+

WO1998019708A3 - Method for enhancing the solubility of substantially water-insoluble compounds - Google Patents

Method for enhancing the solubility of substantially water-insoluble compounds Download PDF

Info

Publication number
WO1998019708A3
WO1998019708A3 PCT/US1997/019831 US9719831W WO9819708A3 WO 1998019708 A3 WO1998019708 A3 WO 1998019708A3 US 9719831 W US9719831 W US 9719831W WO 9819708 A3 WO9819708 A3 WO 9819708A3
Authority
WO
WIPO (PCT)
Prior art keywords
solubility
water
enhancing
compounds
substantially water
Prior art date
Application number
PCT/US1997/019831
Other languages
French (fr)
Other versions
WO1998019708A2 (en
Inventor
David H Donabedian
Lawrence Marlin
Elke M A Clark
Original Assignee
Union Carbide Chem Plastic
David H Donabedian
Lawrence Marlin
Elke M A Clark
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Carbide Chem Plastic, David H Donabedian, Lawrence Marlin, Elke M A Clark filed Critical Union Carbide Chem Plastic
Priority to EP97950577A priority Critical patent/EP0891190A2/en
Publication of WO1998019708A2 publication Critical patent/WO1998019708A2/en
Publication of WO1998019708A3 publication Critical patent/WO1998019708A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

Methods for enhancing the water-solubility of substantially water-insoluble compounds are disclosed by combining such compounds with a water-soluble polymer, e.g., polyalkylene oxide polymer or a cellulose ether, having a molecular weight of from about 50,000 to 7,000,000 grams/per gram in an amount effective to enhance the water-solubility of the compound in an acidic environment, e.g., pH less than about 5. Compositions comprising the compounds having enhanced water solubility are also disclosed.
PCT/US1997/019831 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds WO1998019708A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97950577A EP0891190A2 (en) 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/030,282 1996-11-04
US3028296 1996-11-04

Publications (2)

Publication Number Publication Date
WO1998019708A2 WO1998019708A2 (en) 1998-05-14
WO1998019708A3 true WO1998019708A3 (en) 1998-08-20

Family

ID=21853450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019831 WO1998019708A2 (en) 1996-11-04 1997-10-31 Method for enhancing the solubility of substantially water-insoluble compounds

Country Status (3)

Country Link
EP (1) EP0891190A2 (en)
CN (1) CN1211928A (en)
WO (1) WO1998019708A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0201450A3 (en) 1999-12-08 2003-02-28 Pharmacia Corp Chicago Solid-state form of celecoxib having enhanced bioavailability, pharmaceutical compositions containing it and their preparation
US6818566B2 (en) 2002-10-18 2004-11-16 The Boc Group, Inc. Thermal activation of fluorine for use in a semiconductor chamber
WO2013158992A1 (en) * 2012-04-19 2013-10-24 Purdue Research Foundation Highly branched alpha-d-glucans

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
EP0315964A1 (en) * 1987-11-11 1989-05-17 Laboratoires Pharmascience A novel pharmaceutical composition comprising exifone and water-soluble polymer
WO1996032097A1 (en) * 1995-04-14 1996-10-17 Pharma Pass Solid compositions containing polyethyleneoxide and a non-amorphous active principle
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012523A1 (en) * 1978-11-20 1980-06-25 American Home Products Corporation Therapeutic compositions with enhanced bioavailability and process for their preparation
EP0315964A1 (en) * 1987-11-11 1989-05-17 Laboratoires Pharmascience A novel pharmaceutical composition comprising exifone and water-soluble polymer
WO1996032097A1 (en) * 1995-04-14 1996-10-17 Pharma Pass Solid compositions containing polyethyleneoxide and a non-amorphous active principle
WO1998011879A1 (en) * 1996-09-19 1998-03-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter

Also Published As

Publication number Publication date
CN1211928A (en) 1999-03-24
EP0891190A2 (en) 1999-01-20
WO1998019708A2 (en) 1998-05-14

Similar Documents

Publication Publication Date Title
AU6994200A (en) Hydroabsorbent polymers comprising interstitial compounds, method for producing and using the same
EP1057862A3 (en) Polymer film compositions for capsules
EP1153620A3 (en) Solid compositions exhibiting selective binding to dissolved iron
WO2003015694A3 (en) Agents for enhancing the immune response
WO2002043772A3 (en) Water-soluble polymer conjugates of triazine derivatives
EP0916675A3 (en) Process for preparing sildenafil
WO1994007536A3 (en) Alginate-bioactive agent conjugates
CA2431719A1 (en) Prevention of preservative uptake into biomaterials
CA2405716A1 (en) Chemically modified novel erythropoietin stimulating protein compositions and methods
GB9725084D0 (en) Vaccine compositions
AU5511101A (en) Aldehyde-containing polymers as wet strength additives
CA2229271A1 (en) Compositions containing hydroxy acids or retinoids
WO2003046200A3 (en) Methods for ligand discovery
WO2000049052A3 (en) Polysaccharide compositions and uses thereof
AU4394496A (en) Concentrated, aqueous, surfactant-containing compositions
MY114338A (en) Compositions and methods for inhibiting the deposition of organic contaminants in pulp and papermaking systems
CA2371896A1 (en) Method of increasing the content of flavonoids and phenolic substances in plants
EP0774506A3 (en) High alkali-containing cleaning concentrates
WO2001010408A3 (en) Aqueous pharmaceutical composition containing moxifloxacin or salts thereof
WO1998019708A3 (en) Method for enhancing the solubility of substantially water-insoluble compounds
AU4424785A (en) Aqueous aerosol coating compositions
CA2315633A1 (en) Process to reduce the aox level of wet strength resins by treatment with base
CA2242591A1 (en) Method of obtaining glycols having a low aldehyde content
EP0796624A3 (en) Clathrates and edible compositions comprising the same
WO2002016322A3 (en) Process for the preparation of 2-aminoethylpyridines

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 97192577.1

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): BR CA CN JP MX US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): BR CA CN JP MX US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 1997950577

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2247410

Country of ref document: CA

Ref document number: 2247410

Country of ref document: CA

Kind code of ref document: A

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 09180683

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1997950577

Country of ref document: EP

NENP Non-entry into the national phase

Ref document number: 1998521598

Country of ref document: JP

WWW Wipo information: withdrawn in national office

Ref document number: 1997950577

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载