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WO1998024810A3 - Homologues vertebres de la proteine unc-53 de c. elegans - Google Patents

Homologues vertebres de la proteine unc-53 de c. elegans Download PDF

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Publication number
WO1998024810A3
WO1998024810A3 PCT/EP1997/006956 EP9706956W WO9824810A3 WO 1998024810 A3 WO1998024810 A3 WO 1998024810A3 EP 9706956 W EP9706956 W EP 9706956W WO 9824810 A3 WO9824810 A3 WO 9824810A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
vertebrate
unc
elegans
homologues
Prior art date
Application number
PCT/EP1997/006956
Other languages
English (en)
Other versions
WO1998024810A2 (fr
Inventor
Christ Jules Platteeuw
Arjol Carlos Manuel Buesa
Marc Deraeymaeker
Peter Verhasselt
Nathalie Jeanne Raymonde Pujol
Luc Jacques Simon Maertens
Walter Luyten
Hugo Geerts
Joel Stefaan Vandekerckhove
Johan Geysen
Thierry Andre Olivier Bogaert
Original Assignee
Janssen Pharmaceutica Nv
Christ Jules Platteeuw
Arjol Carlos Manuel Buesa
Marc Deraeymaeker
Peter Verhasselt
Nathalie Jeanne Raymonde Pujol
Luc Jacques Simon Maertens
Walter Luyten
Hugo Geerts
Joel Stefaan Vandekerckhove
Johan Geysen
Thierry Andre Olivier Bogaert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv, Christ Jules Platteeuw, Arjol Carlos Manuel Buesa, Marc Deraeymaeker, Peter Verhasselt, Nathalie Jeanne Raymonde Pujol, Luc Jacques Simon Maertens, Walter Luyten, Hugo Geerts, Joel Stefaan Vandekerckhove, Johan Geysen, Thierry Andre Olivier Bogaert filed Critical Janssen Pharmaceutica Nv
Priority to CA002273827A priority Critical patent/CA2273827A1/fr
Priority to JP52523198A priority patent/JP2001522222A/ja
Priority to AU56622/98A priority patent/AU5662298A/en
Priority to EP97952926A priority patent/EP0941239A1/fr
Publication of WO1998024810A2 publication Critical patent/WO1998024810A2/fr
Publication of WO1998024810A3 publication Critical patent/WO1998024810A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne l'identification d'homologues vertébrés de la protéine UNC-53 de C. elegans et des séquences d'acide nucléotidiques codant pour lesdits homologues ou leurs équivalents fonctionnels. Les séquences nucléotidiques sont utilisées dans un vecteur approprié pour transfecter ou transformer des cellules, des tissus ou des organismes utiles pour identifier des inhibiteurs ou des activateurs de l'homologue vertébré ou d'autres protéines impliquées dans la voie de transduction du signal dont ledit homologue vertébré est un élément. N'importe lequel desdits inhibiteurs ou activateurs identifiés peut être inclus dans une composition pharmaceutique ou dans la préparation d'un médicament destiné à traiter des pathologies (maladie neurologique, trauma aigu, par exemple) ou à promouvoir la régénération neuronale ou inhiber la métastase ou la perte de l'inhibition de contact.
PCT/EP1997/006956 1996-12-04 1997-12-03 Homologues vertebres de la proteine unc-53 de c. elegans WO1998024810A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002273827A CA2273827A1 (fr) 1996-12-04 1997-12-03 Homologues vertebres de la proteine unc-53 de c. elegans
JP52523198A JP2001522222A (ja) 1996-12-04 1997-12-03 線虫のｕｎｃ−５３タンパク質の脊椎動物ホモログ
AU56622/98A AU5662298A (en) 1996-12-04 1997-12-03 Vertebrate homologues of unc-53 protein of c. elegans
EP97952926A EP0941239A1 (fr) 1996-12-04 1997-12-03 Homologues vertebres de la proteine unc-53 de c. elegans

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9625283.8A GB9625283D0 (en) 1996-12-04 1996-12-04 Vertebrate homologues of unc-53 protein of c.elegans or functional eqivalents thereof and cdna sequences coding for said homologue
GB9625283.8 1996-12-04

Publications (2)

Publication Number Publication Date
WO1998024810A2 WO1998024810A2 (fr) 1998-06-11
WO1998024810A3 true WO1998024810A3 (fr) 1999-01-21

Family

ID=10803979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/006956 WO1998024810A2 (fr) 1996-12-04 1997-12-03 Homologues vertebres de la proteine unc-53 de c. elegans

Country Status (6)

Country Link
EP (1) EP0941239A1 (fr)
JP (1) JP2001522222A (fr)
AU (1) AU5662298A (fr)
CA (1) CA2273827A1 (fr)
GB (1) GB9625283D0 (fr)
WO (1) WO1998024810A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9811962D0 (en) * 1998-06-03 1998-07-29 Janssen Pharmaceutica Nv Vertebrate homologue of UNC-53 protein of C.elegans
DE19908423A1 (de) * 1999-02-26 2000-08-31 Deutsches Krebsforsch An der Entwicklung des ZNS beteiligtes Protein (TP)
GB9906018D0 (en) * 1999-03-16 1999-05-12 Devgen Nv Expression of DNA or proteins in C.elegans
DE10042609A1 (de) * 2000-08-30 2002-03-28 Deutsches Krebsforsch Verwendung von T-Proteinen zur differentiellen Charakterisierung und Therapie von Verletzungen und Tumoren des Nervensystems
EP1492884A2 (fr) * 2002-04-05 2005-01-05 The University of Tokyo Methodes de diagnostic et de traitement du cancer colorectal
EP1831366A2 (fr) * 2004-12-30 2007-09-12 Agency for Science, Technology and Research Genes du hamster chinois lies a l'apoptose
TW200640485A (en) * 2005-01-19 2006-12-01 Vaxinnate Corp Compositions of pathogen-associated molecular patterns and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038555A2 (fr) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 de c. elegans, son utilisation en regulation du comportement cellulaire et compositions pharmaceutiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038555A2 (fr) * 1995-05-31 1996-12-05 Thierry Bogaert Unc-53 de c. elegans, son utilisation en regulation du comportement cellulaire et compositions pharmaceutiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HEKIMI, S. AND KERSHAW, D.: "Axonal guidance defects in a Caenorhabditis elegans mutant reveal cell-extrinsic determinants of neuronal morphology", THE JOURNAL OF NEUROSCIENCE, vol. 13, no. 10, October 1993 (1993-10-01), pages 4254 - 4271, XP000612286 *
STERN, M.J. ET AL.: "The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5", MOLECULAR BIOLOGY OF THE CELL, vol. 4, no. 11, November 1993 (1993-11-01), pages 1175 - 1188, XP002079466 *

Also Published As

Publication number Publication date
GB9625283D0 (en) 1997-01-22
EP0941239A1 (fr) 1999-09-15
JP2001522222A (ja) 2001-11-13
CA2273827A1 (fr) 1998-06-11
AU5662298A (en) 1998-06-29
WO1998024810A2 (fr) 1998-06-11

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