WO1997029074A1 - Derives d'acides d'amides n,n-disubstitues - Google Patents

Derives d'acides d'amides n,n-disubstitues Download PDF

Info

Publication number: WO1997029074A1
Authority: WO; WIPO (PCT)
Prior art keywords: group represented; sulfur; lower alkyl; nrb; ethynylene
Prior art date: 1996-02-07

Application number

PCT/JP1997/000305

Other languages

English (en)

French (fr)

Inventor

Yoshikazu Iwasawa

Tetsuya Aoyama

Kumiko Kawakami

Sachie Arai

Toshihiko Satoh

Yoshiaki Monden

Original Assignee

Banyu Pharmaceutical Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-07

Filing date

1997-02-07

Publication date

1997-08-14

1997-02-07 Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.

1997-02-07 Priority to US09/117,532 priority Critical patent/US5981573A/en

1997-02-07 Priority to AT97902607T priority patent/ATE221046T1/de

1997-02-07 Priority to EP97902607A priority patent/EP0989114B1/en

1997-02-07 Priority to DE69714303T priority patent/DE69714303T2/de

1997-02-07 Priority to CA002244870A priority patent/CA2244870C/en

1997-02-07 Priority to AU16193/97A priority patent/AU1619397A/en

1997-08-14 Publication of WO1997029074A1 publication Critical patent/WO1997029074A1/ja

Links

239000002253 acid Substances 0.000 title 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
239000011593 sulfur Substances 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
-1 hydroxy, amino Chemical group 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004980 cyclopropylene group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Carbon And Carbon Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Coloring (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PCT/JP1997/000305 1996-02-07 1997-02-07 Derives d'acides d'amides n,n-disubstitues WO1997029074A1 (fr)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
US09/117,532 US5981573A (en)	1996-02-07	1997-02-07	N,N-disubstituted amic acid derivatives
AT97902607T ATE221046T1 (de)	1996-02-07	1997-02-07	N,n-disubstituierte carbonsaureamid-derivate
EP97902607A EP0989114B1 (en)	1996-02-07	1997-02-07	N,n-disubstituted amic acid derivatives
DE69714303T DE69714303T2 (de)	1996-02-07	1997-02-07	N,n-disubstituierte carbonsaureamid-derivate
CA002244870A CA2244870C (en)	1996-02-07	1997-02-07	N,n-disubstituted amic acid derivatives
AU16193/97A AU1619397A (en)	1996-02-07	1997-02-07	N,n-disubstituted amic acid derivatives

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP8/45503		1996-02-07
JP4550396		1996-02-07

Publications (1)

Publication Number	Publication Date
WO1997029074A1 true WO1997029074A1 (fr)	1997-08-14

Family

ID=12721219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP1997/000305 WO1997029074A1 (fr)	1996-02-07	1997-02-07	Derives d'acides d'amides n,n-disubstitues

Country Status (7)

Country	Link
US (1)	US5981573A (ja)
EP (1)	EP0989114B1 (ja)
AT (1)	ATE221046T1 (ja)
AU (1)	AU1619397A (ja)
CA (1)	CA2244870C (ja)
DE (1)	DE69714303T2 (ja)
WO (1)	WO1997029074A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10110750A1 (de) *	2001-03-07	2002-09-12	Bayer Ag	Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
US7754717B2 (en) *	2005-08-15	2010-07-13	Amgen Inc.	Bis-aryl amide compounds and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07138214A (ja) *	1993-02-12	1995-05-30	Banyu Pharmaceut Co Ltd	置換アミド酸誘導体
WO1996005169A1 (fr) *	1994-08-12	1996-02-22	Banyu Pharmaceutical Co., Ltd.	Derive d'acide amique n,n-bisubstitue
WO1996005168A1 (fr) *	1994-08-11	1996-02-22	Banyu Pharmaceutical Co., Ltd.	Derive d'amide substitue

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2115183A1 (en) *	1993-02-12	1994-08-13	Takashi Nomoto	Substituted amic acid derivatives
AU714072B2 (en) *	1995-06-29	1999-12-16	Banyu Pharmaceutical Co., Ltd.	Combinations of inhibitors of farnesyl-protein transferase

1997
- 1997-02-07 EP EP97902607A patent/EP0989114B1/en not_active Expired - Lifetime
- 1997-02-07 AU AU16193/97A patent/AU1619397A/en not_active Abandoned
- 1997-02-07 AT AT97902607T patent/ATE221046T1/de not_active IP Right Cessation
- 1997-02-07 DE DE69714303T patent/DE69714303T2/de not_active Expired - Fee Related
- 1997-02-07 CA CA002244870A patent/CA2244870C/en not_active Expired - Fee Related
- 1997-02-07 WO PCT/JP1997/000305 patent/WO1997029074A1/ja active IP Right Grant
- 1997-02-07 US US09/117,532 patent/US5981573A/en not_active Expired - Fee Related

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07138214A (ja) *	1993-02-12	1995-05-30	Banyu Pharmaceut Co Ltd	置換アミド酸誘導体
WO1996005168A1 (fr) *	1994-08-11	1996-02-22	Banyu Pharmaceutical Co., Ltd.	Derive d'amide substitue
WO1996005169A1 (fr) *	1994-08-12	1996-02-22	Banyu Pharmaceutical Co., Ltd.	Derive d'acide amique n,n-bisubstitue

Also Published As

Publication number	Publication date
EP0989114A1 (en)	2000-03-29
US5981573A (en)	1999-11-09
CA2244870C (en)	2006-07-11
DE69714303D1 (de)	2002-08-29
EP0989114A4 (en)	2000-08-02
AU1619397A (en)	1997-08-28
CA2244870A1 (en)	1997-08-14
DE69714303T2 (de)	2003-01-23
ATE221046T1 (de)	2002-08-15
EP0989114B1 (en)	2002-07-24

Legal Events

Date	Code	Title	Description
1997-08-14	AK	Designated states	Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN YU AM AZ BY KG KZ MD RU TJ TM
1997-08-14	AL	Designated countries for regional patents	Kind code of ref document: A1 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG
1997-10-09	DFPE	Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
1997-11-05	121	Ep: the epo has been informed by wipo that ep was designated in this application
1998-07-29	ENP	Entry into the national phase	Ref document number: 2244870 Country of ref document: CA Ref country code: CA Ref document number: 2244870 Kind code of ref document: A Format of ref document f/p: F
1998-08-04	WWE	Wipo information: entry into national phase	Ref document number: 09117532 Country of ref document: US
1998-08-07	WWE	Wipo information: entry into national phase	Ref document number: 1997902607 Country of ref document: EP
1998-12-10	REG	Reference to national code	Ref country code: DE Ref legal event code: 8642
2000-03-29	WWP	Wipo information: published in national office	Ref document number: 1997902607 Country of ref document: EP
2002-07-24	WWG	Wipo information: grant in national office	Ref document number: 1997902607 Country of ref document: EP

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