WO1997029075A1 - Derives d'amides substitues - Google Patents
Derives d'amides substitues Download PDFInfo
- Publication number
- WO1997029075A1 WO1997029075A1 PCT/JP1997/000306 JP9700306W WO9729075A1 WO 1997029075 A1 WO1997029075 A1 WO 1997029075A1 JP 9700306 W JP9700306 W JP 9700306W WO 9729075 A1 WO9729075 A1 WO 9729075A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group represented
- halogeno
- hydroxy
- lower alkyl
- ethynylene
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- -1 vinylene, ethynylene Chemical group 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004980 cyclopropylene group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des composés représentés par la formule générale (I), certains de leurs sels ou esters galéniques et des agents antitumoraux les utilisant comme principes actifs. Dans cette formule générale, Ar?1, Ar2 et Ar3¿ sont chacun aryle ou hétéroaryle. A1 est hydrocarbyle en C¿2-6? ou un groupe représenté par -A?1a-W1-A1b- (W1¿ représentant un oxygène, soufre, éthynylène, cyclopropylène ou un groupe représenté par -NRw-). A2 est un groupe hydrocarbyle en C¿2-8?. Q est un groupe représenté par -(CH2)m- ou -(CH2)n-W2-(CH2)p- (W?2¿ étant oxygène, soufre, vinylène, éthynylène ou un groupe représenté par -NHCOCH=CH-). R1 est hydrogène, halogéno, hydroxy, alkyle inférieur, alcoxy inférieur, aryle ou un groupe hétéroaryle. R?2, R6 et R7¿ sont chacun hydrogène, halogéno, hydroxy, alkyle inférieur, alcényle inférieur ou un alcoxy inférieur. R3 et R4 sont chacun hydrogène, halogéno, hydroxy, amino, nitro, cyano, carboxy, alcoxycarbonyle inférieur, carbamyle, alkylcarbamyle, alkyle inférieur, hydroxyalkyle inférieur, fluoroalkyle inférieur ou alcoxy inférieur. R5 est alkyle inférieur.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU16194/97A AU1619497A (en) | 1996-02-07 | 1997-02-07 | Substituted amide derivatives |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8/45504 | 1996-02-07 | ||
| JP4550496 | 1996-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1997029075A1 true WO1997029075A1 (fr) | 1997-08-14 |
Family
ID=12721247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1997/000306 WO1997029075A1 (fr) | 1996-02-07 | 1997-02-07 | Derives d'amides substitues |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU1619497A (fr) |
| WO (1) | WO1997029075A1 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007201276B2 (en) * | 2002-03-12 | 2009-11-05 | Merck Sharp & Dohme Corp. | Substituted amides |
| US9394287B2 (en) | 2010-11-05 | 2016-07-19 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
| US9732071B2 (en) | 2015-10-01 | 2017-08-15 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07138214A (ja) * | 1993-02-12 | 1995-05-30 | Banyu Pharmaceut Co Ltd | 置換アミド酸誘導体 |
| WO1996005168A1 (fr) * | 1994-08-11 | 1996-02-22 | Banyu Pharmaceutical Co., Ltd. | Derive d'amide substitue |
| WO1996005169A1 (fr) * | 1994-08-12 | 1996-02-22 | Banyu Pharmaceutical Co., Ltd. | Derive d'acide amique n,n-bisubstitue |
| WO1997001275A1 (fr) * | 1995-06-29 | 1997-01-16 | Merck & Co., Inc. | Combinaisons d'inhibiteurs de farnesyl-proteine transferase |
-
1997
- 1997-02-07 AU AU16194/97A patent/AU1619497A/en not_active Abandoned
- 1997-02-07 WO PCT/JP1997/000306 patent/WO1997029075A1/fr active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07138214A (ja) * | 1993-02-12 | 1995-05-30 | Banyu Pharmaceut Co Ltd | 置換アミド酸誘導体 |
| WO1996005168A1 (fr) * | 1994-08-11 | 1996-02-22 | Banyu Pharmaceutical Co., Ltd. | Derive d'amide substitue |
| WO1996005169A1 (fr) * | 1994-08-12 | 1996-02-22 | Banyu Pharmaceutical Co., Ltd. | Derive d'acide amique n,n-bisubstitue |
| WO1997001275A1 (fr) * | 1995-06-29 | 1997-01-16 | Merck & Co., Inc. | Combinaisons d'inhibiteurs de farnesyl-proteine transferase |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007201276B2 (en) * | 2002-03-12 | 2009-11-05 | Merck Sharp & Dohme Corp. | Substituted amides |
| US9394287B2 (en) | 2010-11-05 | 2016-07-19 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
| US10016418B2 (en) | 2010-11-05 | 2018-07-10 | Seaomyx, Inc. | Compounds useful as modulators of TRPM8 |
| US10953007B2 (en) | 2010-11-05 | 2021-03-23 | Firmenich Incorporated | Compounds useful as modulators of TRPM8 |
| US9732071B2 (en) | 2015-10-01 | 2017-08-15 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1619497A (en) | 1997-08-28 |
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