+

WO1998048844A3 - Ionenpaare, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel - Google Patents

Ionenpaare, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel Download PDF

Info

Publication number
WO1998048844A3
WO1998048844A3 PCT/EP1998/002031 EP9802031W WO9848844A3 WO 1998048844 A3 WO1998048844 A3 WO 1998048844A3 EP 9802031 W EP9802031 W EP 9802031W WO 9848844 A3 WO9848844 A3 WO 9848844A3
Authority
WO
WIPO (PCT)
Prior art keywords
paris
ion
production
contrast agents
cations
Prior art date
Application number
PCT/EP1998/002031
Other languages
English (en)
French (fr)
Other versions
WO1998048844A2 (de
Inventor
Werner Krause
Michael Bauer
Johannes Platzek
Original Assignee
Schering Ag
Werner Krause
Michael Bauer
Johannes Platzek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Werner Krause, Michael Bauer, Johannes Platzek filed Critical Schering Ag
Priority to AU76418/98A priority Critical patent/AU7641898A/en
Publication of WO1998048844A2 publication Critical patent/WO1998048844A2/de
Publication of WO1998048844A3 publication Critical patent/WO1998048844A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft neuartige Ionenpaare, bestehend aus schwermetallchelathaltigen Kationen und Anionen und deren Verwendung in der Diagnostik und Therapie.
PCT/EP1998/002031 1997-04-29 1998-04-09 Ionenpaare, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel WO1998048844A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU76418/98A AU7641898A (en) 1997-04-29 1998-04-09 Ion paris, method for the production and use thereof as contrast agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19719033.2 1997-04-29
DE19719033A DE19719033C1 (de) 1997-04-29 1997-04-29 Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel

Publications (2)

Publication Number Publication Date
WO1998048844A2 WO1998048844A2 (de) 1998-11-05
WO1998048844A3 true WO1998048844A3 (de) 1999-02-11

Family

ID=7828725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/002031 WO1998048844A2 (de) 1997-04-29 1998-04-09 Ionenpaare, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel

Country Status (3)

Country Link
AU (1) AU7641898A (de)
DE (1) DE19719033C1 (de)
WO (1) WO1998048844A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
WO2006002873A2 (en) * 2004-07-02 2006-01-12 Bracco Imaging Spa 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri )
CN116173247A (zh) 2013-04-26 2023-05-30 法国加柏公司 造影剂配制品与有关制备方法
MX395695B (es) 2015-12-10 2025-03-25 Bracco Imaging Spa Agentes de contraste diméricos.
US10781188B2 (en) * 2015-12-10 2020-09-22 Bracco Imaging S.P.A. Contrast agents
US10793533B2 (en) 2016-12-12 2020-10-06 Bracco Imaging S.P.A. Dimeric contrast agents
CN108148012A (zh) * 2018-01-04 2018-06-12 复旦大学 近红外第二窗口发射小分子稀土配合物荧光探针及其制备方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003804A1 (en) * 1988-09-27 1990-04-19 Salutar, Inc. Chelate compositions
WO1991005762A1 (en) * 1989-10-23 1991-05-02 Cockbain, Julian, Roderick, Michaelson Multi-site metal chelating agents
EP0454078A2 (de) * 1990-04-25 1991-10-30 Bracco International B.V. Dual-Funktionnierende Excipient für Metalchelate-Kontrastmitteln
EP0485045A2 (de) * 1990-11-08 1992-05-13 Schering Aktiengesellschaft Mono-N-substituierte 1,4,7,10-Tetraazacyclododecan-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE4232925A1 (de) * 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
US5330742A (en) * 1991-08-05 1994-07-19 Mallinckrodt Medical, Inc. Methods and compositions for magnetic resonance imaging
WO1995002831A1 (en) * 1993-07-12 1995-01-26 Nycomed Imaging As Methods and compositions for image contrast enhancing
WO1995009848A2 (en) * 1990-01-19 1995-04-13 Nycomed Salutar, Inc. Polyazacycloalkanes as dichelants
WO1995014491A2 (en) * 1993-11-29 1995-06-01 Access Pharmaceuticals, Inc. Metal-ion chelates with acidic saccharides and glycosaminoglycans
EP0709100A1 (de) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Kontrastmittel mit mehreren Detektionsgruppen pro Molekül
DE19627309A1 (de) * 1996-06-27 1998-01-08 Schering Ag Wäßrige injizierbare Formulierungen verwendbar als Kontrastmittel
WO1998013338A1 (de) * 1996-09-24 1998-04-02 Schering Aktiengesellschaft Ionenpaare, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003804A1 (en) * 1988-09-27 1990-04-19 Salutar, Inc. Chelate compositions
WO1991005762A1 (en) * 1989-10-23 1991-05-02 Cockbain, Julian, Roderick, Michaelson Multi-site metal chelating agents
WO1995009848A2 (en) * 1990-01-19 1995-04-13 Nycomed Salutar, Inc. Polyazacycloalkanes as dichelants
EP0454078A2 (de) * 1990-04-25 1991-10-30 Bracco International B.V. Dual-Funktionnierende Excipient für Metalchelate-Kontrastmitteln
EP0485045A2 (de) * 1990-11-08 1992-05-13 Schering Aktiengesellschaft Mono-N-substituierte 1,4,7,10-Tetraazacyclododecan-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5330742A (en) * 1991-08-05 1994-07-19 Mallinckrodt Medical, Inc. Methods and compositions for magnetic resonance imaging
DE4232925A1 (de) * 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
WO1995002831A1 (en) * 1993-07-12 1995-01-26 Nycomed Imaging As Methods and compositions for image contrast enhancing
WO1995014491A2 (en) * 1993-11-29 1995-06-01 Access Pharmaceuticals, Inc. Metal-ion chelates with acidic saccharides and glycosaminoglycans
EP0709100A1 (de) * 1994-09-30 1996-05-01 Nihon Medi-Physics Co., Ltd. Kontrastmittel mit mehreren Detektionsgruppen pro Molekül
DE19627309A1 (de) * 1996-06-27 1998-01-08 Schering Ag Wäßrige injizierbare Formulierungen verwendbar als Kontrastmittel
WO1998013338A1 (de) * 1996-09-24 1998-04-02 Schering Aktiengesellschaft Ionenpaare, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Gadopentetic Acid", 1996, MERCK INDEX, ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS. 12TH. EDITION, BUDAVARI S (ED ), XP002086685 *
"Gadoteridol", 1996, MERCK INDEX, ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS. 12TH. EDITION, BUDAVARI S (ED ), XP002086686 *
PARDO A ET AL: "KINETICS OF TRANSDERMAL PENETRATION OF AN ORGANIC ION PAIR: PHYSOSTIGMINE SALICYLATE", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 81, no. 10, 1 October 1992 (1992-10-01), pages 990 - 995, XP000282116 *
REYNOLDS J E F: "Gadopentetic Acid", 1993, MARTINDALE - THE EXTRA PHARMACOPOEIA, NR. ED. 30, PAGE(S) 706, REYNOLDS J E F, XP002086684 *
RUNGE V M ET AL: "EXPERIMENTAL TRIALS WITH GD(DO3A)- A NONIONIC MAGNETIC RESONANCE CONTRAST AGENT", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART B: NUCLEAR MEDICINE AND BIOLOGY, vol. 16, no. 6, 1989, pages 561 - 565, 567, XP000054547 *

Also Published As

Publication number Publication date
AU7641898A (en) 1998-11-24
WO1998048844A2 (de) 1998-11-05
DE19719033C1 (de) 1999-01-28

Similar Documents

Publication Publication Date Title
ZA965752B (en) Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents.
MXPA03007983A (es) Procedimiento para la preparacion de destilados intermedios.
NO972459D0 (no) Nye flersubst DTPA-derivater og deres metallkomplekser, farmasöytiske preparater inneh slike komplekser, deres anv ved diagnostikk og terapi, fremg for fremst av de kompleksdannende midler og komplekser, samt fremg for frems av de farmasöytiske
WO2000066528A3 (en) Quinones for treatment of diseases
WO2000018439A3 (de) Verwendung von neoangiogenese-markern für diagnose und therapie von tumoren
AP8800106A0 (en) Substituted tetrarins chromans & related compounds in the treatment of asthma,arthritis etc.
AU2002221753A1 (en) Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
CA2167693A1 (en) Melanoma-inhibiting protein
PL362837A1 (en) Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
FI956049L (fi) Menetelmä jauhavien ja/tai dispergoivien aineiden valmistamiseksi fysikaalis-kemiallisella erotuksella, saadut aineet sekä niiden käytöt
AU1974100A (en) 4-trifluoromethyl-3-oxadiazolyl pyridines, methods for the production thereof, agents containing these compounds, and their use as pesticides
WO1998048844A3 (de) Ionenpaare, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel
MY113092A (en) Cisapride extended release
WO2001049654A3 (de) Substituierte aminomethyl-phenyl-cyclohexanderivate
ZA978640B (en) Use of 1-hydroxy-2-pyridones for the treatment of saborrheic dermatitis.
AU8893098A (en) Immuno-modulator exhibiting anti-microbial and anti-mycobacterial activities, method for producing the same and pharmaceutical preparation for treating mycobacterioses as well as lung chronic and non specific conditions, sexually transmitted diseases and the resulting
HU9403134D0 (en) Substituted pyridylsalicylaldehyde-and salicyklicacid derivatives, process for their preparation und their use as herbicide
HK1038510A1 (en) Use of neurotrophic factor stimulators for the treamtent of ophthalmic neurodegenerative diseases.
EP0669361A3 (de) Verfahren zur Herstellung von Polyheterosiloxanen.
EP0679397A3 (de) Verwendung von substituierten Aminen zur Behandlung von Hirnleistungsstörungen.
AU4777997A (en) Ion pairs, process for producing the same and their use as contrast agents
GB9006233D0 (en) Forms,for use,for example,as parking tickets
AU2886595A (en) Technetium-sulphonamide complexes, their use, pharmaceutical agents containing the latter, as well as process for the production of the complexes and agents
WO2000058506A3 (en) Susceptibility to psoriasis
ZA200303236B (en) Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998546530

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载