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WO1999018204A3 - PROTEINES HUMAINES COMPORTANT DES SEQUENCES DE SIGNAUX SECRETOIRES ET ADNc CODANT CES PROTEINES - Google Patents

PROTEINES HUMAINES COMPORTANT DES SEQUENCES DE SIGNAUX SECRETOIRES ET ADNc CODANT CES PROTEINES Download PDF

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Publication number
WO1999018204A3
WO1999018204A3 PCT/JP1998/004476 JP9804476W WO9918204A3 WO 1999018204 A3 WO1999018204 A3 WO 1999018204A3 JP 9804476 W JP9804476 W JP 9804476W WO 9918204 A3 WO9918204 A3 WO 9918204A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
signal sequences
secretory signal
cells
secretory
Prior art date
Application number
PCT/JP1998/004476
Other languages
English (en)
Other versions
WO1999018204A2 (fr
Inventor
Seishi Kato
Tomoko Kimura
Shingo Sekine
Midori Kobayashi
Original Assignee
Sagami Chem Res
Protegene Inc
Seishi Kato
Tomoko Kimura
Shingo Sekine
Midori Kobayashi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chem Res, Protegene Inc, Seishi Kato, Tomoko Kimura, Shingo Sekine, Midori Kobayashi filed Critical Sagami Chem Res
Priority to AU92833/98A priority Critical patent/AU9283398A/en
Priority to CA002305337A priority patent/CA2305337A1/fr
Priority to EP98945604A priority patent/EP1040188A2/fr
Priority to JP2000515002A priority patent/JP2001519155A/ja
Publication of WO1999018204A2 publication Critical patent/WO1999018204A2/fr
Publication of WO1999018204A3 publication Critical patent/WO1999018204A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention concerne des protéines humaines comportant des séquences de signaux sécrétoires et des ADN codant ces protéines ainsi que des cellules eucaryotes formant lesdites protéines par expression sécrétoire. Toutes les protéines sont sécrétées à l'extérieur des cellules et existent dans le liquide extracellulaire ou sur la membrane cellulaire, c'est la raison pour laquelle on les considère comme des protéines contrôlant la prolifération et la différenciation des cellules. Par conséquent, les protéines peuvent être utilisées en tant que substances pharmaceutiques ou en tant qu'antigènes pour préparer des anticorps dirigés contre lesdites protéines. En outre, les ADN peuvent être utilisés pour l'expression desdites protéines en grandes quantités. Les cellules eucaryotes dans lesquelles les vecteurs d'expression desdits ADNc sont introduits peuvent être utilisées pour la production sécrétoire des protéines codées par lesdits ADNc.
PCT/JP1998/004476 1997-10-08 1998-10-05 PROTEINES HUMAINES COMPORTANT DES SEQUENCES DE SIGNAUX SECRETOIRES ET ADNc CODANT CES PROTEINES WO1999018204A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU92833/98A AU9283398A (en) 1997-10-08 1998-10-05 Human proteins having secretory signal sequences and cdnas encoding these prot eins
CA002305337A CA2305337A1 (fr) 1997-10-08 1998-10-05 Proteines humaines comportant des sequences de signaux secretoires et adnc codant ces proteines
EP98945604A EP1040188A2 (fr) 1997-10-08 1998-10-05 PROTEINES HUMAINES COMPORTANT DES SEQUENCES DE SIGNAUX SECRETOIRES ET ADNc CODANT CES PROTEINES
JP2000515002A JP2001519155A (ja) 1998-10-05 1998-10-05 分泌シグナル配列を持つヒト蛋白質およびそれをコードするｃＤＮＡ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27626897 1997-10-08
JP9/276268 1997-10-08

Publications (2)

Publication Number Publication Date
WO1999018204A2 WO1999018204A2 (fr) 1999-04-15
WO1999018204A3 true WO1999018204A3 (fr) 1999-07-29

Family

ID=17567080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/004476 WO1999018204A2 (fr) 1997-10-08 1998-10-05 PROTEINES HUMAINES COMPORTANT DES SEQUENCES DE SIGNAUX SECRETOIRES ET ADNc CODANT CES PROTEINES

Country Status (4)

Country Link
EP (1) EP1040188A2 (fr)
AU (1) AU9283398A (fr)
CA (1) CA2305337A1 (fr)
WO (1) WO1999018204A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001023558A2 (fr) * 1999-09-28 2001-04-05 Incyte Genomics, Inc. Molecules secretoires
WO2001049728A2 (fr) * 2000-01-06 2001-07-12 Protegene Inc. Proteines humaines a domaines hydrophobes et adn codant ces proteines
AU2001284655A1 (en) * 2000-08-24 2002-03-04 Eli Lilly And Company Nucleic acids, vectors, host cells, polypeptides and uses thereof
JPWO2003035872A1 (ja) 2001-10-23 2005-02-10 本庶　佑 ヒトおよび哺乳動物の幹細胞由来神経生存因子

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039419A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Genes et proteines specifiques du colon
WO1998044160A1 (fr) * 1997-03-31 1998-10-08 Abbott Laboratories Reactifs et procedes utilises dans la detection des maladies du tractus gastro-instestinal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039419A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Genes et proteines specifiques du colon
WO1998044160A1 (fr) * 1997-03-31 1998-10-08 Abbott Laboratories Reactifs et procedes utilises dans la detection des maladies du tractus gastro-instestinal

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TASHIRO K ET AL: "SIGNAL SEQUENCE TRAP: A CLONING STRATEGY FOR SECRETED PROTEINS AND TYPE I MEMBRANE PROTEINS", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204 *
YOKOYAMA-KOBAYASHI M ET AL: "A SIGNAL SEQUENCE DETECTION SYSTEM USING SECRETED PROTEASE ACTIVITY AS AN INDICATOR", GENE, vol. 163, 1995, pages 193 - 196, XP002046435 *

Also Published As

Publication number Publication date
AU9283398A (en) 1999-04-27
EP1040188A2 (fr) 2000-10-04
WO1999018204A2 (fr) 1999-04-15
CA2305337A1 (fr) 1999-04-15

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