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WO1997020841A3 - New macrobicyclic compounds, methods of preparing them and pharmaceutical agents containing them - Google Patents

New macrobicyclic compounds, methods of preparing them and pharmaceutical agents containing them Download PDF

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Publication number
WO1997020841A3
WO1997020841A3 PCT/DE1996/002234 DE9602234W WO9720841A3 WO 1997020841 A3 WO1997020841 A3 WO 1997020841A3 DE 9602234 W DE9602234 W DE 9602234W WO 9720841 A3 WO9720841 A3 WO 9720841A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
alkyl
pharmaceutical agents
agents containing
new
Prior art date
Application number
PCT/DE1996/002234
Other languages
German (de)
French (fr)
Other versions
WO1997020841A2 (en
Inventor
Georg Roessling
Celal Albayrak
Johannes Tack
Original Assignee
Schering Ag
Georg Roessling
Celal Albayrak
Johannes Tack
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Georg Roessling, Celal Albayrak, Johannes Tack filed Critical Schering Ag
Priority to AU17181/97A priority Critical patent/AU1718197A/en
Publication of WO1997020841A2 publication Critical patent/WO1997020841A2/en
Publication of WO1997020841A3 publication Critical patent/WO1997020841A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention concerns new macrobicyclic compounds of general formula (I) in which R1-R6 are a -CH(R7)-CO2Y grouping, Y being a hydrogen atom and/or an equivalent of an ion of a metal of atomic number 20-29, 31, 32, 37-39, 42-44, 47, 49 or 57-83 and R7 being a hydrogen atom or a branched or unbranched C¿1?-C30 alkyl, C6-C10 aryl or C7-C30 aralkyl group which may be substituted by 1 to 6 hydroxy groups, whereby the carbon chain in the alkyl groups may also include 1 to 10 oxygen atoms and/or be substituted by 1 to 6 -CO2R?8¿ groups, and R8 being hydrogen or a branched or unbranched C¿1?-C4 alkyl or C7-C10 aralkyl group, plus salts of such compounds with inorganic and/or organic bases, aminoacids or aminoacid amines. The metal complexes of these compounds, or pharmaceutical agents containing them, are suitable for use in particular as contrast agents for NMR and X-ray examination purposes.
PCT/DE1996/002234 1995-12-04 1996-11-18 New macrobicyclic compounds, methods of preparing them and pharmaceutical agents containing them WO1997020841A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU17181/97A AU1718197A (en) 1995-12-04 1996-11-18 New macrobicyclic compounds, methods of preparing them and pharmaceutical agents containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995146234 DE19546234C1 (en) 1995-12-04 1995-12-04 New macrobicyclic compounds, processes for their preparation and pharmaceutical compositions containing these macrobicyclic compounds
DE19546234.3 1995-12-04

Publications (2)

Publication Number Publication Date
WO1997020841A2 WO1997020841A2 (en) 1997-06-12
WO1997020841A3 true WO1997020841A3 (en) 1997-12-11

Family

ID=7779821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/002234 WO1997020841A2 (en) 1995-12-04 1996-11-18 New macrobicyclic compounds, methods of preparing them and pharmaceutical agents containing them

Country Status (3)

Country Link
AU (1) AU1718197A (en)
DE (1) DE19546234C1 (en)
WO (1) WO1997020841A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2563824A (en) * 2017-06-19 2019-01-02 Georg August Univ Gottingen Stiftung Oeffentlichen Rechts Contrast agents for magnetic resonance imaging

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0485045A2 (en) * 1990-11-08 1992-05-13 Schering Aktiengesellschaft Mono-N-substituted 1,4,7,10-Tetraazacyclododecan-derivatives, process for their preparation and pharmaceutical agent containing them
WO1994026276A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
WO1995019185A1 (en) * 1994-01-14 1995-07-20 Mallinckrodt Medical, Inc. Functionalized aza-macrobicyclic ligands for imaging applications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0485045A2 (en) * 1990-11-08 1992-05-13 Schering Aktiengesellschaft Mono-N-substituted 1,4,7,10-Tetraazacyclododecan-derivatives, process for their preparation and pharmaceutical agent containing them
WO1994026276A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
WO1995019185A1 (en) * 1994-01-14 1995-07-20 Mallinckrodt Medical, Inc. Functionalized aza-macrobicyclic ligands for imaging applications

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. DE MENDOZA ET AL.: "A new macrobicyclic tris-bipyridine ligand and its CuI2 and AgI3 complexes", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 30, no. 10, 1991, WEINHEIM, DE, pages 1331 - 3, XP002043564 *

Also Published As

Publication number Publication date
DE19546234C1 (en) 1997-08-28
AU1718197A (en) 1997-06-27
WO1997020841A2 (en) 1997-06-12

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