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WO1999041376A3 - Retinoblastoma protein complexes and retinoblastoma interacting proteins - Google Patents

Retinoblastoma protein complexes and retinoblastoma interacting proteins Download PDF

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Publication number
WO1999041376A3
WO1999041376A3 PCT/US1999/003072 US9903072W WO9941376A3 WO 1999041376 A3 WO1999041376 A3 WO 1999041376A3 US 9903072 W US9903072 W US 9903072W WO 9941376 A3 WO9941376 A3 WO 9941376A3
Authority
WO
WIPO (PCT)
Prior art keywords
retinoblastoma
complexes
glut1
protein complexes
interacting proteins
Prior art date
Application number
PCT/US1999/003072
Other languages
French (fr)
Other versions
WO1999041376A2 (en
WO1999041376A8 (en
WO1999041376A9 (en
Inventor
Meijia Yang
Krishnan Nandabalan
Vincent Peter Schulz
Original Assignee
Curagen Corp
Meijia Yang
Krishnan Nandabalan
Vincent Peter Schulz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP99932509A priority Critical patent/EP1054969A2/en
Application filed by Curagen Corp, Meijia Yang, Krishnan Nandabalan, Vincent Peter Schulz filed Critical Curagen Corp
Priority to CA002319782A priority patent/CA2319782A1/en
Priority to JP2000531557A priority patent/JP2002503466A/en
Priority to AU32917/99A priority patent/AU3291799A/en
Publication of WO1999041376A2 publication Critical patent/WO1999041376A2/en
Publication of WO1999041376A3 publication Critical patent/WO1999041376A3/en
Publication of WO1999041376A8 publication Critical patent/WO1999041376A8/en
Publication of WO1999041376A9 publication Critical patent/WO1999041376A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4736—Retinoblastoma protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to complexes of the retinoblastoma (RB) protein with proteins identified as interacting with RB by an improved, modified yeast two hybrid assay system. The proteins identified to interact with RB are RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392*. Thus, the present invention provides complexes of RB and RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392* and derivatives, fragments and analogs thereof. The invention also provides the CD24*, Set*, GluT1*, and 115392* genes and proteins and derivatives, fragments and analogs thereof. Methods of screening the complexes for efficacy in treating and/of preventing certain diseases and disorders, particularly hyperproliferative disorders, including cancer, neurodegenerative disease, and viral disease, are also disclosed herein.
PCT/US1999/003072 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins WO1999041376A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99932509A EP1054969A2 (en) 1998-02-12 1999-02-10 Retinoblastoma protein complexes and retinoblastoma interacting proteins
CA002319782A CA2319782A1 (en) 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins
JP2000531557A JP2002503466A (en) 1998-02-12 1999-02-12 Retinoblastoma protein complex and retinoblastoma interacting protein
AU32917/99A AU3291799A (en) 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7455998P 1998-02-12 1998-02-12
US24896099A 1999-02-11 1999-02-11
US09/248,960 1999-02-11
US60/074,559 1999-02-11

Publications (4)

Publication Number Publication Date
WO1999041376A2 WO1999041376A2 (en) 1999-08-19
WO1999041376A3 true WO1999041376A3 (en) 2000-02-10
WO1999041376A8 WO1999041376A8 (en) 2000-10-12
WO1999041376A9 WO1999041376A9 (en) 2001-02-01

Family

ID=26755794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/003072 WO1999041376A2 (en) 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins

Country Status (4)

Country Link
EP (1) EP1054969A2 (en)
JP (1) JP2002503466A (en)
CA (1) CA2319782A1 (en)
WO (1) WO1999041376A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476193B1 (en) 1998-10-06 2002-11-05 Curagen Corporation NLK1 protein and NLK1 protein complexes
US20090013420A1 (en) * 2002-08-07 2009-01-08 Tai Albert K Psmcs as Modifiers of the Rb Pathway and Methods of Use
WO2004048541A2 (en) * 2002-11-25 2004-06-10 Exelixis, Inc. Cct6s as modifiers of the rb pathway and methods of use
US7994306B2 (en) 2006-11-13 2011-08-09 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods of treating cancer using siRNA molecules directed against CD24
US20240335147A1 (en) * 2023-04-05 2024-10-10 Medtronic Minimed, Inc. Analyte transporting membranes for use with analyte sensors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005392A1 (en) * 1993-08-12 1995-02-23 Board Of Regents, The University Of Texas System Novel proteins which bind to retinoblastoma protein and their encoding dna sequences
EP0685493A1 (en) * 1994-06-01 1995-12-06 CANJI, Inc. Tumor suppressor fusion proteins
WO1998021228A1 (en) * 1996-11-15 1998-05-22 Canji, Inc. Tissue specific expression of retinoblastoma protein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005392A1 (en) * 1993-08-12 1995-02-23 Board Of Regents, The University Of Texas System Novel proteins which bind to retinoblastoma protein and their encoding dna sequences
EP0685493A1 (en) * 1994-06-01 1995-12-06 CANJI, Inc. Tumor suppressor fusion proteins
WO1998021228A1 (en) * 1996-11-15 1998-05-22 Canji, Inc. Tissue specific expression of retinoblastoma protein

Non-Patent Citations (20)

* Cited by examiner, † Cited by third party
Title
ARRIZA J L ET AL: "FUNCTIONAL COMPARISONS OF THREE GLUTAMATE TRANSPORTER SUBTYPES CLONED FROM HUMAN MOTOR CORTEX", JOURNAL OF NEUROSCIENCE, vol. 14, no. 9, 1 September 1994 (1994-09-01), pages 5559 - 5569, XP002053611, ISSN: 0270-6474 *
B. MATŸSKOVÁ ET AL.: "RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain.", ONCOGENE, vol. 12, 1996, pages 2563 - 2571, XP002111972 *
E. UZVOLGYI ET AL.: "Reintroduction of a normal retinoblastoma gene into retinoblastoma and osteosarcoma cells inhibits the replication associated function of SV40 large T antigen", CELL GROWTH & DIFFERENTIATION, vol. 2, no. 6, June 1991 (1991-06-01), pages 297 - 303, XP002111958 *
H. KAWAKAMI ET AL.: "Cloning and expression of a human glutamate transporter", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 199, no. 1, 28 February 1994 (1994-02-28), pages 171 - 176, XP002111969 *
H.B. CORBEIL ET AL.: "Functional importance of complex formation between the Retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2.", JOURNAL OF VIROLOGY, vol. 68, no. 10, October 1994 (1994-10-01), pages 6697 - 6709, XP002111956 *
J. ADNANE ET AL.: "The retinoblastoma susceptibility gene product regulates Myc-mediated transcription.", ONCOGENE, vol. 10, 1995, pages 381 - 387, XP002111962 *
J.F. PARTRIDGE ET AL.: "A developmentally regulated and tissue-dependent transcription factor complexes with the retinoblastoma gene product.", THE EMBO JOURNAL, vol. 10, no. 12, 1991, pages 3819 - 3827, XP002111959 *
J-M. FRIGERIO ET AL.: "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing.", HUMAN MOLECULAR GENETICS, vol. 4, no. 1, 1995, pages 37 - 43, XP002111970 *
K.M. TIMMS ET AL.: "130kb of DNA sequence reveals two new genes and a regional duplication distal to the Human Iduronate-2-sulfate Sulfatase locus.", GENOME RESEARCH, vol. 5, 1995, pages 71 - 78, XP002111971 *
L-R. HUANG ET AL.: "Cloning and expression of CD24 gene in human hepatocellular carcinoma: a potential early tumor marker gene correlates with p53 mutation and tumor differentiation.", CANCER RESEARCH, vol. 55, 15 October 1995 (1995-10-15), pages 4717 - 4721, XP002111964 *
M. LI ET AL.: "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 19, 10 May 1996 (1996-05-10), pages 11059 - 11062, XP002111967 *
M. VON LINDERN ET AL.: "can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.", MOLECULAR AND CELLULAR BIOLOGY, vol. 12, no. 8, August 1992 (1992-08-01), pages 3346 - 3355, XP002111966 *
N. DYSON ET AL.: "Large T Antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.", JOURNAL OF VIROLOGY, vol. 64, no. 3, March 1990 (1990-03-01), pages 1353 - 1356, XP002111957 *
N. NOMURA ET AL.: "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.", DNA RESEARCH, vol. 1, 1994, pages 27 - 35, XP002913067 *
P. SHASHIDHARAN ET AL.: "Cloning and characterization of a glutamate transporter cDNA from human cerebellum", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1216, 1993, pages 161 - 164, XP002111968 *
P.D. ADAMS ET AL.: "Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes.", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 2, February 1999 (1999-02-01), pages 1068 - 1080, XP002111963 *
R. KAY ET AL.: "CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor", JOURNAL OF IMMUNOLOGY, vol. 147, no. 4, 15 August 1991 (1991-08-15), pages 1412 - 1416, XP002111965 *
S.M. KHAN ET AL.: "A melanoma cell line sensitive to expression of a fusion protein binding the retinoblastoma protein family pocket domain.", EXPERIMENTAL CELL RESEARCH, vol. 223, 1996, pages 171 - 182, XP002111961 *
W G KAELIN ET AL: "Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties", CELL, vol. 70, 24 July 1992 (1992-07-24), pages 351 - 364, XP002089190, ISSN: 0092-8674 *
W-H. LEE ET AL: "The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity.", NATURE, vol. 329, 15 October 1987 (1987-10-15), pages 642 - 645, XP002111960 *

Also Published As

Publication number Publication date
WO1999041376A2 (en) 1999-08-19
CA2319782A1 (en) 1999-08-19
EP1054969A2 (en) 2000-11-29
JP2002503466A (en) 2002-02-05
WO1999041376A8 (en) 2000-10-12
WO1999041376A9 (en) 2001-02-01

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