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WO1997031016A3 - New inhibitors of sh2-mediated processes - Google Patents

New inhibitors of sh2-mediated processes Download PDF

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Publication number
WO1997031016A3
WO1997031016A3 PCT/US1997/002636 US9702636W WO9731016A3 WO 1997031016 A3 WO1997031016 A3 WO 1997031016A3 US 9702636 W US9702636 W US 9702636W WO 9731016 A3 WO9731016 A3 WO 9731016A3
Authority
WO
WIPO (PCT)
Prior art keywords
mediated processes
new inhibitors
compounds
forms
heteroalkyl
Prior art date
Application number
PCT/US1997/002636
Other languages
French (fr)
Other versions
WO1997031016A2 (en
Inventor
Berkley A Lynch
Manfred Weigele
Original Assignee
Ariad Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ariad Pharma Inc filed Critical Ariad Pharma Inc
Priority to AU22775/97A priority Critical patent/AU2277597A/en
Publication of WO1997031016A2 publication Critical patent/WO1997031016A2/en
Publication of WO1997031016A3 publication Critical patent/WO1997031016A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, where A is H, R?1, -CO-R1¿ or -CO-OR1 where R1 is a substituted or unsubstituted alkyl, heteroalkyl, aryl or heteroaryl group and J is H or NO¿2?. L-forms of the compounds are currently preferred, although D- forms and racemic mixtures are also encompassed by this invention.
PCT/US1997/002636 1996-02-23 1997-02-21 New inhibitors of sh2-mediated processes WO1997031016A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU22775/97A AU2277597A (en) 1996-02-23 1997-02-21 New inhibitors of sh2-mediated processes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1220396P 1996-02-23 1996-02-23
US60/012,203 1996-02-23

Publications (2)

Publication Number Publication Date
WO1997031016A2 WO1997031016A2 (en) 1997-08-28
WO1997031016A3 true WO1997031016A3 (en) 1998-02-19

Family

ID=21753844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/002636 WO1997031016A2 (en) 1996-02-23 1997-02-21 New inhibitors of sh2-mediated processes

Country Status (2)

Country Link
AU (1) AU2277597A (en)
WO (1) WO1997031016A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730671B2 (en) 1999-03-02 2004-05-04 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathespin S
US6756372B2 (en) 1999-09-13 2004-06-29 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cysteine proteases

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105307B2 (en) 1997-08-30 2006-09-12 Cyclacel, Ltd. Compositions and methods for screening for modulators of enzymatic activity
AU1457299A (en) * 1997-11-12 1999-05-31 Ariad Pharmaceuticals, Inc. Novel signal transduction inhibitors, compositions containing them
DE69839221T2 (en) * 1997-12-18 2009-04-30 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield PYRIDONE AS AN INHIBITOR OF THE SH2 DOMAIN OF THE SRC FAMILY
US6156784A (en) * 1997-12-18 2000-12-05 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as phosphotyrosine mimics
CA2319493A1 (en) * 1998-03-18 1999-09-23 Regine Bohacek Heterocyclic signal transduction inhibitors, compositions containing them
EP1129068A1 (en) * 1998-11-12 2001-09-05 Ariad Pharmaceuticals, Inc. Bicyclic signal transduction inhibitors, composition containing them and uses thereof
US7405210B2 (en) 2003-05-21 2008-07-29 Osi Pharmaceuticals, Inc. Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
JP2007527904A (en) 2004-03-08 2007-10-04 プロシディオン・リミテッド Pyrrolopyridine-2-carboxylic acid hydrazide compounds as glycogen phosphorylase inhibitors
WO2006059164A2 (en) 2004-12-02 2006-06-08 Prosidion Limited Pyrrolopyridine-2-carboxylic acid amides
CA2571800A1 (en) * 2005-12-23 2007-06-23 Canadian Blood Services Nitrophenyls and related compounds and thimerosal for the inhibition of immune related cell or tissue destruction
EP3672939A1 (en) 2017-08-21 2020-07-01 Celgene Corporation Processes for preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996023813A1 (en) * 1995-02-01 1996-08-08 Affymax Technologies N.V. Peptides and compounds that bind to sh2 domains

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996023813A1 (en) * 1995-02-01 1996-08-08 Affymax Technologies N.V. Peptides and compounds that bind to sh2 domains

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
AUST. J. CHEMISTRY, vol. 32, no. 4, 1979, pages 923 - 925 *
BIOCHEM. J., vol. 113, no. 2, 1969, pages 369 - 375 *
CHEMICAL ABSTRACTS, vol. 102, no. 21, 27 May 1985, Columbus, Ohio, US; abstract no. 185509, I Z SIEMION ET AL.: "Leucime-enkephaline derivatives" XP002049634 *
CHEMICAL ABSTRACTS, vol. 104, no. 11, 17 March 1986, Columbus, Ohio, US; abstract no. 82165, M ALEKSANDROVA ET AL.: "Synthesis, receptor binding affinities and alpha-MSH releasing activities of TRH analogs" XP002049633 *
CHEMICAL ABSTRACTS, vol. 108, no. 1, 4 January 1988, Columbus, Ohio, US; abstract no. 6390, N PANT ET AL.: "Synthetic analogs of peptide-binding antibiotics" page 611; XP002049632 *
CHEMICAL ABSTRACTS, vol. 108, no. 19, 9 May 1988, Columbus, Ohio, US; abstract no. 167944, J-L MORINIÈRE ET AL.: "The use of hydrolases in organic chemistry; synthesis of amides and ester bonds catalyzed by industrial papain" XP002049631 *
CHEMICAL ABSTRACTS, vol. 111, no. 15, 9 October 1989, Columbus, Ohio, US; abstract no. 134720d, A D HAMILTON ET AL.: "Artificial receptors for biologically active molecules" XP002049630 *
CHEMICAL ABSTRACTS, vol. 113, no. 9, 27 August 1990, Columbus, Ohio, US; abstract no. 78953j, XP002049629 *
CHEMICAL ABSTRACTS, vol. 70, no. 11, 17 March 1969, Columbus, Ohio, US; abstract no. 44247, L A COHEN & L FARBER: "Cleavage of tyrosyl-peptide bonds by electrolytic oxidation" XP002049637 *
CHEMICAL ABSTRACTS, vol. 71, no. 13, 29 September 1969, Columbus, Ohio, US; abstract no. 57012, A CORNISH-BOWDEN ET AL.: "Rate-determining step in pepsin-catalyzed reactions and evidence against an acyl-enzyme intermediate" XP002049636 *
CHEMICAL ABSTRACTS, vol. 91, no. 11, 10 September 1979, Columbus, Ohio, US; abstract no. 91943, F H C STEWART ET AL.: "Preparation of anionic active ester derivatives of amino acids" XP002049635 *
EUR. J. MED. CHEM., vol. 22, no. 4, 1987, pages 347 - 357 *
F H CARPENTER ET AL.: "[Tetrakis(3-nitrotyrosine)] insuline", BIOCHEMISTRY., vol. 19, no. 25, 1980, EASTON, PA US, pages 5926 - 5931, XP002049625 *
H BARTOSZ-BECHOWSKI ET AL.: "Further studies on proctolin analogues modified in position 2 of the peptide chain and their influence on heart-beat frequency of insects", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH., vol. 36, 1990, COPENHAGEN DK, pages 450 - 456, XP002049628 *
J. INCLUSION PHENOM., vol. 5, no. 1, 1987, pages 109 - 111 *
K BLAHA: "Amino acids and peptides XCV. Synthesis of some diastereoisomeric 2,5-piperazinediones", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS., vol. 34, no. 12, December 1969 (1969-12-01), PRAGUE CS, pages 4000 - 4005, XP002049627 *
METH. ENZYMOL., vol. 11, 1967, pages 299 - 308 *
N I BAVYKINA ET AL.: "Synthesis of diketopiperazine related to cyclohistidylproline", ZH. OBSHCH. KHIM., vol. 60, no. 1, 1990, pages 170 - 175 *
N PANT & A D HAMILTON: "Carboxylic acid complexation by a synthetic analogue of the "carboxylate-binding pocket" of vancomycin", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 110, no. 6, 1988, DC US, pages 2002 - 2003, XP002049626 *
POL. J. PHARMACOL. PHARM., vol. 37, no. 2, 1985, pages 197 - 207 *
PURE APPL. CHEM., vol. 60, no. 4, 1988, pages 533 - 538 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730671B2 (en) 1999-03-02 2004-05-04 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathespin S
US6756372B2 (en) 1999-09-13 2004-06-29 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cysteine proteases
US6982272B2 (en) 1999-09-13 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cysteine proteases
US7056915B2 (en) 1999-09-13 2006-06-06 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cysteine proteases
US7265132B2 (en) 1999-09-13 2007-09-04 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cysteine proteases
US7279472B2 (en) 1999-09-13 2007-10-09 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cysteine proteases
US6858623B2 (en) 2000-09-08 2005-02-22 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cysteine proteases

Also Published As

Publication number Publication date
AU2277597A (en) 1997-09-10
WO1997031016A2 (en) 1997-08-28

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