WO1999018204A3 - HUMAN PROTEINS HAVING SECRETORY SIGNAL SEQUENCES AND cDNAS ENCODING THESE PROTEINS - Google Patents
HUMAN PROTEINS HAVING SECRETORY SIGNAL SEQUENCES AND cDNAS ENCODING THESE PROTEINS Download PDFInfo
- Publication number
- WO1999018204A3 WO1999018204A3 PCT/JP1998/004476 JP9804476W WO9918204A3 WO 1999018204 A3 WO1999018204 A3 WO 1999018204A3 JP 9804476 W JP9804476 W JP 9804476W WO 9918204 A3 WO9918204 A3 WO 9918204A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proteins
- signal sequences
- secretory signal
- cells
- secretory
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 9
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 230000003248 secreting effect Effects 0.000 title abstract 4
- 108020004635 Complementary DNA Proteins 0.000 title abstract 3
- 102000003839 Human Proteins Human genes 0.000 title abstract 2
- 108090000144 Human Proteins Proteins 0.000 title abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 108020004414 DNA Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention provides human proteins having secretory signal sequences and DNAs coding for these proteins as well as eucaryotic cells forming said proteins by secretory expression. All of the proteins are secreted outside the cells and exist in the extracellular liquid or on the cell membrane, so that they are considered to be proteins controlling the proliferation and the differentiation of the cells. Accordingly, the proteins can be employed as pharmaceuticals or as antigens for preparing antibodies against said proteins. Furthermore, said DNAs can be utilized for expression of said proteins in large amounts. Eucaryotic cells wherein expression vectors of said cDNAs are introduced can be utilized for secretory production of the proteins encoded by said cDNAs.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002305337A CA2305337A1 (en) | 1997-10-08 | 1998-10-05 | Human proteins having secretory signal sequences and cdnas encoding these proteins |
| JP2000515002A JP2001519155A (en) | 1998-10-05 | 1998-10-05 | Human protein having secretory signal sequence and cDNA encoding the same |
| AU92833/98A AU9283398A (en) | 1997-10-08 | 1998-10-05 | Human proteins having secretory signal sequences and cdnas encoding these prot eins |
| EP98945604A EP1040188A2 (en) | 1997-10-08 | 1998-10-05 | HUMAN PROTEINS HAVING SECRETORY SIGNAL SEQUENCES AND cDNAS ENCODING THESE PROTEINS |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27626897 | 1997-10-08 | ||
| JP9/276268 | 1997-10-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1999018204A2 WO1999018204A2 (en) | 1999-04-15 |
| WO1999018204A3 true WO1999018204A3 (en) | 1999-07-29 |
Family
ID=17567080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1998/004476 WO1999018204A2 (en) | 1997-10-08 | 1998-10-05 | HUMAN PROTEINS HAVING SECRETORY SIGNAL SEQUENCES AND cDNAS ENCODING THESE PROTEINS |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1040188A2 (en) |
| AU (1) | AU9283398A (en) |
| CA (1) | CA2305337A1 (en) |
| WO (1) | WO1999018204A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1220907A2 (en) * | 1999-09-28 | 2002-07-10 | Incyte Genomics, Inc. | Human secretory molecules |
| US20040034192A1 (en) * | 2000-01-06 | 2004-02-19 | Seishi Kato | Human proteins having hyprophobic domains and dnas encoding these proteins |
| AU2001284655A1 (en) * | 2000-08-24 | 2002-03-04 | Eli Lilly And Company | Nucleic acids, vectors, host cells, polypeptides and uses thereof |
| ATE484588T1 (en) | 2001-10-23 | 2010-10-15 | Ono Pharmaceutical Co | HUMAN AND MAMMALIAL STEM CELL-DERIVED NEURONAL SURVIVAL POLYPEPTIDES |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996039419A1 (en) * | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Colon specific genes and proteins |
| WO1998044160A1 (en) * | 1997-03-31 | 1998-10-08 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the gastrointestinal tract |
-
1998
- 1998-10-05 WO PCT/JP1998/004476 patent/WO1999018204A2/en not_active Application Discontinuation
- 1998-10-05 AU AU92833/98A patent/AU9283398A/en not_active Abandoned
- 1998-10-05 EP EP98945604A patent/EP1040188A2/en not_active Withdrawn
- 1998-10-05 CA CA002305337A patent/CA2305337A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996039419A1 (en) * | 1995-06-06 | 1996-12-12 | Human Genome Sciences, Inc. | Colon specific genes and proteins |
| WO1998044160A1 (en) * | 1997-03-31 | 1998-10-08 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the gastrointestinal tract |
Non-Patent Citations (2)
| Title |
|---|
| TASHIRO K ET AL: "SIGNAL SEQUENCE TRAP: A CLONING STRATEGY FOR SECRETED PROTEINS AND TYPE I MEMBRANE PROTEINS", SCIENCE, vol. 261, 30 July 1993 (1993-07-30), pages 600 - 603, XP000673204 * |
| YOKOYAMA-KOBAYASHI M ET AL: "A SIGNAL SEQUENCE DETECTION SYSTEM USING SECRETED PROTEASE ACTIVITY AS AN INDICATOR", GENE, vol. 163, 1995, pages 193 - 196, XP002046435 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1040188A2 (en) | 2000-10-04 |
| AU9283398A (en) | 1999-04-27 |
| WO1999018204A2 (en) | 1999-04-15 |
| CA2305337A1 (en) | 1999-04-15 |
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