+

WO1999006598A3 - Determining common functional alleles in a population and uses therefor - Google Patents

Determining common functional alleles in a population and uses therefor Download PDF

Info

Publication number
WO1999006598A3
WO1999006598A3 PCT/US1998/016574 US9816574W WO9906598A3 WO 1999006598 A3 WO1999006598 A3 WO 1999006598A3 US 9816574 W US9816574 W US 9816574W WO 9906598 A3 WO9906598 A3 WO 9906598A3
Authority
WO
WIPO (PCT)
Prior art keywords
population
common functional
uses therefor
alleles
determining common
Prior art date
Application number
PCT/US1998/016574
Other languages
French (fr)
Other versions
WO1999006598A2 (en
Inventor
Patricia D Murphy
Original Assignee
Oncormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncormed Inc filed Critical Oncormed Inc
Priority to AU87768/98A priority Critical patent/AU8776898A/en
Publication of WO1999006598A2 publication Critical patent/WO1999006598A2/en
Publication of WO1999006598A3 publication Critical patent/WO1999006598A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for identifying functional allele profiles of a given gene are disclosed. Functional allele profiles comprise the commonly occurring alleles in a population, and the relative frequencies at which such alleles of a given gene occur. Functional allele profiles are useful in treatment and diagnosis of diseases, for genetic and pharmacogenetic applications and for evaluating the degree to which the gene(s) are under selective pressure.
PCT/US1998/016574 1997-08-04 1998-08-04 Determining common functional alleles in a population and uses therefor WO1999006598A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU87768/98A AU8776898A (en) 1997-08-04 1998-08-04 Determining common functional alleles in a population and uses therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90577297A 1997-08-04 1997-08-04
US08/905,772 1997-08-04
US8447198A 1998-05-22 1998-05-22
US09/084,471 1998-05-22

Publications (2)

Publication Number Publication Date
WO1999006598A2 WO1999006598A2 (en) 1999-02-11
WO1999006598A3 true WO1999006598A3 (en) 1999-04-29

Family

ID=26771013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/016574 WO1999006598A2 (en) 1997-08-04 1998-08-04 Determining common functional alleles in a population and uses therefor

Country Status (2)

Country Link
AU (1) AU8776898A (en)
WO (1) WO1999006598A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9206478B2 (en) 2002-12-31 2015-12-08 Branhaven LLC Methods and systems for inferring bovine traits

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001075163A2 (en) * 2000-04-04 2001-10-11 Polygenyx, Inc. High throughput methods for haplotyping
US6844154B2 (en) 2000-04-04 2005-01-18 Polygenyx, Inc. High throughput methods for haplotyping
ITMI20030434A1 (en) 2003-03-07 2004-09-08 Istituto Oncologico Romagnolo Coope Rativa Sociale METHOD FOR THE DETECTION OF COLON-RECTUM TUMORS.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654155A (en) * 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene
WO1998005677A1 (en) * 1996-08-05 1998-02-12 Oncormed, Inc. Susceptibility mutations for breast and ovarian cancer
WO1998044157A2 (en) * 1997-03-28 1998-10-08 Oncormed, Inc. Methods for identifying variations in polynucleotide sequences

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654155A (en) * 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene
WO1998005677A1 (en) * 1996-08-05 1998-02-12 Oncormed, Inc. Susceptibility mutations for breast and ovarian cancer
WO1998044157A2 (en) * 1997-03-28 1998-10-08 Oncormed, Inc. Methods for identifying variations in polynucleotide sequences

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AL MOUDALLAL Z ET AL.: "Monoclonal antibodies as probes of the antigenic structure of tobacco mosaic virus", THE EMBO JOURNAL, vol. 1, no. 8, 1982, pages 1005 - 1010, XP002095330 *
HACIA J G ET AL: "DETECTION OF HETEROZYGOUS MUTATIONS IN BRCA1 USING HIGH DENSITY OLIGONUCLEOTIDE ARRAYS AND TWO-COLOUR FLUORESCENCE ANALYSIS", NATURE GENETICS, vol. 14, no. 4, December 1996 (1996-12-01), pages 441 - 447, XP000615885 *
MADSEN H O ET AL: "A NEW FREQUENT ALLELE IS THE MISSING LINK IN THE STRUCTURAL POLYMORPHISM OF THE HUMAN MANNAN-BINDING PROTEIN", IMMUNOGENETICS, vol. 40, no. 1, 1994, pages 37 - 44, XP000609909 *
MATTILA P S ET AL.: "Extensive allele sequence variation in the J region of the human immunoglobin heavy chain gene locus", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 25, 1995, pages 2578 - 2582, XP002095329 *
MERAJVER ET AL: "Risk assessment and presymptomatic molecular diagnosis in hereditary breast cancer", CLINICS IN LABORATORY MEDICINE, vol. 1, no. 16, March 1996 (1996-03-01), pages 139 139, XP002079197 *
MORRISON N ET AL: "Frequent alleles of the human vitamin D receptor gene are functionally distinct", JOURNAL OF CELLULAR BIOCHEMISTRY. SUPPLEMENT, no. SUPPL. 16C, 21 February 1992 (1992-02-21), pages 20, XP002080808 *
WAINSCOAT J S ET AL.: "Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms", NATURE, vol. 319, 1986, pages 491 - 493, XP002095332 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9206478B2 (en) 2002-12-31 2015-12-08 Branhaven LLC Methods and systems for inferring bovine traits

Also Published As

Publication number Publication date
WO1999006598A2 (en) 1999-02-11
AU8776898A (en) 1999-02-22

Similar Documents

Publication Publication Date Title
WO2003074723A3 (en) Methods for detection of genetic disorders
CA2205382A1 (en) Enzymatic dna molecules
CA2171110A1 (en) Detection of amplified or deleted chromosomal regions
WO1997026270A3 (en) Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
AU2096097A (en) Nucleic acid molecules coding for debranching enzymes from maize
WO2001047944A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
AU6147096A (en) Use of nucleic acid ligands in flow cytometry
AU5671096A (en) Methods, nucleotide sequences and host cells for assaying ex ogenous and endogenous protease activity
WO2000017369A3 (en) Alzheimer's disease secretase
WO2001049097A3 (en) Alzheimer's disease secretase, app substrates therefor, and uses therefor
AU8132194A (en) Single nucleotide polymorphisms and their use in genetic analysis
WO2001018248A3 (en) Quorum sensing signaling in bacteria
AU4882296A (en) DNA molecules, preparation and use in gene therapy
WO1997025416A3 (en) Novel dna glycosylases and their use
WO1999055858A3 (en) Human nucleic acid sequences obtained from pancreas tumor tissue
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO1999051727A3 (en) Human nucleic acid sequences of normal ovary tissue
DE69534685D1 (en) TRANSFERASE AND AMYLASE, METHOD FOR PRODUCING THESE ENZYMES, THEIR USE AND THE CODING GENES
WO2003102216A3 (en) Multiplexed systems for nucleic acid sequencing
WO2001042474A3 (en) Interferon-like molecules and uses thereof
WO2000022122A3 (en) Genes, proteins and biallelic markers related to central nervous system disease
WO1999006598A3 (en) Determining common functional alleles in a population and uses therefor
AU5137498A (en) Iga nephropathy-associated gene
WO1997024974A3 (en) Compositions and methods for diagnosis of mutation in the von hippel-lindau tumor suppressor gene
WO1999011799A3 (en) Human aminopeptidase p gene

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载