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WO1999048868A3 - Heterocyclic classes of compounds for the modulating tyrosine protein kinase - Google Patents

Heterocyclic classes of compounds for the modulating tyrosine protein kinase Download PDF

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Publication number
WO1999048868A3
WO1999048868A3 PCT/US1999/006468 US9906468W WO9948868A3 WO 1999048868 A3 WO1999048868 A3 WO 1999048868A3 US 9906468 W US9906468 W US 9906468W WO 9948868 A3 WO9948868 A3 WO 9948868A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
protein kinase
tyrosine protein
modulating
modulating tyrosine
Prior art date
Application number
PCT/US1999/006468
Other languages
French (fr)
Other versions
WO1999048868A2 (en
WO1999048868A9 (en
Inventor
Annie Fong
Alison Hannah
David G Harris
Peter Hirth
Steven R Hubbard
Peter Langecker
Congxin Liang
Gerald Mcmahon
Moosa Mohammadi
Joseph Schlessinger
Laura K Shawver
Li Sun
Peng C Tang
Axel Ullrich
Original Assignee
Sugen Inc
Univ New York
Max Planck Inst Fur Biochemie
Annie Fong
Alison Hannah
David G Harris
Peter Hirth
Steven R Hubbard
Peter Langecker
Congxin Liang
Gerald Mcmahon
Moosa Mohammadi
Joseph Schlessinger
Laura K Shawver
Li Sun
Peng C Tang
Axel Ullrich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Univ New York, Max Planck Inst Fur Biochemie, Annie Fong, Alison Hannah, David G Harris, Peter Hirth, Steven R Hubbard, Peter Langecker, Congxin Liang, Gerald Mcmahon, Moosa Mohammadi, Joseph Schlessinger, Laura K Shawver, Li Sun, Peng C Tang, Axel Ullrich filed Critical Sugen Inc
Priority to EP99915018A priority Critical patent/EP1066257A2/en
Priority to AU33635/99A priority patent/AU3363599A/en
Priority to JP2000537851A priority patent/JP2002507598A/en
Priority to CA002325935A priority patent/CA2325935A1/en
Publication of WO1999048868A2 publication Critical patent/WO1999048868A2/en
Publication of WO1999048868A3 publication Critical patent/WO1999048868A3/en
Publication of WO1999048868A9 publication Critical patent/WO1999048868A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
PCT/US1999/006468 1998-03-26 1999-03-26 Heterocyclic classes of compounds for the modulating tyrosine protein kinase WO1999048868A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99915018A EP1066257A2 (en) 1998-03-26 1999-03-26 Heterocylic classes of compounds for the modulating tyrosine protein kinase
AU33635/99A AU3363599A (en) 1998-03-26 1999-03-26 Heterocyclic families of compounds for the modulation of tyrosine protein kinase
JP2000537851A JP2002507598A (en) 1998-03-26 1999-03-26 A family of heterocyclic compounds for regulating tyrosine protein kinase
CA002325935A CA2325935A1 (en) 1998-03-26 1999-03-26 Heterocyclic families of compounds for the modulation of tyrosine protein kinase

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US7971398P 1998-03-26 1998-03-26
US8042298P 1998-04-02 1998-04-02
US8179298P 1998-04-15 1998-04-15
US8205698P 1998-04-16 1998-04-16
US8939798P 1998-06-15 1998-06-15
US8952198P 1998-06-16 1998-06-16
US9878398P 1998-09-01 1998-09-01
US60/079,713 1998-09-01
US60/080,422 1998-09-01
US60/089,521 1998-09-01
US60/082,056 1998-09-01
US60/089,397 1998-09-01
US60/081,792 1998-09-01
US60/098,783 1998-09-01

Publications (3)

Publication Number Publication Date
WO1999048868A2 WO1999048868A2 (en) 1999-09-30
WO1999048868A3 true WO1999048868A3 (en) 2000-02-24
WO1999048868A9 WO1999048868A9 (en) 2000-04-20

Family

ID=27568389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/006468 WO1999048868A2 (en) 1998-03-26 1999-03-26 Heterocyclic classes of compounds for the modulating tyrosine protein kinase

Country Status (5)

Country Link
EP (1) EP1066257A2 (en)
JP (1) JP2002507598A (en)
AU (1) AU3363599A (en)
CA (1) CA2325935A1 (en)
WO (1) WO1999048868A2 (en)

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Also Published As

Publication number Publication date
EP1066257A2 (en) 2001-01-10
AU3363599A (en) 1999-10-18
CA2325935A1 (en) 1999-09-30
WO1999048868A2 (en) 1999-09-30
JP2002507598A (en) 2002-03-12
WO1999048868A9 (en) 2000-04-20

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