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WO1997005170A3 - Anticorps a large specificite - Google Patents

Anticorps a large specificite Download PDF

Info

Publication number
WO1997005170A3
WO1997005170A3 PCT/GB1996/001889 GB9601889W WO9705170A3 WO 1997005170 A3 WO1997005170 A3 WO 1997005170A3 GB 9601889 W GB9601889 W GB 9601889W WO 9705170 A3 WO9705170 A3 WO 9705170A3
Authority
WO
WIPO (PCT)
Prior art keywords
generic
antibodies
broad specificity
receptor
enzyme
Prior art date
Application number
PCT/GB1996/001889
Other languages
English (en)
Other versions
WO1997005170A2 (fr
Inventor
Michael Robert Anthony Morgan
Colin Malcolm Ward
Andrew Philip Wilkinson
Heather Avril Lee
Original Assignee
Mini Agriculture & Fisheries
Michael Robert Anthony Morgan
Colin Malcolm Ward
Andrew Philip Wilkinson
Heather Avril Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mini Agriculture & Fisheries, Michael Robert Anthony Morgan, Colin Malcolm Ward, Andrew Philip Wilkinson, Heather Avril Lee filed Critical Mini Agriculture & Fisheries
Priority to JP9507384A priority Critical patent/JPH11510691A/ja
Priority to EP96926469A priority patent/EP0842197A2/fr
Priority to CA002227599A priority patent/CA2227599A1/fr
Priority to AU66638/96A priority patent/AU6663896A/en
Publication of WO1997005170A2 publication Critical patent/WO1997005170A2/fr
Publication of WO1997005170A3 publication Critical patent/WO1997005170A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention se rapporte à un procédé permettant de fabriquer des anticorps génériques, à large spécificité, ayant une affinité de liaison spécifique pour deux ou plusieurs composés d'une classe de composés présentant un mode commun d'activité biologique (par exemple les pesticides à organophosphates). Ce procédé permet aussi de sélectionner un récepteur ou un enzyme par lequel la classe de composés exerce son activité biologique, de développer des anticorps monoclonaux intermédiaires (AMI) contre le site de reconnaissance du récepteur ou de l'enzyme, d'inoculer à un animal ces AMI ou leurs fragments, et de récupérer les anticorps génériques à partir d'un liquide organique ou d'un tissu de cet animal. Cette invention porte également sur les polysérums génériques, sur les anticorps génériques et les lignées cellulaires qui permettent de les produire, ainsi que sur les procédés et les matériels permettant de cribler un échantillon pour détecter la présence ou l'absence de composés qui présentent un mode commun d'activité en utilisant des anticorps génériques.
PCT/GB1996/001889 1995-08-02 1996-08-01 Anticorps a large specificite WO1997005170A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP9507384A JPH11510691A (ja) 1995-08-02 1996-08-01 広い特異性の抗体
EP96926469A EP0842197A2 (fr) 1995-08-02 1996-08-01 Anticorps a large specificite
CA002227599A CA2227599A1 (fr) 1995-08-02 1996-08-01 Anticorps a large specificite
AU66638/96A AU6663896A (en) 1995-08-02 1996-08-01 Broad specificity antibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515850.7A GB9515850D0 (en) 1995-08-02 1995-08-02 Broad specificity antibodies
GB9515850.7 1995-08-02

Publications (2)

Publication Number Publication Date
WO1997005170A2 WO1997005170A2 (fr) 1997-02-13
WO1997005170A3 true WO1997005170A3 (fr) 1997-03-13

Family

ID=10778655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/001889 WO1997005170A2 (fr) 1995-08-02 1996-08-01 Anticorps a large specificite

Country Status (6)

Country Link
EP (1) EP0842197A2 (fr)
JP (1) JPH11510691A (fr)
AU (1) AU6663896A (fr)
CA (1) CA2227599A1 (fr)
GB (1) GB9515850D0 (fr)
WO (1) WO1997005170A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252050B1 (en) 1998-06-12 2001-06-26 Genentech, Inc. Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
CN113049812B (zh) * 2021-03-26 2024-03-19 信达安检测技术(天津)有限公司 一种检测克百威的elisa方法及其试剂盒

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000472A1 (fr) * 1986-07-23 1988-01-28 Aphton Corporation Immunogenes et procedes ameliores de production d'immunogenes
WO1993017030A1 (fr) * 1992-02-27 1993-09-02 The Horticulture And Food Research Institute Of New Zealand Limited Detection immunologique d'organophosphates
WO1994027149A1 (fr) * 1993-05-18 1994-11-24 The Minister Of Agriculture Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Procedes, agents et trousses de detection de composes d'organophosphore

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000472A1 (fr) * 1986-07-23 1988-01-28 Aphton Corporation Immunogenes et procedes ameliores de production d'immunogenes
WO1993017030A1 (fr) * 1992-02-27 1993-09-02 The Horticulture And Food Research Institute Of New Zealand Limited Detection immunologique d'organophosphates
WO1994027149A1 (fr) * 1993-05-18 1994-11-24 The Minister Of Agriculture Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Procedes, agents et trousses de detection de composes d'organophosphore

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A. WILKINSON ET AL.: "Antibodies to the pesticide interaction sites of parathion hydrolase and cutinase.", FOOD AND AGRICULTURAL IMMUNOLOGY, vol. 7, no. 3, 1995, ABINGDON, GB, pages 273 - 281, XP000614947 *
C. SPINKS ET AL.: "Production and characterization of monoclonal anti-idiotype mimics for the pyrethroid insecticides and the herbicide paraquat.", FOOD AND AGRICULTURAL IMMUNOLOGY, vol. 5, no. 1, 1993, ADINGDON, GB, pages 13 - 25, XP000614951 *
E. HELDMAN ET AL.: "A novel immunoassay with direct relevance to protection against organophosphate poisoning.", FEBS LETTERS, vol. 180, no. 2, January 1985 (1985-01-01), AMSTERDAM, NL, pages 243 - 248, XP002023908 *
J. SKERRITT ET AL.: "Testing cereal products and samples by immunoassay. Tests for organophosphate, carbamate, and pyrethroid grain protectants.", ACS SYMPOSIUM SERIES, vol. 451, 1991, WASHINGTON, DC, USA, pages 124 - 138, XP002023909 *

Also Published As

Publication number Publication date
WO1997005170A2 (fr) 1997-02-13
GB9515850D0 (en) 1995-10-04
AU6663896A (en) 1997-02-26
CA2227599A1 (fr) 1997-02-13
JPH11510691A (ja) 1999-09-21
EP0842197A2 (fr) 1998-05-20

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