WO1998005685B1 - Peptides s'alignant automatiquement et derives de l'elastine et d'autres proteines fibreuses - Google Patents
Peptides s'alignant automatiquement et derives de l'elastine et d'autres proteines fibreusesInfo
- Publication number
- WO1998005685B1 WO1998005685B1 PCT/CA1997/000560 CA9700560W WO9805685B1 WO 1998005685 B1 WO1998005685 B1 WO 1998005685B1 CA 9700560 W CA9700560 W CA 9700560W WO 9805685 B1 WO9805685 B1 WO 9805685B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptide
- amino acid
- beta
- sheet
- acid sequence
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 47
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 47
- 102000034240 fibrous proteins Human genes 0.000 title claims abstract 7
- 108091005899 fibrous proteins Proteins 0.000 title claims abstract 7
- 102000016942 Elastin Human genes 0.000 title claims abstract 4
- 108010014258 Elastin Proteins 0.000 title claims abstract 4
- 229920002549 elastin Polymers 0.000 title claims abstract 4
- 229920001184 polypeptide Polymers 0.000 claims abstract 46
- 239000000463 material Substances 0.000 claims 20
- 125000000539 amino acid group Chemical group 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 238000004132 cross linking Methods 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 229920001872 Spider silk Polymers 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 108010062713 lamprin Proteins 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229920002994 synthetic fiber Polymers 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000013013 elastic material Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Abstract
L'invention concerne un polypeptide, lequel présente une structure secondaire, caractérisée par au moins trois structures à feuillet bêta/virage bêta, et n'est pas une protéine fibreuse naturelle. De tels polypeptides, à l'exemple d'un polypeptide construit sur le modèle de l'élastine, sont utiles dans des prothèses.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP50741998A JP2001505539A (ja) | 1996-08-07 | 1997-08-07 | エラスチン及び他の線維状タンパク質由来の自己整列ペプチド |
AU38438/97A AU728480B2 (en) | 1996-08-07 | 1997-08-07 | Self-aligning peptides derived from elastin and other fibrous proteins |
EP97935396A EP0922058A2 (fr) | 1996-08-07 | 1997-08-07 | Peptides s'alignant automatiquement et derives de l'elastine et d'autres proteines fibreuses |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2355296P | 1996-08-07 | 1996-08-07 | |
US60/023,552 | 1997-08-07 | ||
US08/911,364 US5969106A (en) | 1996-08-07 | 1997-08-07 | Self-aligning peptides modeled on human elastin and other fibrous proteins |
US08/911,364 | 1997-08-07 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1998005685A2 WO1998005685A2 (fr) | 1998-02-12 |
WO1998005685A3 WO1998005685A3 (fr) | 1998-04-30 |
WO1998005685B1 true WO1998005685B1 (fr) | 1998-07-02 |
Family
ID=26697313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1997/000560 WO1998005685A2 (fr) | 1996-08-07 | 1997-08-07 | Peptides s'alignant automatiquement et derives de l'elastine et d'autres proteines fibreuses |
Country Status (6)
Country | Link |
---|---|
US (1) | US5969106A (fr) |
EP (1) | EP0922058A2 (fr) |
JP (1) | JP2001505539A (fr) |
AU (1) | AU728480B2 (fr) |
CA (1) | CA2262446A1 (fr) |
WO (1) | WO1998005685A2 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030198956A1 (en) * | 2002-02-21 | 2003-10-23 | Lee Makowski | Staged assembly of nanostructures |
US5969106A (en) * | 1996-08-07 | 1999-10-19 | The Hospital For Sick Children | Self-aligning peptides modeled on human elastin and other fibrous proteins |
US6489446B1 (en) * | 1996-08-07 | 2002-12-03 | Hsc Research And Development Limited Partnership | Self-aligning peptides modeled on human elastin and other fibrous proteins |
US6369626B1 (en) | 1997-03-21 | 2002-04-09 | Rambus Inc. | Low pass filter for a delay locked loop circuit |
US20050204408A1 (en) * | 1998-07-17 | 2005-09-15 | Weiss Anthony S. | Tropoelastin derivatives |
AUPO811797A0 (en) * | 1997-07-18 | 1997-08-14 | University Of Sydney, The | Tropoelastin derivatives |
US7193043B1 (en) * | 1998-07-17 | 2007-03-20 | Weiss Anthony S | Tropoelastin derivatives |
AUPP472398A0 (en) | 1998-07-17 | 1998-08-13 | University Of Sydney, The | Protease susceptibility II |
US6903244B1 (en) * | 1999-02-26 | 2005-06-07 | University Of Utah Research Foundation | Mice which are +/− or −/− for the elastin gene as models for vascular disease |
US20010053931A1 (en) * | 1999-11-24 | 2001-12-20 | Salvatore J. Abbruzzese | Thin-layered, endovascular silk-covered stent device and method of manufacture thereof |
US6808707B2 (en) * | 2000-02-04 | 2004-10-26 | Matrix Design | Wound healing compositions and methods using tropoelastin and lysyl oxidase |
GB0108767D0 (en) * | 2001-04-07 | 2001-05-30 | Univ Leeds | Coatings |
US6902932B2 (en) * | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
CA2473772A1 (fr) * | 2002-02-14 | 2003-08-21 | The University Of British Columbia | Materiaux a base de proteine helicoidale - .alpha. et procedes de fabrication de ces derniers |
AU2003902483A0 (en) * | 2003-05-21 | 2003-06-05 | Commonwealth Scientific And Industrial Research Organisation | A bioelastomer ii |
AU2003902474A0 (en) * | 2003-05-21 | 2003-06-05 | Commonwealth Scientific And Industrial Research Organisation | A bioelastomer i |
CN101553262A (zh) | 2006-11-13 | 2009-10-07 | 悉尼大学 | 原弹性蛋白用于组织修复或恢复的用途 |
CA2686895A1 (fr) * | 2007-05-10 | 2008-11-20 | Elastin Specialties, Inc. | Materiaux peptidiques synthetiques pour reconstruction, reparation et amortissement d'articulation |
US9308070B2 (en) | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
WO2010102337A1 (fr) | 2009-03-10 | 2010-09-16 | The University Of Sydney | Biomatériaux injectables |
MX377200B (es) | 2013-08-13 | 2025-03-07 | Allergan Pharmaceuticals Int Ltd | Regeneracion de tejido dañado. |
CN113993885B (zh) * | 2019-04-12 | 2025-04-25 | 格尔托公司 | 重组弹性蛋白及其生产 |
CN112745394B (zh) * | 2020-12-09 | 2022-12-06 | 肽源(广州)生物科技有限公司 | 一种重组类人胶原蛋白及其制备方法和应用 |
Family Cites Families (29)
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---|---|---|---|---|
US4132746A (en) * | 1976-07-09 | 1979-01-02 | University Of Alabama, Birmingham Medical & Education Foundation | Synthetic elastomeric insoluble cross-linked polypentapeptide |
NL7713618A (nl) * | 1976-12-11 | 1978-06-13 | Bayer Ag | Werkwijze voor de bereiding van een cosmetisch preparaat. |
DE2705670C3 (de) * | 1977-02-11 | 1983-11-17 | Fa. Carl Freudenberg, 6940 Weinheim | Verfahren zur Herstellung von wasserlöslichen Elastin-Hydrolysaten |
US4419288A (en) * | 1981-08-27 | 1983-12-06 | Seton Company | Elastin hydrolyzate |
US4474851A (en) * | 1981-10-02 | 1984-10-02 | The University Of Alabama In Birmingham | Elastomeric composite material comprising a polypeptide |
US4474763A (en) * | 1982-07-07 | 1984-10-02 | Lubowe Irwin I | Skin preparation |
US4960423A (en) * | 1982-11-17 | 1990-10-02 | Smith Donald W | Method of enhancing the attachment of endothelial cells on a matrix and vascular prosthesis with enhanced anti-thrombogenic characteristics |
US4589882A (en) * | 1983-09-19 | 1986-05-20 | Urry Dan W | Enzymatically crosslinked bioelastomers |
US4659740A (en) * | 1985-02-14 | 1987-04-21 | Polydex Pharmaceuticals Ltd. | Cosmetic preparations comprising novel elastin derivatives |
FR2598423B1 (fr) * | 1985-03-01 | 1989-03-17 | Inst Nat Sante Rech Med | Produit a base d'elastine, procede pour sa preparation et ses applications biologiques, en particulier en tant que biomateriaux et supports artificiels |
US5223420A (en) * | 1985-03-01 | 1993-06-29 | Institut National De La Sante Et De La Recherche Medicale | Elastin-based product, a procedure for its preparation and its biological applications; in particular as biomaterials and artificial supports |
US4870055A (en) * | 1986-04-17 | 1989-09-26 | University Of Alabama At Birmingham | Segmented polypeptide bioelastomers to modulate elastic modulus |
US5250516A (en) * | 1986-04-17 | 1993-10-05 | Uab Research Foundation | Bioelastomeric materials suitable for the protection of burn areas or the protection of wound repair sites from the occurrence of adhesions |
US4783523A (en) * | 1986-08-27 | 1988-11-08 | Urry Dan W | Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides |
US5336256A (en) * | 1986-04-17 | 1994-08-09 | Uab Research Foundation | Elastomeric polypeptides as vascular prosthetic materials |
GB8618374D0 (en) * | 1986-07-28 | 1986-09-03 | Hsc Res Dev Corp | Biological vascular prostheses |
US4979959A (en) * | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
EP0293443B1 (fr) * | 1986-11-04 | 2003-02-26 | Protein Polymer Technologies, Inc. | Structure d'adn synthetique et son emploi dans la synthese de polypeptides de grande dimension |
US5243038A (en) * | 1986-11-04 | 1993-09-07 | Protein Polymer Technologies, Inc. | Construction of synthetic DNA and its use in large polypeptide synthesis |
JP2549118B2 (ja) * | 1987-05-30 | 1996-10-30 | 三省製薬株式会社 | 乳化組成物 |
US5606019A (en) * | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
EP0406357B1 (fr) * | 1988-11-09 | 1998-01-07 | Protein Polymer Technologies, Inc. | Polymere fonctionnel a base de proteine synthetique produit grace a un procede recombinant |
FR2649982B1 (fr) * | 1989-07-20 | 1991-09-27 | Inst Nat Sante Rech Med | Membrane biologique artificielle |
EP0600869A1 (fr) * | 1990-05-03 | 1994-06-15 | New England Deaconess Hospital Corporation | Peptides synthetiques utilises en imagerie arterielle |
CA2095861C (fr) * | 1990-11-28 | 2002-06-11 | Ronald H. Hoess | Structurel proteines de genes artificiels |
GB2273459A (en) * | 1992-12-21 | 1994-06-22 | Anthony Joseph Cesaroni | Bonding tubes to articles e.g in making panel heat exchangers. |
DE69334243D1 (de) * | 1992-12-22 | 2008-12-04 | Univ Sydney | Synthetische polynukleotide |
US5527610A (en) * | 1994-05-20 | 1996-06-18 | The Uab Research Foundation | Elastomeric polypeptide matrices for preventing adhesion of biological materials |
US5969106A (en) * | 1996-08-07 | 1999-10-19 | The Hospital For Sick Children | Self-aligning peptides modeled on human elastin and other fibrous proteins |
-
1997
- 1997-08-07 US US08/911,364 patent/US5969106A/en not_active Expired - Lifetime
- 1997-08-07 AU AU38438/97A patent/AU728480B2/en not_active Ceased
- 1997-08-07 JP JP50741998A patent/JP2001505539A/ja not_active Withdrawn
- 1997-08-07 EP EP97935396A patent/EP0922058A2/fr not_active Withdrawn
- 1997-08-07 CA CA002262446A patent/CA2262446A1/fr not_active Abandoned
- 1997-08-07 WO PCT/CA1997/000560 patent/WO1998005685A2/fr active Application Filing
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