WO1998015535B1 - 1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck - Google Patents
1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cckInfo
- Publication number
- WO1998015535B1 WO1998015535B1 PCT/JP1997/003483 JP9703483W WO9815535B1 WO 1998015535 B1 WO1998015535 B1 WO 1998015535B1 JP 9703483 W JP9703483 W JP 9703483W WO 9815535 B1 WO9815535 B1 WO 9815535B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- cycloalkyl
- benzodiazepinones
- pharmaceutically acceptable
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- RGGLEJFUEMKQSH-UHFFFAOYSA-N 1,4-benzodiazepin-2-one Chemical class O=C1C=NC=C2C=CC=CC2=N1 RGGLEJFUEMKQSH-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims 5
- -1 N,N-dimethylamino Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102100025841 Cholecystokinin Human genes 0.000 abstract 1
- 101800001982 Cholecystokinin Proteins 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 229940107137 cholecystokinin Drugs 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 1
Abstract
L'invention concerne des dérivés de benzodiazépine de formule (I), qui sont utiles en tant qu'antogonistes de la cholécystokinine. Dans la formule (I), R2 représente alkyle ou cycloalkyle-alkyle lorsque R4 représente hydrogène, ou R2 représente divers groupes spécifiés lorsque R4 représente alkyle, halogène ou dialkylamino.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97941281A EP0934282A1 (fr) | 1996-10-08 | 1997-09-29 | 1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck |
| US09/269,752 US6291452B1 (en) | 1996-10-08 | 1997-09-29 | 1,4-benzodiazepinones and their uses as CCK antagonists |
| JP51737298A JP2001504454A (ja) | 1996-10-08 | 1997-09-29 | ベンゾジアゼピン誘導体 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO2843 | 1996-10-08 | ||
| AUPO2843A AUPO284396A0 (en) | 1996-10-08 | 1996-10-08 | Benzodiazepine derivatives |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/269,752 A-371-Of-International US6291452B1 (en) | 1996-10-08 | 1997-09-29 | 1,4-benzodiazepinones and their uses as CCK antagonists |
| US09/897,888 Continuation US20020002163A1 (en) | 1996-10-08 | 2001-07-05 | 1,4-benzodiazepinones and their uses as CCK antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998015535A1 WO1998015535A1 (fr) | 1998-04-16 |
| WO1998015535B1 true WO1998015535B1 (fr) | 1998-06-11 |
Family
ID=3797154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1997/003483 WO1998015535A1 (fr) | 1996-10-08 | 1997-09-29 | 1,4-benzodiazepinones et leurs utilisations en tant qu'antagonistes de cck |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6291452B1 (fr) |
| EP (1) | EP0934282A1 (fr) |
| JP (1) | JP2001504454A (fr) |
| AU (1) | AUPO284396A0 (fr) |
| WO (1) | WO1998015535A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825160B1 (en) | 1999-08-27 | 2004-11-30 | Procter & Gamble Company | Color safe laundry methods employing cationic formulation components |
| DE60028387T2 (de) * | 1999-08-27 | 2007-05-24 | The Procter & Gamble Company, Cincinnati | Bleichverstärkende verbindungen, zusammensetzungen und waschverfahren |
| US6818607B1 (en) | 1999-08-27 | 2004-11-16 | Procter & Gamble Company | Bleach boosting components, compositions and laundry methods |
| MXPA02002124A (es) | 1999-08-27 | 2002-09-18 | Procter & Gamble | Componentes de formulacion de incremento de estabilidad y composiciones y metodos de lavanderia que emplean los mismos. |
| US7109156B1 (en) | 1999-08-27 | 2006-09-19 | Procter & Gamble Company | Controlled availability of formulation components, compositions and laundry methods employing same |
| US6903060B1 (en) | 1999-08-27 | 2005-06-07 | Procter & Gamble Company | Stable formulation components, compositions and laundry methods employing same |
| US6821935B1 (en) | 1999-08-27 | 2004-11-23 | Procter & Gamble Company | Color safe laundry methods employing zwitterionic formulation components |
| US7557076B2 (en) | 2002-06-06 | 2009-07-07 | The Procter & Gamble Company | Organic catalyst with enhanced enzyme compatibility |
| US7169744B2 (en) | 2002-06-06 | 2007-01-30 | Procter & Gamble Company | Organic catalyst with enhanced solubility |
| JP4705908B2 (ja) * | 2003-04-15 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｇｒｐ受容体拮抗薬 |
| EP1641781B1 (fr) * | 2003-06-26 | 2013-03-06 | Merck Sharp & Dohme Corp. | Antagonistes du récepteur CGRP de benzodiazépine |
| CA2529196A1 (fr) * | 2003-06-26 | 2005-02-17 | Merck & Co., Inc. | Antagonistes du recepteur du cgrp de |
| AU2004285636A1 (en) * | 2003-10-23 | 2005-05-12 | Bayer Cropscience Aktiengesellschaft | Isopentyl carboxanilides for combating undesired micro-organisms |
| DE10352067A1 (de) * | 2003-10-23 | 2005-05-25 | Bayer Cropscience Ag | Isopentylcarboxanilide |
| CA2554351A1 (fr) * | 2004-01-29 | 2005-08-11 | Merck & Co., Inc. | Antagonistes des recepteurs du cgrp |
| AR051659A1 (es) | 2005-06-17 | 2007-01-31 | Procter & Gamble | Una composicion que comprende un catalizador organico con compatibilidada enzimatica mejorada |
| GB201414116D0 (en) | 2014-08-08 | 2014-09-24 | Trio Medicines Ltd | Benzodiazepine derivatives |
| GB201513979D0 (en) | 2015-08-07 | 2015-09-23 | Trio Medicines Ltd | Synthesis of benzodiazepine derivatives |
| CN113816914B (zh) * | 2021-09-28 | 2024-04-09 | 华中药业股份有限公司 | 一种劳拉西泮中间体的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| US4970207A (en) | 1988-07-07 | 1990-11-13 | Fujisawa Pharmaceutical Company, Ltd. | Benzodiazepine derivatives |
| US5264433A (en) | 1988-07-07 | 1993-11-23 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| IL91361A (en) | 1988-09-09 | 1994-10-07 | Fujisawa Pharmaceutical Co | Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5248679A (en) | 1988-09-09 | 1993-09-28 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclic compounds |
| IL96613A0 (en) * | 1989-12-18 | 1991-09-16 | Merck & Co Inc | Pharmaceutical compositions containing benzodiazepine analogs |
| GB9018601D0 (en) | 1990-08-24 | 1990-10-10 | Fujisawa Pharmaceutical Co | Tricyclic compounds |
| CA2068355A1 (fr) * | 1991-05-14 | 1992-11-15 | Mark S. Chambers | Derives de benzodiazepines, compositions les contenant et leur utilisation therapeutique |
| EP0549039B1 (fr) * | 1991-12-20 | 1995-08-09 | MERCK SHARP & DOHME LTD. | 3-phényluréido-1,4-benzodiazépinones et leur utilisation comme antagonistes de cholécystokinine ou de gastrine |
| GB9203790D0 (en) * | 1992-02-21 | 1992-04-08 | Merck Sharp & Dohme | Therapeutic agents |
| IL104853A (en) * | 1992-02-27 | 1997-11-20 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them |
| AU670939B2 (en) * | 1992-03-16 | 1996-08-08 | Merck Sharp & Dohme Limited | Benzodiazepine derivatives, compositions containing them and their use in therapy |
| AU670431B2 (en) * | 1992-03-24 | 1996-07-18 | Merck Sharp & Dohme Limited | 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy |
| US5360802A (en) * | 1992-05-11 | 1994-11-01 | Merck Sharpe & Dohme Ltd. | Benzodiazepine derivatives, compositions containing them and their use in therapy |
| GB9225492D0 (en) * | 1992-12-05 | 1993-01-27 | Glaxo Group Ltd | Amine derivatives |
| JPH09511998A (ja) * | 1994-04-15 | 1997-12-02 | グラクソ、ウェルカム、インコーポレーテッド | １，４ − ベンゾジアゼピン化合物を用いたコレシストキニンアゴニスト活性の誘導方法 |
| EP0804425A2 (fr) | 1994-07-29 | 1997-11-05 | Fujisawa Pharmaceutical Co., Ltd. | Derives de benzodiazepine |
| US5556969A (en) * | 1994-12-07 | 1996-09-17 | Merck Sharp & Dohme Ltd. | Benzodiazepine derivatives |
| US5929071A (en) * | 1996-07-02 | 1999-07-27 | Merck & Co., Inc. | Method for the treatment of preterm labor |
-
1996
- 1996-10-08 AU AUPO2843A patent/AUPO284396A0/en not_active Abandoned
-
1997
- 1997-09-29 US US09/269,752 patent/US6291452B1/en not_active Expired - Fee Related
- 1997-09-29 JP JP51737298A patent/JP2001504454A/ja active Pending
- 1997-09-29 EP EP97941281A patent/EP0934282A1/fr not_active Withdrawn
- 1997-09-29 WO PCT/JP1997/003483 patent/WO1998015535A1/fr not_active Application Discontinuation
-
2001
- 2001-07-05 US US09/897,888 patent/US20020002163A1/en not_active Abandoned
-
2002
- 2002-03-20 US US10/101,297 patent/US20020183313A1/en not_active Abandoned
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