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WO1999021992A3 - Nucleic acid molecules encoding a glutamate receptor - Google Patents

Nucleic acid molecules encoding a glutamate receptor Download PDF

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Publication number
WO1999021992A3
WO1999021992A3 PCT/EP1998/006748 EP9806748W WO9921992A3 WO 1999021992 A3 WO1999021992 A3 WO 1999021992A3 EP 9806748 W EP9806748 W EP 9806748W WO 9921992 A3 WO9921992 A3 WO 9921992A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
molecules encoding
glutamate receptor
receptor
Prior art date
Application number
PCT/EP1998/006748
Other languages
French (fr)
Other versions
WO1999021992A2 (en
WO1999021992A9 (en
Inventor
Rainer Metzger
Ludwig Laxhuber
Original Assignee
Ganimed Pharmaceuticals Gmbh
Rainer Metzger
Ludwig Laxhuber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ganimed Pharmaceuticals Gmbh, Rainer Metzger, Ludwig Laxhuber filed Critical Ganimed Pharmaceuticals Gmbh
Publication of WO1999021992A2 publication Critical patent/WO1999021992A2/en
Publication of WO1999021992A9 publication Critical patent/WO1999021992A9/en
Publication of WO1999021992A3 publication Critical patent/WO1999021992A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Described is a novel subtype of metabotropic glutamate receptors, nucleic acid molecules encoding such receptors, vectors comprising the described nucleic acid molecules, as well as antibodies directed against said receptor. Furthermore, nucleic acid probes are described which specifically hybridize with the nucleic acid molecules, pharmaceutical and diagnostic compositions, transgenic non-human animals as well as methods to identify agonists and antagonists of the described receptor.
PCT/EP1998/006748 1997-10-23 1998-10-23 Nucleic acid molecules encoding a glutamate receptor WO1999021992A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97118459.3 1997-10-23
EP97118459 1997-10-23

Publications (3)

Publication Number Publication Date
WO1999021992A2 WO1999021992A2 (en) 1999-05-06
WO1999021992A9 WO1999021992A9 (en) 1999-07-15
WO1999021992A3 true WO1999021992A3 (en) 1999-09-10

Family

ID=8227516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/006748 WO1999021992A2 (en) 1997-10-23 1998-10-23 Nucleic acid molecules encoding a glutamate receptor

Country Status (1)

Country Link
WO (1) WO1999021992A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
KR101520086B1 (en) 2007-09-14 2015-05-14 얀센 파마슈티칼스 인코포레이티드 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2'-ones
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
BRPI0921333A2 (en) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa indole and benzoxazine derivatives as metabotropic glutamate receptor modulators
AU2010246607B2 (en) 2009-05-12 2012-09-27 Addex Pharma S.A. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
SG10201402250TA (en) 2009-05-12 2014-07-30 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2552455T3 (en) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
CN103298809B (en) 2010-11-08 2016-08-31 杨森制药公司 1,2,4-triazol [4,3-a] pyridine derivate and the purposes of the positive allosteric modulators as MGLUR2 acceptor thereof
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6, 7- dihydropyrazolu [5,1-a] pyrazine-4 (5 hands) -on compounds and their use as negative excretory regulators of Miglore 2 receptors.
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
MY182627A (en) 2014-01-21 2021-01-27 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
PH12019500127B1 (en) 2014-01-21 2022-05-04 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027602A1 (en) * 1993-06-01 1994-12-08 Cortex Pharmaceuticals, Inc. Use of metabotropic receptor agonists in progressive neurodegenerative deseases
WO1995022609A2 (en) * 1994-02-21 1995-08-24 The Wellcome Foundation Limited Human glutamate receptor proteins
WO1996006167A1 (en) * 1994-08-19 1996-02-29 Novartis Ag Glutamate receptor
WO1997005252A2 (en) * 1995-07-26 1997-02-13 Nps Pharmaceuticals, Inc. Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027602A1 (en) * 1993-06-01 1994-12-08 Cortex Pharmaceuticals, Inc. Use of metabotropic receptor agonists in progressive neurodegenerative deseases
WO1995022609A2 (en) * 1994-02-21 1995-08-24 The Wellcome Foundation Limited Human glutamate receptor proteins
WO1996006167A1 (en) * 1994-08-19 1996-02-29 Novartis Ag Glutamate receptor
WO1997005252A2 (en) * 1995-07-26 1997-02-13 Nps Pharmaceuticals, Inc. Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERTINO L ET AL: "Evidence for a metabotropic glutamate receptor in liver", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 23, no. 1-2, 25 August 1997 (1997-08-25), pages 939, XP002107669 *
DATABASE EMEST17 E.M.B.L. DATABASES; 26 July 1996 (1996-07-26), HILLIER L ET AL: "r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone", XP002107673 *
SCHOEPP D ET AL: "Metabotropic Glutamate Receptors in Brain Function and Pathology", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 14, January 1993 (1993-01-01), pages 13 - 20, XP002107671 *
SUREDA F ET AL: "Metabotropic glutamate Receptor Agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes", EUR J PHARMACOL, vol. 338, no. 2, 5 November 1997 (1997-11-05), pages R1 - R2, XP002107670 *
WATSON S AND ARKINSTALL S: "The G-Protein linked Receptor Factsbook - Passage", 1994, ACADEMIC PRESS, LONDON, GB, XP002107672 *

Also Published As

Publication number Publication date
WO1999021992A2 (en) 1999-05-06
WO1999021992A9 (en) 1999-07-15

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