WO2000053579A3 - Solid phase synthesis of 4-aminoproline derivatives and/or combinatorial libraries thereof - Google Patents
Solid phase synthesis of 4-aminoproline derivatives and/or combinatorial libraries thereof Download PDFInfo
- Publication number
- WO2000053579A3 WO2000053579A3 PCT/US2000/006021 US0006021W WO0053579A3 WO 2000053579 A3 WO2000053579 A3 WO 2000053579A3 US 0006021 W US0006021 W US 0006021W WO 0053579 A3 WO0053579 A3 WO 0053579A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- solid phase
- phase synthesis
- optionally substituted
- aminoproline
- Prior art date
Links
- 238000010532 solid phase synthesis reaction Methods 0.000 title abstract 2
- SHINASQYHDCLEU-BKLSDQPFSA-N (2s)-4-aminopyrrolidine-2-carboxylic acid Chemical class NC1CN[C@H](C(O)=O)C1 SHINASQYHDCLEU-BKLSDQPFSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU35174/00A AU3517400A (en) | 1999-03-10 | 2000-03-08 | Proline derivatives and synthesis thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12363199P | 1999-03-10 | 1999-03-10 | |
US60/123,631 | 1999-03-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000053579A2 WO2000053579A2 (en) | 2000-09-14 |
WO2000053579A3 true WO2000053579A3 (en) | 2000-12-21 |
Family
ID=22409844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/006021 WO2000053579A2 (en) | 1999-03-10 | 2000-03-08 | Solid phase synthesis of 4-aminoproline derivatives and/or combinatorial libraries thereof |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU3517400A (en) |
WO (1) | WO2000053579A2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994024314A1 (en) * | 1993-04-19 | 1994-10-27 | Kauffman Stuart A | Random chemistry for the generation of new compounds |
WO1998020350A1 (en) * | 1996-11-05 | 1998-05-14 | Pharmacopeia, Inc. | Combinatorial hydroxy-amino acid amide libraries |
-
2000
- 2000-03-08 AU AU35174/00A patent/AU3517400A/en not_active Abandoned
- 2000-03-08 WO PCT/US2000/006021 patent/WO2000053579A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994024314A1 (en) * | 1993-04-19 | 1994-10-27 | Kauffman Stuart A | Random chemistry for the generation of new compounds |
WO1998020350A1 (en) * | 1996-11-05 | 1998-05-14 | Pharmacopeia, Inc. | Combinatorial hydroxy-amino acid amide libraries |
Non-Patent Citations (4)
Title |
---|
BALKENHOHL F. ET AL.: "Combinatorial synthesis of small organic molecules", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, DE, VERLAG CHEMIE. WEINHEIM, vol. 35, no. 20, 1996, pages 2288 - 2337, XP002065423, ISSN: 0570-0833 * |
BRAY A.M. ET AL.: "Rapid optimization of organic reactions on solid phase using the multipin approach: Synthesis of 4-aminoproline analogues by reductive amination", TETRAHEDRON LETTERS, NL, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 36, no. 28, 10 July 1995 (1995-07-10), pages 5081 - 5084, XP004027743, ISSN: 0040-4039 * |
NEFZI A. ET AL.: "The current status of heterocyclic combinatorial libraries", CHEMICAL REVIEWS, US, AMERICAN CHEMICAL SOCIETY. EASTON, vol. 97, no. 2, 1 April 1997 (1997-04-01), pages 449 - 472, XP002144163 * |
TERRETT N K ET AL: "Combinatorial synthesis - The design of compound libraries and their application to drug discovery", TETRAHEDRON, NL, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 51, no. 30, 24 July 1995 (1995-07-24), pages 8135 - 8173, XP000644580, ISSN: 0040-4020 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000053579A2 (en) | 2000-09-14 |
AU3517400A (en) | 2000-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1008592A3 (en) | Cyclic amide derivatives which inhibit cathepsin K | |
MY130830A (en) | Inhibitors | |
AP9901538A0 (en) | 8-Azabicyclo(3,2,1) octane-88-azabicycle(3,2,1) oct-6-ene-, 9- azabicycle(3,3,1) nonana-9-aza-3- oxabicylo(3,3,1) nonane-and 9-aza-3- thiabicyclo(3,3,1) nonane derivatives, their preparation and their use as insecticides. | |
WO2002000650A3 (en) | Novel compounds possessing antibacterial, antifungal or antitumor activity | |
CA2155104A1 (en) | Heterocyclic-substituted alkyl amide acat inhibitors | |
ATE394373T1 (en) | SYNTHESIS OF INDOLTHIAZOLE COMPOUNDS AS LIGANDS OF THE AH RECEPTOR | |
TW200724136A (en) | Pharmaceutical compositions comprising PPAR modulator | |
AU6241894A (en) | 4-alkoxy-2,6-di-t-butylphenol derivative | |
CA1317960C (en) | Derivatives of bicyclic aminocarboxylic acids, a process and intermediates for their preparation, and their use | |
WO2003095427A1 (en) | Spiro-ring compound | |
EP0792880A4 (en) | Osteoporosis remedy and triazepine compound | |
WO1997031016A3 (en) | New inhibitors of sh2-mediated processes | |
WO2001094318A3 (en) | Method for synthesis of substituted azole libraries | |
WO2000053579A3 (en) | Solid phase synthesis of 4-aminoproline derivatives and/or combinatorial libraries thereof | |
RU94036445A (en) | Derivatives of oxadiazolecarbonamide, method of their synthesis, intermediate compounds, method of their synthesis, herbicide composition, method of struggle against weed | |
EP1908752A4 (en) | Novel 2-quinolone derivative | |
WO2001094317A3 (en) | Method for synthesis of substituted azole libraries | |
CA2203850A1 (en) | Novel n-phenyl-n-phenyliminonethylbenzamidines and their analogues as muscarinic receptor agonists | |
WO1998045254A3 (en) | Oxime compounds, their use, and intermediates for their production | |
EP0717039A4 (en) | Novel triazole compound, process for producing the same, and pest control agent | |
EA200101209A1 (en) | NEW DERIVATIVES OF BENZENE, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
WO2002074050A3 (en) | Asymmetric synthesis of (s, s, r)-(-)-actinonin and its analogs and uses therefor | |
EP0656355A4 (en) | Biphenylmethane derivative and medicine containing the same. | |
WO2000064902A3 (en) | Process for the preparation of calanolide precursors | |
DK0727423T3 (en) | Process for the preparation of sulfonylurea derivatives and intermediates for this process |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase |