WO1998005685B1 - Self-aligning peptides derived from elastin and other fibrous proteins - Google Patents
Self-aligning peptides derived from elastin and other fibrous proteinsInfo
- Publication number
- WO1998005685B1 WO1998005685B1 PCT/CA1997/000560 CA9700560W WO9805685B1 WO 1998005685 B1 WO1998005685 B1 WO 1998005685B1 CA 9700560 W CA9700560 W CA 9700560W WO 9805685 B1 WO9805685 B1 WO 9805685B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptide
- amino acid
- beta
- sheet
- acid sequence
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 47
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 47
- 102000034240 fibrous proteins Human genes 0.000 title claims abstract 7
- 108091005899 fibrous proteins Proteins 0.000 title claims abstract 7
- 102000016942 Elastin Human genes 0.000 title claims abstract 4
- 108010014258 Elastin Proteins 0.000 title claims abstract 4
- 229920002549 elastin Polymers 0.000 title claims abstract 4
- 229920001184 polypeptide Polymers 0.000 claims abstract 46
- 239000000463 material Substances 0.000 claims 20
- 125000000539 amino acid group Chemical group 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 238000004132 cross linking Methods 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 229920001872 Spider silk Polymers 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 108010062713 lamprin Proteins 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229920002994 synthetic fiber Polymers 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000013013 elastic material Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 210000003709 heart valve Anatomy 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Abstract
A polypeptide is provided that has a secondary structure characterized by at least three beta-sheet/beta-turn structures, and that is not a naturally occurring fibrous protein. Such polypeptides, illustrated by one modeled on elastin, are useful in prosthesis.
Claims
1. A polypeptide that comprises at least three beta-sheet/beta-turn structures and at least one amino acid residue capable of participating in cross-linking, and that is not a naturally occurring fibrous protein.
2. The polypeptide of claim 1, wherein each of the beta-sheet structures comprises from 3 to about 7 amino acid residues.
3. The polypeptide of claim 2, wherein each of the beta-sheet structures comprises from about 5 to about 7 amino acid residues.
4. The polypeptide of claim 1, wherein the polypeptide consists essentially of a portion of the amino acid sequence set forth in Figure IB.
5. The polypeptide of claim 4, wherein the polypeptide comprises an amino acid sequence selected from the group consisting of amino acid residues 374-499, 19-160, 188-367 and 607-717, respectively, of Figure IB.
6. The polypeptide of claim 4, wherein the portion of the amino acid sequence set forth in Figure IB is modified by the addition, deletion or substitution of from 1 to about 10 amino acid residues.
7. The polypeptide of claim 4, wherein the polypeptide comprises tandem repeats of a portion of the amino acid sequence set forth in Figure IB.
8. The polypeptide of claim 7, wherein the polypeptide consists essentially of the amino acid sequence set forth in Figure 4C.
9. The polypeptide of claim 7, wherein the polypeptide consists essentially of the amino acid -35- sequence set forth in Figure 4C, modified by the addition, deletion or substitution of from 1 to about 10 amino acid residues.
10. A prosthesis comprising an animal material, wherein a surface of the animal material is coated with a polypeptide according to claim 4.
11. A prosthesis comprising a synthetic material, wherein a surface of the synthetic material is coated with a polypeptide according to claim 4.
12. A prosthesis comprising a metal, wherein a surface of the metal is coated with a polypeptide according to claim 4.
13. Material suitable for implantation into humans, wherein the material consists essentially of a polypeptide according to claim 4.
14. The material of claim 13, wherein the material is selected from the groups consisting of materials for blood vessel replacement, materials for heart valve replacement, materials for covering burns, materials for covering wounds, and stents.
15. A cosmetic material comprising the polypeptide of claim 4.
16. An elastic material comprising the polypeptide of claim 1.
17. A high tensile-strength material comprising the polypeptide of claim 1.
18. The polypeptide of claim 1, wherein the polypeptide consists essentially of a portion of the amino acid sequence of an animal elastin.
19. The polypeptide of claim 1, wherein the polypeptide consists essentially of a portion of the amino acid sequence of lamprin.
20. The polypeptide of claim 1, wherein the polypeptide consists essentially of a portion of the amino acid sequence of a spider silk protein.
21. A material comprising two or more polypeptides selected from the group consisting of:
(A) a polypeptide consisting essentially of a portion of the amino acid sequence set forth in Figure IB comprising at least three beta-sheet/beta-turn structures;
(B) a polypeptide consisting essentially of a portion of the amino acid sequence of an animal elastin comprising at least three beta-sheet/beta-turn structures;
(C) a polypeptide consisting essentially of a portion of the amino acid sequence of lamprin comprising at least three beta-sheet/beta-turn structures; and
(D) a polypeptide consisting essentially of a portion of the amino acid sequence of a spider silk protein comprising at least three beta-sheet/beta-turn structures, wherein the two or more polypeptides may be the same or different.
22. The material of claim 21, wherein the material comprises a mixture of the two or more polypeptides.
23. The material of claim 21, wherein the material comprises a fusion protein comprising the two or more polypeptides.
24. The material of claim 21, wherein the two or more polypeptides are chemically linked together. -37-
25. A polypeptide having the primary structure of a portion of a naturally occurring fibrous protein and a secondary structure comprising at least three beta- sheet/beta-turn structures, wherein
(A) the polypeptide comprises at least one amino acid residue capable of participating in cross-linking,
(B) each of the beta-sheet/beta-turn structures comprises from 3 to about 7 amino acid residues and (C) the polypeptide is not a naturally occurring fibrous protein.
26. A material comprising: a first polypeptide that comprises at least three beta-sheet/beta-turn structures and at least one first amino acid residue capable of participating in cross- linking, that is not a naturally occurring fibrous protein, and a second polypeptide that comprises at least three beta-sheet/beta-turn structures and at least one second amino acid residue capable of participating in cross- linking, that is not a naturally occurring fibrous protein, wherein the first polypeptide may be the same as or different from the second polypeptide, and the first and second polypeptides are aligned such that the first amino acid residue can participate in cross-linking with the second amino acid residue.
27. The material of claim 26, wherein the first amino acid residue is enzymatically cross-linked with the second amino acid residue.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50741998A JP2001505539A (en) | 1996-08-07 | 1997-08-07 | Self-aligned peptides from elastin and other filamentous proteins |
| EP97935396A EP0922058A2 (en) | 1996-08-07 | 1997-08-07 | Self-aligning peptides derived from elastin and other fibrous proteins |
| AU38438/97A AU728480B2 (en) | 1996-08-07 | 1997-08-07 | Self-aligning peptides derived from elastin and other fibrous proteins |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2355296P | 1996-08-07 | 1996-08-07 | |
| US60/023,552 | 1996-08-07 | ||
| US08/911,364 US5969106A (en) | 1996-08-07 | 1997-08-07 | Self-aligning peptides modeled on human elastin and other fibrous proteins |
| US08/911,364 | 1997-08-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1998005685A2 WO1998005685A2 (en) | 1998-02-12 |
| WO1998005685A3 WO1998005685A3 (en) | 1998-04-30 |
| WO1998005685B1 true WO1998005685B1 (en) | 1998-07-02 |
Family
ID=26697313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CA1997/000560 WO1998005685A2 (en) | 1996-08-07 | 1997-08-07 | Self-aligning peptides derived from elastin and other fibrous proteins |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5969106A (en) |
| EP (1) | EP0922058A2 (en) |
| JP (1) | JP2001505539A (en) |
| AU (1) | AU728480B2 (en) |
| CA (1) | CA2262446A1 (en) |
| WO (1) | WO1998005685A2 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030198956A1 (en) * | 2002-02-21 | 2003-10-23 | Lee Makowski | Staged assembly of nanostructures |
| EP0922058A2 (en) * | 1996-08-07 | 1999-06-16 | Protein Specialities Ltd. | Self-aligning peptides derived from elastin and other fibrous proteins |
| US6489446B1 (en) | 1996-08-07 | 2002-12-03 | Hsc Research And Development Limited Partnership | Self-aligning peptides modeled on human elastin and other fibrous proteins |
| US6369626B1 (en) | 1997-03-21 | 2002-04-09 | Rambus Inc. | Low pass filter for a delay locked loop circuit |
| US20050204408A1 (en) * | 1998-07-17 | 2005-09-15 | Weiss Anthony S. | Tropoelastin derivatives |
| AUPO811797A0 (en) * | 1997-07-18 | 1997-08-14 | University Of Sydney, The | Tropoelastin derivatives |
| AUPP472398A0 (en) | 1998-07-17 | 1998-08-13 | University Of Sydney, The | Protease susceptibility II |
| US7193043B1 (en) * | 1998-07-17 | 2007-03-20 | Weiss Anthony S | Tropoelastin derivatives |
| US6903244B1 (en) * | 1999-02-26 | 2005-06-07 | University Of Utah Research Foundation | Mice which are +/− or −/− for the elastin gene as models for vascular disease |
| US20010053931A1 (en) * | 1999-11-24 | 2001-12-20 | Salvatore J. Abbruzzese | Thin-layered, endovascular silk-covered stent device and method of manufacture thereof |
| US6808707B2 (en) * | 2000-02-04 | 2004-10-26 | Matrix Design | Wound healing compositions and methods using tropoelastin and lysyl oxidase |
| GB0108767D0 (en) * | 2001-04-07 | 2001-05-30 | Univ Leeds | Coatings |
| US6902932B2 (en) * | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| CA2473772A1 (en) * | 2002-02-14 | 2003-08-21 | The University Of British Columbia | .alpha.-helical protein based materials and methods for making same |
| AU2003902483A0 (en) * | 2003-05-21 | 2003-06-05 | Commonwealth Scientific And Industrial Research Organisation | A bioelastomer ii |
| AU2003902474A0 (en) * | 2003-05-21 | 2003-06-05 | Commonwealth Scientific And Industrial Research Organisation | A bioelastomer i |
| WO2008058323A1 (en) | 2006-11-13 | 2008-05-22 | The University Of Sydney | Use of tropoelastin for repair or restoration of tissue |
| JP2010526582A (en) * | 2007-05-10 | 2010-08-05 | エラスティン・スペシャルティーズ，インコーポレイテッド | Synthetic peptide materials for joint reconstruction, repair and cushioning |
| US9308070B2 (en) | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
| EP3881825B1 (en) | 2009-03-10 | 2024-12-25 | Allergan Pharmaceuticals International Limited | Injectable biomaterials |
| CN110464837A (en) | 2013-08-13 | 2019-11-19 | 爱力根制药国际有限公司 | The regeneration of damaged tissues |
| CA3136691A1 (en) * | 2019-04-12 | 2020-10-15 | Geltor, Inc. | Recombinant elastin and production thereof |
| CN112745394B (en) * | 2020-12-09 | 2022-12-06 | 肽源（广州）生物科技有限公司 | Recombinant human-like collagen and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132746A (en) * | 1976-07-09 | 1979-01-02 | University Of Alabama, Birmingham Medical & Education Foundation | Synthetic elastomeric insoluble cross-linked polypentapeptide |
| NL7713618A (en) * | 1976-12-11 | 1978-06-13 | Bayer Ag | PROCESS FOR THE PREPARATION OF A COSMETIC PREPARATION. |
| DE2705670C3 (en) * | 1977-02-11 | 1983-11-17 | Fa. Carl Freudenberg, 6940 Weinheim | Process for the production of water-soluble elastin hydrolysates |
| US4419288A (en) * | 1981-08-27 | 1983-12-06 | Seton Company | Elastin hydrolyzate |
| US4474851A (en) * | 1981-10-02 | 1984-10-02 | The University Of Alabama In Birmingham | Elastomeric composite material comprising a polypeptide |
| US4474763A (en) * | 1982-07-07 | 1984-10-02 | Lubowe Irwin I | Skin preparation |
| US4960423A (en) * | 1982-11-17 | 1990-10-02 | Smith Donald W | Method of enhancing the attachment of endothelial cells on a matrix and vascular prosthesis with enhanced anti-thrombogenic characteristics |
| US4589882A (en) * | 1983-09-19 | 1986-05-20 | Urry Dan W | Enzymatically crosslinked bioelastomers |
| US4659740A (en) * | 1985-02-14 | 1987-04-21 | Polydex Pharmaceuticals Ltd. | Cosmetic preparations comprising novel elastin derivatives |
| FR2598423B1 (en) * | 1985-03-01 | 1989-03-17 | Inst Nat Sante Rech Med | ELASTINE-BASED PRODUCT, PROCESS FOR ITS PREPARATION AND BIOLOGICAL APPLICATIONS, PARTICULARLY AS BIOMATERIALS AND ARTIFICIAL SUPPORTS |
| US5223420A (en) * | 1985-03-01 | 1993-06-29 | Institut National De La Sante Et De La Recherche Medicale | Elastin-based product, a procedure for its preparation and its biological applications; in particular as biomaterials and artificial supports |
| US5336256A (en) * | 1986-04-17 | 1994-08-09 | Uab Research Foundation | Elastomeric polypeptides as vascular prosthetic materials |
| US5250516A (en) * | 1986-04-17 | 1993-10-05 | Uab Research Foundation | Bioelastomeric materials suitable for the protection of burn areas or the protection of wound repair sites from the occurrence of adhesions |
| US4870055A (en) * | 1986-04-17 | 1989-09-26 | University Of Alabama At Birmingham | Segmented polypeptide bioelastomers to modulate elastic modulus |
| US4783523A (en) * | 1986-08-27 | 1988-11-08 | Urry Dan W | Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides |
| GB8618374D0 (en) * | 1986-07-28 | 1986-09-03 | Hsc Res Dev Corp | Biological vascular prostheses |
| US4979959A (en) * | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
| US5243038A (en) * | 1986-11-04 | 1993-09-07 | Protein Polymer Technologies, Inc. | Construction of synthetic DNA and its use in large polypeptide synthesis |
| ATE233273T1 (en) * | 1986-11-04 | 2003-03-15 | Protein Polymer Tech Inc | PRODUCTION OF SYNTHETIC DNA AND ITS USE IN THE SYNTHESIS OF LARGE POLYPEPTIDES |
| JP2549118B2 (en) * | 1987-05-30 | 1996-10-30 | 三省製薬株式会社 | Emulsified composition |
| US5606019A (en) * | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
| WO1990005177A1 (en) * | 1988-11-09 | 1990-05-17 | Syntro Corporation | Functional recombinantly prepared synthetic protein polymer |
| FR2649982B1 (en) * | 1989-07-20 | 1991-09-27 | Inst Nat Sante Rech Med | ARTIFICIAL BIOLOGICAL MEMBRANE |
| CA2080493A1 (en) * | 1990-05-03 | 1991-11-04 | Robert S. Lees | Synthetic peptides for arterial imaging |
| DE69133317T2 (en) * | 1990-11-28 | 2004-07-22 | E.I. Du Pont De Nemours And Co., Wilmington | Structural proteins through artificial genes |
| GB2273459A (en) * | 1992-12-21 | 1994-06-22 | Anthony Joseph Cesaroni | Bonding tubes to articles e.g in making panel heat exchangers. |
| EP0746612B1 (en) * | 1992-12-22 | 2008-10-22 | The University Of Sydney | Synthetic polynucleotides |
| US5527610A (en) * | 1994-05-20 | 1996-06-18 | The Uab Research Foundation | Elastomeric polypeptide matrices for preventing adhesion of biological materials |
| EP0922058A2 (en) * | 1996-08-07 | 1999-06-16 | Protein Specialities Ltd. | Self-aligning peptides derived from elastin and other fibrous proteins |
-
1997
- 1997-08-07 EP EP97935396A patent/EP0922058A2/en not_active Withdrawn
- 1997-08-07 CA CA002262446A patent/CA2262446A1/en not_active Abandoned
- 1997-08-07 AU AU38438/97A patent/AU728480B2/en not_active Ceased
- 1997-08-07 WO PCT/CA1997/000560 patent/WO1998005685A2/en active Application Filing
- 1997-08-07 JP JP50741998A patent/JP2001505539A/en not_active Withdrawn
- 1997-08-07 US US08/911,364 patent/US5969106A/en not_active Expired - Lifetime
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