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WO1999041376A8 - Retinoblastoma protein complexes and retinoblastoma interacting proteins - Google Patents

Retinoblastoma protein complexes and retinoblastoma interacting proteins

Info

Publication number
WO1999041376A8
WO1999041376A8 PCT/US1999/003072 US9903072W WO9941376A8 WO 1999041376 A8 WO1999041376 A8 WO 1999041376A8 US 9903072 W US9903072 W US 9903072W WO 9941376 A8 WO9941376 A8 WO 9941376A8
Authority
WO
WIPO (PCT)
Prior art keywords
retinoblastoma
complexes
glut1
protein complexes
interacting proteins
Prior art date
Application number
PCT/US1999/003072
Other languages
French (fr)
Other versions
WO1999041376A9 (en
WO1999041376A2 (en
WO1999041376A3 (en
Inventor
Meijia Yang
Krishnan Nandabalan
Vincent Peter Schulz
Original Assignee
Curagen Corp
Meijia Yang
Krishnan Nandabalan
Vincent Peter Schulz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP99932509A priority Critical patent/EP1054969A2/en
Application filed by Curagen Corp, Meijia Yang, Krishnan Nandabalan, Vincent Peter Schulz filed Critical Curagen Corp
Priority to CA002319782A priority patent/CA2319782A1/en
Priority to JP2000531557A priority patent/JP2002503466A/en
Priority to AU32917/99A priority patent/AU3291799A/en
Publication of WO1999041376A2 publication Critical patent/WO1999041376A2/en
Publication of WO1999041376A3 publication Critical patent/WO1999041376A3/en
Publication of WO1999041376A8 publication Critical patent/WO1999041376A8/en
Publication of WO1999041376A9 publication Critical patent/WO1999041376A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4736—Retinoblastoma protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to complexes of the retinoblastoma (RB) protein with proteins identified as interacting with RB by an improved, modified yeast two hybrid assay system. The proteins identified to interact with RB are RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392*. Thus, the present invention provides complexes of RB and RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392* and derivatives, fragments and analogs thereof. The invention also provides the CD24*, Set*, GluT1*, and 115392* genes and proteins and derivatives, fragments and analogs thereof. Methods of screening the complexes for efficacy in treating and/of preventing certain diseases and disorders, particularly hyperproliferative disorders, including cancer, neurodegenerative disease, and viral disease, are also disclosed herein.
PCT/US1999/003072 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins WO1999041376A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99932509A EP1054969A2 (en) 1998-02-12 1999-02-10 Retinoblastoma protein complexes and retinoblastoma interacting proteins
CA002319782A CA2319782A1 (en) 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins
JP2000531557A JP2002503466A (en) 1998-02-12 1999-02-12 Retinoblastoma protein complex and retinoblastoma interacting protein
AU32917/99A AU3291799A (en) 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7455998P 1998-02-12 1998-02-12
US60/074,559 1998-02-12
US24896099A 1999-02-11 1999-02-11
US09/248,960 1999-02-11

Publications (4)

Publication Number Publication Date
WO1999041376A2 WO1999041376A2 (en) 1999-08-19
WO1999041376A3 WO1999041376A3 (en) 2000-02-10
WO1999041376A8 true WO1999041376A8 (en) 2000-10-12
WO1999041376A9 WO1999041376A9 (en) 2001-02-01

Family

ID=26755794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/003072 WO1999041376A2 (en) 1998-02-12 1999-02-12 Retinoblastoma protein complexes and retinoblastoma interacting proteins

Country Status (4)

Country Link
EP (1) EP1054969A2 (en)
JP (1) JP2002503466A (en)
CA (1) CA2319782A1 (en)
WO (1) WO1999041376A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476193B1 (en) 1998-10-06 2002-11-05 Curagen Corporation NLK1 protein and NLK1 protein complexes
AU2003274911A1 (en) * 2002-08-07 2004-02-25 Exelixis, Inc. Mrbs as modifiers of the rb pathway and methods of use
WO2004048541A2 (en) * 2002-11-25 2004-06-10 Exelixis, Inc. Cct6s as modifiers of the rb pathway and methods of use
US7994306B2 (en) 2006-11-13 2011-08-09 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods of treating cancer using siRNA molecules directed against CD24
US20240335147A1 (en) * 2023-04-05 2024-10-10 Medtronic Minimed, Inc. Analyte transporting membranes for use with analyte sensors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071715A (en) * 1993-08-12 2000-06-06 Board Of Regents, The University Of Texas System Nucleic acids encoding novel proteins which bind to retinoblastoma protein
EP0685493A1 (en) * 1994-06-01 1995-12-06 CANJI, Inc. Tumor suppressor fusion proteins
CN100338219C (en) * 1996-11-15 2007-09-19 坎吉有限公司 Tissue specific expression of retinoblastoma protein

Also Published As

Publication number Publication date
WO1999041376A9 (en) 2001-02-01
WO1999041376A2 (en) 1999-08-19
JP2002503466A (en) 2002-02-05
EP1054969A2 (en) 2000-11-29
CA2319782A1 (en) 1999-08-19
WO1999041376A3 (en) 2000-02-10

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