+

WO1997030178A3 - Diagnosing trinucleotide repeat diseases and genes involved therein - Google Patents

Diagnosing trinucleotide repeat diseases and genes involved therein Download PDF

Info

Publication number
WO1997030178A3
WO1997030178A3 PCT/FR1997/000297 FR9700297W WO9730178A3 WO 1997030178 A3 WO1997030178 A3 WO 1997030178A3 FR 9700297 W FR9700297 W FR 9700297W WO 9730178 A3 WO9730178 A3 WO 9730178A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosing
trinucleotide repeat
genes involved
repeat diseases
sequences
Prior art date
Application number
PCT/FR1997/000297
Other languages
French (fr)
Other versions
WO1997030178A2 (en
Inventor
Christian Neri
Howard M Cann
Daniel Cohen
Original Assignee
Fondation Jean Dausset Ceph
Christian Neri
Howard M Cann
Daniel Cohen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fondation Jean Dausset Ceph, Christian Neri, Howard M Cann, Daniel Cohen filed Critical Fondation Jean Dausset Ceph
Priority to JP9529061A priority Critical patent/JP2000505293A/en
Priority to EP97905219A priority patent/EP0894144A2/en
Publication of WO1997030178A2 publication Critical patent/WO1997030178A2/en
Publication of WO1997030178A3 publication Critical patent/WO1997030178A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A transcribed DNA sequence with a high level of CAG or CTG repeat codons corresponding to sequences A to I on the table, and alleles and complementary sequences thereof, are disclosed. The sequences are particularly useful for diagnosing trinucleotide repeat diseases.
PCT/FR1997/000297 1996-02-15 1997-02-17 Diagnosing trinucleotide repeat diseases and genes involved therein WO1997030178A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP9529061A JP2000505293A (en) 1996-02-15 1997-02-17 Diagnosis of trinucleotide repeat disease and genes involved in this disease
EP97905219A EP0894144A2 (en) 1996-02-15 1997-02-17 Diagnosing trinucleotide repeat diseases and genes involved therein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9601864A FR2745007B1 (en) 1996-02-15 1996-02-15 DIAGNOSIS OF TRINUCLEOTIDE REPEATED DISEASES AND GENES INVOLVED IN SUCH DISEASES
FR96/01864 1996-02-15

Publications (2)

Publication Number Publication Date
WO1997030178A2 WO1997030178A2 (en) 1997-08-21
WO1997030178A3 true WO1997030178A3 (en) 1997-10-16

Family

ID=9489220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1997/000297 WO1997030178A2 (en) 1996-02-15 1997-02-17 Diagnosing trinucleotide repeat diseases and genes involved therein

Country Status (5)

Country Link
EP (1) EP0894144A2 (en)
JP (1) JP2000505293A (en)
CA (1) CA2246362A1 (en)
FR (1) FR2745007B1 (en)
WO (1) WO1997030178A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764611B1 (en) * 1997-06-11 2002-02-01 Fond Jean Dausset Ceph REPEATED TRIPLET-RICH DNA SEQUENCES USEFUL IN THE DIAGNOSIS OF TRINUCLEOTIDE REPETITIVE DISEASES
KR20030013019A (en) * 2001-08-06 2003-02-14 주식회사 바이오메드랩 Diagnosis kit and diagnosis apparatus for multiplication disease of trinucleotide repeated sequence

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016197A1 (en) * 1992-02-06 1993-08-19 University Of Wales College Of Medicine Nucleotide sequences and materials and methods for the diagnosis of myotonic dystrophy
WO1993016196A2 (en) * 1992-02-18 1993-08-19 The University Of Ottawa Myotonic dystrophy
WO1995001437A2 (en) * 1993-06-29 1995-01-12 Regents Of The University Of Minnesota Gene sequence for spinocerebellar ataxia type 1 and method for diagnosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016197A1 (en) * 1992-02-06 1993-08-19 University Of Wales College Of Medicine Nucleotide sequences and materials and methods for the diagnosis of myotonic dystrophy
WO1993016196A2 (en) * 1992-02-18 1993-08-19 The University Of Ottawa Myotonic dystrophy
WO1995001437A2 (en) * 1993-06-29 1995-01-12 Regents Of The University Of Minnesota Gene sequence for spinocerebellar ataxia type 1 and method for diagnosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
C. NERI ET AL.: "Survey of CAG/CTG repeats in human cDNAs representing new genes: candidates for inherited neurological diseases", HUMAN MOLECULAR GENETICS, vol. 5, no. 7, July 1996 (1996-07-01), OXFORD GB, pages 1001 - 1009, XP000763216 *
EMBL Nucleotide Sequence Data Bank Ac. No.: Emest3:Hs39047, 01 Avril 1995, L. Hillier et al. *
EMBL Nucleotide Sequence Data Bank Ac. Nr.: Emest2:Hs24911, 24 Mai 1995, L. Hillier et al. *
EMBL Nucleotide Sequence Data Bank Ac. Nr.: Emest5:Hst49359, 3 Mars 1995, L. Hillier et al., *
EMBL Nucleotide Sequence Data Bank, Ac. Nr.: Emest3:Hs517168, 7 Juillet 1995, L. Hillier et al., *
EMBL Nucleotide Sequence Data Bank, Ac. Nr.: Emest3:Hs58086, 22 Avril 1995, L. Hillier et al., *
EMBL Nucleotide Sequence Data Bank, Ac. Nr.: Emsts:Hs543187, 17 Aout 1995, J. Murray et al., *
G.J. RIGGINS ET AL.: "Human genes containing polymorphic trinucleotide repeats", NATURE GENETICS, vol. 2, no. 3, November 1992 (1992-11-01), OXFORD GB, pages 186 - 191, XP000196593 *
S.H. LI ET AL.: "Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms", GENOMICS, vol. 16, no. 3, June 1993 (1993-06-01), US, pages 572 - 579, XP000196589 *

Also Published As

Publication number Publication date
EP0894144A2 (en) 1999-02-03
FR2745007A1 (en) 1997-08-22
JP2000505293A (en) 2000-05-09
CA2246362A1 (en) 1997-08-21
FR2745007B1 (en) 1998-05-07
WO1997030178A2 (en) 1997-08-21

Similar Documents

Publication Publication Date Title
AU1018097A (en) Two stage hydroprocessing reaction scheme with series recycle gas flow
AU3143795A (en) Isoamylase gene from flaviobacterium sp., compositions containing it and methods using it
CA2296769A1 (en) Modified dorsal tissue affecting factor and compositions
EP2028274A3 (en) An antisense oligonucleotide against the TGF-beta2 gene
AU5716098A (en) Customized oligonucleotide microchips as multiple biosensors
DE69525057D1 (en) HYDROGENATED RING OPENING POLYMER
ZA200006039B (en) Novel nucleotide sequences coding for the poxB gene.
AU2317095A (en) Dna sequences
WO1995006740A3 (en) Medium chain-specific thioesterases
ZA976490B (en) Chemical process tower deentrainment assembly.
WO1995006764A3 (en) Oligonucleotides with rna cleavage activity
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
AU2682495A (en) Novel transferase and amylase, process for producing the enzymes,use thereof, and gene coding for the same
DE69816125D1 (en) PRESSURE SALES, PRESSURE SLEEVES AND METHOD FOR THE PRODUCTION THEREOF
AU4433299A (en) Genotyping the human phenol sulfotransferase 2 gene (stp2)
CY2333B1 (en) 10-Aminoaliphatyl-dibenz (b,f) oxepins with antineur odegenarative activity.
WO1997030178A3 (en) Diagnosing trinucleotide repeat diseases and genes involved therein
AUPO684997A0 (en) Polyphenol oxidase genes from banana, tobacco & pineapple
EP0669402A3 (en) Nucleic acid sequences specific for mycobacterium kansasii.
AU2549995A (en) Processes, apparatus and compositions for characterizing nucleotide sequences
AU4390099A (en) Nucleotide sequences of the apple lrpkm1 gene, encoded amino acid sequence and uses thereof
WO1998030717A3 (en) Vegetal sequences including a polymorphic site and their uses
ZA983196B (en) Oxidative stress resistance gene.
AU697722B2 (en) Novel topoisomerase IV, corresponding nucleotide sequences and uses thereof
WO2001048245A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2246362

Country of ref document: CA

Ref country code: CA

Ref document number: 2246362

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1997905219

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1997905219

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1997905219

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载