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WO1998019708A3 - Procede pour ameliorer la solubilite de composes sensiblement insolubles dans l'eau - Google Patents

Procede pour ameliorer la solubilite de composes sensiblement insolubles dans l'eau Download PDF

Info

Publication number
WO1998019708A3
WO1998019708A3 PCT/US1997/019831 US9719831W WO9819708A3 WO 1998019708 A3 WO1998019708 A3 WO 1998019708A3 US 9719831 W US9719831 W US 9719831W WO 9819708 A3 WO9819708 A3 WO 9819708A3
Authority
WO
WIPO (PCT)
Prior art keywords
solubility
water
enhancing
compounds
substantially water
Prior art date
Application number
PCT/US1997/019831
Other languages
English (en)
Other versions
WO1998019708A2 (fr
Inventor
David H Donabedian
Lawrence Marlin
Elke M A Clark
Original Assignee
Union Carbide Chem Plastic
David H Donabedian
Lawrence Marlin
Elke M A Clark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Carbide Chem Plastic, David H Donabedian, Lawrence Marlin, Elke M A Clark filed Critical Union Carbide Chem Plastic
Priority to EP97950577A priority Critical patent/EP0891190A2/fr
Publication of WO1998019708A2 publication Critical patent/WO1998019708A2/fr
Publication of WO1998019708A3 publication Critical patent/WO1998019708A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

Cette invention concerne des procédés pouvant améliorer la solubilité de composés sensiblement insolubles dans l'eau, par combinaison desdits composés avec un polymère soluble dans l'eau, par exemple un polymère de polyoxyde d'alkylène ou un éther de cellulose, ayant un poids moléculaire compris entre environ 50 000 et 7 000 000 grammes par gramme dans une quantité effective pour améliorer la solubilité desdits composés dans l'eau, en milieu acide à un pH inférieur à environ 5, par exemple. L'invention concerne également des compositions contenant les composés ayant une solubilité dans l'eau améliorée.
PCT/US1997/019831 1996-11-04 1997-10-31 Procede pour ameliorer la solubilite de composes sensiblement insolubles dans l'eau WO1998019708A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97950577A EP0891190A2 (fr) 1996-11-04 1997-10-31 Procede pour ameliorer la solubilite de composes sensiblement insolubles dans l'eau

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3028296 1996-11-04
US60/030,282 1996-11-05

Publications (2)

Publication Number Publication Date
WO1998019708A2 WO1998019708A2 (fr) 1998-05-14
WO1998019708A3 true WO1998019708A3 (fr) 1998-08-20

Family

ID=21853450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019831 WO1998019708A2 (fr) 1996-11-04 1997-10-31 Procede pour ameliorer la solubilite de composes sensiblement insolubles dans l'eau

Country Status (3)

Country Link
EP (1) EP0891190A2 (fr)
CN (1) CN1211928A (fr)
WO (1) WO1998019708A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU784572B2 (en) 1999-12-08 2006-05-04 Pharmacia Corporation Solid-state form of celecoxib having enhanced bioavailability
US6818566B2 (en) 2002-10-18 2004-11-16 The Boc Group, Inc. Thermal activation of fluorine for use in a semiconductor chamber
US10117937B2 (en) 2012-04-19 2018-11-06 Purdue Research Foundation Highly branched alpha-D-glucans

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (fr) * 1978-11-20 1980-06-25 American Home Products Corporation Compositions thérapeutiques à biodisponibilité accrue et procédé pour leur préparation
EP0315964A1 (fr) * 1987-11-11 1989-05-17 Laboratoires Pharmascience Composition pharmaceutique comprenant l'exifone et un polymère soluble dans l'eau
WO1996032097A1 (fr) * 1995-04-14 1996-10-17 Pharma Pass Compositions solides contenant du polyethyleneoxyde et un principe actif non amorphe
WO1998011879A1 (fr) * 1996-09-19 1998-03-26 Depomed, Inc. Formes galeniques orales retenues dans l'estomac, pour la liberation controlee de medicaments faiblement solubles et de substance insoluble

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (fr) * 1978-11-20 1980-06-25 American Home Products Corporation Compositions thérapeutiques à biodisponibilité accrue et procédé pour leur préparation
EP0315964A1 (fr) * 1987-11-11 1989-05-17 Laboratoires Pharmascience Composition pharmaceutique comprenant l'exifone et un polymère soluble dans l'eau
WO1996032097A1 (fr) * 1995-04-14 1996-10-17 Pharma Pass Compositions solides contenant du polyethyleneoxyde et un principe actif non amorphe
WO1998011879A1 (fr) * 1996-09-19 1998-03-26 Depomed, Inc. Formes galeniques orales retenues dans l'estomac, pour la liberation controlee de medicaments faiblement solubles et de substance insoluble

Also Published As

Publication number Publication date
EP0891190A2 (fr) 1999-01-20
CN1211928A (zh) 1999-03-24
WO1998019708A2 (fr) 1998-05-14

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