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WO1999053296A1 - Procede de miniaturisation d'un polarimetre pour analyser des constituants de faible concentration dans un produit liquide a mesurer a base optique et dispositif permettant de mettre ledit procede en oeuvre - Google Patents

Procede de miniaturisation d'un polarimetre pour analyser des constituants de faible concentration dans un produit liquide a mesurer a base optique et dispositif permettant de mettre ledit procede en oeuvre Download PDF

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Publication number
WO1999053296A1
WO1999053296A1 PCT/EP1999/002196 EP9902196W WO9953296A1 WO 1999053296 A1 WO1999053296 A1 WO 1999053296A1 EP 9902196 W EP9902196 W EP 9902196W WO 9953296 A1 WO9953296 A1 WO 9953296A1
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WO
WIPO (PCT)
Prior art keywords
measuring
measured
measuring beam
prisms
light
Prior art date
Application number
PCT/EP1999/002196
Other languages
German (de)
English (en)
Inventor
Klaus Lang
Harald Pötzschke
Kai Zirk
Wolfgang Barnikol
Original Assignee
Glukomeditech Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glukomeditech Ag filed Critical Glukomeditech Ag
Priority to JP2000543812A priority Critical patent/JP2002511580A/ja
Priority to EP99919164A priority patent/EP1084393A1/fr
Publication of WO1999053296A1 publication Critical patent/WO1999053296A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J4/00—Measuring polarisation of light

Definitions

  • the invention relates to a method for miniaturizing a polarimeter with a very long light path for analysis, in particular low-concentration components, in the liquid material to be measured on an optical basis, and a device for carrying it out with the features of the claims.
  • the invention relates specifically to a method and an arrangement for measuring the concentration of optically active substances, in particular the glucose concentration in body fluids, by polarization measurement: If an optically isotropic (non-absorbing) medium is irradiated with linearly polarized, single-color light, one obtains from a Polarization analysis of the emerging light no maximum brightness when polarizer and analyzer are in parallel and no darkness when crossed, as would be expected. This phenomenon can be interpreted as a rotation of the plane of oscillation of the polarized light. Media that have this property are called optically active.
  • the angle ⁇ by which the plane of vibration is rotated is proportional to the length d of the light path in the material to be measured, and in the case of solutions it is also proportional to the concentration c of the optically active substance:
  • the proportionality factor [ ⁇ ] is the specific rotation, it is dependent on the material and the wavelength.
  • a linear extension of the optical path length cannot be implemented, for example in the case of miniaturized measuring systems which are used for monitoring chemical processes in production plants or are to be implanted for measurements in the human body (for example for the continuous measurement of the glucose level), i.e. the measuring arrangements cannot be made one or two meters long.
  • this problem is solved in that the measuring beam is passed through the material to be measured several times, the deflection preferably taking place by means of total reflection of appropriately arranged mirrors and particularly preferably using prisms.
  • linearly polarized light it is particularly favorable if linearly polarized light is used, and this remains linearly polarized when the direction changes due to reflections, since in the analysis 3 of the polarization state, a rotational position of the analyzer can be found, in which the light is completely extinguished and thus an increased sensitivity to elliptically polarized light can be achieved by using linearly polarized light.
  • a linearly polarized light should preferably remain linearly polarized after the total reflection (change in direction). This can be achieved by compensating for the phase difference ⁇ after one or more total reflections. If one calculates the phase difference ⁇ in the area of total reflection with the aid of the FRESNEL equations, the result is (BERGMANN SCHAEFER,
  • ⁇ 45 ° (angle of incidence) is selected so that the following combination 4 menhang results in:
  • Fig. 1 is a schematic representation of a device according to the invention
  • Fig. 2 is a schematic representation of a further embodiment similar to Fig. 1
  • Fig. 3 is a schematic representation of a further design according to the invention.
  • Fig. 1 shows a measuring chamber (1) with two right-angled, isosceles prisms (2,3), which are arranged with their base on parallel opposite surfaces of the measuring chamber so that part of the measuring chamber surface for the entry of the light source (4th ) outgoing, through the polarizer (5) measuring beam remains free.
  • the prism (2) covers the entire surface of the measuring chamber (1) and is cut off at its tip parallel to the base in order to allow the measuring beam to exit there. 5
  • the measuring beam is then evaluated after it emerges in the analyzer (6) in accordance with the measuring method selected.
  • a phase shifter (7,8) is arranged behind each prism. This ensures that the phase shift that occurs after each total reflection is compensated for and the polarization state of the light remains unchanged, this relates both to the orientation of the main axis and to the ellipticity. In the best case, the light is linearly polarized.
  • Fig. 2 shows a design similar to Fig.1, in which the total reflection of the measuring beam prisms (9) are arranged within the measuring chamber (10).
  • the measuring chamber (10) has an extension at a diagonally opposite corner in the form of a right-angled isosceles triangle, which with one leg form a continuation of a measuring chamber wall and whose base (11) is arranged parallel to the legs of the prisms and at right angles to the measuring beam.
  • the triangular widening of the measuring chamber on the outlet side of the measuring beam is omitted and an edge of the measuring chamber is cut off in such a way that the additional chamber wall (12) is arranged parallel to the base (11).
  • Phase shifters (13, 14, 15, 16) are arranged parallel to the legs of the prisms and at right angles to the measuring beam. In the light path, the light has a phase shift ⁇ between total reflection (beam deflection) and phase shifter. With such a design, a self-contained construction that is particularly accessible to miniaturization is possible.
  • Fig. 3 shows a design similar to Fig. 1, but in which the prisms (2, 3) are replaced by a pair of prisms (17, 19 and 21, 23), with the pair of prisms and behind the second prism (19 , 23) of these pairs of prisms phase shifters (18, 20, 22, 24) are arranged.
  • This ensures that the phase shift that occurs after each total reflection is compensated for.
  • the light has no phase shift ⁇ in the entire measuring chamber.
  • the measuring chamber can be open on one or both sides transversely to the direction of the measuring beam or closed with a membrane permeable to the medium to be measured.
  • the method according to the invention and the device proposed for its implementation allow, in particular, a strongly miniaturized construction of the entire measuring device, which can be implanted in a person, for example for the continuous measurement of the blood sugar concentration.
  • Other areas of application are the monitoring of, in particular, chemical process sequences or their control.
  • Another area of application is microreactors, in which conventional measuring arrangements cannot be used for dimensional reasons.
  • mirrors can also be used to deflect the measuring beam, in particular when no particularly small dimensions are required.
  • the transfer of the solution forms described above for prisms to designs using mirrors is within the knowledge of the person skilled in the art.

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un procédé de miniaturisation d'un polarimètre à très long trajet optique pour analyser en particulier des constituants de faible concentration dans un produit liquide à mesurer à base optique. Le faisceau de mesure optique est guidé plusieurs fois à travers le produit à mesurer. Le coudage du faisceau de mesure s'effectue par réflexion totale dans des prismes disposés sur les faces extérieures de la chambre de mesure ou par réflexion sur des miroirs disposés à l'intérieur de la chambre de mesure. Une structure optique déterminée permet de parvenir à ce que l'état de polarisation de la lumière, c.-à-d. son angle de rotation et son ellipticité, ne se modifie pas.
PCT/EP1999/002196 1998-04-09 1999-03-30 Procede de miniaturisation d'un polarimetre pour analyser des constituants de faible concentration dans un produit liquide a mesurer a base optique et dispositif permettant de mettre ledit procede en oeuvre WO1999053296A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2000543812A JP2002511580A (ja) 1998-04-09 1999-03-30 光学的ベースの液体測定対象物中の低濃度の成分の分析のための偏光計の小型化のための方法並びにこの方法の実施のための装置
EP99919164A EP1084393A1 (fr) 1998-04-09 1999-03-30 Procede de miniaturisation d'un polarimetre pour analyser des constituants de faible concentration dans un produit liquide a mesurer a base optique et dispositif permettant de mettre ledit procede en oeuvre

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19815932.3 1998-04-09
DE1998115932 DE19815932C2 (de) 1998-04-09 1998-04-09 Verfahren zur Miniaturisierung eines Polarimeters zur Analyse niedrig konzentrierter Komponenten im flüssigen Meßgut auf optischer Basis sowie Vorrichtung zu seiner Durchführung

Publications (1)

Publication Number Publication Date
WO1999053296A1 true WO1999053296A1 (fr) 1999-10-21

Family

ID=7864108

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/002196 WO1999053296A1 (fr) 1998-04-09 1999-03-30 Procede de miniaturisation d'un polarimetre pour analyser des constituants de faible concentration dans un produit liquide a mesurer a base optique et dispositif permettant de mettre ledit procede en oeuvre

Country Status (4)

Country Link
EP (1) EP1084393A1 (fr)
JP (1) JP2002511580A (fr)
DE (1) DE19815932C2 (fr)
WO (1) WO1999053296A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202012007771U1 (de) 2011-12-02 2013-03-07 Schildtec GmbH Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes

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WO2001046679A1 (fr) * 1999-12-22 2001-06-28 Applied Optics Center Of Delaware, Inc. Procede et dispositif d'analyse d'echantillons dans un analyseur clinique utilisant un rayonnement coherent
DE10030927C1 (de) * 2000-06-24 2002-05-23 Glukomeditech Ag Refraktometrisches Verfahren zur langzeitstabilen genauen Messung der Konzentrationen gelöster Stoffe sowie eine miniaturisierbare Vorrichtung zu seiner Durchführung
DE10030920C2 (de) * 2000-06-24 2003-01-02 Glukomeditech Ag Messvorrichtung zur gleichzeitigen refraktrometrischen und ATR-spektrometrischen Messung der Konzentration flüssiger Medien und Verwendung dieser Vorrichtung s
DE10321356A1 (de) * 2003-05-13 2004-12-23 Ses-Entwicklung Gmbh Verfahren zur reflexions-polarimetrischen Bestimmung der Konzentration optisch aktiver Bestandteile in Medien sowie eine Vorrichtung zur Durchführung dieses Verfahrens
DE10360111B3 (de) * 2003-12-12 2005-08-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Untersuchung von Gasen oder Gasgemischen mittels Laserdiodenspektroskopie
KR101842639B1 (ko) 2016-11-22 2018-05-14 한국해양과학기술원 다중광원 구조를 이용한 광분석장치 및 그 방법

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
DE202012007771U1 (de) 2011-12-02 2013-03-07 Schildtec GmbH Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes
US9808187B2 (en) 2011-12-02 2017-11-07 Schildtec GmbH Measuring chamber for an optical sensor for determining a concentration of a substance in the tissue fluid of a mammal

Also Published As

Publication number Publication date
EP1084393A1 (fr) 2001-03-21
JP2002511580A (ja) 2002-04-16
DE19815932C2 (de) 2000-06-21
DE19815932A1 (de) 1999-10-21

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