WO2000053259A1

WO2000053259A1 - Gene therapeutic method and apparatus therefor using electro-magnetic pulse and wave

Info

Publication number: WO2000053259A1
Application number: PCT/KR2000/000198
Authority: WO
Inventors: Sangyong Kim; Kunil Kim
Original assignee: Sangyong Kim; Kunil Kim
Priority date: 1999-03-11
Filing date: 2000-03-11
Publication date: 2000-09-14
Also published as: AU3331800A; KR20000060068A

Abstract

A gene therapeutic method and an apparatus therefor using electro-magneticpulse and wave are disclosed. The gene therapeutic method includes laying a genetic disease patient on the magnetic field generating apparatus, supplying a power to the magnetic field generating apparatus and sending pre-set voltage intensity and frequency to the apparatus to generate an alternating magnetic field, and irradiating the generated magnetic field to the affected part of the patient and stimulating inactive or latent genes to transform into normal genes. The gene therapeutic apparatus includes a main body integrally formed of upper and lower parts; a tunnel-shaped upper magnetic field generating part attached inside of the main body; a lower magnetic field generating part which is capable of moving back and forth and horizontal for patients to lie down and attached to the lower part of the upper magnetic field generating part; a guide casing supporting the upper magnetic field generating part and formed with a protrusion part to be inserted into a groove; an actuating part attached at the lower end of the guide casing and having a motor which drives a rack and a pinion causing the lower magnetic field generating part to move back and forth according to the height and a motor for driving a jack which is regulated in the upward and downward direction; and a control part having a regulating part which regulates the actuating part, a frequency regulating part which regulates the oscillation frequency, a timer, and a magnetic field regulating part which regulates the intensity of magnetic field and collectively controlling the respective parts.

Description

GENE THERAPEUTIC METHOD AND APPARATUS THEREFOR USING ELECTRO-MAGNETIC PULSE AND WAVE

TECHNICAL FIELD

The present invention relates to a gene therapy and more particularly, to a gene therapeutic method and an apparatus therefor using electro-magnetic pulse and wave.

BACKGROUND ART

As social life has been getting more complicated, there have been a number of incurable diseases whose causes had not been accounted for in modern medicine. There has been a lot of studies and investments going on the causes and therapies of the incurable diseases. As a result, the investigators have been trying to find out the causes by genetic variation.

In the conventional magnetic field generating therapeutic apparatus, generally magnetic field generator was installed within a box or a casing. The third party or non-curer have held and applied the therapeutic apparatus on the affected parts of the body so that the alternating magnetic field might operate on the affected part (Korean Utility Model Laid-open No. 85-3806). This conventional therapeutic apparatus does not relate to the present invention directly. In the above mentioned magnetic field generating therapeutic apparatus, the alternating magnetic field apparatus was placed within the casing and each casing is connected to mutually rotate freely. The therapeutic apparatus wraps the affected part and a connecting member is mounted at the end of each casing. The conventional therapeutic apparatus constructed as the above leads to inconvenience that the magnetic field therapeutic apparatus should be attached to the body of patients in every time. Furthermore, since the magnetic field generating therapeutic apparatus has a limited application range of the alternating magnetic field, it could offer only partial therapy and in applying to wide range of affected parts the therapeutic apparatus should be moved. In the conventional therapeutic apparatus, it is impossible to regulate the intensity of magnetic field according to the affected part. Also, since the therapeutic apparatus has a protruded structure, loss of magnetic field and weak thermotherapy are present, and owing to the harmful surrounding wave, curative value is reduced.

DISCLOSURE OF THE INVENTION

The present invention has been made under the circumstances mentioned above and therefore it is an object of the present invention to provide a gene therapeutic method and an apparatus therefor using electro-magnetic pulse and wave, characterized in differing intensity of the generation of electro-magnetic fluctuating magnetic field according to body portion, regulating height according to the heights of patients, with little loss of magnetic field by generating a line of magnetic force within the tunnel, especially thermotherapy by keeping the heat generated by a line of magnetic force, and metabolism is facilitated by promoting blood circulation.

It is another object of the present invention to provide a gene therapeutic method and an apparatus therefor using electro-magnetic pulse and wave, characterized in that it activates cells by stimulating latent genes using the magnetic force and the heat generated in the magnetic field.

To achieve these objects according to the present invention, there are provided a gene therapeutic method using electro-magnetic pulse and wave, which comprises the steps of: laying a genetic disease patient on the magnetic field generating apparatus; supplying a power to the magnetic field generating apparatus and sending pre-adjusted voltage intensity and frequency to the apparatus to generate a alternating magnetic field; and irradiating the generated magnetic field to the affected part of the patient and stimulating inactive or latent genes to transform into normal genes.

The gene therapeutic apparatus using electro-magnetic pulse and wave comprises a main body integrally formed of upper and lower parts; a tunnel- shaped upper magnetic field generating part attached inside of the main body; a lower magnetic field generating part which is capable of moving back and forth and horizontal for patients to lie down and attached to the lower part of the upper magnetic field generating part; a guide casing supporting the upper magnetic field generating part and formed with a protrusion part to be inserted into a groove; an actuating part attached at the lower end of the guide casing and having a motor which drives a rack and a pinion causing the lower magnetic field generating part to move back and forth according to the height and a motor for driving a jack which is regulated in the upward and downward direction; and a control part having a regulating part which regulates the actuating part, a frequency regulating part which regulates the oscillation frequency, a timer, and a magnetic field regulating part which regulates the intensity of magnetic field and collectively controlling the respective parts, thereby it is possible to regulate voltage as 10-250N by applying alternating current, and to maintain l~l,000Hz in frequency, l~5,000gauss in magnetic flux density for 1—60 min, 1-5 times /day.

BRIEF DESCRIPTION OF THE DRAWINGS

Other objects and aspects of the invention will become apparent from the following description of an embodiment with reference to the accompanying drawings in which:

Fig. 1 is a perspective view illustrating a gene therapeutic apparatus using electro-magnetic pulse and wave according to a preferred embodiment of the present invention;

Fig. 2 is a sectional view illustrating the lower magnetic field generating part of the gene therapeutic apparatus according to the present invention;

Fig. 3 is an exploded perspective view of the gene therapeutic apparatus according to the present invention; and

Fig. 4 is a schematic view illustrating the magnetic field generating part of the gene therapeutic apparatus according to the present invention.

BEST MODES FOR CARRYING OUT THE INVENTION

Hereinafter, an explanation on the gene therapeutic method and the apparatus therefor using electro-magnetic pulse according to the present invention will be in detail discussed with reference to Figs. 1 to 4.

A gene therapeutic apparatus using using electro-magnetic pulse and wave according to the present invention has a plurality of magnetic field parts 10 to which the elements are combined. Each magnetic field part 10 is interconnected with electric wires 110. The pulse and wave generated in each magnetic field part 10 is irradiated at the affected part to stimulate inactive or latent genes and to transform into normal genes.

As shown in Figs. 1 to 4, the gene therapeutic apparatus according to the present invention comprises a main body 120 integrally formed of upper and lower parts; a tunnel-shaped upper magnetic field generating part 100 attached inside of main body 120; a lower magnetic field generating part 50 which is capable of moving back and forth and horizontal for patients to lie down and attached to the lower part of upper magnetic field generating part 120; a guide casing 70 supporting upper magnetic field generating part 50 and formed with a protrusion part to be inserted into a groove; an actuating part 40 attached at the lower end of guide casing 70 and having a motor 85 which drives a rack 15 and a pinion 20 causing lower magnetic field generating part 50 to move back and forth according to the height and a motor 105 for driving a jack 95 which is regulated in the upward and downward direction; and a control part 30 having a regulating part which regulates the actuating part, a frequency regulating part which regulates the oscillation frequency, a timer, and a magnetic field regulating part which regulates the intensity of magnetic field and collectively controlling the respective parts.

Main body 120 is made of dampproof stainless material and has an oval figure covered by lead plates, to thereby keep it from emission of electro-magnetic field outside. The upper surface of lower magnetic field generating part 50 is formed of a board structure and is provided with a thin cushion. In upper magnetic field generating part 100, a plurality of magnetic field parts 10 are comprised of a structure that the coil bobbin fitted within iron cores is attached to the upper tunnel and is connected by electric wire for supply of electric power. A plurality of magnetic field parts are arranged in a row and a column on the tunnel for generating magnetic field to each body portion. Each magnetic field part 10 is 20-50cm in length, 10~20cm in width,

2-10cm in height. The casing of each magnetic field part 10 is made of natural plastic and an electro-magnetic field generating material is filled within the casing.

In lower magnetic field generating part 50, a plurality of magnetic field parts 55 are arranged in a row and column inside of the board. A magnetic field regulating part regulates the intensity of magnetic field, to thereby apply the magnetic field only to the affected part.

In lower magnetic field generating part 50, a support bar inserted into a side groove 65 plays a role of a guide and a rack 15 and a pinion 20 are connected on lateral side to move back and forth and a jack 75 is operated by a motor 80 attached at the lower surface of a guide casing 70 to thereby regulate vertically.

The upper plate of lower magnetic field generating part 50 is regulated vertically and guide bars 85 are attached at the four edges for smooth movement. A vertical plate 25, which magnetic field parts put inside, is vertically installed at the front plate and an axial rod 35 installed to set the vertical plate up when used. A footboard 55 is installed at the other end to thereby the magnetic field be reached on the sole of the foot.

The magnetic field part, which is installed within the upper/lower magnetic field generating parts 100, 50 is comprised of coil bobbin fitted within iron cores. The coils of the bobbin are connected simultaneously to thereby strengthen alternating magnetic field generated by flowing the electric current.

Magnetic flux density generated at the magnetic field can be regulated in the range of l~5,000gauss. The frequency regulator regulates the frequency generated at the respective magnetic field parts of upper/lower magnetic field generating parts 100,

50. The range of an oscillation frequency which is repeated per second is set between l~l,000Hz in alternating voltage or current.

The timer regulates time intervals in the range of 1-120 min according to the state of the affected part. If the setting time reaches, power supply is stopped and all systems are completed.

In a control part 30, a control plate, a magnetic field regulating part, a frequency regulator, timer, power switch, and a regulating part which regulates the lower magnetic field generating part vertically and horizontally are attached to the upper part of a panel, to thereby control the therapeutic apparatus collectively. The control part is connected to external computer or monitor. Since the circuit in each magnetic field part is equipped independently, it is possible to control each magnetic field part by changing the intensity of magnetic field and frequency according to the body portion.

The frequency is fluctuated by changing wavelength of the alternating magnetic force of the electro-magnetic field by means of the frequency regulator, to thereby give a diversified change to the affected parts of a patient and to promote a remedial effect.

Also, a power supply is separately connected to each magnetic field part 50 and a safety device (not shown) having a temperature sensor is installed within each magnetic field part, to thereby automatically shut off the power when the setting temperature is over and to prevent the therapeutic apparatus from being damaged.

In the gene therapeutic apparatus according to the present invention, a patient is laid on lower magnetic field generating part 50 and is moved intoward the tunnel by regulating the regulator attached to control part 30. Thereafter, the intervals betweens the surface of the upper magnetic field generating part and the patient are regulated to the least (10cm).

Lower magnetic field generating part 50 has a motor 85 which drives a rack 15 and a pinion 20 causing lower magnetic field generating part 50 to move back and forth according to the height and a motor 105 for driving a jack 95 which is regulated in the upward and downward direction.

Regulating the height according to the size of the body is followed by regulating the intensity of magnetic field, frequency and timer. A power is supplied to the upper/lower magnetic field generating part by turning on the switch. When voltage intensity and frequency are set, magnetic field is generated and irradiated to the affected part of the body continuously and repeatedly. For activating an abnormal or inactive gene, that is an intron, magnetic field stimulates latent gene and mutated gene repeatedly, to thereby operate gene expression mechanism of the body. Therefore, abnormal or inactive gene is activated, which is effective on the affected part, especially on prevention, improvement and remedy of genetic disease.

INDUSTRIAL APPLICABILITY

As described hereinbefore, since the patient feels no physical pain for magnetic field generated by electro-magnetic field and no side effect and little loss of magnetic field for within the tunnel, a gene therapeutic method and apparatus of the present invention has a remarkable effect on the selective therapy according to the affected part. Also, a gene therapeutic method and apparatus of the present invention activates latent or inactivated gene by stimulating them, which has notable effect on prevention, improvement and remedy of genetic disease by transforming the impaired gene to normal one. Therefore, the present invention will be very useful in the medical industry. The present invention has been described in an illustrative manner, and it is to be understood the terminology used is intended to be in the nature of description rather than of limitation.

Many modifications and variations of the present invention are possible in light of the above teachings. Therefore, it is to be understood that within the scope of the appended claims, the invention may be practiced otherwise than as specifically described.

Claims

1. A gene therapeutic method using electro-magnetic pulse and wave comprising the steps of: laying a genetic disease patient on the magnetic field generating apparatus; supplying a power to the magnetic field generating apparatus and sending pre-set voltage intensity and frequency to the apparatus to generate a alternating magnetic field; and irradiating the generated magnetic field to the affected part of the patient and stimulating inactive or latent genes to transform into normal genes.

2. A gene therapeutic apparatus using electro-magnetic pulse and wave comprising: a main body 120 integrally formed of upper and lower parts; a tunnel-shaped upper magnetic field generating part 100 attached inside of said main body 120; a lower magnetic field generating part 50 which is capable of moving back and forth and horizontal for patients to lie down and attached to the lower part of said upper magnetic field generating part 120; a guide casing 70 supporting said upper magnetic field generating part 50 and formed with a protrusion part to be inserted into a groove; an actuating part

40 attached at the lower end of said guide casing 70 and having a motor 85 which drives a rack 15 and a pinion 20 causing said lower magnetic field generating part 50 to move back and forth according to the height and a motor 105 for driving a jack 95 which is regulated in the upward and downward direction; and a control part 30 having a regulating part which regulates said actuating part, a frequency regulating part which regulates the oscillation frequency, a timer, and a magnetic field regulating part which regulates the intensity of magnetic field and collectively controlling the respective parts.

3. The apparatus as set forth in claim 2, wherein said upper or lower magnetic field generating part comprises a plurality of magnetic field parts interconnected with electric wires 110.

4. The apparatus as set forth in claim 2, wherein said lower magnetic field generating part comprises a vertical plate 25 which is installed at the front side thereof and a footboard 55 which is installed at the rear side thereof.