WO1997014966B1 - Procede d'activation d'une nouvelle voie de regulation de ligand - Google Patents
Procede d'activation d'une nouvelle voie de regulation de ligandInfo
- Publication number
- WO1997014966B1 WO1997014966B1 PCT/CA1996/000679 CA9600679W WO9714966B1 WO 1997014966 B1 WO1997014966 B1 WO 1997014966B1 CA 9600679 W CA9600679 W CA 9600679W WO 9714966 B1 WO9714966 B1 WO 9714966B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- receptor tyrosine
- tyrosine kinase
- eph subfamily
- subfamily receptor
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title claims abstract 10
- 238000000034 method Methods 0.000 title claims abstract 7
- 230000037361 pathway Effects 0.000 title claims abstract 7
- 230000001105 regulatory effect Effects 0.000 title claims abstract 6
- 230000003213 activating effect Effects 0.000 title abstract 3
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims abstract 14
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims abstract 14
- 230000007472 neurodevelopment Effects 0.000 claims abstract 2
- 230000009689 neuronal regeneration Effects 0.000 claims abstract 2
- 238000011069 regeneration method Methods 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102000001708 Protein Isoforms Human genes 0.000 claims 7
- 108010029485 Protein Isoforms Proteins 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 3
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 230000003197 catalytic effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 230000028600 axonogenesis Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Abstract
L'invention porte sur une nouvelle voie de régulation de ligand ainsi que sur des procédés d'activation de cette nouvelle voie dans une cellule exprimant un ligand pour une protéine tyrosine kinase réceptrice de la sous-famille Eph. Elle concerne également des procédés permettant d'identifier des substances capables d'activer la voie de régulation du ligand. Elle a, en outre, trait à des techniques thérapeutiques visant à influer sur le développement et la régénération des neurones, ainsi qu'à des compositions pharmaceutiques utilisant ces substances et des protéines tyrosine kinase réceptrices de la sous-famille Eph.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2234090 CA2234090A1 (fr) | 1995-10-13 | 1996-10-10 | Procede d'activation d'une nouvelle voie de regulation de ligand |
| EP96932414A EP1019728A1 (fr) | 1995-10-13 | 1996-10-10 | Procede d'activation d'une nouvelle voie de regulation de ligand |
| JP9515370A JPH11515105A (ja) | 1995-10-13 | 1996-10-10 | 新規リガンド調節経路の活性化方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US551895P | 1995-10-13 | 1995-10-13 | |
| US60/005,518 | 1995-10-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997014966A1 WO1997014966A1 (fr) | 1997-04-24 |
| WO1997014966B1 true WO1997014966B1 (fr) | 1997-06-05 |
Family
ID=21716280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CA1996/000679 WO1997014966A1 (fr) | 1995-10-13 | 1996-10-10 | Procede d'activation d'une nouvelle voie de regulation de ligand |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1019728A1 (fr) |
| JP (1) | JPH11515105A (fr) |
| WO (1) | WO1997014966A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998001548A1 (fr) * | 1996-07-05 | 1998-01-15 | Mount Sinai Hospital Corporation | Recepteurs oligomerises modulant des voies regulees par des ligands transmembranaires pour des recepteurs tyrosine-kinases type elk |
| AU9594598A (en) | 1997-10-02 | 1999-04-27 | Millennium Pharmaceuticals, Inc. | Modulation of lerk-2-mediated cell adhesion |
| AUPP674898A0 (en) * | 1998-10-27 | 1998-11-19 | Walter And Eliza Hall Institute Of Medical Research, The | A method of treatment |
| AU2004201391B2 (en) * | 1998-10-27 | 2007-08-23 | The Council Of The Queensland Institute Of Medical Research | A method of the treatment |
| AU1764200A (en) * | 1998-12-18 | 2000-07-12 | Mount Sinai Hospital Corporation | Three dimensional structure of a sterile alpha motif domain |
| WO2002000939A2 (fr) * | 2000-06-28 | 2002-01-03 | Diadexus, Inc. | Procede de diagnostic, de surveillance, de determination du stade, d'imagerie et de traitement du cancer du colon |
| CN117854628A (zh) * | 2022-09-30 | 2024-04-09 | 苏州雅深智慧科技有限公司 | 一种药物研发数据库的配置方法及系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3955316B2 (ja) * | 1991-06-21 | 2007-08-08 | ザ・ワルター・アンド・エリザ・ホール・インスティテュート・オヴ・メディカル・リサーチ | 新規レセプター型チロシンキナーゼ及びその用途 |
| JPH09506250A (ja) * | 1993-11-23 | 1997-06-24 | ジェネンテク，インコーポレイテッド | Ｒｓｅと命名される蛋白チロシンキナーゼ |
| CA2187167A1 (fr) * | 1994-04-04 | 1995-10-12 | Samuel Davis | Ligands de la famille des eph a activite biologique |
| EP0756627A1 (fr) * | 1994-04-15 | 1997-02-05 | Amgen Inc. | Nouvelles proteines tyrosine kinases receptrices analogues a l'eph, du type hek5, hek7, hek8, hek11 |
| CA2122874A1 (fr) * | 1994-04-29 | 1995-10-30 | Anthony Pawson | Tyrosine kinase de recepteur neural |
| WO1996026958A2 (fr) * | 1995-02-27 | 1996-09-06 | President And Fellows Of Harvard College | L'elf-2, ligand du recepteur eph |
-
1996
- 1996-10-10 JP JP9515370A patent/JPH11515105A/ja not_active Withdrawn
- 1996-10-10 EP EP96932414A patent/EP1019728A1/fr not_active Withdrawn
- 1996-10-10 WO PCT/CA1996/000679 patent/WO1997014966A1/fr not_active Application Discontinuation
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