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WO1990007351A1 - Inhalateur oral - Google Patents

Inhalateur oral Download PDF

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Publication number
WO1990007351A1
WO1990007351A1 PCT/DK1990/000005 DK9000005W WO9007351A1 WO 1990007351 A1 WO1990007351 A1 WO 1990007351A1 DK 9000005 W DK9000005 W DK 9000005W WO 9007351 A1 WO9007351 A1 WO 9007351A1
Authority
WO
WIPO (PCT)
Prior art keywords
product
gas flow
flow passage
chamber
restriction
Prior art date
Application number
PCT/DK1990/000005
Other languages
English (en)
Inventor
Hans Gernot Schenk
Søren PEDERSEN
Original Assignee
Hans Gernot Schenk
Pedersen Soeren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK6589A external-priority patent/DK6589D0/da
Priority claimed from DK65989A external-priority patent/DK65989D0/da
Application filed by Hans Gernot Schenk, Pedersen Soeren filed Critical Hans Gernot Schenk
Publication of WO1990007351A1 publication Critical patent/WO1990007351A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • B05B11/065—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material the particulate material being separated from a main storage in discrete quantities delivered one at a time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • B05B11/065—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material the particulate material being separated from a main storage in discrete quantities delivered one at a time
    • B05B11/067—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material the particulate material being separated from a main storage in discrete quantities delivered one at a time the particulate material being separated from the main storage by a dosing device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • the present invention relates to an oral inhaler for use in inhaling a powdered or particulate medical product.
  • bronchial asthma and other diseases may be performed in different ways.
  • the most effective manner of administra ⁇ tion is to let the patient inhale the medical product directly into the bronchial tubes of the lungs.
  • the medical product par ⁇ ticles cannot penetrate sufficiently deeply into the bronchial tubes unless they are very small.
  • Particles having such a small size that they may be deposited in the bronchial tree by aspiration are called "respirable particles".
  • an aerosol spray is discharged from a small aerosol container in which the medical product particles having a size of about 3 ⁇ m are dispersed by means of Freon under high pres ⁇ sure (400 kPa) .
  • Freon under high pres ⁇ sure (400 kPa)
  • surface tension reducing agents and lubricants which for some patients may give rise to side effects when inhaled.
  • Due to the high pressure within the aerosol container a etered amount of the medical product is discharged therefrom at a rather high velocity (100 km/- hour) . For that reason it is rather difficult for many patients to inhale the medical product from a usual aerosol container in a cor ⁇ rect manner.
  • a powder inhaler with a powdered medical product is used.
  • Such pow- dered product tends to lump together and form rather big particles with a diameter of several hundred ⁇ m.
  • the various known powder inhalers vary with respect to the manner in which the correct amount of the medical product is metered. Thus, in some inhaler packings or . capsules in which metered amounts of the medical product is packed separately are used. In other powder inhalers quite different prin ⁇ ciples are used, but for all such powder inhalers it is a common feature that the medical product cannot be inhaled by the patient in the form in which the product is present in the inhaler, because the medical product particles are too big.
  • the patient has to supply energy to the particles so that each of them is disintegrated in several thousand smaller pieces with a diameter of 1-50 ⁇ m.
  • This energy supply to the product particles must come from the inhaling force of the patient.
  • fast inhalation gives rise to the formation of many respirable particles, but causes simultaneously that the number of respirable particles reaching the outer branches of the bronchial tubes is reduced, because it is necessary to inhale rather slowly in order to get the particles into the outer branches of the bronchial tubes.
  • the present invention provides an oral inhaler of the above type in which the proportion of respirable particles obtainable is drastical ⁇ ly increased.
  • the present invention provides an oral inhaler for use in inhaling a powdered or particulate medical product and comprising a chamber for containing the medical product, a gas flow passage defin ⁇ ing a restriction or throat, and means defining a connecting passage interconnecting the product chamber and the flow passage at the restriction or adjacent thereto so as to allow product to be drawn into the gas flow passage by ejector effect, and the inhaler accord- ing to the invention is characterized in a pressure gas source com ⁇ municating with the gas flow passage for briefly providing a superat- mospheric pressure in one end of the gas flow passage so as to pro ⁇ vide a high velocity gas flow through the restriction or throat.
  • the pressure gas source may be of any suitable type, such as a con ⁇ tainer or can containing pressurized or liquefied gas or air and having a valve for releasing small amounts of air or gas at a super- atmospheric pressure.
  • the pressure and the amount of gas released should be sufficient to generate a gas flow through the restriction of the flow passage at such a velocity that product is drawn from the product chamber into the gas flow and that most of the product particles are disintegrated to such an extent that the disintegrated particles become respirable.
  • the pressure gas source is a container containing pressurized air, the inhaler will be too bulky to be carried by the patient, and the use of a container containing a liquefied propellant gas, such as Freon, may involve undesirable side effects as explained above.
  • the pressure gas source com ⁇ prises a manually operatable pumping device comprising a pumping chamber communicating with the gas flow passage, the volume of the pumping chamber being reducible by operating the pumping device.
  • the pumping chamber may totally or partly be defined by a displaceable or deformable wall part which may possibly be moved by means of manually operatable moving means.
  • the pumping chamber may be formed like a balloon, a bulb, or any other elastically compressible body.
  • the pumping device may comprise a piston pump having a displaceable wall part formed like a piston which Is ar- ranged within the pumping chamber of the inhaler, and a piston rod connected to the piston and having a free end which extends from the inhaler and is provided with an actuating member.
  • a pumping device may generate a flow of gas or air, which is sufficient to suck.or draw the medical product from the product chamber into the gas flow and to disintegrate the product particles to such sizes that they are respi ⁇ rable and may be dispersed in the gas or air being pumped.
  • the propellant may be atmospheric air, and the use of a special propellant gas, which may have undesired side ef- fects for the surroundings as well as for the patient when inhaled, is avoided.
  • the amounts of the medical product to be inhaled are normally very small provided that the inhaler is able to disintegrate the powdered or particulate product into particles of which substantially all are respirable. If this is the case the dose necessary normally amounts too 25-500 micrograms provided that no filler agents are used. It has been found that by using the inhaler according to the invention, doses of this order and also substantially greater doses may effi ⁇ ciently be sucked from the product chamber into the restriction of the gas flow passage and dispersed in the air flow In a respirable condition even though a relatively small air volume is pumped through the gas flow passage by means of the pumping device.
  • the piston may, for example, be actuated by a coil spring or another spring device, which may be prestressed when the piston is moved to a retracted position in which the piston may be releasably retained by a locking device.
  • the prestressed spring may move the piston through a short pumping stroke under the influence of a high spring force.
  • the deformable wall part may comprise a curved, sprin ⁇ gy diaphragm-like wall part movable between two stable positions, in which the wall part is convexly and concavely curved, respectively.
  • the volume of the pumping chamber may be reduced rather suddenly due to the fast movement of the membrane, whereby a high velocity air flow of a short time duration is obtained in the gas flow passage, whereby it is obtained that most of the medical pro ⁇ duct, which is drawn into the gas flow passage becomes respirable.
  • the gas flow passage may be closed by a manually operatable valve arranged between the pumping chamber and the restriction.
  • the pumping device may be operated so as to obtain a suitable superatmospheric pressure within the pumping chamber.
  • the pressurized air within the pumping chamber may then be released through the restriction of the gas flow passage when desired by opening the valve. Consequently, this embodiment of the inhaler will function like a kind of air gun or air pistol, by means of which a high velocity air flow of a short time duration may be provided through the gas flow passage correspon ⁇ ding to the barrel of the gun or pistol.
  • the flow emerging from the restrie- tion or throat will soon expand, whereby the flow velocity is rather rapidly reduced to about 0 even when the expansion volume is rela ⁇ tively small. Then the air or gas with the respirable particles dispersed therein may be inhaled in a normal manner.
  • the vigo ⁇ rous gas or air flow formed in the restriction of the gas flow pas- sage has a double function.
  • the product chamber may be adapted to receive a single dose of the medical product, which may be packed in a manner known per se, for example in a blister packing or in a capsule, which must be punctured or opened before use of the medical product.
  • the product chamber is in the form of a metering chamber connected or connectable to a product reservoir arranged within the inhaler.
  • the product reservoir may then contain a product supply comprising several doses, an each time the inhaler is to be used medical product may be transferred from the reservoir to the metering chamber in a suitable manner.
  • the metering chamber may have such a size that it contains a suitable dose when filled.
  • the medical pro- duct may be transferred from the product reservoir to the metering chamber in any suitable manner, for example by means of a mechanism as that disclosed in Swedish patent No. 453,566.
  • the product reservoir may be connected to the metering chamber through a plurality of small openings, such as the openings defined in a sieve- or grid-like wall part. Particles lumped together in the product reservoir may then to some extent be disintegrated when the product is transferred to the metering chamber.
  • the restriction of the gas flow passage may open directly into a mouth piece formed on the inhaler.
  • the patient has to put the mouth piece into the mouth prior to operating the inhaler, and the brief air flow provided by means of the pumping device as well as the product particles dispersed therein flow directly into the oral cavity of the patient, where the velocity of the air flow is drastically reduced.
  • the patient may then inhale the medical product dispersed in the oral cavity.
  • the restriction of the gas flow passage may open into one end of a mixing chamber having another end communicating with an inhaling mouth piece.
  • the velocity of the air flow emerging from the gas flow passage will be reduced to a rather small value within the mixing chamber, so that the mixing chamber is filled or almost filled with the gas or air forced through the restriction of the gas flow passage and by the respirable product particles dispersed therein.
  • the patient may then operate the pumping device or another pressure gas source for providing a gas or air flow with dispersed product particles, and, subsequently, when the gas flow has ceased, the dose of aerosol formed in the mixing chamber may be inhaled therefrom.
  • Means for creating turbulence in the gas or air flow may be provided in the gas flow passage or in the mixing chamber downstream of the restriction or throat.
  • Such means which may, for example, be helical ⁇ ly shaped guiding fins or other turbulence creating means, may partly promote the disintegration of the product into respirable particles and partly promote a Uniform distribution of the particles in the air or gas flow.
  • the diameter of the restriction or throat In order to obtain a sufficiently high velocity of the gas or air flow in the restriction of the air flow passage to form the desired respirable particles, the diameter of the restriction or throat must be relatively small. In a preferred embodiment the diameter of the restriction should be greater than 0.1 mm and smaller than 1 mm, for example 0.7-0.8 mm.
  • the diameter could be 0.1-0.5 mm, for example 0.3-0.4 mm.
  • the passage connecting the product chamber with the restriction of the gas flow passage should have a diameter which is greater than the diameter of the restriction. Otherwise, the frictional forces influencing the product flowing from the product chamber Into the gas flow passage would be too high.
  • the diame ⁇ ter of the connecting passage preferably exceeds 0.5 mm and is prefe ⁇ rably 0.5-1.5 mm, for example about 1 mm.
  • Fig. 1 is a diagrammatic sectional view showing part of a first embodiment of the inhaler according to the invention
  • Fig. 2 is a side view and partially sectional view of a second em ⁇ bodiment of the inhaler according to the invention
  • Fig. 3 is a side view and a partially sectional view of a third embodiment of the inhaler according to the invention
  • Fig. 4 is a side view and partially sectional view of fourth embodi ⁇ ment of the inhaler according to the invention
  • Fig. 5 Is a diagrammatic plan view and partially sectional view of a fifth embodiment of the inhaler according to the invention
  • Fig. 6 is a side view and partially sectional view of the embodiment shown in Fig. 5.
  • All of the embodiments of the inhaler according to the invention shown in the drawings comprise a housing 10 defining a reservoir 11 for a medical product.
  • the reservoir 11 may receive a supply of a powdered or particulate product which may, for example be contained in a perforatable product package, and the reservoir 11 may be con ⁇ nected a metering chamber 14, for example via a plurality of narrow openings or bores 13.
  • the metering chamber 14 is communicating with a mixing chamber 16 via a connecting passage 15.
  • the mixing chamber 16 is connected to a pressure gas source 12 through a gas flow passage 17, which defines a nozzle-like restriction 18 at its one end opening into the mixing chamber 16.
  • the connecting passage 15 opens into the gas flow passage 17 at or immediately adjacent to the restriction 18, so that the ejector effect caused by gas or air flowing through the nozzle-like restriction 18 generates a vacuum within the connecting passage.
  • the product reservoir 11 may be closed by a releasable lid or cap 19 so that a new supply of product or a new product package may be inserted into the product reservoir 11 from time to time.
  • the product package may be perforated or opened before it is inserted into the reservoir.
  • cutting or puncturing means (not shown ) may be arranged in the reservoir for automatically opening the pro ⁇ duct passage when it is inserted. It is also possible - but less convenient - to pour the powdered product into the product reservoir from a larger supply container.
  • the housing 10 is preferably made from metal and/or plastic, but may be made from any other suitable material. Depending on the material and the shape chosen, the housing may be made as a unitary body or be composed by two or more separately manufactured parts.
  • the housing has a mouth piece 20 which is adapted to be put between the lips of a patient when the inhaler is used.
  • the pressure gas source comprises a piston pump in which the gas flow passage 17 defines a continuation of the pump cylinder 21 in which a piston 22 is arranged so as to be displaceable therein.
  • the piston 22 is connected to a piston rod 23 which may be connected to an actuat ⁇ ing member or an actuating mechanism by means of which a fast forward movement may be imparted to the piston.
  • the piston may be returned to its retracted starting position by means of a return spring or ano ⁇ ther return means, not shown.
  • the inhaler When the inhaler is to be used it is positioned with the mouth piece 20 in an upward direction. Powdered medical product may then flow from the product reservoir 11 through the openings or bores 13 into the metering chamber 14 so as to fill the same.
  • the wall part in which the narrow openings or bores 13 are defined may be sieve- or grid-like so that only particles not exceeding a certain size may be passed into the metering chamber.
  • the actuating member connected to the piston rod 23 the user may move the piston 12 towards the restriction 18 to obtain a short, quick pressure stroke. This action generates such a superatmospheric pressure within the pumping cylinder that a vigorous air flow, which is directed towards the mouth piece 20, is created with the gas flow passage 17.
  • the velocity of the air flow will be rather high, for example 200-400 km/hour. This creates a rather low sub-atmospheric static pressure within the restriction. Because the connecting passage 15 opens into the restriction, the vacuum generated therein causes powdered product to be drawn from the metering chamber 14 and into the air flow through the restriction 18. The high velocity of the air flow and the vigorous turbulence created thereby cause that almost all of the product is disintegrated into respirable particles. The suction of powdered product from the metering chamber 14 into the restriction 18 is made possible by a venting passage 24 in the housing 10 communica ⁇ ting the ambient atmosphere with the metering chamber.
  • the vacuum generated in the restriction 18 causes air to flow from the ambient atmosphere through the venting passage 24, the metering chamber 14, the connecting passage 15 and into the restriction 18, whereby product from the metering chamber 14 is entrained with the air flow and introduced into the restriction 18.
  • the patient may insert the mouth piece 20 between the lips and inhale the air and the respirable medical product particles dispersed therein from the mixing chamber 16.
  • Turbulence generating means not shown, for im ⁇ proving disintegration of the medical product particles may be posi- tioned between the restriction 18 and the mixing chamber 16.
  • the pressure gas source 12 is also in the form of a piston pump, but in this case the axis of the pump ⁇ ing cylinder 21 extends transversely to the longitudinal axis of the inhaler.
  • the free end of the piston rod 23 is pivotally connected to one end of an operating member 25 formed like a lever of second order, and the other end of the operating member is pivotally con ⁇ nected to the housing by means of a hinge connection 26.
  • a spring 27 surrounding the free end of the piston rod 23 is adapted to move the piston through its suction stroke.
  • the mixing chamber 16 Adjacent to the mouth piece 20 the mixing chamber 16 comprises an enlargement 29, which may serve as a reservoir for the medical par- tides, which have been drawn out from the metering chamber 14 and are dispersed in air by operation of the inhaler.
  • the inhaler shown in Fig. 2 functions in substantially the same manner as described above in connection with Fig. 1.
  • the enlargement 29 may have such a size that substantially all of the dispersion of air and medical particles formed by operation of the inhaler remains in the mixing chamber 16 and its enlargement 29. That means that the patient need not inhale until the medical product has been dispersed by operating the operating member 25.
  • replacement air may flow into the mixing chamber 16, 29 via bores, now shown, extending through the wall of the mixing chamber, whereby the inner space of the mixing chamber is in communication with the atmosphere.
  • the mouth piece may be protected by a removable lid or casing 30 when the inhaler is not in use.
  • the pressure gas source 12 also comprises a piston pump with a pumping cylinder 21 having a movable piston therein mounted on a piston rod 23.
  • the opposite end of the piston rod is connected to a cap-shaped member 31 surrounding one end of the housing 10, and the piston rod 23 is surrounded by a coil spring 32 functioning as a tension spring and serving for biassing the piston 22 towards a retracted position.
  • the piston may be retained in an advanced position shown in Fig. 3 by means of a locking member 33.
  • the locking member 33 is surrounded by a spring 34 for moving the inner end of the locking member 33 into the piston path.
  • a valve member is mounted in the gas flow passage 17 and is biassed towards a closed position by a spring 36, in which position the connection between the pump cylinder 21 and the throat 18 of the gas flow passage is tightly closed.
  • the valve member 35 may, however, be moved to an open position by means of an operating member 36, which is shaped like a lever of first order and mounted in a recess 37 of the housing wall.
  • the operating member 36 is moved to the open position towards the bias of the spring 34.
  • the valve member 35 is In its closed position. Now, the user may apply an inwardly directed pressure to the cap-shaped member 31, whereby the piston 22 is moved inwardly in the cylinder 21 so as to compress the amount of air trapped within the cylinder.
  • a cam surface formed at the free end of the locking member 33 may during the forward movement of the piston 22 cooperate with a corresponding surface at the front side of the piston so as to move the locking member 33 from the path of the piston towards the bias of the spring 34.
  • the piston has passed the locking member 33 it is returned to a position in which it extends into the path of the piston behind the piston under the bias of the spring 34.
  • the piston 22 is locked in its advanced position.
  • the user may now place the mouth piece 20 between the lips and move the valve member 35 to its open position by operating the operating member 36.
  • Medical product from the metering chamber 14 will then be sucked into the restriction 18 and dispersed in the air flow as explained above.
  • the piston 22 may be released by withdrawing the locking member 33 from the path of the piston.
  • the inhaler comprises a metering mechanism having a rotatable drum or disc 38 with an annular arrange ⁇ ment of metering chambers 14.
  • the meter ⁇ ing chambers 14 are successively positioned opposite to the product reservoir 11 and the connecting passage 15, respectively.
  • This meter ⁇ ing mechanism may be of a type similar to that described in Swedish patent No. 453,566.
  • the pressure gas source 12 comprises a pumping chamber 39 partly defined by a concave arched depression at one end of the housing 10 and partly by a springy diaphragm or membrane 40 which is convexly domed in its unstressed condition.
  • This spring membrane may be moved between its convexly domed position shown in Fig. 4 and a concavely arched position in which the membrane is substantially in abutting engagement with the arched wall surface of the housing 10 as indicated in broken lines in Fig. 4.
  • the spring membrane 40 may be provided with a centrally arranged pressure button 41.
  • the protecting cap 30 is unscrewed from the housing 10, and it should be ascertained that the drum 38 has been moved to a position in which a metering chamber filled with medical product is in communication with the connecting passage 15. Thereafter, a pressure force is applied to the button 41 by a finger so as to rapidly move the spring membrane 40 from the position shown in solid lines to the position shown in broken lines in Fig. 4.
  • a high velocity air flow of short duration is generated in the gas flow passage 17 and in its restriction 18, whereby medical product is drawn from the metering chamber 14 into the restriction 18 through the connecting passage 15 as previously explained, and the product sucked into the restriction is dispersed in the air contained in the mixing chamber 16.
  • the patient may now inhale the air and the respirable medical particles dispersed therein from the mixing chamber 16.
  • the spring membrane 40 is now moved back to its convexly domed position shown in solid lines in Fig. 4 and the drum 38 is advanced by one step. Thereafter, the inhaler is again ready for use.
  • the embodiment of the inhaler shown In Figs. 5 and 6 are of a gene ⁇ rally flat shape, and the pressure gas source comprises a piston pump with a piston 12 having a relatively large diameter and a pumping cylinder with a relatively short axial length.
  • the piston may be operated by means of an integral pressure button extending outwardly from the housing 10, and a return spring member 43 is arranged within the pumping cylinder.
  • the gas flow passage 17 comprises a narrow bore forming the restriction 18 opening into a wider end portion 44, which communicates with the mixing chamber 16 through a plurality of transverse discharge openings 45.
  • a wall or projection 46 arranged at the end of the wider portion 44 of the gas flow passage extends transversely from a side wall of the housing so that the mixing chamber 16 communicates with the opening of the mouth piece through a passage 47 defined between the free edge of the projection 46 and the housing wall. Replacement air may flow into the mixing chamber 16 throug venting openings 48.
  • the piston pump shown in Fig. 3 may be replaced by a pumping device with a pumping chamber defined by elastically deformable wall parts.
  • the pumping chamber may be formed like a rubber bulb or a balloon provided with one-way valves.
  • the piston pump 21, 22 may, for example, be replaced by a pumping chamber defined by a spring membrane 40 as that shown in Fig. 4.
  • This spring membrane may be operated by the lever-like operating member 25, whereby the neces ⁇ sary operating pressure may be substantially reduced.
  • the operating member 25 may possibly be adapted to deform the spring membrane to such an extent only that it automatically moves back to Its starting position when the operating member is released.
  • the operating member for operating the spring membrane 40 may be shaped like a cap corresponding to the cap 31 shown in Fig. 3 and connected to the housing 10 by screw threads having a large pitch. The spring membrane 40 may then be operated by rotating such cap.
  • the pressure gas source 12 may comprise any device by means of which a high velocity air or gas flow of short duration may be provided in the gas flow passage 17.
  • the outer diameter of the piston 22 is 50 mm and the piston stroke is 6-10 mm. This means that for each operation of the piston of the inhaler a volume of 10-20 ml air is compressed rather suddenly and discharged through the gas flow passage 17.
  • the gas flow passage 17 has a minimum diame ⁇ ter of 0.7 mm, and the connecting passage 15 is a bore with a diame ⁇ ter of about 1 mm.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un inhalateur oral utilisé pour inhaler un produit médical en poudre ou particulaire, comprend une chambre (14) contenant un produit médical, une chambre de mélange (16), un passage (17) d'écoulement de gaz relié à la chambre de prélange, ainsi qu'une source de gaz sous pression ou un dispositif de pompage (40) destiné à envoyer brièvement dans le passage d'écoulement de gaz un écoulement de gaz vigoureux dirigé vers ladite chambre de mélange. Afin d'obtenir une vitesse élevée de l'écoulement de gaz, le passage (17) d'écoulement de gaz présente un resserrement (18) analogue à un ajutage. Ladite chambre de produit (14) communique avec ledit passage (17) d'écoulement de gaz au niveau du resserrement (18) ou à proximité de celui-ci, de manière à aspirer du produit de la chambre de produit dans l'écoulement de gaz par un effet d'éjection, de sorte que le produit est désintégré dans des petites particules respirables intimement mélangées à l'écoulement de gaz. On peut prévoir un réservoir de produit (11) destiné à contenir une alimentation en produit suffisante pour plusieurs opérations d'inhalation. Le produit médical peut, par exemple, être transféré d'un réservoir de produit à des chambres de produit ou des chambres de mesure (14), définies dans un cylindre ou un tambour rotatif (38). La source de gaz sous pression peut être un dispositif de pompage tel qu'une pompe à position. Toutefois, ledit dispositif de pompage comprend de préférence une chambre de pompage comportant une partie (40) de paroi résiliente analogue à un diaphragme.
PCT/DK1990/000005 1989-01-06 1990-01-08 Inhalateur oral WO1990007351A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK65/89 1989-01-06
DK6589A DK6589D0 (da) 1989-01-06 1989-01-06 Fremgangsmaade til inhaleringsterapi samt inhalator til udoevelse af fremgangsmaaden.
DK65989A DK65989D0 (da) 1989-01-06 1989-02-10 Fremgangsmaade og inhalator til inhalering af medicinpartikler
DK659/89 1989-02-10
DK4791/89 1989-09-28
DK479189A DK479189D0 (da) 1989-01-06 1989-09-28 Inhalator

Publications (1)

Publication Number Publication Date
WO1990007351A1 true WO1990007351A1 (fr) 1990-07-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1990/000005 WO1990007351A1 (fr) 1989-01-06 1990-01-08 Inhalateur oral

Country Status (3)

Country Link
AU (1) AU4947590A (fr)
DK (1) DK479189D0 (fr)
WO (1) WO1990007351A1 (fr)

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US7138141B2 (en) 1994-03-07 2006-11-21 Nektar Therapeutics Dispersible macromolecule compositions and methods for their preparation and use
US7521069B2 (en) 1994-03-07 2009-04-21 Novartis Ag Methods and compositions for pulmonary delivery of insulin
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