WO1998037055B1 - Composes, compositions et procedes relatifs a l'imagerie et au traitement du cancer - Google Patents
Composes, compositions et procedes relatifs a l'imagerie et au traitement du cancerInfo
- Publication number
- WO1998037055B1 WO1998037055B1 PCT/US1998/003215 US9803215W WO9837055B1 WO 1998037055 B1 WO1998037055 B1 WO 1998037055B1 US 9803215 W US9803215 W US 9803215W WO 9837055 B1 WO9837055 B1 WO 9837055B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- methods
- compounds
- therapy
- compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 12
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 238000001959 radiotherapy Methods 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- -1 cycloalkyenyl Chemical group 0.000 claims 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Abstract
On décrit des composés de bisaminothiol et des composés amino comprenant des pharmacophores adjoints, des complexes de ces composés comprenant 99mTc(V)O, Re(V)O, In?+3, 67Ga+3, 90Y+3, 109Pd+2 ou 105Rh+3¿ et des compositions pharmaceutiques contenant ces complexes. On décrit également des procédés permettant de diagnostiquer chez un mammifère la présence d'une tumeur, des procédés permettant de détecter in vitro une cellule cancéreuse dans un échantillon de tissu de mammifère et des procédés permettant de traiter un mammifère ayant une tumeur.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX9911116A MX257801B (en) | 1997-06-02 | 1998-02-18 | Plant transformation methods |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/802,275 US5919934A (en) | 1997-02-19 | 1997-02-19 | Compounds, compositions, and methods for cancer imaging and therapy |
| US08/802,275 | 1997-02-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998037055A1 WO1998037055A1 (fr) | 1998-08-27 |
| WO1998037055B1 true WO1998037055B1 (fr) | 1998-10-01 |
Family
ID=25183282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1998/003215 WO1998037055A1 (fr) | 1997-02-19 | 1998-02-18 | Composes, compositions et procedes relatifs a l'imagerie et au traitement du cancer |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US5919934A (fr) |
| WO (1) | WO1998037055A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751645B1 (fr) * | 1996-07-29 | 1998-12-24 | Sanofi Sa | Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6489312B1 (en) | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
| CA2400856C (fr) | 2000-02-22 | 2011-03-29 | Biostream Therapeutics, Inc. | Agents d'imagerie pour le diagnostic de la maladie de parkinson |
| WO2001074297A2 (fr) | 2000-03-31 | 2001-10-11 | Wake Forest University | Methodes et compositions utilisant un variant d'epissage alternatif du recepteur de sigma-1 |
| DE60127951T2 (de) * | 2000-04-28 | 2008-01-17 | President And Fellows Of Harvard College, Cambridge | Kleine technetium-99m und rhenium markierte mittel und verfahren zum tumor-imaging |
| CA2454419A1 (fr) * | 2001-07-20 | 2003-01-30 | Children's Medical Center Corporation | Complexe d'invasion et procedes de ciblage |
| CN102133407A (zh) * | 2002-03-01 | 2011-07-27 | 图兰恩教育基金管理人 | 治疗剂或细胞毒性剂与生物活性肽的偶联物 |
| US20060159617A1 (en) * | 2002-11-08 | 2006-07-20 | Ashfaq Mahmood | Small technetium-99m and rhenium labeled agents and methods for imaging tissues, organs and tumors |
| WO2009126160A1 (fr) * | 2008-04-10 | 2009-10-15 | University Of Florida Research Foundation | Compositions et procédés pour le traitement du cancer de la prostate |
| CN103732595B (zh) | 2011-08-17 | 2017-02-08 | 默克及其合伙人公司 | 叶酸的白蛋白‑结合实体缀合物 |
| US10457642B2 (en) | 2015-05-04 | 2019-10-29 | The Trustees Of The University Of Pennsylvania | 211-astatine containing radiotherapeutics for the treatment of cancer |
| JP2023526515A (ja) | 2020-05-20 | 2023-06-21 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | リソソーム蓄積症をヒスタチンペプチドで処置するための方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4584187A (en) * | 1981-04-01 | 1986-04-22 | Wieland Donald M | Imaging agent and method of use |
| US5154913A (en) * | 1987-11-19 | 1992-10-13 | Vanderbilt University | Radioiodinated benzamines method of their use as radioimaging agents |
| US4925650A (en) * | 1988-11-16 | 1990-05-15 | Mallinckrodt, Inc. | Technetium -99m complex for examining the renal function |
| FR2642972B1 (fr) * | 1989-02-14 | 1994-08-05 | Inst Nat Sante Rech Med | Agents pour le diagnostic et le traitement des melanomes, derives halogenes aromatiques utilisables comme de tels agents et leur preparation |
| US5122361A (en) * | 1989-04-17 | 1992-06-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and imaging agents |
| US5262175A (en) * | 1989-05-10 | 1993-11-16 | Solanki Kishor K | Stabilization of radiopharmaceutical compositions |
| US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| ES2137996T3 (es) * | 1992-07-17 | 2000-01-01 | Janssen Pharmaceutica Nv | 4-amino-n-(4-metil-4-piperidinil)-2-metoxibenzamidas, su preparacion y su empleo como antagonistas 5-ht2. |
| GB9223168D0 (en) * | 1992-11-05 | 1992-12-16 | Johnson Matthey Plc | Improvements in molecule labelling |
| WO1994026314A1 (fr) * | 1993-05-06 | 1994-11-24 | John Christy S | Composes destines a la visualisation et a la therapie du cancer |
| US5387614A (en) * | 1993-07-27 | 1995-02-07 | University Of Iowa Research Foundation | Use of sigma receptor ligands as salivary gland stimulants |
| US5457207A (en) * | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
| US5499761A (en) * | 1994-01-21 | 1996-03-19 | Reimers; Eric W. | Adjustable balance golf bag |
-
1997
- 1997-02-19 US US08/802,275 patent/US5919934A/en not_active Expired - Fee Related
-
1998
- 1998-02-18 WO PCT/US1998/003215 patent/WO1998037055A1/fr active Application Filing
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