WO1998037055B1 - Compounds, compositions, and methods for cancer imaging and therapy - Google Patents
Compounds, compositions, and methods for cancer imaging and therapyInfo
- Publication number
- WO1998037055B1 WO1998037055B1 PCT/US1998/003215 US9803215W WO9837055B1 WO 1998037055 B1 WO1998037055 B1 WO 1998037055B1 US 9803215 W US9803215 W US 9803215W WO 9837055 B1 WO9837055 B1 WO 9837055B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- methods
- compounds
- therapy
- compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 12
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 238000001959 radiotherapy Methods 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- -1 cycloalkyenyl Chemical group 0.000 claims 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Abstract
Disclosed are bisaminothiol and amino compounds with appended pharmacophores, complexes of these compounds with 99mTc(V)0, Re(V)0, In?+3, 67Ga+3, 90Y+3, 109Pd+2 or 105Rh+3¿, and pharmaceutical compositions containing the complexes. Also disclosed are methods of diagnosing a mammal for the presence of a mammalian tumor, methods for in vitro detection of a cancer cell in a mammalian tissue sample, and methods of treating a mammal having a tumor.
Claims
AMENDED CLAIMS
[received by the International Bureau on 10 August 1998 (10.08.98); original claims 1, 2 and 16 amended; new claims 65 and 66 added; remaining claims unchanged (4 pages)]
1. A compound, for use in radioimaging and radiotherapy, of the formula K1 or
K2
wherein:
R., and R2 are H or Me:
R3 is H, lower alkyl, lower alkylene, cycloalkyenyl, aryl, or arylalkane;
R4 and R5 are independently —
Rs is — (CH2)j — CZ — NRΪ 0 — ( Chfe) m— Rg
177
A compound as claimed in claim 1 , wherein the compound is
wherein Z, j, m, R3, R9, and R10 are as defined above, and R7 further comprises -C(CH3)2-.
3. A compound as claimed in claim 1 , wherein the compound is
wherein Z, j, m, R9 and R10 are as defined above.
78
6. A compound according to claim 1 , wherein R6 further comprises
-CH2— CH2-N
wherein R, and R, are as defined above.
79
65. A compound for use in radioimaging and radiotherapy, wherein said
compound is:
66. A compound for use in radioimaging and radiotherapy, wherein said
compound is:
80
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX9911116A MX257801B (en) | 1997-06-02 | 1998-02-18 | Plant transformation methods |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/802,275 US5919934A (en) | 1997-02-19 | 1997-02-19 | Compounds, compositions, and methods for cancer imaging and therapy |
| US08/802,275 | 1997-02-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998037055A1 WO1998037055A1 (en) | 1998-08-27 |
| WO1998037055B1 true WO1998037055B1 (en) | 1998-10-01 |
Family
ID=25183282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1998/003215 WO1998037055A1 (en) | 1997-02-19 | 1998-02-18 | Compounds, compositions, and methods for cancer imaging and therapy |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US5919934A (en) |
| WO (1) | WO1998037055A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751645B1 (en) * | 1996-07-29 | 1998-12-24 | Sanofi Sa | AMINES FOR THE MANUFACTURE OF DRUGS TO PREVENT THE PROLIFERATION OF TUMOR CELLS |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6489312B1 (en) | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
| US6515131B2 (en) | 2000-02-22 | 2003-02-04 | Biostream Therapeutics, Inc. | Imagining agents for diagnosis of Parkinson's disease |
| AU2001287287A1 (en) | 2000-03-31 | 2001-10-15 | Wake Forest University | Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor |
| EP1276718B1 (en) * | 2000-04-28 | 2007-04-18 | President And Fellows Of Harvard College | Small technetium-99m and rhenium labeled agents and methods for imaging tumors |
| EP1417328A2 (en) * | 2001-07-20 | 2004-05-12 | Children's Medical Center Corporation | Invasion complex and methods of targeting |
| CN102133407A (en) * | 2002-03-01 | 2011-07-27 | 图兰恩教育基金管理人 | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
| US20060159617A1 (en) * | 2002-11-08 | 2006-07-20 | Ashfaq Mahmood | Small technetium-99m and rhenium labeled agents and methods for imaging tissues, organs and tumors |
| WO2009126160A1 (en) * | 2008-04-10 | 2009-10-15 | University Of Florida Research Foundation | Compositions and methods for the treatment of prostate carcinoma |
| EP2766364B1 (en) | 2011-08-17 | 2024-07-31 | Merck & Cie | Folate conjugates of albumin-binding entities |
| US10457642B2 (en) | 2015-05-04 | 2019-10-29 | The Trustees Of The University Of Pennsylvania | 211-astatine containing radiotherapeutics for the treatment of cancer |
| JP2023526515A (en) | 2020-05-20 | 2023-06-21 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | Methods for treating lysosomal storage diseases with histatin peptides |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4584187A (en) * | 1981-04-01 | 1986-04-22 | Wieland Donald M | Imaging agent and method of use |
| US5154913A (en) * | 1987-11-19 | 1992-10-13 | Vanderbilt University | Radioiodinated benzamines method of their use as radioimaging agents |
| US4925650A (en) * | 1988-11-16 | 1990-05-15 | Mallinckrodt, Inc. | Technetium -99m complex for examining the renal function |
| FR2642972B1 (en) * | 1989-02-14 | 1994-08-05 | Inst Nat Sante Rech Med | AGENTS FOR THE DIAGNOSIS AND TREATMENT OF MELANOMAS, HALOGENATED AROMATIC DERIVATIVES SUITABLE FOR USE AS SUCH AGENTS AND THEIR PREPARATION |
| US5122361A (en) * | 1989-04-17 | 1992-06-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and imaging agents |
| US5262175A (en) * | 1989-05-10 | 1993-11-16 | Solanki Kishor K | Stabilization of radiopharmaceutical compositions |
| US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| CA2138150C (en) * | 1992-07-17 | 2005-04-19 | Josepha E. M. F. Leysen | 4-amino-n-(4-methyl-4-piperidinyl)-2-methoxybenzamides |
| GB9223168D0 (en) * | 1992-11-05 | 1992-12-16 | Johnson Matthey Plc | Improvements in molecule labelling |
| EP0650372A4 (en) * | 1993-05-06 | 1996-07-03 | Christy S John | Compounds for cancer imaging and therapy. |
| US5387614A (en) * | 1993-07-27 | 1995-02-07 | University Of Iowa Research Foundation | Use of sigma receptor ligands as salivary gland stimulants |
| US5457207A (en) * | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
| US5499761A (en) * | 1994-01-21 | 1996-03-19 | Reimers; Eric W. | Adjustable balance golf bag |
-
1997
- 1997-02-19 US US08/802,275 patent/US5919934A/en not_active Expired - Fee Related
-
1998
- 1998-02-18 WO PCT/US1998/003215 patent/WO1998037055A1/en active Application Filing
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1318615C (en) | Radiohalogenated compounds for site specific labeling | |
| WO1998037055B1 (en) | Compounds, compositions, and methods for cancer imaging and therapy | |
| US5434287A (en) | Bifunctional DTPA-type ligand | |
| EP0452858B1 (en) | Metal complexes of acid adducts to dioxime ligands useful in labelling proteins and other amine-containing compounds | |
| DE3855564T2 (en) | Functionalized polyamine chelating agents, their complexes and processes for their preparation | |
| US4401592A (en) | Pharmaceutical composition having antitumor activity | |
| CA1336739C (en) | Diphosphonate-derivatized macromolecules | |
| RU94042922A (en) | Novel compounds, method for their production, pharmaceutical composition | |
| EA200100766A1 (en) | QUINOLIN-2-ON-SUBSTITUTED HETEROAARYNE DERIVATIVES USED AS ANTI-TUMOR AGENTS | |
| JPH08502719A (en) | Compounds, compositions, and methods for binding bioactive agents to bioparticle surface membranes | |
| GB1581075A (en) | Radiolabeled derivatives of folic acid | |
| CN119192214B (en) | Targeted binding fibroblast activation protein multimeric compound and application thereof | |
| WO1998037055A1 (en) | Compounds, compositions, and methods for cancer imaging and therapy | |
| WO1992011039A1 (en) | Derivatized tris-catechol chelating agents | |
| Eckelman et al. | Iodinated bleomycin: an unsatisfactory radiopharmaceutical for tumor localization | |
| EP0688313B1 (en) | Ligands and metal complexes thereof | |
| Delpassand et al. | Synthesis, Biodistribution, and Estrogen Receptor Scintigraphy of Indium-111—Diethylenetriaminepentaacetic Acid–Tamoxifen Analogue | |
| Anghileri et al. | 57Co-hematoporphyrin accumulation by experimental tumors | |
| US5635158A (en) | Peptides modified by the phosphine group for marking with 99M TC and 186-188 RE or paramagnetic agents | |
| JP2007509047A (en) | Use of metal tricarbonyl complexes as chemical toxicants for radiation therapy. | |
| Mangin et al. | Synthesis of a DOTA-C-glyco bifunctional chelating agent and preliminary in vitro and in vivo study of [68 Ga] Ga-DOTA-C-glyco-RGD | |
| Shysh et al. | Radioimmunodetection of murine mammary adenocarcinoma (TA3/Ha) lung and liver metastases with radioiodinated PNA | |
| US5633372A (en) | Heterocycle based nitrogen sulfur ligands useful in radiographic imaging agents | |
| SEKI et al. | Radioimmunoassay of bleomycins | |
| US5623077A (en) | Imidazole based nitrogen sulfur ligands useful in radiographic imaging agents |