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WO1998000539A3 - (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip) - Google Patents

(mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip) Download PDF

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Publication number
WO1998000539A3
WO1998000539A3 PCT/US1997/010866 US9710866W WO9800539A3 WO 1998000539 A3 WO1998000539 A3 WO 1998000539A3 US 9710866 W US9710866 W US 9710866W WO 9800539 A3 WO9800539 A3 WO 9800539A3
Authority
WO
WIPO (PCT)
Prior art keywords
kinase
mip
mkk3
protein
mitogen
Prior art date
Application number
PCT/US1997/010866
Other languages
French (fr)
Other versions
WO1998000539A2 (en
Inventor
Venkatakrishna Shyamala
Michael W Kavanaugh
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to AU43260/97A priority Critical patent/AU4326097A/en
Publication of WO1998000539A2 publication Critical patent/WO1998000539A2/en
Publication of WO1998000539A3 publication Critical patent/WO1998000539A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A novel human gene encoding a protein termed MKK3-Interacting Protein (MIP) is disclosed. MIP expression is indicative of a tissue selected from the group of consisting of brain, kidney, liver, lung, pancreas, and spleen. MIP binds to a dominant interfering mutant of MAPK kinase-3 (MKK3) and may be involved in the transduction of extracellular signals into the nucleus which result in the activation of p38 kinase.
PCT/US1997/010866 1996-07-03 1997-07-02 (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip) WO1998000539A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43260/97A AU4326097A (en) 1996-07-03 1997-07-02 (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2122496P 1996-07-03 1996-07-03
US60/021,224 1996-07-03
US2164196P 1996-07-12 1996-07-12
US60/021,641 1996-07-12
US88657297A 1997-07-01 1997-07-01
US08/886,572 1997-07-01

Publications (2)

Publication Number Publication Date
WO1998000539A2 WO1998000539A2 (en) 1998-01-08
WO1998000539A3 true WO1998000539A3 (en) 1998-03-26

Family

ID=27361599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010866 WO1998000539A2 (en) 1996-07-03 1997-07-02 (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip)

Country Status (2)

Country Link
AU (1) AU4326097A (en)
WO (1) WO1998000539A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756332A (en) * 1996-12-26 1998-05-26 Incyte Pharmaceuticals, Inc. Guanosine monophosphate reductase
US6372473B1 (en) 1997-05-28 2002-04-16 Human Genome Sciences, Inc. Tissue plasminogen activator-like protease
US6165461A (en) * 1998-04-14 2000-12-26 Board Of Regents, University Of Texas System Tao protein kinases and methods of use therefor
JP2004521892A (en) 2000-12-20 2004-07-22 メルク　エンド　カムパニー　インコーポレーテッド (Halo-benzocarbonyl) heterocyclic fused phenyl p38 kinase inhibitors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B. DÉRIJARD ET AL.: "Independent Human MAP kinase signal transduction pathways defined by MEK and MKK isoforms.", SCIENCE, vol. 267, 3 February 1995 (1995-02-03), pages 682 - 685, XP002054336 *
H. KANNO ET AL.: "Two structural genes on different chromosomes are required for encoding the major subunit of human cell glucose-6-phosphate dehydrogenase.", CELL, vol. 58, 11 August 1989 (1989-08-11), pages 595 - 606, XP002054262 *
S. HENIKOFF ET AL.: "The human mRNA that provides the N-terminus of chimeric G6PD encodes GMP reductase.", CELL, vol. 58, 22 September 1989 (1989-09-22), pages 1021 - 1022, XP002054263 *
T. KONDOH ET AL.: "Genomic structure and expression of human guanosine monophosphate reductase.", HUMAN GENETICS, vol. 88, 1991, pages 219 - 224, XP002054264 *
Z. XIA ET AL.: "Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis.", SCIENCE, vol. 270, 24 November 1995 (1995-11-24), pages 1326 - 1331, XP002054337 *

Also Published As

Publication number Publication date
AU4326097A (en) 1998-01-21
WO1998000539A2 (en) 1998-01-08

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