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WO1998039358B1 - Oligomeric cationic lipids - Google Patents

Oligomeric cationic lipids

Info

Publication number
WO1998039358B1
WO1998039358B1 PCT/US1998/004344 US9804344W WO9839358B1 WO 1998039358 B1 WO1998039358 B1 WO 1998039358B1 US 9804344 W US9804344 W US 9804344W WO 9839358 B1 WO9839358 B1 WO 9839358B1
Authority
WO
WIPO (PCT)
Prior art keywords
cationic lipids
oligomeric cationic
oligomeric
present
compositions
Prior art date
Application number
PCT/US1998/004344
Other languages
French (fr)
Other versions
WO1998039358A9 (en
WO1998039358A1 (en
Filing date
Publication date
Priority claimed from US08/812,775 external-priority patent/US5877220A/en
Application filed filed Critical
Priority to AU66879/98A priority Critical patent/AU6687998A/en
Publication of WO1998039358A1 publication Critical patent/WO1998039358A1/en
Publication of WO1998039358B1 publication Critical patent/WO1998039358B1/en
Publication of WO1998039358A9 publication Critical patent/WO1998039358A9/en

Links

Abstract

The present invention provides novel oligomeric cationic lipids. The present invention further provides compositions of these novel cationic lipids with anionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.

Claims

60AMENDED CLAIMS[received by the International Bureau on 11 September 1998 (11.09.98); original claim 1 amended; remaining claims unchanged (1 page)]
1. A compound of the formula
Figure imgf000003_0001
wherein Z is
Figure imgf000003_0002
wherein
(a) n is 0, 1 or 2;
(b) Rj. is hydroxy, a glyceryl moiety or a lipophilic moiety;
(c) R2 is
(i) -NH- [alki-NHjnj.- wherein nl is an integer from 0 to 2 and alkj. is an alkylene group of 2 to 6 carbon atoms ;
PCT/US1998/004344 1997-03-06 1998-03-05 Oligomeric cationic lipids WO1998039358A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66879/98A AU6687998A (en) 1997-03-06 1998-03-05 Oligomeric cationic lipids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/812,775 1997-03-06
US08/812,775 US5877220A (en) 1997-03-06 1997-03-06 Amide-based oligomeric cationic lipids

Publications (3)

Publication Number Publication Date
WO1998039358A1 WO1998039358A1 (en) 1998-09-11
WO1998039358B1 true WO1998039358B1 (en) 1998-11-26
WO1998039358A9 WO1998039358A9 (en) 1999-02-25

Family

ID=25210592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004344 WO1998039358A1 (en) 1997-03-06 1998-03-05 Oligomeric cationic lipids

Country Status (3)

Country Link
US (1) US5877220A (en)
AU (1) AU6687998A (en)
WO (1) WO1998039358A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001013933A2 (en) * 1999-08-25 2001-03-01 Gmp Companies, Inc. Agents for the enhanced oxygen delivery in mammals
CN101041079A (en) * 1999-12-30 2007-09-26 诺瓦提斯公司 Novel colloid synthetic vectors for gene therapy
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
EP1315699B1 (en) * 2000-03-22 2013-01-02 Solulink, Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
WO2003040399A2 (en) * 2001-11-02 2003-05-15 Intradigm Corporation Therapeutic methods for nucleic acid delivery vehicles
ATE485031T1 (en) 2002-06-28 2010-11-15 Protiva Biotherapeutics Inc METHOD AND DEVICE FOR PRODUCING LIPOSOMES
CN1882693B (en) 2003-09-15 2012-08-15 普洛体维生物治疗公司 Polyethyleneglycol-modified lipid compounds and uses thereof
US7158353B2 (en) * 2003-11-06 2007-01-02 Seagate Technology Llc Magnetoresistive sensor having specular sidewall layers
CN1934127B (en) 2003-12-17 2015-08-19 杨森阿尔茨海默氏症免疫治疗公司 Α β immunogenicity peptide carrier conjugates and production method thereof
DK1701968T3 (en) * 2003-12-17 2015-06-22 Wyeth Llc THE IMMUNOGENE PEPTID-CARRIER CONJUGATES AND PROCEDURES FOR THEIR PREPARATION
WO2005121348A1 (en) * 2004-06-07 2005-12-22 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
WO2006053430A1 (en) * 2004-11-17 2006-05-26 Protiva Biotherapeutics, Inc. Sirna silencing of apolipoprotein b
WO2007051303A1 (en) 2005-11-02 2007-05-10 Protiva Biotherapeutics, Inc. MODIFIED siRNA MOLECULES AND USES THEREOF
CA2710713C (en) * 2007-12-27 2017-09-19 Protiva Biotherapeutics, Inc. Silencing of polo-like kinase expression using interfering rna
EP3100718B1 (en) * 2008-01-02 2019-11-27 Arbutus Biopharma Corporation Improved compositions and methods for the delivery of nucleic acids
US8058069B2 (en) 2008-04-15 2011-11-15 Protiva Biotherapeutics, Inc. Lipid formulations for nucleic acid delivery
EP2350043B9 (en) 2008-10-09 2014-08-20 TEKMIRA Pharmaceuticals Corporation Improved amino lipids and methods for the delivery of nucleic acids
CA2750561C (en) 2009-01-26 2017-10-10 Protiva Biotherapeutics, Inc. Compositions and methods for silencing apolipoprotein c-iii expression
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US8283333B2 (en) 2009-07-01 2012-10-09 Protiva Biotherapeutics, Inc. Lipid formulations for nucleic acid delivery
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011011447A1 (en) 2009-07-20 2011-01-27 Protiva Biotherapeutics, Inc. Compositions and methods for silencing ebola virus gene expression
WO2011084721A2 (en) * 2009-12-21 2011-07-14 Agave Pharma Inc Cationic molecule and method of use
US8455455B1 (en) 2010-03-31 2013-06-04 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes involved in hemorrhagic fever
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
US8466122B2 (en) 2010-09-17 2013-06-18 Protiva Biotherapeutics, Inc. Trialkyl cationic lipids and methods of use thereof
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
US11013905B2 (en) 2017-05-11 2021-05-25 Tci Llc Thermal interconnect for implantable blood pump
JP2023553343A (en) 2020-11-25 2023-12-21 アカゲラ・メディスンズ，インコーポレイテッド Lipid nanoparticles and related methods of use for delivering nucleic acids
AU2023275780A1 (en) 2022-05-25 2024-12-05 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5693622A (en) * 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
FR2645866B1 (en) * 1989-04-17 1991-07-05 Centre Nat Rech Scient NEW LIPOPOLYAMINES, THEIR PREPARATION AND THEIR USE
US5614617A (en) * 1990-07-27 1997-03-25 Isis Pharmaceuticals, Inc. Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
EP0558634A4 (en) * 1990-11-23 1995-06-28 Gilead Sciences Inc Triplex-forming oligomers containing modified bases
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
CA2223088A1 (en) * 1995-06-07 1996-12-19 Bob Dale Brown Novel carbamate-based cationic lipids
EP0869937A4 (en) * 1995-07-21 2004-07-21 Promega Biosciences Inc Novel amide-based cationic lipids

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