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WO1999012597A1 - Production d'un aerosol de poudre seche - Google Patents

Production d'un aerosol de poudre seche Download PDF

Info

Publication number
WO1999012597A1
WO1999012597A1 PCT/GB1998/002685 GB9802685W WO9912597A1 WO 1999012597 A1 WO1999012597 A1 WO 1999012597A1 GB 9802685 W GB9802685 W GB 9802685W WO 9912597 A1 WO9912597 A1 WO 9912597A1
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
aerosol
passageway
powder
closure means
Prior art date
Application number
PCT/GB1998/002685
Other languages
English (en)
Inventor
Philip Wilson Braithwaite
Original Assignee
Innovata Biomed Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovata Biomed Limited filed Critical Innovata Biomed Limited
Priority to AU90829/98A priority Critical patent/AU9082998A/en
Publication of WO1999012597A1 publication Critical patent/WO1999012597A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • This invention relates to a method and apparatus for producing an aerosol of a dry, micronised powder. More especially, it is concerned with medical inhalers in which a medicinal substance forms at least part of the micronised powder.
  • the medicinal substance may be for use in the treatment of diseases of the respiratory tract.
  • a propellant- free inhaler is disclosed in DE-A 1-4027390, wherein a medicinal substance is accommodated in powder form in a storage container. A dose of the powder is removed by means of a dosing device, prior to the fitting of a mouthpiece, and thereafter the substance is entrained by the air flow which results from an act of inhalation by the patient. An air chamber is situated in the resulting air flow in order to distribute the substance therein and provide inhalable particles.
  • the particle size achieved is largely dependent upon the nature and intensity of inhalation by the patient and, consequently, it is difficult to ensure consistency of treatment when using this device; in particular, the presence of sufficient, adequately small particles cannot be guaranteed.
  • the process is not suitable for mass production, since it is not possible to produce the medicinal substance in a standard form for use by all patients.
  • a further propellant-free inhaler is disclosed in DE-A 1-4027391, in which the problem of reproducibility is addressed by providing a cylinder containing a volume of air which is automatically released through a nozzle as a result of the action of breathing-in, and thereby provides an active air flow which ensures consistency in the provision of inhalable particles to the patient.
  • a cylinder containing a volume of air which is automatically released through a nozzle as a result of the action of breathing-in, and thereby provides an active air flow which ensures consistency in the provision of inhalable particles to the patient.
  • VVO-A- 90/07351 in which the airflow is generated by means of a pressurised gas source or a piston/cylinder arrangement and fed via a nozzle in order that a controlled flow rate may be achieved.
  • a duct When approaching the maximum flow rate, a duct is opened into the flow path, providing a connection to a storage vessel containing the pulverulent substance, which is thereby sucked into the airflow and conveyed into a mixing chamber in order to achieve a good distribution of particles therein.
  • a duct is opened into the flow path, providing a connection to a storage vessel containing the pulverulent substance, which is thereby sucked into the airflow and conveyed into a mixing chamber in order to achieve a good distribution of particles therein.
  • the arrangement requires that a bed of powder is provided and, in certain instances, the situation is unsatisfactory since the amount of micronised powder required to form the bed may have to be 2 to 3 times the total amount expected to be administered from the device in the form of inhalable aerosol. Furthermore, with multi-dose devices, it is often not appropriate to store certain drugs in such a bulk fashion for a length of time within the device.
  • a device for producing an aerosol of a micronised powder comprising a chamber having openable closure means operable to allow at least a partial vacuum to be created and maintained within the chamber, means for introducing substantially simultaneously into the at least partially evacuated chamber both a measured quantity of powder and a gas whereby an aerosol is formed within the chamber, said chamber also being provided with aerosol exit means whereby the aerosol may be withdrawn from the chamber.
  • the chamber may conveniently be of substantially spherical shape.
  • the closure means may be in the form of a one-way valve. Such a valve may be located within a duct connected to the chamber, said duct providing the aerosol exit means.
  • the duct may serve as a mouthpiece.
  • the duct may also be connectable to a pump or other device for forming the at least partial vacuum within the chamber.
  • the means for introducing substantially simultaneously into the chamber both the powder and a gas may be in the form of a passageway, connected to the chamber, indeed, said passageway may extend from the exterior of the chamber to a position located within the chamber. Where the chamber is of substantially spherical shape, the passageway may extend substantially radially inwardly within said chamber.
  • the passageway has mounted therein means for storing the measured quantity of powder. More preferably the passageway includes passageway closing means operable to allow communication between the interior and exterior of the chamber whereby gas may enter the chamber carrying with it the micronised powder located within the passageway.
  • the passageway closure means may be in the form of a moveable element which has associated with it the measured dose of powder. Movement of said movable element is effective to open the passageway whereby gas enters the chamber taking with it the measured dose of powder.
  • the moveable element may be of such dimension as to be able to move within the passageway while maintaining sealing contact with the inner walls of the passageway, thereby ensuring that the reduced pressure within the chamber may be maintained until such time as the element reaches the end of its path of travel. At this point the powder is released into the chamber simultaneously with the release of the vacuum in the chamber.
  • the moveable element may typically be in the form of a spool including enlarged end portions interconnected by an intermediate portion of reduced cross-section.
  • the shape of the moveable element between the end elements may be such that a space of the desired dose volume is defined between the moveable element and the inner walls of the passageway, in which space the micronised powder is enclosed.
  • the aerosol is then caused to exit from the chamber.
  • the device inhaler
  • the device may be provided with a mouthpiece within which is located the chamber closure means in the form of a one-way valve.
  • This one-way valve is used both for evacuation of the chamber and also allows inhalation of medicament by the patient.
  • the one-way valve is located within the mouthpiece.
  • the present invention also provides a method for producing an aerosol of a micronised powder, said method comprising providing a chamber having openable closure means, operating the closure means to provide at least a partial vacuum within the chamber, introducing substantially simultaneously into the at least partially evacuated chamber both a measured quantity of powder and a gas to form an aerosol within the chamber and withdrawing the aerosol from the chamber via aerosol exit means.
  • apparatus in accordance with the present invention includes a chamber 1 in the form of a spherical container.
  • Chamber 1 is provided with an opening 2 within which is mounted a one-way valve 3.
  • a mouthpiece 4 Extending from opening 2 radially outwardly from the outside surface of chamber 1 is a mouthpiece 4 in the form of a duct which surrounds the main body of one-way valve 3.
  • Diametrically opposite opening 2 chamber 1 is provided with a further opening 5 within which is mounted powder injector 6.
  • Injector 6 includes a relatively large diameter duct 6a of short length which extends outwardly from opening 5, and a relatively narrow diameter passageway 6b which extends radially inwardly from opening 5.
  • Passageway 6b itself comprises two portions.
  • Portion 6c extending inwardly from opening 5 is of relatively small internal diameter and is housed within portion 6d, which is of relatively larger diameter and extends inwardly from opening 5 to a position approximately in the centre of the chamber 1 and well beyond the limit of the extension of portion 6c.
  • portion 6d At its free inner end passageway 6b includes openings through which the powder may enter the chamber 1, but the passageway is at least partially closed by means of end wall 6e.
  • portion 6c and passageway 6b there is located within portion 6c and passageway 6b a spool 7 having enlarged ends and an intermediate portion of relatively narrow diameter. Spool 7 and the inner wall portion 6c of passageway 6b together define a space within which is located a micronised powder 8.
  • the line of a vacuum pump is first attached to mouthpiece 4 and the sphere 1 is evacuated to create a vacuum therein.
  • one-way valve 3 moves away from its seating position on sphere 1 to allow air to be withdrawn from the interior of the sphere.
  • the pump line is withdrawn and one-way valve 3 now sits firmly on its seat on sphere 1 thereby maintaining the vacuum within the sphere.
  • the patient then operates a mechanism (not shown) to cause spool 7 to be move from the position shown in Figure 1 to the position shown in Figure 2.
  • a mechanism (not shown) to cause spool 7 to be move from the position shown in Figure 1 to the position shown in Figure 2.
  • air is able to enter the sphere via duct 6a and passageway 6b.
  • High speed air flow takes place around spool 7 causing the powder to deagglomorate and be carried in to the main cavity of chamber 1. In so doing it forms an aerosol with the incoming air, as illustrated in Figure 2.
  • the patient places mouthpiece 4 in his mouth and inhales causing one-way valve 3 to move to the position shown in Figure 3 and the aerosol is drawn out of the sphere and in to the patient's mouth. This position is illustrated in Figure 3.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif destiné à produire un aérosol de poudre micronisée. Ce dispositif est constitué d'une chambre (1) comprenant des organes de fermeture (2, 3), que l'on peut ouvrir afin de créer et d'entretenir au moins partiellement un vide à l'intérieur de cette chambre. Ce dispositif est en outre constitué d'organes (5, 6, 7, 8) conçus pour introduire sensiblement simultanément dans la chambre, laquelle est au moins partiellement sous vide, une quantité définie de poudre et d'un gaz, de manière à produire un aérosol à l'intérieur de cette chambre, qui est également pourvue d'organes de sortie permettant de retirer ledit aérosol. L'invention concerne enfin un procédé de production d'un aérosol de poudre micronisée.
PCT/GB1998/002685 1997-09-10 1998-09-10 Production d'un aerosol de poudre seche WO1999012597A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU90829/98A AU9082998A (en) 1997-09-10 1998-09-10 Dry powder aerosol production

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9719093.8 1997-09-10
GBGB9719093.8A GB9719093D0 (en) 1997-09-10 1997-09-10 Improvements to dry powder inhalers

Publications (1)

Publication Number Publication Date
WO1999012597A1 true WO1999012597A1 (fr) 1999-03-18

Family

ID=10818755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002685 WO1999012597A1 (fr) 1997-09-10 1998-09-10 Production d'un aerosol de poudre seche

Country Status (3)

Country Link
AU (1) AU9082998A (fr)
GB (1) GB9719093D0 (fr)
WO (1) WO1999012597A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2364919A (en) * 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
US6550493B2 (en) 2001-06-13 2003-04-22 Baxter International Inc. Vacuum demand valve
US6554023B2 (en) 2001-06-13 2003-04-29 Baxter International Inc. Vacuum demand flow valve
US6675839B1 (en) 1998-01-03 2004-01-13 Innovata Biomed Limited Filling method
USD499793S1 (en) 2003-03-17 2004-12-14 Baxter International Inc. Valve
US6863261B2 (en) 2002-03-12 2005-03-08 Baxter International Inc. Valve stop
USD507631S1 (en) 2003-03-17 2005-07-19 Baxter International Inc. Valve
US7207330B1 (en) 1999-06-05 2007-04-24 Innovata Biomed Limited Delivery system
US7219665B1 (en) 1999-09-04 2007-05-22 Innovata Biomed Limited Delivery device
US7246617B1 (en) 1999-06-23 2007-07-24 Vectura Delivery Devices Limited Inhalers
US7464704B2 (en) 2001-11-23 2008-12-16 Innovata Biomed Limited Medicament delivery assembly
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007351A1 (fr) 1989-01-06 1990-07-12 Hans Gernot Schenk Inhalateur oral
DE4027391A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
DE4027390A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
WO1992004066A1 (fr) * 1990-09-12 1992-03-19 Hans Bisgaard Dispositif d'inhalation
US5239992A (en) * 1991-05-30 1993-08-31 Societe Francaise D'aerosols Et De Bouchage Loose powder inhaler with inhalation-actuated dosing piston
EP0722746A1 (fr) 1995-01-21 1996-07-24 Dieter Prof. Dr. med. KÖHLER Appareil générateur d'aérosol à partir d'une substance pulvérulente
EP0667793B1 (fr) 1992-11-06 1997-01-08 Dieter Prof. Dr. med. KÖHLER Procede et dispositif permettant de produire un aerosol a partir d'une substance pulverulente
WO1997001365A1 (fr) * 1995-06-29 1997-01-16 Fisons Plc Dispositif et procede d'inhalation

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007351A1 (fr) 1989-01-06 1990-07-12 Hans Gernot Schenk Inhalateur oral
DE4027391A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
DE4027390A1 (de) 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
WO1992004066A1 (fr) * 1990-09-12 1992-03-19 Hans Bisgaard Dispositif d'inhalation
US5239992A (en) * 1991-05-30 1993-08-31 Societe Francaise D'aerosols Et De Bouchage Loose powder inhaler with inhalation-actuated dosing piston
EP0667793B1 (fr) 1992-11-06 1997-01-08 Dieter Prof. Dr. med. KÖHLER Procede et dispositif permettant de produire un aerosol a partir d'une substance pulverulente
EP0722746A1 (fr) 1995-01-21 1996-07-24 Dieter Prof. Dr. med. KÖHLER Appareil générateur d'aérosol à partir d'une substance pulvérulente
WO1997001365A1 (fr) * 1995-06-29 1997-01-16 Fisons Plc Dispositif et procede d'inhalation

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6675839B1 (en) 1998-01-03 2004-01-13 Innovata Biomed Limited Filling method
US7207330B1 (en) 1999-06-05 2007-04-24 Innovata Biomed Limited Delivery system
US7246617B1 (en) 1999-06-23 2007-07-24 Vectura Delivery Devices Limited Inhalers
US7571723B2 (en) 1999-09-04 2009-08-11 Innovata Biomed Limited Delivery device
US7571724B2 (en) 1999-09-04 2009-08-11 Innovata Biomed Limited Delivery device
US7219665B1 (en) 1999-09-04 2007-05-22 Innovata Biomed Limited Delivery device
US6948496B2 (en) 2000-07-21 2005-09-27 Vectura, Limited Inhalers
GB2364919A (en) * 2000-07-21 2002-02-13 Cambridge Consultants Inhalers
US6672333B2 (en) 2001-06-13 2004-01-06 Baxter International Inc. Vacuum demand valve
US6604545B2 (en) 2001-06-13 2003-08-12 Baxter International Inc. Vacuum demand valve
US6550493B2 (en) 2001-06-13 2003-04-22 Baxter International Inc. Vacuum demand valve
US6863083B2 (en) 2001-06-13 2005-03-08 Baxter International Inc. Vacuum demand flow valve
US6554023B2 (en) 2001-06-13 2003-04-29 Baxter International Inc. Vacuum demand flow valve
US6712095B2 (en) 2001-06-13 2004-03-30 Baxter International Inc. Vacuum demand valve
US6684903B2 (en) 2001-06-13 2004-02-03 Baxter International Inc. Vacuum demand valve
US6679288B2 (en) 2001-06-13 2004-01-20 Baker International Inc. Vacuum demand valve
US6648011B2 (en) 2001-06-13 2003-11-18 Baxter International Inc. Vacuum demand valve
US7464704B2 (en) 2001-11-23 2008-12-16 Innovata Biomed Limited Medicament delivery assembly
US6863261B2 (en) 2002-03-12 2005-03-08 Baxter International Inc. Valve stop
USD507631S1 (en) 2003-03-17 2005-07-19 Baxter International Inc. Valve
USD499793S1 (en) 2003-03-17 2004-12-14 Baxter International Inc. Valve
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products

Also Published As

Publication number Publication date
AU9082998A (en) 1999-03-29
GB9719093D0 (en) 1997-11-12

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