+

WO1997004783A3 - Alcaloides de bis-1 oxaquinolizidine provenant d'une eponge marine et presentant une activite antitumorale - Google Patents

Alcaloides de bis-1 oxaquinolizidine provenant d'une eponge marine et presentant une activite antitumorale Download PDF

Info

Publication number
WO1997004783A3
WO1997004783A3 PCT/GB1996/001852 GB9601852W WO9704783A3 WO 1997004783 A3 WO1997004783 A3 WO 1997004783A3 GB 9601852 W GB9601852 W GB 9601852W WO 9704783 A3 WO9704783 A3 WO 9704783A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxaquinolizidine
alkaloids
bis
antitumor activity
marine sponge
Prior art date
Application number
PCT/GB1996/001852
Other languages
English (en)
Other versions
WO1997004783A2 (fr
Inventor
Jun-Ichi Tanaka
Tatsuo Higa
Gravalos Dolores Garcia
Original Assignee
Pharma Mar Sa
Ruffles Graham Keith
Tanaka Jun Ichi
Tatsuo Higa
Gravalos Dolores Garcia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa, Ruffles Graham Keith, Tanaka Jun Ichi, Tatsuo Higa, Gravalos Dolores Garcia filed Critical Pharma Mar Sa
Priority to AU66256/96A priority Critical patent/AU6625696A/en
Publication of WO1997004783A2 publication Critical patent/WO1997004783A2/fr
Publication of WO1997004783A3 publication Critical patent/WO1997004783A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne les composés présentant la formule générale (II) ou un sel pharmaceutiquement acceptable de ces derniers, et leur utilisation comme agents anti-tumoraux. Dans la formule, R1 et R2 sont similaires ou différents, et chaque groupe représente -H ou -OH; le groupe R2 représente -H ou -CH¿3? et le groupe R?3¿ représente -H ou -CH¿3?. Ces composés peuvent être isolés dans des éponges marines.
PCT/GB1996/001852 1995-07-28 1996-07-29 Alcaloides de bis-1 oxaquinolizidine provenant d'une eponge marine et presentant une activite antitumorale WO1997004783A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66256/96A AU6625696A (en) 1995-07-28 1996-07-29 Bis-1-oxaquinolizidine alkaloids from a marine sponge with antitumor activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515469.6A GB9515469D0 (en) 1995-07-28 1995-07-28 Bis-1-oxaquinolizidine alkaloids from a marine sponge with antitumor activity
GB9515469.6 1995-07-28

Publications (2)

Publication Number Publication Date
WO1997004783A2 WO1997004783A2 (fr) 1997-02-13
WO1997004783A3 true WO1997004783A3 (fr) 1997-04-17

Family

ID=10778389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/001852 WO1997004783A2 (fr) 1995-07-28 1996-07-29 Alcaloides de bis-1 oxaquinolizidine provenant d'une eponge marine et presentant une activite antitumorale

Country Status (3)

Country Link
AU (1) AU6625696A (fr)
GB (1) GB9515469D0 (fr)
WO (1) WO1997004783A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143756A (en) * 1998-05-15 2000-11-07 National University Of Singapore Antimalarial activity of β-carboline alkaloids
AU2002214886A1 (en) * 2000-11-09 2002-05-21 Contrimmune Biotechnology Inc Therapeutic uses for IP3 receptor-mediated calcium channel modulators
US9845067B2 (en) 2015-08-28 2017-12-19 Autoliv Asp, Inc. Frontal airbag systems for oblique crash protection
WO2023147678A1 (fr) * 2022-02-07 2023-08-10 Universidad Mayor Procédé de synthèse du composé desméthyl xestospongine b (dmxeb)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227885A (ja) * 1983-06-09 1984-12-21 Suntory Ltd １−オキサキノリチジン類

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227885A (ja) * 1983-06-09 1984-12-21 Suntory Ltd １−オキサキノリチジン類

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8506, Derwent World Patents Index; AN 85-034355, XP002025798 *
HOYE, T.R. ET AL: "Additions and corrections", JOURNAL OF ORGANIC CHEMISTRY, vol. 60, no. 15, 1995, pages 4958 *
HOYE, T.R. ET AL: "Conformational considerations in 1-oxaquinolizidines related to the xestospongin/araguspongine family: Reassignment of stereostructures for araguspongines B and E", JOURNAL OF ORGANIC CHEMISTRY, vol. 59, no. 23, 1994, pages 6904 - 6910, XP000644369 *
KOBAYASHI, M. ET AL: "Aragopetrosine A, a new vasodilative macrocyclic quinolizidine alkaloid from an Okinawan marine sponge Xestospongia sp.", TETRAHEDRON LETTERS, vol. 30, no. 31, 1989, pages 4149 - 4152, XP000615876 *
KOBAYASHI, M. ET AL: "Araguspongines B, C, D, E, F, G, H, and J. New vasodilative bis-1-oxaquinolizidine alkaloids from an Okinawan marine sponge, Xestospongia sp.", CHEM. PHARM. BULL., vol. 37, no. 6, 1989, pages 1676 - 1678, XP000617987 *
NAKAGAWA, M. ET AL: "Structures of xestospongin A,B,C and D novel vasodilative compounds from marine sponge, Xestospongia exigua", TETRAHEDRON LETTERS, vol. 25, no. 30, 1984, pages 3227 - 3230, XP000615875 *
PETTIT, G.R. ET AL: "Isolation and X-ray crystal structure of racemic Xestospongin D from the singapore marine sponge Niphates sp.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 12, 1996, pages 1313 - 1318, XP000617820 *
QUIRION, J.-C. ET AL: "Two new alkaloids from Xestospongia sp., a New Caledonian sponge", JOURNAL OF NATURAL PRODUCTS, vol. 55, no. 10, 1992, pages 1505 - 1508, XP000617818 *
STINGL, J. ET AL: "In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 30, no. 5, 1992, pages 401 - 406, XP000617821 *
VASSAS, A. ET AL: "Naturally occurring somatostatin and vasoactive intestinal peptide inhibitors. Isolation of alkaloids from two marine sponges.", PLANTA MEDICA, vol. 62, no. 1, February 1996 (1996-02-01), pages 28 - 30, XP000617775 *
VENKATESWARLU, Y. ET AL: "bis-1-Oxaquinolizidines from the sponge Haliclona exigua", JOURNAL OF NATURAL PRODUCTS, vol. 57, no. 9, 1994, pages 1283 - 1285, XP000617823 *

Also Published As

Publication number Publication date
WO1997004783A2 (fr) 1997-02-13
AU6625696A (en) 1997-02-26
GB9515469D0 (en) 1995-09-27

Similar Documents

Publication Publication Date Title
AU6613896A (en) Chemical compounds
CA2201477A1 (fr) Nouveaux derives pyrimidone a activite antifongique
EP0575123A3 (fr) Composition d'un copolymère d'éthylène.
CA2165819A1 (fr) Derives de dc-89
HK1026909A1 (en) Substituted phenyl derivatives, their preparation and use
AU6925696A (en) Leisure trousers with attachable protecting elements
AU9050291A (en) Tacking agent
AU4064597A (en) Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
AU674358B2 (en) Novel 1,2-benzoisoxazole derivative or its salt and brain -protecting agent comprising the same
EP0990648A4 (fr) Derives de 4-quinolinol et bactericides pour l'agriculture et l'horticulture contenant lesdits derives comme principe actif
AU6318196A (en) Novel benzimidazole derivatives having cgmp-phosphodisterase inhibiting activity
EP0671911A4 (fr) Derives de carboxy-peptidyle utilises comme agents anti-degeneratifs actifs.
AU7855191A (en) 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
AU4329396A (en) Use of 3,4-diphenylchromans
AU8757891A (en) Photo-labile compounds, their synthesis and use as fluorophores
CA2237189A1 (fr) 3-azetidinylalkylpiperidines ou -pyrrolidines en tant qu'antagonistes des tachykinines
CA2078662A1 (fr) Derive de 4-desoxy-epipodophyllotoxine ou sel pharmaceutiquement acceptable
AU3256193A (en) 5-isoquinolinesulfonamide derivatives as protein kinase inhibiting agents
AU7352491A (en) Substituted amine derivatives having anti-hyperlipemia activity
AU7671198A (en) Methods for the inhibition of neuronal activity by local delivery of adenosi ne
AU3421493A (en) Use of spiperone or spiperone derivatives as immunosuppressant agents
CA2204204A1 (fr) Derives de glucides
AU4094293A (en) Methods for the diagnosis of fungal infections
WO1997004783A3 (fr) Alcaloides de bis-1 oxaquinolizidine provenant d'une eponge marine et presentant une activite antitumorale
CA2380455A1 (fr) 9a-azalides a activite antibacterienne

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载