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WO1999035907A3 - Xenobiotic animal model of h. pylori infection - Google Patents

Xenobiotic animal model of h. pylori infection Download PDF

Info

Publication number
WO1999035907A3
WO1999035907A3 PCT/IB1999/000217 IB9900217W WO9935907A3 WO 1999035907 A3 WO1999035907 A3 WO 1999035907A3 IB 9900217 W IB9900217 W IB 9900217W WO 9935907 A3 WO9935907 A3 WO 9935907A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal model
xenobiotic
pylori infection
animal
model
Prior art date
Application number
PCT/IB1999/000217
Other languages
French (fr)
Other versions
WO1999035907A2 (en
Inventor
Giudice Giuseppe Del
Rino Rappuoli
Original Assignee
Chiron Spa
Giudice Giuseppe Del
Rino Rappuoli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801000.2A external-priority patent/GB9801000D0/en
Priority claimed from GBGB9809398.2A external-priority patent/GB9809398D0/en
Priority claimed from GBGB9820976.0A external-priority patent/GB9820976D0/en
Application filed by Chiron Spa, Giudice Giuseppe Del, Rino Rappuoli filed Critical Chiron Spa
Priority to AU20709/99A priority Critical patent/AU2070999A/en
Priority to CA002283401A priority patent/CA2283401A1/en
Priority to EP99901086A priority patent/EP0967858A2/en
Priority to NZ500160A priority patent/NZ500160A/en
Priority to JP53695899A priority patent/JP2001523116A/en
Publication of WO1999035907A2 publication Critical patent/WO1999035907A2/en
Publication of WO1999035907A3 publication Critical patent/WO1999035907A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

An animal model for experimental infection with Helicobacter pylori which displays the acute symptoms of Helicobacter pylori infection. The model can be prepared by injecting an animal, such as a xenobiotic dog, with a dose of bacteria previously adapted to the mouse. The invention also relates to the use of the animal model for the development of vaccines, chemotherapeutics and diagnostics.
PCT/IB1999/000217 1998-01-16 1999-01-15 Xenobiotic animal model of h. pylori infection WO1999035907A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU20709/99A AU2070999A (en) 1998-01-16 1999-01-15 Xenobiotic animal model of H. Pylori infection
CA002283401A CA2283401A1 (en) 1998-01-16 1999-01-15 Xenobiotic animal model of h. pylori infection
EP99901086A EP0967858A2 (en) 1998-01-16 1999-01-15 Xenobiotic animal model of h. pylori infection
NZ500160A NZ500160A (en) 1998-01-16 1999-01-15 Xenobiotic canine model of Helicobacter pylori infection
JP53695899A JP2001523116A (en) 1998-01-16 1999-01-15 H. xylogen animal model of P. pylori infection

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9801000.2A GB9801000D0 (en) 1998-01-16 1998-01-16 Crystalline carbapenem intermediates and process for synthesis thereof
GB9801000.2 1998-01-16
GBGB9809398.2A GB9809398D0 (en) 1998-04-30 1998-04-30 Immunization and treatment
GB9809398.2 1998-04-30
GB9820976.0 1998-09-25
GBGB9820976.0A GB9820976D0 (en) 1998-09-25 1998-09-25 Immunization and treatment

Publications (2)

Publication Number Publication Date
WO1999035907A2 WO1999035907A2 (en) 1999-07-22
WO1999035907A3 true WO1999035907A3 (en) 1999-09-23

Family

ID=27269175

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000217 WO1999035907A2 (en) 1998-01-16 1999-01-15 Xenobiotic animal model of h. pylori infection

Country Status (6)

Country Link
EP (1) EP0967858A2 (en)
JP (1) JP2001523116A (en)
AU (1) AU2070999A (en)
CA (1) CA2283401A1 (en)
NZ (1) NZ500160A (en)
WO (1) WO1999035907A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003506101A (en) * 1999-08-19 2003-02-18 ボード・オブ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム A large animal model of invasive pulmonary aspergillosis in an immunocompromised host
CN116369278B (en) * 2023-05-17 2024-09-20 上海溯源生物技术有限公司 Animal model construction method for helicobacter pylori infection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009757A1 (en) * 1994-09-28 1996-04-04 Biocine Spa Mouse model for helicobacter pylori infection
EP0757888A1 (en) * 1994-12-13 1997-02-12 Yoshitomi Pharmaceutical Industries, Ltd. Helicobacter pylori-colonized mongolian gerbil, process for preparation thereof, medium for separating helicobacter pylori, and method of screening anti-helicobacter pylori-active substance by using the same
WO1997011721A1 (en) * 1995-09-25 1997-04-03 Astra Aktiebolag Method to identify therapeutically active compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009757A1 (en) * 1994-09-28 1996-04-04 Biocine Spa Mouse model for helicobacter pylori infection
EP0757888A1 (en) * 1994-12-13 1997-02-12 Yoshitomi Pharmaceutical Industries, Ltd. Helicobacter pylori-colonized mongolian gerbil, process for preparation thereof, medium for separating helicobacter pylori, and method of screening anti-helicobacter pylori-active substance by using the same
WO1997011721A1 (en) * 1995-09-25 1997-04-03 Astra Aktiebolag Method to identify therapeutically active compounds

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KRAKOWKA S ET AL: "Establishment of Campylobacter pylori infection in the neonatal gnotobiotic piglet", INFECTION AND IMMUNITY, vol. 55, no. 11, 1987, pages 2789 - 2796, XP002107381 *
LEE A: "Animal models for host-pathogen interaction studies", BR MED BULL, vol. 54, no. 1, 1998, pages 163 - 173, XP002107384 *
MARCHETTI M ET AL: "Development of a mouse model of Helicobacter pylori infection that mimics human disease", SCIENCE, vol. 267, 17 March 1995 (1995-03-17), pages 1655 - 1658, XP002107382 *
RADIN M ET AL: "Helicobacter pylori gastric infection in gnotobiotic beagle dogs", INFECTION AND IMMUNITY, vol. 58, no. 8, August 1990 (1990-08-01), pages 2606 - 2612, XP002107383 *
ROSSI G ET AL: "A conventional beagle dog model for acute and chronic infection with helicobacter pylori", INFECTION AND IMMUNITY, vol. 67, no. 6, June 1999 (1999-06-01), pages 3112 - 3120, XP002107385 *

Also Published As

Publication number Publication date
AU2070999A (en) 1999-08-02
EP0967858A2 (en) 2000-01-05
CA2283401A1 (en) 1999-07-22
NZ500160A (en) 2002-03-01
JP2001523116A (en) 2001-11-20
WO1999035907A2 (en) 1999-07-22

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