en not_active Abandoned
- 2001-02-26 EP EP01913838A patent/EP1267871A2/en not_active Withdrawn

Also Published As

Publication number	Publication date
JP2003525238A (en)	2003-08-26
EP1267871A2 (en)	2003-01-02
WO2001064198A2 (en)	2001-09-07
CA2397256A1 (en)	2001-09-07
WO2001064198A3 (en)	2002-03-21

Publication	Publication Date	Title
AU2001239275A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
AU2001240658A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with camptothecin compounds
AU2001246477A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with platinum compounds
AU2001256166A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives
AU2001254672A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with an her2 antibody
AU2001235496A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents
AU6622396A (en)	1997-03-05	4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors
AU2001252147A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations
IL143409A0 (en)	2002-04-21	Farnesyl protein transferase inhibitors
AU2001293835A1 (en)	2002-04-02	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
AU2001246478A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with taxane compounds
AU2001247882A1 (en)	2001-10-08	Tricyclic protein kinase inhibitors
AU2001244167A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives
IL154528A0 (en)	2003-09-17	Tricyclic antitumor compounds being farnesyl protein transferase inhibitors
AU2001253197A1 (en)	2001-11-07	Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
AU2001264280A1 (en)	2002-03-14	Vitamin D derivatives
IL163673A0 (en)	2005-12-18	Farnesyl protein transferase inhibitors as antitumor agents
AU2001248777A1 (en)	2001-10-30	Vitamin d derivatives
AU2001250321A1 (en)	2001-09-03	Homogentisate phytyl transferase
AU4020897A (en)	1998-03-06	3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
AU2001242434A1 (en)	2001-09-12	Farnesyl protein transferase inhibitor combinations with vinca alkaloids
IL143408A0 (en)	2002-04-21	Tricyclic farnesyl protein transferase inhibitors
AU2435199A (en)	1999-08-30	Farnesyl transferase inhibitors
AU1304801A (en)	2001-05-30	Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect
PL355887A1 (en)	2004-05-31	Farnesyl transferase inhibitors