+

WO1998041250A2 - Injecteur sans aiguille et support associe - Google Patents

Injecteur sans aiguille et support associe Download PDF

Info

Publication number
WO1998041250A2
WO1998041250A2 PCT/GB1998/000716 GB9800716W WO9841250A2 WO 1998041250 A2 WO1998041250 A2 WO 1998041250A2 GB 9800716 W GB9800716 W GB 9800716W WO 9841250 A2 WO9841250 A2 WO 9841250A2
Authority
WO
WIPO (PCT)
Prior art keywords
injector
capsule
holder
ram
piston
Prior art date
Application number
PCT/GB1998/000716
Other languages
English (en)
Other versions
WO1998041250A3 (fr
Inventor
Terence Edward Weston
Matthew Simon Nussey
Original Assignee
Weston Medical Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weston Medical Limited filed Critical Weston Medical Limited
Priority to AU64086/98A priority Critical patent/AU6408698A/en
Publication of WO1998041250A2 publication Critical patent/WO1998041250A2/fr
Publication of WO1998041250A3 publication Critical patent/WO1998041250A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion

Definitions

  • Needleless injectors are available as alternatives to conventional hypodermic syringes for delivering medicaments through the skin.
  • a high pressure piston pump is employed to force the injectate through a small orifice with sufficient force to pierce the skin.
  • Such devices have been known for more than sixty years, and whilst they promised freedom from the pain of injection and overcame the problems of disposing of contaminated needles, inconvenient operation and sterilisation procedures and poor ergonomic design have meant that they have not enjoyed commercial success.
  • present designs of single dose injectors have bodies of at least 18mm diameter, so if an assembly of such injectors were used, the surface area of the skin covered by multiple nozzles would be too great, particularly where the subject is emaciated, or the target area is small.
  • the present invention seeks to overcome these obstacles to a viable simultaneous multiple injector by providing a very low cost, small diameter, single use disposable injector, and an optional holder into which one or more of the injectors may be assembled.
  • the holder enables an unskilled user to give consistently high quality injections with the minimum training.
  • a single-use, needleless injector which comprises a capsule which contains a substance to be injected and has an outlet orifice at the distal end thereof, a power unit which has a pre-loaded power source and which is assembled to the proximal end of the capsule and adapted, when released, to cause the said substance to be expelled from the outlet orifice of the capsule, and a sleeve located on the exterior of the injector and slidable in a direction towards the distal end of the capsule to cause the power source to be released.
  • the invention further provides a holder for holding and operating at least one injector according to the invention, which comprises a housing, and a respective support member for the or each injector, mounted in the housing and arranged to receive the proximal portion of the injector and engage the sleeve thereof.
  • a liquid drug or other medicament or vaccine is contained within a capsule, which capsule has an outlet or injection orifice and a free piston in contact with the injectate.
  • a sealing cap protects the orifice and injectate from contamination.
  • the capsule is assembled to a pre-loaded power source, preferably a compressed gas, or compression spring, for example a helical coil spring, which biases a ram against a latch.
  • a trigger mechanism is provided comprising a sliding sleeve which cooperates with a latch in response to the user pressing the injection orifice onto the skin. The latch is released when the sliding sleeve is moved towards the skin, allowing the ram to accelerate to a high velocity and strike the free piston in the drug capsule.
  • a single use single dose needleless injector is provided, which may be operated to deliver a single dose by holding the trigger sleeve in the hand and pressing the nozzle of the injector.
  • This embodiment is a rudimentary injector and the ergonomics may be imported to suit certain applications by placing the injector into a plastic holder.
  • this preferred embodiment includes a suitable holder, which preferably comprises a hydraulic chamber into which a number of small pistons are located.
  • the pistons are free to move in and out of the chamber and slide within seals to prevent loss of hydraulic fluid.
  • the outer ends of the pistons are formed as support tubes into which injectors may be inserted. The open ends of the tubes engage the trigger sleeve of the injectors.
  • Figure 1 is a cross section through a single dose injector
  • Figure 2 is a cross section through a holder for a plurality of injectors
  • Figure 3 is a detailed view of the area marked "Y" in Figure 1.
  • Figure 1 shows a substantially cylindrical injector 100 comprising a drug capsule 1.
  • a drug capsule 1 This contains a liquid medicament 3 and a piston 2, which is slidingly and sealingly located within the bore of capsule 1 and which is preferably in contact with the medicament 3.
  • the capsule has an injection orifice which is sealed by a cap 4 and a resilient plug 6.
  • Cap 4 is configured to aid the filling process, and a full description of suitable versions is contained in PCT publication WO 96/19252 of the same inventor.
  • capsule 1 is made from stainless steel or other metal suitable for contact with the medicament. These are relatively strong materials and enable the capsule to be of a minimum size. Of course, as new plastic or ceramic materials are developed, these may be suitable alternatives.
  • a metal capsule may be coated with a suitable material such as glass or plastics deposited from a vapour phase, or having a lining of gold or other compatible metal, for example.
  • the capsule 1 is assembled to a power unit comprising a cylindrical gas cartridge 7 (which may be made from thin metal, again to minimise the size) containing a ram 10, preferably also made from metal, and having a groove 11 in which a resilient seal 12 is located.
  • a cross-hole 13 in ram 10 contains a sliding latch 14 having a conical tip 21, which is biased by a spring 15 to engage with a hole 16 in the wall of the gas cartridge 7.
  • the capsule 1 is retained onto the gas cartridge 7 by lugs 8 engaging with holes 9 in the capsule 1.
  • a triggering sleeve 17, having a ramp 18, prevents the latch 14 from falling out of the cross-hole 13.
  • the cartridge 7 is filled with compressed permanent gas 28 which biases the ram 10 in the direction of arrow A, but the engagement of the latch 14 in the hole 16 prevents movement of the ram 10.
  • the gas cartridge 7 Prior to assembly to the drug capsule, the gas cartridge 7 is filled by extending the ram 10 so that a filling hole 20 is uncovered. Pressurised gas is then introduced through the hole 20, and the ram is pushed back to further compress the gas until the latch 14 engages with hole 9 in capsule 1.
  • the assembly of the filled drug capsule and the gas power unit comprises the injector 100.
  • the cap 4 is removed and the injection orifice 5 is placed on the subject's skin.
  • the injector is pressed onto the skin by acting on the trigger sleeve 17, which causes the trigger sleeve 17 to move relative to the gas cartridge 7, and the ramp 18 therefore pushes the latch 14 into the cross-hole 13 of the ram 10.
  • the force of the ram 10 in the direction of arrow A causes the latch 14 to snap completely into the cross-hole 13 in ram 10, so releasing the ram 10.
  • the ram 10 accelerates rapidly to hit the piston 2, causing a very high initial pressure in the drug 3, and thereafter urges the piston 2 with a lower force to discharge the remainder of the drug 3 from the capsule 1.
  • a gap X between the ram 10 and piston 2 there is a gap X between the ram 10 and piston 2.
  • these two items can be integral with one another). This is to allow momentum to build in order to create the impact for high pressure, and to compensate for the relatively slow release characteristics of the latch mechanism. After operating the injector, the residual gas bleeds away through the filling hole 20, so that there is no hazard when the injector is discarded.
  • FIG. 2 shows three injectors 100 assembled into a holder 300.
  • the injectors may be configured in a straight row, or in any other arrangement, and more may be used in any required pattern.
  • the injector has a handle 30 which supports a housing 31.
  • An hydraulic tank 32 is attached to the housing 31, and is filled with hydraulic liquid 33.
  • Pistons 34E, F, G are sealingly and slidingly assembled to the tank, so that by operating piston 34F for example, pistons 34E and 34G would move in an opposite direction.
  • a respective injector 100 is located in each sleeve 37, so that the trigger sleeves 17 thereof just touch the ends of sleeves 37.
  • the operator grasps the handle 30, and presses the drug capsules 1 of the injectors 100 onto the subject's skin 38. Assuming that the skin is not flat, and that the injectors are not perpendicular to the skin, the injectors 100 will move relative to each other until there is the same load on each. For example, in the drawing, skin 38 is not flat and the injector 100G has pushed on the sleeve 37G and therefore the piston 34G. This pressurises the hydraulic fluid 33, which causes pistons 24E and 34F to be forced out, so that the capsule 1 of injectors 100E and 100F move out to contact the skin 38. When equilibrium is reached, i.e. the force of each capsule 1 of the skin 38 is equal, further force on the injectors will cause the triggers 17 to operate the latches 14 to fire the injectors 100 simultaneously.
  • the injectors may be assembled into a simple frame (not shown).
  • the holder 300 may be fitted with a means for ejecting the frame containing the injectors.
  • the multidose injector described provides a simple means of administering a number of different vaccines or other drugs simultaneously.
  • the power is already provided in each injector, so that each injector may be precisely configured as regards dose, viscosity, and depth of penetration.
  • the multidose injection could consist of three subcutaneous injections and one intradermal injection.
  • the holder has no power requirements, and serves to control the placement conditions of the injectors on the skin so that optimum performance is realised.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un injecteur sans aiguille, jetable, comprenant une capsule renfermant une substance à injecter et possédant, en son extrémité distale, un orifice de sortie. Un bloc de commande à source d'énergie à précontrainte est relié à l'extrémité distale de la capsule. Lorsque la source d'énergie est libérée, elle provoque l'expulsion de la substance à travers l'orifice de sortie de la capsule. Une gaine, disposée à l'extérieur de l'injecteur, coulisse en direction de l'extrémité distale de la capsule de façon à libérer la source d'énergie. L'invention concerne également un support permettant de tenir et d'actionner cet injecteur au moins. Ledit support comporte un logement et un élément de support respectif pour le ou les injecteurs, élément qui est fixé sur le logement et disposé de manière à recevoir la partie proximale de l'injecteur et à venir au contact de sa gaine.
PCT/GB1998/000716 1997-03-14 1998-03-10 Injecteur sans aiguille et support associe WO1998041250A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64086/98A AU6408698A (en) 1997-03-14 1998-03-10 Needleless injector and holder therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9705292.2 1997-03-14
GBGB9705292.2A GB9705292D0 (en) 1997-03-14 1997-03-14 Multidose injector

Publications (2)

Publication Number Publication Date
WO1998041250A2 true WO1998041250A2 (fr) 1998-09-24
WO1998041250A3 WO1998041250A3 (fr) 1998-12-10

Family

ID=10809222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/000716 WO1998041250A2 (fr) 1997-03-14 1998-03-10 Injecteur sans aiguille et support associe

Country Status (4)

Country Link
AU (1) AU6408698A (fr)
GB (1) GB9705292D0 (fr)
WO (1) WO1998041250A2 (fr)
ZA (1) ZA982066B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1110570A1 (fr) * 1999-12-23 2001-06-27 Arnold Neracher Dispositif d'injection hypodermique
WO2002049697A1 (fr) 2000-12-21 2002-06-27 Arnold Neracher Dispositif d'injection a moyen de generation de pression reutilisable
JP2012223562A (ja) * 2011-04-19 2012-11-15 Palo Alto Research Center Inc コリメートされたガス流及び粒子源を用いる送達機器及び方法
AU2008203046B2 (en) * 2007-07-13 2013-10-17 Cobbett Technologies Pty Ltd Needleless Injector Head

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019252A1 (fr) 1994-12-20 1996-06-27 Weston Medical Limited Dispositif de remplissage pour cartouche d'injecteur sans aiguille

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB691966A (en) * 1949-07-07 1953-05-27 Scherer Corp R P Jacket or casing for jet-injection ampoule
US3217712A (en) * 1963-01-22 1965-11-16 Otto Konigslow Mfg Company Ampoule applicator
US4124024A (en) * 1977-03-03 1978-11-07 Schwebel Paul R Disposable hypodermic injection ampule
HU200699B (en) * 1989-07-05 1990-08-28 Gyula Erdelyi Neddleless hypodermic syringe particularly for blinds and poor-sighted persons
US5190523A (en) * 1991-08-16 1993-03-02 Idee International R & D Inc. Disposable syringe and injector
FR2691904A1 (fr) * 1992-06-04 1993-12-10 Applic Tech Et Dispositif d'actionnement automatique d'une seringue.
WO1995025555A1 (fr) * 1994-03-18 1995-09-28 Vitajet Corporation Injecteur hypodermique pneumatique sans aiguille
GB9504878D0 (en) * 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019252A1 (fr) 1994-12-20 1996-06-27 Weston Medical Limited Dispositif de remplissage pour cartouche d'injecteur sans aiguille

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1110570A1 (fr) * 1999-12-23 2001-06-27 Arnold Neracher Dispositif d'injection hypodermique
WO2002049697A1 (fr) 2000-12-21 2002-06-27 Arnold Neracher Dispositif d'injection a moyen de generation de pression reutilisable
AU2008203046B2 (en) * 2007-07-13 2013-10-17 Cobbett Technologies Pty Ltd Needleless Injector Head
JP2012223562A (ja) * 2011-04-19 2012-11-15 Palo Alto Research Center Inc コリメートされたガス流及び粒子源を用いる送達機器及び方法

Also Published As

Publication number Publication date
ZA982066B (en) 1998-12-14
GB9705292D0 (en) 1997-04-30
AU6408698A (en) 1998-10-12
WO1998041250A3 (fr) 1998-12-10

Similar Documents

Publication Publication Date Title
US8529540B2 (en) Injection system with hidden needles
US7618393B2 (en) Needle-less injector and method of fluid delivery
EP2268342B1 (fr) Dispositif de sécurité pour injecteur
EP0879609B1 (fr) Injecteur à jet à deux étages
JP3993169B2 (ja) 皮内注射器
KR100233672B1 (ko) 바늘 없는 주사기
EP1102606B1 (fr) Sonde d'aide a l'injection pour ensemble injecteur medical
US4447225A (en) Multidose jet injector
US20070021716A1 (en) Nozzle device with skin stretching means
US20070049864A1 (en) Impulse chamber for jet delivery device
US20050165349A1 (en) Needle-free injection device
TW200808398A (en) A vial system and method for a needle-less injector
US7449009B2 (en) Device for needle-free injection of a medium into the tissue of a human or an animal, device for needle free production of an injection channel and method for the needle free injection of a medium in the tissue
WO1998041250A2 (fr) Injecteur sans aiguille et support associe
WO2005070483A1 (fr) Dispositif d'injection sans aiguille
JP4790846B2 (ja) 注射装置
WO2005058392A2 (fr) Cartouche pour dispositif d'administration

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998540219

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载