WO2000053259A1 - Methode de therapie genique et appareil correspondant a impulsions et ondes electro-magnetiques - Google Patents
Methode de therapie genique et appareil correspondant a impulsions et ondes electro-magnetiques Download PDFInfo
- Publication number
- WO2000053259A1 WO2000053259A1 PCT/KR2000/000198 KR0000198W WO0053259A1 WO 2000053259 A1 WO2000053259 A1 WO 2000053259A1 KR 0000198 W KR0000198 W KR 0000198W WO 0053259 A1 WO0053259 A1 WO 0053259A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- magnetic field
- field generating
- generating part
- regulates
- gene therapeutic
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 37
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 15
- 230000001105 regulatory effect Effects 0.000 claims abstract description 27
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 23
- 208000026350 Inborn Genetic disease Diseases 0.000 claims abstract description 5
- 208000016361 genetic disease Diseases 0.000 claims abstract description 5
- 230000010355 oscillation Effects 0.000 claims abstract description 5
- 230000004936 stimulating effect Effects 0.000 claims abstract description 5
- 230000001276 controlling effect Effects 0.000 claims abstract description 4
- 230000001678 irradiating effect Effects 0.000 claims abstract description 3
- 230000005672 electromagnetic field Effects 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000000015 thermotherapy Methods 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000007614 genetic variation Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000246 remedial effect Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/06—Electromagnets; Actuators including electromagnets
Definitions
- the present invention relates to a gene therapy and more particularly, to a gene therapeutic method and an apparatus therefor using electro-magnetic pulse and wave.
- the conventional magnetic field generating therapeutic apparatus generally magnetic field generator was installed within a box or a casing.
- the third party or non-curer have held and applied the therapeutic apparatus on the affected parts of the body so that the alternating magnetic field might operate on the affected part (Korean Utility Model Laid-open No. 85-3806).
- This conventional therapeutic apparatus does not relate to the present invention directly.
- the alternating magnetic field apparatus was placed within the casing and each casing is connected to mutually rotate freely.
- the therapeutic apparatus wraps the affected part and a connecting member is mounted at the end of each casing.
- the conventional therapeutic apparatus constructed as the above leads to inconvenience that the magnetic field therapeutic apparatus should be attached to the body of patients in every time.
- the magnetic field generating therapeutic apparatus since the magnetic field generating therapeutic apparatus has a limited application range of the alternating magnetic field, it could offer only partial therapy and in applying to wide range of affected parts the therapeutic apparatus should be moved. In the conventional therapeutic apparatus, it is impossible to regulate the intensity of magnetic field according to the affected part. Also, since the therapeutic apparatus has a protruded structure, loss of magnetic field and weak thermotherapy are present, and owing to the harmful surrounding wave, curative value is reduced.
- the present invention has been made under the circumstances mentioned above and therefore it is an object of the present invention to provide a gene therapeutic method and an apparatus therefor using electro-magnetic pulse and wave, characterized in differing intensity of the generation of electro-magnetic fluctuating magnetic field according to body portion, regulating height according to the heights of patients, with little loss of magnetic field by generating a line of magnetic force within the tunnel, especially thermotherapy by keeping the heat generated by a line of magnetic force, and metabolism is facilitated by promoting blood circulation.
- a gene therapeutic method using electro-magnetic pulse and wave which comprises the steps of: laying a genetic disease patient on the magnetic field generating apparatus; supplying a power to the magnetic field generating apparatus and sending pre-adjusted voltage intensity and frequency to the apparatus to generate a alternating magnetic field; and irradiating the generated magnetic field to the affected part of the patient and stimulating inactive or latent genes to transform into normal genes.
- the gene therapeutic apparatus using electro-magnetic pulse and wave comprises a main body integrally formed of upper and lower parts; a tunnel- shaped upper magnetic field generating part attached inside of the main body; a lower magnetic field generating part which is capable of moving back and forth and horizontal for patients to lie down and attached to the lower part of the upper magnetic field generating part; a guide casing supporting the upper magnetic field generating part and formed with a protrusion part to be inserted into a groove; an actuating part attached at the lower end of the guide casing and having a motor which drives a rack and a pinion causing the lower magnetic field generating part to move back and forth according to the height and a motor for driving a jack which is regulated in the upward and downward direction; and a control part having a regulating part which regulates the actuating part, a frequency regulating part which regulates the oscillation frequency, a timer, and a magnetic field regulating part which regulates the intensity of magnetic field and collectively controlling the respective parts, thereby it is possible to regulate
- Fig. 1 is a perspective view illustrating a gene therapeutic apparatus using electro-magnetic pulse and wave according to a preferred embodiment of the present invention
- Fig. 2 is a sectional view illustrating the lower magnetic field generating part of the gene therapeutic apparatus according to the present invention
- Fig. 3 is an exploded perspective view of the gene therapeutic apparatus according to the present invention.
- Fig. 4 is a schematic view illustrating the magnetic field generating part of the gene therapeutic apparatus according to the present invention.
- a gene therapeutic apparatus using using electro-magnetic pulse and wave according to the present invention has a plurality of magnetic field parts 10 to which the elements are combined. Each magnetic field part 10 is interconnected with electric wires 110. The pulse and wave generated in each magnetic field part 10 is irradiated at the affected part to stimulate inactive or latent genes and to transform into normal genes.
- the gene therapeutic apparatus comprises a main body 120 integrally formed of upper and lower parts; a tunnel-shaped upper magnetic field generating part 100 attached inside of main body 120; a lower magnetic field generating part 50 which is capable of moving back and forth and horizontal for patients to lie down and attached to the lower part of upper magnetic field generating part 120; a guide casing 70 supporting upper magnetic field generating part 50 and formed with a protrusion part to be inserted into a groove; an actuating part 40 attached at the lower end of guide casing 70 and having a motor 85 which drives a rack 15 and a pinion 20 causing lower magnetic field generating part 50 to move back and forth according to the height and a motor 105 for driving a jack 95 which is regulated in the upward and downward direction; and a control part 30 having a regulating part which regulates the actuating part, a frequency regulating part which regulates the oscillation frequency, a timer, and a magnetic field regulating part which regulates the intensity of magnetic
- Main body 120 is made of dampproof stainless material and has an oval figure covered by lead plates, to thereby keep it from emission of electro-magnetic field outside.
- the upper surface of lower magnetic field generating part 50 is formed of a board structure and is provided with a thin cushion.
- a plurality of magnetic field parts 10 are comprised of a structure that the coil bobbin fitted within iron cores is attached to the upper tunnel and is connected by electric wire for supply of electric power.
- a plurality of magnetic field parts are arranged in a row and a column on the tunnel for generating magnetic field to each body portion.
- Each magnetic field part 10 is 20-50cm in length, 10 ⁇ 20cm in width,
- each magnetic field part 10 is made of natural plastic and an electro-magnetic field generating material is filled within the casing.
- a plurality of magnetic field parts 55 are arranged in a row and column inside of the board.
- a magnetic field regulating part regulates the intensity of magnetic field, to thereby apply the magnetic field only to the affected part.
- a support bar inserted into a side groove 65 plays a role of a guide and a rack 15 and a pinion 20 are connected on lateral side to move back and forth and a jack 75 is operated by a motor 80 attached at the lower surface of a guide casing 70 to thereby regulate vertically.
- the upper plate of lower magnetic field generating part 50 is regulated vertically and guide bars 85 are attached at the four edges for smooth movement.
- a vertical plate 25, which magnetic field parts put inside, is vertically installed at the front plate and an axial rod 35 installed to set the vertical plate up when used.
- a footboard 55 is installed at the other end to thereby the magnetic field be reached on the sole of the foot.
- the magnetic field part which is installed within the upper/lower magnetic field generating parts 100, 50 is comprised of coil bobbin fitted within iron cores.
- the coils of the bobbin are connected simultaneously to thereby strengthen alternating magnetic field generated by flowing the electric current.
- Magnetic flux density generated at the magnetic field can be regulated in the range of l ⁇ 5,000gauss.
- the frequency regulator regulates the frequency generated at the respective magnetic field parts of upper/lower magnetic field generating parts 100,
- the range of an oscillation frequency which is repeated per second is set between l ⁇ l,000Hz in alternating voltage or current.
- the timer regulates time intervals in the range of 1-120 min according to the state of the affected part. If the setting time reaches, power supply is stopped and all systems are completed.
- a control plate In a control part 30, a control plate, a magnetic field regulating part, a frequency regulator, timer, power switch, and a regulating part which regulates the lower magnetic field generating part vertically and horizontally are attached to the upper part of a panel, to thereby control the therapeutic apparatus collectively.
- the control part is connected to external computer or monitor. Since the circuit in each magnetic field part is equipped independently, it is possible to control each magnetic field part by changing the intensity of magnetic field and frequency according to the body portion.
- the frequency is fluctuated by changing wavelength of the alternating magnetic force of the electro-magnetic field by means of the frequency regulator, to thereby give a diversified change to the affected parts of a patient and to promote a remedial effect.
- a power supply is separately connected to each magnetic field part 50 and a safety device (not shown) having a temperature sensor is installed within each magnetic field part, to thereby automatically shut off the power when the setting temperature is over and to prevent the therapeutic apparatus from being damaged.
- a patient is laid on lower magnetic field generating part 50 and is moved intoward the tunnel by regulating the regulator attached to control part 30. Thereafter, the intervals betweens the surface of the upper magnetic field generating part and the patient are regulated to the least (10cm).
- Lower magnetic field generating part 50 has a motor 85 which drives a rack 15 and a pinion 20 causing lower magnetic field generating part 50 to move back and forth according to the height and a motor 105 for driving a jack 95 which is regulated in the upward and downward direction.
- Regulating the height according to the size of the body is followed by regulating the intensity of magnetic field, frequency and timer.
- a power is supplied to the upper/lower magnetic field generating part by turning on the switch.
- voltage intensity and frequency are set, magnetic field is generated and irradiated to the affected part of the body continuously and repeatedly.
- an abnormal or inactive gene that is an intron
- magnetic field stimulates latent gene and mutated gene repeatedly, to thereby operate gene expression mechanism of the body. Therefore, abnormal or inactive gene is activated, which is effective on the affected part, especially on prevention, improvement and remedy of genetic disease.
- a gene therapeutic method and apparatus of the present invention has a remarkable effect on the selective therapy according to the affected part. Also, a gene therapeutic method and apparatus of the present invention activates latent or inactivated gene by stimulating them, which has notable effect on prevention, improvement and remedy of genetic disease by transforming the impaired gene to normal one. Therefore, the present invention will be very useful in the medical industry.
- the present invention has been described in an illustrative manner, and it is to be understood the terminology used is intended to be in the nature of description rather than of limitation.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Power Engineering (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
Cette invention concerne une méthode de thérapie génique et un appareil correspondant qui font intervenir des impulsions et des ondes électro-magnetiques. Cette méthode de thérapie génique consiste à faire étendre un patient sur un appareil qui produit un champ magnétique, à enclencher cet appareil, à soumettre ledit appareil à une tension, à une intensité et à une fréquence prédéterminées de manière à produire un champ magnétique alternatif auquel on soumet la région du corps à traiter dans le but de transformer des gènes inactifs ou latents en gènes actifs. Le dispositif de thérapie génique comprend les éléments constitutifs suivants : élément principal formé de parties supérieures et inférieures ; organe supérieur en forme de tunnel qui produit un champ magnétique et qui est relié à l'élément principal; organe inférieur qui produit un champ magnétique pouvant coulisser dans le plan horizontal par rapport à un patient allongé, et qui est relié à la partie inférieure de l'organe supérieur de production de champ magnétique ; élément de guidage qui supporte l'organe supérieur de production de champ magnétique et qui comporte une pièce saillante destinée à venir s'insérer dans une gorge ; organe de commande solidaire de la partie inférieure de l'élément de guidage, qui est muni d'un moteur agissant d'une part sur un ensemble pignon-crémaillère, lequel imprime à l'organe inférieur de production de champ magnétique un mouvement de va-et-vient selon la hauteur, d'autre part sur d'un moteur d'entraînement de crémaillère fonctionnant dans le plan vertical; et organe de commande dont l'élément régulateur agit sur l'actionneur ; organe régulateur de fréquence réglant la tension d'oscillation ; minuterie ; et organe de régulation de champ magnétique qui règle l'intensité du champ magnétique et commande l'ensemble des pièces et organes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU33318/00A AU3331800A (en) | 1999-03-11 | 2000-03-11 | Gene therapeutic method and apparatus therefor using electro-magnetic pulse and wave |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019990008105A KR20000060068A (ko) | 1999-03-11 | 1999-03-11 | 전자기장의 펄스와 파장에 의한 유전자 치료법 및 그 치료장치 |
| KR1999/8105 | 1999-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2000053259A1 true WO2000053259A1 (fr) | 2000-09-14 |
Family
ID=19576242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2000/000198 WO2000053259A1 (fr) | 1999-03-11 | 2000-03-11 | Methode de therapie genique et appareil correspondant a impulsions et ondes electro-magnetiques |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR20000060068A (fr) |
| AU (1) | AU3331800A (fr) |
| WO (1) | WO2000053259A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2195974C2 (ru) * | 2000-10-09 | 2003-01-10 | Рязанская государственная радиотехническая академия | Способ формирования магнитотерапевтического воздействия и устройство для его осуществления |
| EP1563869A1 (fr) * | 2004-02-11 | 2005-08-17 | Richard Markoll | Appareil pour le traitement d'un patient en utilisant un champ électromagnétique |
| CN106345061A (zh) * | 2016-08-17 | 2017-01-25 | 王兆英 | 神经内科低频磁刺激装置 |
| CN118161752A (zh) * | 2024-02-22 | 2024-06-11 | 中国人民解放军南部战区总医院 | 采用电磁脉冲和离子释放的康复理疗装置及控制方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010086944A (ko) * | 2000-03-04 | 2001-09-15 | 원인호 | 자장기 및 이의 제조 |
| KR101596350B1 (ko) * | 2013-08-30 | 2016-02-22 | (주)국보싸이언스 | 우레탄-우레아 복합 마이크로캡슐화 살충제 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR850003806U (ko) * | 1983-11-28 | 1985-07-08 | 유겐가이샤 닛본덴지하지료기겐규쇼 | 자계발생 치료구 |
| WO1997000639A2 (fr) * | 1995-06-19 | 1997-01-09 | Holcomb Robert R | Dispositif de traitement electromagnetique et procede d'utilisation de celui-ci |
-
1999
- 1999-03-11 KR KR1019990008105A patent/KR20000060068A/ko active Pending
-
2000
- 2000-03-11 AU AU33318/00A patent/AU3331800A/en not_active Abandoned
- 2000-03-11 WO PCT/KR2000/000198 patent/WO2000053259A1/fr active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR850003806U (ko) * | 1983-11-28 | 1985-07-08 | 유겐가이샤 닛본덴지하지료기겐규쇼 | 자계발생 치료구 |
| WO1997000639A2 (fr) * | 1995-06-19 | 1997-01-09 | Holcomb Robert R | Dispositif de traitement electromagnetique et procede d'utilisation de celui-ci |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2195974C2 (ru) * | 2000-10-09 | 2003-01-10 | Рязанская государственная радиотехническая академия | Способ формирования магнитотерапевтического воздействия и устройство для его осуществления |
| EP1563869A1 (fr) * | 2004-02-11 | 2005-08-17 | Richard Markoll | Appareil pour le traitement d'un patient en utilisant un champ électromagnétique |
| US7588529B2 (en) | 2004-02-11 | 2009-09-15 | Richard Markoll | Apparatus for treating a patient's body using an electromagnetic field |
| CN106345061A (zh) * | 2016-08-17 | 2017-01-25 | 王兆英 | 神经内科低频磁刺激装置 |
| CN118161752A (zh) * | 2024-02-22 | 2024-06-11 | 中国人民解放军南部战区总医院 | 采用电磁脉冲和离子释放的康复理疗装置及控制方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3331800A (en) | 2000-09-28 |
| KR20000060068A (ko) | 2000-10-16 |
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