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WO1997020841A3 - Nouveaux composes macrobicycliques, leur procede de fabrication et agents pharmaceutiques les renfermant - Google Patents

Nouveaux composes macrobicycliques, leur procede de fabrication et agents pharmaceutiques les renfermant Download PDF

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Publication number
WO1997020841A3
WO1997020841A3 PCT/DE1996/002234 DE9602234W WO9720841A3 WO 1997020841 A3 WO1997020841 A3 WO 1997020841A3 DE 9602234 W DE9602234 W DE 9602234W WO 9720841 A3 WO9720841 A3 WO 9720841A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
alkyl
pharmaceutical agents
agents containing
new
Prior art date
Application number
PCT/DE1996/002234
Other languages
German (de)
English (en)
Other versions
WO1997020841A2 (fr
Inventor
Georg Roessling
Celal Albayrak
Johannes Tack
Original Assignee
Schering Ag
Georg Roessling
Celal Albayrak
Johannes Tack
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Georg Roessling, Celal Albayrak, Johannes Tack filed Critical Schering Ag
Priority to AU17181/97A priority Critical patent/AU1718197A/en
Publication of WO1997020841A2 publication Critical patent/WO1997020841A2/fr
Publication of WO1997020841A3 publication Critical patent/WO1997020841A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne de nouveaux composés macrobicycliques de formule générale (I), dans laquelle R1-R6 représentent le reste -CH(R7)-CO2Y, où Y est un atome d'hydrogène et/ou un équivalent d'ion métal d'un élément de nombre atomique 20-29, 31, 32, 37-39, 42-44, 47, 49 ou 57-83, R7 désigne un atome d'hydrogène ou un groupe alkyle en C¿1?-C30, aryle en C6-C10 ou aralkyle en C7-C30, ramifié ou non ramifié, éventuellement substitué par 1 à 6 groupes hydroxy, les groupes alkyle étant éventuellement interrompus par 1 à 10 atomes d'oxygène et/ou substitués par 1 à 6 groupes -CO2R?8, et R8¿ désigne un hydrogène ou un groupe alkyle en C¿1?-C4 ou aralkyle en C7-C10 ramifié ou non ramifié, ainsi que leurs sels avec des bases inorganiques et/ou organiques, aminoacides ou aminoacide-amides. Les complexes métalliques de ces composés ou les agents pharmaceutiques les renfermant sont utilisés en particulier comme agents de contraste pour diagnostic par RMN et par rayons X.
PCT/DE1996/002234 1995-12-04 1996-11-18 Nouveaux composes macrobicycliques, leur procede de fabrication et agents pharmaceutiques les renfermant WO1997020841A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU17181/97A AU1718197A (en) 1995-12-04 1996-11-18 New macrobicyclic compounds, methods of preparing them and pharmaceutical agents containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995146234 DE19546234C1 (de) 1995-12-04 1995-12-04 Neue makrobicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese makrobicyclischen Verbindungen enthaltende pharmazeutische Mittel
DE19546234.3 1995-12-04

Publications (2)

Publication Number Publication Date
WO1997020841A2 WO1997020841A2 (fr) 1997-06-12
WO1997020841A3 true WO1997020841A3 (fr) 1997-12-11

Family

ID=7779821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/002234 WO1997020841A2 (fr) 1995-12-04 1996-11-18 Nouveaux composes macrobicycliques, leur procede de fabrication et agents pharmaceutiques les renfermant

Country Status (3)

Country Link
AU (1) AU1718197A (fr)
DE (1) DE19546234C1 (fr)
WO (1) WO1997020841A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2563824A (en) * 2017-06-19 2019-01-02 Georg August Univ Gottingen Stiftung Oeffentlichen Rechts Contrast agents for magnetic resonance imaging

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0485045A2 (fr) * 1990-11-08 1992-05-13 Schering Aktiengesellschaft Dérivés du 1,4,7,10-Tétraazacyclododécane-mono-N-substitués, leur procédé de préparation et produits pharmaceutiques les contenant
WO1994026276A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Acides tricyclopolyazamacrocyclophosphoniques, leurs complexes et leurs derives, pour une utilisation en tant qu'agents de contraste
WO1995019185A1 (fr) * 1994-01-14 1995-07-20 Mallinckrodt Medical, Inc. Ligands aza-macrobicycliques fonctionnalises pour des applications en imagerie

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0485045A2 (fr) * 1990-11-08 1992-05-13 Schering Aktiengesellschaft Dérivés du 1,4,7,10-Tétraazacyclododécane-mono-N-substitués, leur procédé de préparation et produits pharmaceutiques les contenant
WO1994026276A1 (fr) * 1993-05-06 1994-11-24 The Dow Chemical Company Acides tricyclopolyazamacrocyclophosphoniques, leurs complexes et leurs derives, pour une utilisation en tant qu'agents de contraste
WO1995019185A1 (fr) * 1994-01-14 1995-07-20 Mallinckrodt Medical, Inc. Ligands aza-macrobicycliques fonctionnalises pour des applications en imagerie

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. DE MENDOZA ET AL.: "A new macrobicyclic tris-bipyridine ligand and its CuI2 and AgI3 complexes", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 30, no. 10, 1991, WEINHEIM, DE, pages 1331 - 3, XP002043564 *

Also Published As

Publication number Publication date
AU1718197A (en) 1997-06-27
DE19546234C1 (de) 1997-08-28
WO1997020841A2 (fr) 1997-06-12

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