WO1998008499A1 - Compositions biocides - Google Patents
Compositions biocides Download PDFInfo
- Publication number
- WO1998008499A1 WO1998008499A1 PCT/IB1997/001068 IB9701068W WO9808499A1 WO 1998008499 A1 WO1998008499 A1 WO 1998008499A1 IB 9701068 W IB9701068 W IB 9701068W WO 9808499 A1 WO9808499 A1 WO 9808499A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzoic acid
- derivative
- animal
- composition
- animals
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 78
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 39
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 39
- 241001465754 Metazoa Species 0.000 claims abstract description 38
- 241000282887 Suidae Species 0.000 claims abstract description 18
- 150000001413 amino acids Chemical class 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 6
- 239000003651 drinking water Substances 0.000 claims abstract description 3
- 235000020188 drinking water Nutrition 0.000 claims abstract description 3
- 235000005911 diet Nutrition 0.000 claims description 6
- 230000037213 diet Effects 0.000 claims description 6
- 235000001014 amino acid Nutrition 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- 150000001558 benzoic acid derivatives Chemical class 0.000 claims description 4
- 239000003792 electrolyte Substances 0.000 claims description 4
- 235000019752 Wheat Middilings Nutrition 0.000 claims description 3
- -1 alkali metal benzoates Chemical class 0.000 claims description 3
- 239000003139 biocide Substances 0.000 claims description 3
- 235000012054 meals Nutrition 0.000 claims description 3
- 235000019737 Animal fat Nutrition 0.000 claims description 2
- 241000283690 Bos taurus Species 0.000 claims description 2
- 244000068988 Glycine max Species 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- 235000019735 Meat-and-bone meal Nutrition 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 241000209140 Triticum Species 0.000 claims description 2
- 235000021307 Triticum Nutrition 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 2
- 235000019270 ammonium chloride Nutrition 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 235000005822 corn Nutrition 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- KWIPUXXIFQQMKN-UHFFFAOYSA-N 2-azaniumyl-3-(4-cyanophenyl)propanoate Chemical compound OC(=O)C(N)CC1=CC=C(C#N)C=C1 KWIPUXXIFQQMKN-UHFFFAOYSA-N 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 229940090948 ammonium benzoate Drugs 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 235000019621 digestibility Nutrition 0.000 abstract description 5
- 239000002253 acid Substances 0.000 abstract description 4
- 239000003242 anti bacterial agent Substances 0.000 abstract description 3
- 230000007423 decrease Effects 0.000 abstract description 3
- 150000001559 benzoic acids Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 208000012868 Overgrowth Diseases 0.000 description 1
- 235000019772 Sunflower meal Nutrition 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- VWSRWGFGAAKTQG-UHFFFAOYSA-N ammonium benzoate Chemical class [NH4+].[O-]C(=O)C1=CC=CC=C1 VWSRWGFGAAKTQG-UHFFFAOYSA-N 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000010815 organic waste Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
Definitions
- This invention relates to the use of compositions comprising benzoic acid for use as a medicament for animals, especially pigs, at the same time promoting growth thereof and improving the digestibility of amino acids fed to such animals.
- animal feed compositions comprising benzoic acid or salts thereof can be used to minimise the emission of odoriferous ammonia from organic wastes, especially animal excrements and manure.
- benzoic acid can be used instead of relatively expensive antibiotics for such animals and furthermore, such acid/salts have the advantage of being able to promote growth, decrease feed conversion and improve digestibility of amino acids in animal feeds.
- the present invention is a composition comprising benzoic acid or a derivative of benzoic acid capable of giving rise to free benzoic acid / ' // vivo for use as a medicament for animals Benzoic acid or a derivative thereof capable of giving rise to benzoic acid
- benzoic acid and derivatives thereof may be suitably administered to the animals as a component of the animal feed or in their drinking water.
- Specific examples of derivatives of benzoic acid which can give rise to benzoic acid /// vivo include salts of benzoic acid such as eg the alkali metal- alkaline earth metal- and ammonium benzoates.
- the amount of benzoic acid oi a derivative thereof administered to the animal is suitably such that ii is sufficient to prevent/cure any infection in the animal in its capacity as a biocide
- Such an amount is suitably in the range from 0.001 - 5% based on the total weight of each feed fed to the animal.
- This amount may. however, be higher if the function of benzoic acid or a derivative thereof is not only to act as a biocide but also to control the pH of the animal excreta fed on such a diet in order to suppress the emission of ammonia from the excreta.
- Such higher amounts are suitably limited to a maximum of about 10% based on the total animal feed composition.
- the benzo e acid/salt functions inter alia as an antibiotic, promotes growth, decreases feed conversion and improves digestibility of amino acids administered in animal feeds.
- benzoic acid or a derivative thereof may be used in combination with conventional ingredients present in an animal feed composition (diet) such as calcium carbonates, electrolytes such as eg ammonium chloride, proteins such as soya bean meal, wheat, starch, sunflower meal, corn, meat and bone meal, amino acids, animal fat, vitamins and trace minerals.
- Diet animal feed composition
- electrolytes such as eg ammonium chloride
- proteins such as soya bean meal, wheat, starch, sunflower meal, corn, meat and bone meal
- amino acids animal fat, vitamins and trace minerals.
- the ratio of the electrolyte to the benzoic acid or a derivative thereof is suitably in the range from 0.5 : 1 to 5 : 1 w/w, preferably from 1.5 : 1 to 3 : I w/w.
- Benzoic acid or a derivative thereof is particularly effective as a medicament for animals such as poultry, pigs or cattle, especially pigs.
- *-lt is a blend of Ca (25%) and a mixture of carboxylic acids (75%) - the acids and their amounts in the mixture being formic (30%). acetic (30%) propionic (30%) and citric (10%).
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Birds (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
L'invention concerne une composition contenant de l'acide benzoïque ou un dérivé de l'acide benzoïque, pouvant donner de l'acide benzoïque libre in vivo et être utilisée comme médicament pour les animaux. Ledit acide ou dérivé fait fonction d'antibiotique, favorise la croissance, diminue l'indice de transformation et améliore la digestibilité des acides aminés administrés dans les aliments pour animaux. L'acide benzoïque ou son dérivé peut être administré à l'animal soit dans sa composition alimentaire, soit dans son eau de boisson. Il est particulièrement efficace chez les porcs.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97937758A EP0921792A1 (fr) | 1996-08-27 | 1997-08-19 | Compositions biocides |
| CA2265046A CA2265046C (fr) | 1996-08-27 | 1997-08-19 | Compositions biocides |
| PL331763A PL191241B1 (pl) | 1996-08-27 | 1997-08-19 | Sposób pobudzania przyrostu, zmniejszania przemiany pokarmu i poprawienia strawności aminokwasów u świń |
| BR9711977A BR9711977A (pt) | 1996-08-27 | 1997-08-19 | Composi-{es biocidas |
| AU40277/97A AU4027797A (en) | 1996-08-27 | 1997-08-19 | Biocidal compositions |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9618008.8 | 1996-08-27 | ||
| GBGB9618008.8A GB9618008D0 (en) | 1996-08-27 | 1996-08-27 | Biocidal compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998008499A1 true WO1998008499A1 (fr) | 1998-03-05 |
Family
ID=10799084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB1997/001068 WO1998008499A1 (fr) | 1996-08-27 | 1997-08-19 | Compositions biocides |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0921792A1 (fr) |
| KR (1) | KR100505971B1 (fr) |
| CN (1) | CN1236314A (fr) |
| AU (1) | AU4027797A (fr) |
| BR (1) | BR9711977A (fr) |
| CA (1) | CA2265046C (fr) |
| GB (1) | GB9618008D0 (fr) |
| PL (1) | PL191241B1 (fr) |
| WO (1) | WO1998008499A1 (fr) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1016974C2 (nl) * | 2000-12-22 | 2002-06-25 | Dsm Nv | BenzoÙzuurdeeltjes. |
| WO2007079970A1 (fr) | 2006-01-13 | 2007-07-19 | Dsm Ip Assets B.V. | Nouvelle utilisation d'une composition nutraceutique dans l'alimentation animale |
| DE102006021392A1 (de) * | 2006-05-08 | 2007-11-15 | Ligrana Gmbh | Zusammensetzung |
| JP2009029789A (ja) * | 2007-06-26 | 2009-02-12 | Marubeni Nisshin Feed Co Ltd | 家畜の尿路感染症予防・治療用組成物 |
| EP2042041A3 (fr) * | 2007-06-29 | 2009-05-13 | DSMIP Assets B.V. | Utilisation d'acide benzoique et de thymol, eugénol et piperine dans l'alimentation du bétail |
| DE102016203477A1 (de) | 2016-03-03 | 2017-09-07 | Addcon Europe Gmbh | Herstellung und Verwendung von Alkalimetalldiformiaten mit mittelkettigen Fettsäurederivaten |
| WO2020002595A1 (fr) | 2018-06-29 | 2020-01-02 | Dsm Ip Assets B.V. | Acide benzoïque à libération rapide dans des aliments pour bétail |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104686814A (zh) * | 2015-02-16 | 2015-06-10 | 广州英赛特生物技术有限公司 | 对甲基苯甲酸或其盐作为动物饲料添加剂的应用 |
| DE102016101603B3 (de) | 2016-01-29 | 2017-05-11 | Hanon Systems | Befestigungselement und Verfahren zur Befestigung von Fluidrohrleitungsenden |
| CN105661046B (zh) * | 2016-02-23 | 2020-12-18 | 广州英赛特生物技术有限公司 | 苯甲酸钙在制备动物饲料添加剂中的应用 |
| CN108617856A (zh) * | 2018-03-14 | 2018-10-09 | 广州英赛特生物技术有限公司 | 苯甲酸锌在制备动物饲料添加剂中的应用 |
| KR102703901B1 (ko) * | 2023-07-26 | 2024-09-06 | 남이현 | 면역력 증강 및 증체량 향상을 위한 돼지 사료 조성물 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1535233A (en) * | 1975-02-19 | 1978-12-13 | Plate Kofasil Gmbh | Method for preventing aerobic decomposition processes in fermentated fodder |
| GB2008381A (en) * | 1977-11-19 | 1979-06-06 | Basf Ag | Animal Feed supplements |
| GB2109217A (en) * | 1981-08-04 | 1983-06-02 | Nitrokemia Ipartelepek | Fodder and fodder additives promoting the weight increase of domestic animals and a process for the preparation thereof |
| WO1993016611A1 (fr) * | 1992-02-27 | 1993-09-02 | Kemira Oy | Compositions d'agent de conservation pour des produits vegetaux |
| JPH06298641A (ja) * | 1993-02-19 | 1994-10-25 | Takeda Chem Ind Ltd | ペットの尿結石症治療・予防剤および治療方法 |
| JPH07228533A (ja) * | 1994-02-17 | 1995-08-29 | Jun Kimura | 動物用ドリンク剤 |
| EP0683985A1 (fr) * | 1994-05-27 | 1995-11-29 | Verdugt B.V. | Contrôle de l'émission d'ammoniac et de l'odeur d'excréments d'animaux |
| WO1996024248A1 (fr) * | 1995-02-06 | 1996-08-15 | Kemira Chemicals Oy | Composition microbicide et ses emplois |
| US5603945A (en) * | 1993-02-19 | 1997-02-18 | Takeda Chemical Industries, Ltd. | Therapeutic/prophylactic agents and method of treating for urinary calculosis in pets |
-
1996
- 1996-08-27 GB GBGB9618008.8A patent/GB9618008D0/en active Pending
-
1997
- 1997-08-19 WO PCT/IB1997/001068 patent/WO1998008499A1/fr not_active Application Discontinuation
- 1997-08-19 CN CN97198985A patent/CN1236314A/zh active Pending
- 1997-08-19 EP EP97937758A patent/EP0921792A1/fr not_active Ceased
- 1997-08-19 KR KR10-1999-7001506A patent/KR100505971B1/ko not_active Expired - Lifetime
- 1997-08-19 CA CA2265046A patent/CA2265046C/fr not_active Expired - Lifetime
- 1997-08-19 AU AU40277/97A patent/AU4027797A/en not_active Abandoned
- 1997-08-19 BR BR9711977A patent/BR9711977A/pt active Search and Examination
- 1997-08-19 PL PL331763A patent/PL191241B1/pl unknown
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1535233A (en) * | 1975-02-19 | 1978-12-13 | Plate Kofasil Gmbh | Method for preventing aerobic decomposition processes in fermentated fodder |
| GB2008381A (en) * | 1977-11-19 | 1979-06-06 | Basf Ag | Animal Feed supplements |
| GB2109217A (en) * | 1981-08-04 | 1983-06-02 | Nitrokemia Ipartelepek | Fodder and fodder additives promoting the weight increase of domestic animals and a process for the preparation thereof |
| WO1993016611A1 (fr) * | 1992-02-27 | 1993-09-02 | Kemira Oy | Compositions d'agent de conservation pour des produits vegetaux |
| JPH06298641A (ja) * | 1993-02-19 | 1994-10-25 | Takeda Chem Ind Ltd | ペットの尿結石症治療・予防剤および治療方法 |
| US5603945A (en) * | 1993-02-19 | 1997-02-18 | Takeda Chemical Industries, Ltd. | Therapeutic/prophylactic agents and method of treating for urinary calculosis in pets |
| JPH07228533A (ja) * | 1994-02-17 | 1995-08-29 | Jun Kimura | 動物用ドリンク剤 |
| EP0683985A1 (fr) * | 1994-05-27 | 1995-11-29 | Verdugt B.V. | Contrôle de l'émission d'ammoniac et de l'odeur d'excréments d'animaux |
| WO1996024248A1 (fr) * | 1995-02-06 | 1996-08-15 | Kemira Chemicals Oy | Composition microbicide et ses emplois |
| WO1996024247A1 (fr) * | 1995-02-06 | 1996-08-15 | Kemira Chemicals Oy | Nouvelle composition conservatrice |
Non-Patent Citations (2)
| Title |
|---|
| DATABASE WPI Section Ch Week 9502, Derwent World Patents Index; Class B05, AN 95-011742, XP002046599 * |
| DATABASE WPI Section Ch Week 9543, Derwent World Patents Index; Class B05, AN 95-332478, XP002046600 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1016974C2 (nl) * | 2000-12-22 | 2002-06-25 | Dsm Nv | BenzoÙzuurdeeltjes. |
| WO2002051785A1 (fr) * | 2000-12-22 | 2002-07-04 | Dsm N.V. | Particules d'acide benzoique |
| WO2007079970A1 (fr) | 2006-01-13 | 2007-07-19 | Dsm Ip Assets B.V. | Nouvelle utilisation d'une composition nutraceutique dans l'alimentation animale |
| DE102006021392A1 (de) * | 2006-05-08 | 2007-11-15 | Ligrana Gmbh | Zusammensetzung |
| DE102006021392B4 (de) * | 2006-05-08 | 2013-06-27 | Ligrana Gmbh | Zusammensetzung |
| JP2009029789A (ja) * | 2007-06-26 | 2009-02-12 | Marubeni Nisshin Feed Co Ltd | 家畜の尿路感染症予防・治療用組成物 |
| EP2042041A3 (fr) * | 2007-06-29 | 2009-05-13 | DSMIP Assets B.V. | Utilisation d'acide benzoique et de thymol, eugénol et piperine dans l'alimentation du bétail |
| RU2400101C2 (ru) * | 2007-06-29 | 2010-09-27 | ДСМ АйПи АССЕТС Б.В. | Композиция корма для животных |
| EP2368440A1 (fr) * | 2007-06-29 | 2011-09-28 | DSM IP Assets B.V. | Additif pour l'alimentation du bétail comprenant un acide organique et une huile essentielle adsorbée |
| JP2014057591A (ja) * | 2007-06-29 | 2014-04-03 | Dsm Ip Assets Bv | 飼料添加剤組成物及びその使用 |
| DE102016203477A1 (de) | 2016-03-03 | 2017-09-07 | Addcon Europe Gmbh | Herstellung und Verwendung von Alkalimetalldiformiaten mit mittelkettigen Fettsäurederivaten |
| WO2020002595A1 (fr) | 2018-06-29 | 2020-01-02 | Dsm Ip Assets B.V. | Acide benzoïque à libération rapide dans des aliments pour bétail |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000035832A (ko) | 2000-06-26 |
| CA2265046C (fr) | 2010-05-25 |
| GB9618008D0 (en) | 1996-10-09 |
| CA2265046A1 (fr) | 1998-03-05 |
| EP0921792A1 (fr) | 1999-06-16 |
| PL191241B1 (pl) | 2006-04-28 |
| CN1236314A (zh) | 1999-11-24 |
| PL331763A1 (en) | 1999-08-02 |
| BR9711977A (pt) | 1999-08-24 |
| KR100505971B1 (ko) | 2005-08-05 |
| AU4027797A (en) | 1998-03-19 |
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