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WO1995025555A1 - Injecteur hypodermique pneumatique sans aiguille - Google Patents

Injecteur hypodermique pneumatique sans aiguille Download PDF

Info

Publication number
WO1995025555A1
WO1995025555A1 PCT/US1995/003088 US9503088W WO9525555A1 WO 1995025555 A1 WO1995025555 A1 WO 1995025555A1 US 9503088 W US9503088 W US 9503088W WO 9525555 A1 WO9525555 A1 WO 9525555A1
Authority
WO
WIPO (PCT)
Prior art keywords
medicine
chamber
nozzle
air
needleless hypodermic
Prior art date
Application number
PCT/US1995/003088
Other languages
English (en)
Inventor
Timothy J. Salo
Sergio Landau
Glenn D. Austin
T. Patrick Lennon
Original Assignee
Vitajet Corporation
P.A.T.H.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitajet Corporation, P.A.T.H. filed Critical Vitajet Corporation
Priority to AU19904/95A priority Critical patent/AU1990495A/en
Publication of WO1995025555A1 publication Critical patent/WO1995025555A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Definitions

  • the present invention relates to a liquid medicament injector and, more particularly, to a needleless liquid medicament hypodermic injector.
  • Disposable syringes and needles have been used to alleviate the risk of disease transmission.
  • these disposable units create hazardous medical waste and waste disposal problems.
  • disposable syringes and needles often do not reach the users in adequate quantities. As a result, these disposable units are used more than once.
  • a further drawback to disposable syringes and needles are the high costs when the units are provided for worldwide use.
  • Mass-campaign jet injectors such as the PEDOJET
  • PEDOJET a complex fluid path with dead space therein, such that a substantial amount of residual medicine is retained in the fluid path.
  • the residual fluid When changing from one injectant to another, the residual fluid must be cleared to prevent unacceptable mixing of medicines. This clearing process wastes a relatively large amount of medicine before the injector is ready to inject another patient.
  • medicine as referred to hereinafter is synonymous with all liquid medicaments and vaccines.
  • Low-workload jet injectors such as the VITAJET or the SICIM HYPODERMIC INJECTOR JET 2000 have also been used to provide needleless injections. These low-workload jet injectors are typically effective for individual use. However, they are not sufficiently durable to accommodate an increased workload, e.g., several thousand injections, without requiring repair or maintenance. These low- workload injectors also utilize a complex fluid path that retains residual medicine. Accordingly, the units are difficult to sterilize, and medicine is wasted through purging when changing between medicines to be administered. Many of the existing needleless injectors utilize two-piece nozzles that have gaps or seams in which blood or other material may accumulate. The injectors are also designed such that the nozzle directly contacts the patient's skin during an injection.
  • the injector assembly includes a main housing connected to a low pressure air source, an air powered driving piston in the housing, and a removable medicine delivery unit engaging the air piston.
  • the delivery unit mounts in the housing's front end, and has a medicine chamber with a fill port, a one-piece nozzle connected to the chamber, and a discharge piston slidably mounted in the chamber.
  • the delivery unit of the invention does not use the check valves and washers of prior art units.
  • the resulting delivery unit has almost no dead space and requires no disassembly for cleaning and/or sterilization.
  • the air piston drives the discharge piston through its discharge stroke as low pressure air causes the air piston to slide.
  • a safety interlock coupled to an injector activating mechanism is provided to protect against inadvertent discharge of the injector and resulting injury to health workers or patients.
  • the medicine delivery assembly of the subject invention further includes a medicine vial holder removably connected to the main housing and coupled to a medicine chamber filling mechanism.
  • the filling mechanism utilizes positive pressure to drive medicine into the delivery unit's medicine chamber.
  • a moveable spacer collar connects to the main housing and can be moved into a position in front of the nozzle, such that an air gap is created between the nozzle and the spacer.
  • the injector fires a focused stream of medicine at high pressure through the nozzle, across the air gap, through an opening in the spacer, and into the awaiting patient.
  • Figure 1 is a schematic representation of the needleless injector with a medicine chamber filling mechanism attached thereto.
  • Figure 2 is an exploded side view of the needleless injector.
  • Figure 3 A is a plan view of the needleless injector with a schematic representation of an attached medicine chamber filling mechanism and spacer.
  • Figure 3B is a partial plan view of the needleless injector with the fire button and activation valve in the fired position.
  • Figure 4 is a side cross-section view of the needleless injector along line 4-4 in Figure 3 A.
  • Figure 5 is a side cross-section view of the removable medicine chamber filling mechanism.
  • Figure 6 is a schematic representation of the needleless injector with an attached medicine chamber filling mechanism shown in two operative positions.
  • the housing 16 of the needleless hypodermic injector assembly 10 is connected to a low pressure air pump 12 or any other pressurized air source by an air hose 14.
  • the hose 14 may either be permanently attached to the housing 16, or attached to the housing 16 by a quick disconnect mechanism 15 within the housing's handle 18, thereby facilitating efficient attachment to the pump 12.
  • the assembly 10 utilizes low pressure air from the pump 12 to effectively administer a needleless injection to a patient.
  • a spacer 26 is movably carried by the filling mechanism 100, such that an air gap 28 is formed when the spacer 26 is positioned adjacent to the nozzle 24.
  • an injector activating mechanism such as a "fire" button 30
  • the low pressure air supply causes a very narrow, highly focused stream of medicine to be ejected under high pressure through the nozzle 24, across the air gap 28, through an opening 25 in the spacer 26, and into an awaiting patient.
  • the needleless hypodermic injector assembly 10 incorporates several components.
  • the hose 14 releasably connects to the housing's handle 18.
  • a second length of pressurized air hose 36 extends through the handle 18 and connects, with a conventional hose connecting mechanism, to an air passage 38 within the main housing 16.
  • the passage 38 communicates with a valve insert 42 that contains an activation valve 44 and the fire button 30.
  • a spring 46 engages the fire button 30, thereby biasing the button 30 to a retracted ready position 48.
  • the activation valve 44 slides within the valve insert 42 to an open position, unblocks the air passage 38, and exposes an air port 50.
  • the port 50 is connected to an air chamber 54 formed by a cylinder 52 within the housing 16.
  • An air piston 56 serving as a driving piston, is slidably mounted within the pressurized air chamber 54, such that when the activation valve 44 is in the open position, the low pressure air rushes through the passage 38 and the port 50, and the air piston 56 is instantaneously driven forward within the air chamber 54.
  • a sufficient seal is maintained between the air piston 56 and the surrounding cylinder 52 by an O-ring 58.
  • a sufficient seal is maintained between the valve 44 and the insert 42 by an O-ring 45.
  • a medicine delivery unit 62 detachably mounts in the main housing 16 and comprises a cylindrical wall 65 having a circumferential shoulder on the outer forward end with an O-ring 1 14 therein, said wall defining a medicine chamber 64 with a medicine fill port 61 and a discharge piston 60.
  • the nozzle 24 is threaded into the outside of the forward end of the wall 65 and is in sealing engagement with O-ring 1 14. Alternatively, the nozzle 24 may simply be welded to wall 65 or insert molded in chamber 64.
  • the piston 60 has a rear rod extension 61 on which a biasing mechanism, such as a spring 66 is sleeved. The forward end of the spring engages a fitting 68 that, in turn, is seated at the rear of the discharge chamber 64.
  • the rod 61 has an enlarged head 70 retaining the spring 66 and detachably engaging a recess 71 in the air piston 56.
  • the piston 60 has a discharge stroke within the medicine chamber 64 from a retracted start position 72, to a finished, discharge position 73 adjacent to the nozzle 24.
  • the biasing spring 66 automatically returns the piston 60 to the retracted position 72 after medicine has been delivered.
  • the activation valve 44 snaps to the open position, and low pressure air rushes into the air chamber 54.
  • the air piston 56 is instantaneously driven forward, thereby driving the discharge piston 60 through its discharge stroke within the medicine chamber 64.
  • Any medicine contained within the medicine chamber 64 is forced through an ejection orifice 74 in the nozzle 24.
  • the piston's head is sealed by threaded cap 78 bearing against O-ring 76. A close fit tolerance between the piston's head and the wall 65 ensures all of the medicine within the medicine chamber 64 will be discharged during the discharge stroke.
  • a quick disconnect mechanism 80 installed in the housing's front end portion 81, secures the delivery unit 62 within the housing 16.
  • the disconnect mechanism 80 slidably mounts in the front end portion 81, and a spring 82 biases the disconnect mechanism 80 in a securing position.
  • the delivery unit has a beveled nose 83 at the rear, so that as the delivery unit 62 is installed into the front of the main housing 16, the beveled nose 83 engages and pushes the disconnect mechanism 80 upward, thereby compressing the spring 82.
  • the piston's foot ends in threaded cap 70 which engages the recess 71 in the drive piston 56, such that the biasing spring 66 is slightly compressed. Accordingly, when the quick disconnect mechanism 80 is depressed and the delivery unit 62 is released, the biasing spring 66 partially ejects the delivery unit 62 from the main housing 16.
  • the housing 16 and handle 18 are made of a durable and lightweight plastic, and the medicine delivery unit 62 is primarily made of stainless steel components.
  • the entire steel delivery unit 62 may be quickly ejected from the needleless hypodermic injector assembly 10, dropped into a sterilizing bath, and a new, sterile delivery unit may be inserted within the needleless hypodermic injector assembly 10. This sequence can be accomplished in a matter of seconds, and the assembly is ready for safe injections with the same or a different medicine.
  • the invention makes possible a lightweight ergonomic design having a long useful life and providing economical, easily sterilizable use in rural clinics having few amenities.
  • the fill port 67 is located very close to the piston head 78 when the piston 60 is in its retracted position 72. Accordingly, the fill port 67 is positioned so as to be closed at the beginning of the piston's discharge stroke. Such positioning of the fill port 67 alleviates the requirement of a check valve to prevent medicine from flowing out of the fill port 67 during the discharge stroke.
  • the fill port 67 is a small orifice normally about 10 thousandths of an inch in diameter and about 10-20 thousandths of an inch long through which a medicine dose of approximately 0.5 ml is transferred into the medicine chamber.
  • the needleless hypodermic injector assembly 10 further includes a removable medicine chamber filling mechanism 100, which includes a medicine distributor 106 and a medicine vial holder 108, described in greater detail below, that engages the housing 16.
  • a filling nozzle 104 on the filling mechanism 100 is received by the housing 16 through a passage 102 located in the housing's front end 81.
  • the passage 102 coaxially aligns the nozzle 104 with the fill port 67 when delivery unit 62 has been properly installed. Accordingly, medicine may be transported into the medicine chamber 64 through the nozzle 104 and fill port 67 by using positive pressure to force the medicine into the medicine chamber 64.
  • the delivery unit 62 indicates when the filling mechanism 100 has completely filled the medicine chamber 64 when medicine begins to dribble through the nozzle's orifice 74.
  • the filling mechanism 100 and spacer 26 may be pivoted from a "ready to fire” position 110, with the spacer 26 in front of the nozzle 24, to a raised “filling position” 112 ( Figure 6, discussed in detail below), with the spacer 26 moved away from the nozzle 24.
  • the medicine distributor 106 is used to push medicine through the nozzle 104 and filling port 67 and into the medicine chamber 64.
  • the spacer 26 is integral to the removable filling mechanism 100, and when pivoted into the "ready to fire” position 110, the resulting air gap has a range from about 1.5 mm to 6.0 mm. The preferred size is 3.0 mm.
  • the spacer 26 may be movably mounted to other structures of the needleless hypodermic injector assembly 10 and still achieve the goal of maintaining an air gap 28 between the nozzle 24 and the patient.
  • the spacer 26 has a small opening 25 through which the highly focused stream of medicine passes.
  • an opening of about 4 mm. is preferred. This combination of gap distance and size of opening 25 have been found highly efficient in reducing splash-back, contact and capillary contamination of medicine and blood from contaminating the nozzle as compared to prior devices (such as a recessed nozzle orifice) which permit bunching of a patient's skin and otherwise do not adequately shield the nozzle and orifice from contamination.
  • the needleless hypodermic injector assembly 10 may be prohibited from firing by a safety mechanism 116.
  • the safety 116 includes a safety interlock 118 and a safety rod 120 within the housing 16.
  • the safety interlock 118 which has a foot 124 and a notch 122, engages the firing button 30.
  • One end of the safety rod 120 communicates with the notch 122, and the other end communicates with the medicine distributor 106.
  • the safety interlock 1 18 is pressed inward to the "safe" position 123 ( Figure 3 A)
  • the rod 120 rests within the notch 122 In this position, the safety rod 120 does not extend into the medicine distributor 106 and interfere with the rotation of distributor 106.
  • a cam is provided in medicine distributor 106 by means of a slot 127 along an arc of distributor 106.
  • the activation valve 44 When the needleless hypodermic injector is ready to fire, as best seen in Figure 3A, the activation valve 44 is closed, the low pressure air supply is blocked, and the air piston 56 and delivery piston 60 are at rest in the retracted position.
  • a valve block 134 on the fire button 30 fits into a notch 136 in the activation valve 44.
  • the valve block 134 moves forwardly out of the notch 136, thereby allowing the activation valve 44 to slide from the closed position to an open position, whereat the pressurized air moves from passage 38 to port 50.
  • the pressurized air within the passage 38 is sufficiently strong to instantaneously drive the activation valve 44 to the open position.
  • the velocity or extent of force used is independent of the speed in which said activating valve 44 will move to the open position. Once the valve block is no longer interfering with the activation valve 44, the valve will snap to the open position.
  • the safety interlock 118 After the needleless hypodermic injector has been fired, the safety interlock 118 must be returned to the "safe" position 123 in order to refill the medicine chamber 64. As the safety interlock 1 18 moves into the housing 16, the foot 124 engages the activation valve 44 and drives the valve 44 back to the closed position. In addition, the fire button's spring 46 forces the valve block 134 back into the notch 136 so as to prevent the valve 44 from sliding back to the open position.
  • the safety interlock is interconnected with the filling mechanism 100 and the spacer 26, such that the safety interlock 1 18 may not be moved to the "fire position" until the spacer 26 has been moved to a particular predetermined orientation relative to the nozzle 24.
  • the low pressure air from the pump 12 has a pressure in the range of about 50 to 250 pounds per square inch (gauge) (psig). Good performance is achieved when the starting pressure is in the range of about 80 psig to 140 psig.
  • the air pressure within the assembly 10 drops, and after the injection, the pressurized air in the assembly 10 is in the range of about 60 psig to 100 psig.
  • a preferred embodiment is to have an accumulator maintained at a base pressure of about 65-70 psig by a spring. A single stroke of an air pump raises this pressure to about 80 psig. After an injection, the pressure drops to the base pressure.
  • the low pressure air drives the pistons 56 and 60 forward, and the medicine within the medicine chamber 64 achieves a pressure in the range of about 2,500 psi to 4,500 psi as the fluid is forced through the nozzle's shaped orifice 74.
  • the fluid stream have either a coherent cylindrical configuration or a cone shape with the apex at or just beyond the outer side of opening 25.
  • One way of producing the desired fluid stream shape is to use a cylindrical orifice 74, optionally with the upstream edge created by a spherical counterbore.
  • orifice 74 has a diameter of about 6 thousandths of an inch and a length of about 15-18 thousandths of an inch.
  • the resulting high pressure fluid stream has a diameter ranging from about .004 inch to .008 inch, which is smaller than most hypodermic needles.
  • This high pressure within the medicine chamber 64 is generated by the low pressure air because of the relationship between the air piston's surface area and the discharge piston's surface area in the medicine chamber.
  • the ratio between the surface areas utilized in the preferred embodiment ranges from about 20: 1 to 45: 1.
  • the preferred area ratio is 36: 1. It is to be noted that these ranges represent the design of the preferred embodiment, but the ranges are not to limit the scope of this patent.
  • the low pressure air hose 14 enters an on ⁇ board air chamber 40 that, in turn, connects to the air passage 38.
  • the chamber 40 holds enough pressurized air for the discharge assembly 10 to administer at least one injection.
  • the hose 14 can be removed, and the delivery assembly 10 may be transported away from the air source 12 to give an injection.
  • the mobility of this embodiment allows for substantial flexibility in using the assembly 10.
  • the removable filling mechanism 100 includes a medicine vial holder 108 operatively connected to a medicine distributor 106.
  • the medicine distributor 106 utilizes positive pressure to distribute medicine from a vial 144 into the first medicine chamber 64.
  • the vial holder 108 has a vial receiving unit 146 with a clamping mechanism 148 that clamps the vial 144 into the receiving unit 146.
  • the clamp 148 comprises a scissor-type clamp that engages the vial 144 around the vial's necked portion 150 adjacent to the vial's cap 152.
  • the scissor clamp 148 allows for different sized vials to be securely held within the receiving unit 146.
  • the vial holder 108 uses a medicine transport mechanism, such as a hollow needle 154, to pierce a membrane 156 on the vial 144 and gain access to the medicine therein.
  • the medicine is drawn from the vial 144, through the hollow needle 154, through second filling port 162 and into a second medicine chamber 158 formed by a distributor housing 160.
  • the medicine is prevented from flowing back into the vial 144 by a check valve 162 located between the second chamber 158 and the needle 154.
  • the medicine is drawn into the second chamber 158 by withdrawing a plunger 164 that is slidably mounted in the chamber 158 while check valve 174 prevents the entrance of air through distributor orifice 170 from delivery unit 62.
  • the plunger 164 is used to generate positive pressure that drives the medicine through a channel 166 in the filler tube 168, and through the distributor orifice 170.
  • medicine is prevented from flowing back through the distributor orifice 170 toward the vial 144 by a check valve 174 located at the beginning of the channel 166.
  • the filler tube 168 includes a filler nozzle 172 having a predetermined size allowing for efficient transfer of medicine from the filler nozzle 172 into the first medicine chamber 64 through the filler ports 102 and 67.
  • a button operated pump diaphragm is substituted for plunger 164. A first depression of the button fills the chamber 158 and subsequent depressions provide the positive pressure that drives the medicine into the medicine chamber 64 and refills the chamber 158.
  • the medicine chamber filling mechanism 100 can pivot to the loading position 1 12 as the medicine delivery assembly 10 is oriented such that the vial 144 is coaxially aligned with the nozzle 24 When the assembly is pointed upward, the medicine in the vial 144 covers the needle 154 After a dose of medicine has been loaded into the first chamber 64, and the filling mechanism 100 is pivoted back to the injecting position 110, the safety interlock 118 may be moved to the fire position 125, and the medicine delivery assembly is ready to deliver a dose of medicine upon depressing the fire button 30

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un injecteur de médicament sans aiguille et mû par de l'air basse pression, qui comporte un ensemble distributeur de médicament (62) monté amovible sur le boîtier de l'injecteur et se démontant rapidement. De l'air basse pression entraîne un piston à ressort dans une course de refoulement, en partant de la position rétractée pour aboutir dans la chambre de médicament, faisant ainsi passer de force le médicament par un ajutage monobloc (24). Un mécanisme amovible (100) de remplissage de la chambre, relié au boîtier, est couplé à la chambre de médicament par des orifices de remplissage, de telle manière que la chambre de médicament est remplie à l'aide d'un distributeur de médicament à pression positive. Une collerette d'espacement mobile (25) positionnée devant l'ajutage assure une couche d'air intermédiaire entre la peau d'un patient et l'ajutage monobloc. Un système de verrouillage de sécurité (118) accouplé à un mécanisme d'actionnement et au mécanisme de remplissage de la chambre empêche le refoulement intempestif de l'injection
PCT/US1995/003088 1994-03-18 1995-03-06 Injecteur hypodermique pneumatique sans aiguille WO1995025555A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19904/95A AU1990495A (en) 1994-03-18 1995-03-06 Air-powered needleless hypodermic injector

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21503794A 1994-03-18 1994-03-18
US08/215,037 1994-03-18

Publications (1)

Publication Number Publication Date
WO1995025555A1 true WO1995025555A1 (fr) 1995-09-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/003088 WO1995025555A1 (fr) 1994-03-18 1995-03-06 Injecteur hypodermique pneumatique sans aiguille

Country Status (2)

Country Link
AU (1) AU1990495A (fr)
WO (1) WO1995025555A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041250A3 (fr) * 1997-03-14 1998-12-10 Weston Medical Ltd Injecteur sans aiguille et support associe
US5994624A (en) * 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
US9974904B2 (en) 2008-05-20 2018-05-22 Avant Medical Corp. Autoinjector system
US10092706B2 (en) 2011-04-20 2018-10-09 Amgen Inc. Autoinjector apparatus
US10092703B2 (en) 2013-03-15 2018-10-09 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
US10492990B2 (en) 2013-03-15 2019-12-03 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
USD898908S1 (en) 2012-04-20 2020-10-13 Amgen Inc. Pharmaceutical product cassette for an injection device
USD1076075S1 (en) 2020-09-11 2025-05-20 Amgen Inc. Pharmaceutical product cassette for an injection device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1499582A (fr) * 1966-11-02 1967-10-27 Appareil d'injection sans aiguille, notamment pour l'administration de solutions médicamenteuses
EP0119286A1 (fr) * 1983-03-18 1984-09-26 Internationales Forschungsinstitut für Reproduktionsmedizin und -biologie Pistolet à injections actionné sous pression
DE3328173A1 (de) * 1982-05-27 1985-02-14 Preci-Tech Ltd., Ville St. Laurent, Quebec Nadelloser hypodermatischer injektor
EP0133471A1 (fr) * 1983-06-29 1985-02-27 "FEG" Fegyver- és Gázkészülékgyár Dispositif d'inoculation sans aiguille , par exemple pour injection d'insuline
FR2630010A1 (fr) * 1988-04-19 1989-10-20 Bearn Mecanique Aviat Sa Appareil d'injection sans aiguille, notamment pour l'injection simultanee d'au moins deux produits distincts

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1499582A (fr) * 1966-11-02 1967-10-27 Appareil d'injection sans aiguille, notamment pour l'administration de solutions médicamenteuses
DE3328173A1 (de) * 1982-05-27 1985-02-14 Preci-Tech Ltd., Ville St. Laurent, Quebec Nadelloser hypodermatischer injektor
EP0119286A1 (fr) * 1983-03-18 1984-09-26 Internationales Forschungsinstitut für Reproduktionsmedizin und -biologie Pistolet à injections actionné sous pression
EP0133471A1 (fr) * 1983-06-29 1985-02-27 "FEG" Fegyver- és Gázkészülékgyár Dispositif d'inoculation sans aiguille , par exemple pour injection d'insuline
FR2630010A1 (fr) * 1988-04-19 1989-10-20 Bearn Mecanique Aviat Sa Appareil d'injection sans aiguille, notamment pour l'injection simultanee d'au moins deux produits distincts

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041250A3 (fr) * 1997-03-14 1998-12-10 Weston Medical Ltd Injecteur sans aiguille et support associe
US5994624A (en) * 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US10792426B2 (en) 2008-05-20 2020-10-06 Avant Medical Corp. Autoinjector system
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
US11883633B2 (en) 2008-05-20 2024-01-30 Avant Medical Corp. Autoinjector system
US9925336B2 (en) 2008-05-20 2018-03-27 Avant Medical Corp. Cassette for a hidden injection needle
US9974904B2 (en) 2008-05-20 2018-05-22 Avant Medical Corp. Autoinjector system
US10864324B2 (en) 2008-05-20 2020-12-15 Avant Medical Corp. Autoinjector system
US12186535B2 (en) 2008-07-23 2025-01-07 Avant Medical Corp. System and method for an injection using a syringe needle
US10639422B2 (en) 2008-07-23 2020-05-05 Avant Medical Corp. System and method for an injection using a syringe needle
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
US9616173B2 (en) 2008-07-23 2017-04-11 Avant Medical Corporation System and method for an injection using a syringe needle
US11724032B2 (en) 2008-07-23 2023-08-15 Avant Medical Corp. System and method for an injection using a syringe needle
US11986643B2 (en) 2011-04-20 2024-05-21 Amgen Inc. Autoinjector apparatus
US10092706B2 (en) 2011-04-20 2018-10-09 Amgen Inc. Autoinjector apparatus
US11419990B2 (en) 2011-04-20 2022-08-23 Amgen Inc. Autoinjector apparatus
US10918805B2 (en) 2011-04-20 2021-02-16 Amgen Inc. Autoinjector apparatus
USD898908S1 (en) 2012-04-20 2020-10-13 Amgen Inc. Pharmaceutical product cassette for an injection device
US11020537B2 (en) 2013-03-15 2021-06-01 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
US10786629B2 (en) 2013-03-15 2020-09-29 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
US11944798B2 (en) 2013-03-15 2024-04-02 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
US10492990B2 (en) 2013-03-15 2019-12-03 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
US10092703B2 (en) 2013-03-15 2018-10-09 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
USD1076075S1 (en) 2020-09-11 2025-05-20 Amgen Inc. Pharmaceutical product cassette for an injection device

Also Published As

Publication number Publication date
AU1990495A (en) 1995-10-09

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