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WO1997036919A3 - Cytokine designated lerk-8 - Google Patents

Cytokine designated lerk-8 Download PDF

Info

Publication number
WO1997036919A3
WO1997036919A3 PCT/US1997/004533 US9704533W WO9736919A3 WO 1997036919 A3 WO1997036919 A3 WO 1997036919A3 US 9704533 W US9704533 W US 9704533W WO 9736919 A3 WO9736919 A3 WO 9736919A3
Authority
WO
WIPO (PCT)
Prior art keywords
lerk
cytokine designated
designated lerk
cytokine
dna
Prior art date
Application number
PCT/US1997/004533
Other languages
French (fr)
Other versions
WO1997036919A2 (en
Inventor
Douglas P Cerretti
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Priority to EP97916886A priority Critical patent/EP0904287A3/en
Priority to CA 2248550 priority patent/CA2248550A1/en
Priority to AU25386/97A priority patent/AU2538697A/en
Priority to JP53531997A priority patent/JP2001521368A/en
Priority to IL12591997A priority patent/IL125919A0/en
Publication of WO1997036919A2 publication Critical patent/WO1997036919A2/en
Priority to NO984233A priority patent/NO984233L/en
Publication of WO1997036919A3 publication Critical patent/WO1997036919A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention is directed to a protein designated Lerk-8, DNA encoding the Lerk-8, and host cells transformed with Lerk-8 DNA. Antibodies that are immunoreactive with Lerk-8 are also provided. The Lerk-8 protein binds to the cell surface receptors known as elk and hek.
PCT/US1997/004533 1996-03-21 1997-03-19 Cytokine designated lerk-8 WO1997036919A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP97916886A EP0904287A3 (en) 1996-03-21 1997-03-19 Cytokine designated lerk-8
CA 2248550 CA2248550A1 (en) 1996-03-21 1997-03-19 Cytokine designated lerk-8
AU25386/97A AU2538697A (en) 1996-03-21 1997-03-19 Cytokine designated lerk-8
JP53531997A JP2001521368A (en) 1996-03-21 1997-03-19 Cytokine called Lerk-8
IL12591997A IL125919A0 (en) 1996-03-21 1997-03-19 Cytokine designated lerk-8
NO984233A NO984233L (en) 1996-03-21 1998-09-14 Cytokine called Larch-8

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62114696A 1996-03-21 1996-03-21
US08/621,146 1996-03-21

Publications (2)

Publication Number Publication Date
WO1997036919A2 WO1997036919A2 (en) 1997-10-09
WO1997036919A3 true WO1997036919A3 (en) 2000-10-12

Family

ID=24488927

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/004533 WO1997036919A2 (en) 1996-03-21 1997-03-19 Cytokine designated lerk-8

Country Status (7)

Country Link
EP (1) EP0904287A3 (en)
JP (1) JP2001521368A (en)
KR (1) KR19990087793A (en)
AU (1) AU2538697A (en)
IL (1) IL125919A0 (en)
NO (1) NO984233L (en)
WO (1) WO1997036919A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004091A1 (en) * 1995-07-20 1997-02-06 Amrad Operations Pty. Ltd. Novel receptor ligands and genetic sequences encoding same
WO1997015667A1 (en) * 1995-10-25 1997-05-01 Regeneron Pharmaceuticals, Inc. Biologically active eph family ligands
EP1553963A4 (en) 2002-09-24 2006-05-03 Burnham Inst NOVEL AGENTS MODULATING EPH RECEPTOR ACTIVITY
AU2006208068B2 (en) 2005-01-27 2011-08-04 The Burnham Institute EphB receptor-binding peptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001839A1 (en) * 1994-07-08 1996-01-25 Immunex Corporation Novel cytokine designated lerk-5
WO1996010911A1 (en) * 1994-10-05 1996-04-18 Immunex Corporation Cytokine designated lerk-6
WO1996017925A1 (en) * 1994-12-06 1996-06-13 Immunex Corporation Cytokine designated lerk-7

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001839A1 (en) * 1994-07-08 1996-01-25 Immunex Corporation Novel cytokine designated lerk-5
WO1996010911A1 (en) * 1994-10-05 1996-04-18 Immunex Corporation Cytokine designated lerk-6
WO1996017925A1 (en) * 1994-12-06 1996-06-13 Immunex Corporation Cytokine designated lerk-7

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BECKMANN ET AL.: "Molecular characterization of a family of ligands for Eph-related tyrosine kinase receptors", EMBO, vol. 13, no. 16, 15 August 1994 (1994-08-15), pages 3757 - 3762, XP002016759 *
FLETCHER ET AL.: "Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk", GENOMICS, vol. 24, 1994, pages 127 - 132, XP000608355 *
SHAO ET AL.: "cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 43, 28 October 1994 (1994-10-28), pages 26608 *

Also Published As

Publication number Publication date
EP0904287A3 (en) 2000-12-20
NO984233D0 (en) 1998-09-14
IL125919A0 (en) 1999-04-11
NO984233L (en) 1998-11-23
WO1997036919A2 (en) 1997-10-09
KR19990087793A (en) 1999-12-27
AU2538697A (en) 1997-10-22
EP0904287A2 (en) 1999-03-31
JP2001521368A (en) 2001-11-06

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