WO1998039358B1 - Lipides cationiques oligomeres - Google Patents
Lipides cationiques oligomeresInfo
- Publication number
- WO1998039358B1 WO1998039358B1 PCT/US1998/004344 US9804344W WO9839358B1 WO 1998039358 B1 WO1998039358 B1 WO 1998039358B1 US 9804344 W US9804344 W US 9804344W WO 9839358 B1 WO9839358 B1 WO 9839358B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cationic lipids
- oligomeric cationic
- oligomeric
- present
- compositions
- Prior art date
Links
- 125000002091 cationic group Chemical group 0.000 title abstract 3
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Abstract
La présente invention concerne de nouveaux lipides cationiques oligomères. La présente invention concerne également des compositions de ces nouveaux lipides cationiques avec des macromolécules anioniques, des méthodes d'interférence avec une expression de protéines dans une cellule faisant appel à ces compositions, ainsi qu'une trousse destinée à leur préparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU66879/98A AU6687998A (en) | 1997-03-06 | 1998-03-05 | Oligomeric cationic lipids |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/812,775 | 1997-03-06 | ||
| US08/812,775 US5877220A (en) | 1997-03-06 | 1997-03-06 | Amide-based oligomeric cationic lipids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1998039358A1 WO1998039358A1 (fr) | 1998-09-11 |
| WO1998039358B1 true WO1998039358B1 (fr) | 1998-11-26 |
| WO1998039358A9 WO1998039358A9 (fr) | 1999-02-25 |
Family
ID=25210592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1998/004344 WO1998039358A1 (fr) | 1997-03-06 | 1998-03-05 | Lipides cationiques oligomeres |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US5877220A (fr) |
| AU (1) | AU6687998A (fr) |
| WO (1) | WO1998039358A1 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003507430A (ja) * | 1999-08-25 | 2003-02-25 | ジーエムピー カンパニーズ，インコーポレーテッド | 哺乳動物中で酸素運搬を向上する薬剤 |
| CN101041079A (zh) * | 1999-12-30 | 2007-09-26 | 诺瓦提斯公司 | 用于基因治疗的新的胶体合成载体 |
| US6686461B1 (en) * | 2000-03-22 | 2004-02-03 | Solulink Bioscience, Inc. | Triphosphate oligonucleotide modification reagents and uses thereof |
| CA2391316A1 (fr) * | 2000-03-22 | 2001-09-27 | Solulink, Incorporated | Agents de reticulation bifonctionnels a base d'hydrazine et de carbonyle |
| US7102024B1 (en) | 2000-08-01 | 2006-09-05 | Schwartz David A | Functional biopolymer modification reagents and uses thereof |
| AU2002348163A1 (en) * | 2001-11-02 | 2003-05-19 | Intradigm Corporation | Therapeutic methods for nucleic acid delivery vehicles |
| WO2004002453A1 (fr) | 2002-06-28 | 2004-01-08 | Protiva Biotherapeutics Ltd. | Appareil liposomal et procedes de fabrication |
| KR101164256B1 (ko) | 2003-09-15 | 2012-07-10 | 프로티바 바이오쎄라퓨틱스, 인코포레이티드 | 폴리에틸렌글리콜 개질된 지질 화합물 및 그의 용도 |
| US7158353B2 (en) * | 2003-11-06 | 2007-01-02 | Seagate Technology Llc | Magnetoresistive sensor having specular sidewall layers |
| EA011239B1 (ru) * | 2003-12-17 | 2009-02-27 | Элан Фарма Интернэшнл Лимитед | КОНЪЮГАТЫ Aβ ИММУНОГЕННЫХ ПЕПТИДНЫХ НОСИТЕЛЕЙ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
| SI1701968T1 (sl) * | 2003-12-17 | 2015-08-31 | Wyeth Llc | Imunogeni konjugati peptidnih nosilcev in postopek izdelave istih |
| WO2005121348A1 (fr) * | 2004-06-07 | 2005-12-22 | Protiva Biotherapeutics, Inc. | Arn interferant encapsule dans des lipides |
| EP1828219A4 (fr) * | 2004-11-17 | 2008-07-23 | Protiva Biotherapeutics Inc | Silence arnsi de l'apolipoproteine b |
| EP1948674A4 (fr) | 2005-11-02 | 2009-02-04 | Protiva Biotherapeutics Inc | Molecules d'arnsi modifiees et utilisations de celles-ci |
| CA2710713C (fr) * | 2007-12-27 | 2017-09-19 | Protiva Biotherapeutics, Inc. | Silencage de l'expression de la polo-like kinase a l'aide d'un arn interferent |
| WO2009086558A1 (fr) * | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Compositions et procédés améliorés pour la délivrance d'acides nucléiques |
| PT2279254T (pt) | 2008-04-15 | 2017-09-04 | Protiva Biotherapeutics Inc | Novas formulações lipídicas para entrega de ácido nucleico |
| CA2740000C (fr) | 2008-10-09 | 2017-12-12 | Tekmira Pharmaceuticals Corporation | Lipides amines ameliores et procedes d'administration d'acides nucleiques |
| WO2010083615A1 (fr) | 2009-01-26 | 2010-07-29 | Protiva Biotherapeutics, Inc. | Compositions et procédés d'inactivation de l'expression de l'apolipoprotéine c-iii |
| WO2011000107A1 (fr) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Formulations lipidiques inédites permettant l'administration d'agents thérapeutiques en direction de tumeurs solides |
| US8569256B2 (en) | 2009-07-01 | 2013-10-29 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| US9018187B2 (en) | 2009-07-01 | 2015-04-28 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| WO2011011447A1 (fr) | 2009-07-20 | 2011-01-27 | Protiva Biotherapeutics, Inc. | Compositions et méthodes pour rendre silencieuse l’expression du gène du virus ebola |
| WO2011084721A2 (fr) * | 2009-12-21 | 2011-07-14 | Agave Pharma Inc | Molécule cationique et procédé d'utilisation |
| US8455455B1 (en) | 2010-03-31 | 2013-06-04 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing genes involved in hemorrhagic fever |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| US8466122B2 (en) | 2010-09-17 | 2013-06-18 | Protiva Biotherapeutics, Inc. | Trialkyl cationic lipids and methods of use thereof |
| US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
| EP4295895A3 (fr) | 2017-05-11 | 2024-03-27 | Tc1 Llc | Interconnexion thermique pour pompe à sang implantable |
| US11591544B2 (en) | 2020-11-25 | 2023-02-28 | Akagera Medicines, Inc. | Ionizable cationic lipids |
| US12064479B2 (en) | 2022-05-25 | 2024-08-20 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5693622A (en) * | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| FR2645866B1 (fr) * | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
| DE69126530T2 (de) * | 1990-07-27 | 1998-02-05 | Isis Pharmaceutical, Inc., Carlsbad, Calif. | Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren |
| EP0558634A4 (en) * | 1990-11-23 | 1995-06-28 | Gilead Sciences Inc | Triplex-forming oligomers containing modified bases |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US5777153A (en) * | 1994-07-08 | 1998-07-07 | Gilead Sciences, Inc. | Cationic lipids |
| AU701106B2 (en) * | 1995-06-07 | 1999-01-21 | Promega Biosciences, Inc. | Novel carbamate-based cationic lipids |
| AU707947B2 (en) * | 1995-07-21 | 1999-07-22 | Promega Biosciences, Inc. | Novel amide-based cationic lipids |
-
1997
- 1997-03-06 US US08/812,775 patent/US5877220A/en not_active Expired - Fee Related
-
1998
- 1998-03-05 AU AU66879/98A patent/AU6687998A/en not_active Abandoned
- 1998-03-05 WO PCT/US1998/004344 patent/WO1998039358A1/fr active Application Filing
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