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WO1998027114A3 - Antigenes de surface mammaliens et reactifs associes - Google Patents

Antigenes de surface mammaliens et reactifs associes Download PDF

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Publication number
WO1998027114A3
WO1998027114A3 PCT/US1997/023321 US9723321W WO9827114A3 WO 1998027114 A3 WO1998027114 A3 WO 1998027114A3 US 9723321 W US9723321 W US 9723321W WO 9827114 A3 WO9827114 A3 WO 9827114A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell surface
mammalian cell
surface antigens
related reagents
reagents
Prior art date
Application number
PCT/US1997/023321
Other languages
English (en)
Other versions
WO1998027114A2 (fr
Inventor
Daniel M Gorman
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU57058/98A priority Critical patent/AU5705898A/en
Publication of WO1998027114A2 publication Critical patent/WO1998027114A2/fr
Publication of WO1998027114A3 publication Critical patent/WO1998027114A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des gènes purifiés codant pour un antigène de surface de lymphocyte T de mammifère, des réactifs associés, comprenant des protéines purifiées, des anticorps spécifiques et des acides nucléiques codant pour ledit antigène. Des procédés d'utilisation desdits réactifs et des kits de diagnostic sont également décrits.
PCT/US1997/023321 1996-12-17 1997-12-16 Antigenes de surface mammaliens et reactifs associes WO1998027114A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57058/98A AU5705898A (en) 1996-12-17 1997-12-16 Mammalian cell surface antigens; related reagents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3360196P 1996-12-17 1996-12-17
US60/033,601 1996-12-17

Publications (2)

Publication Number Publication Date
WO1998027114A2 WO1998027114A2 (fr) 1998-06-25
WO1998027114A3 true WO1998027114A3 (fr) 1998-10-22

Family

ID=21871343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023321 WO1998027114A2 (fr) 1996-12-17 1997-12-16 Antigenes de surface mammaliens et reactifs associes

Country Status (2)

Country Link
AU (1) AU5705898A (fr)
WO (1) WO1998027114A2 (fr)

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US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
CA2232743A1 (fr) * 1997-04-02 1998-10-02 Smithkline Beecham Corporation Tl5, homologue tnf
WO1998055621A1 (fr) * 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Membre ntn-2 de la famille des ligands du facteur de necrose tumorale (tnf)
AU743490B2 (en) * 1997-06-06 2002-01-24 Regeneron Pharmaceuticals, Inc. NTN-2 member of TNF ligand family
AU9376498A (en) * 1997-09-05 1999-03-22 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
AU9315298A (en) * 1997-09-12 1999-03-29 Apotech S.A. Kay - a novel immune system protein
CA2310987A1 (fr) * 1997-11-26 1999-06-03 Eli Lilly And Company Gene de la famille des ligands du tnf
WO1999033980A2 (fr) * 1997-12-30 1999-07-08 Chiron Corporation Membres de familles de tnf et de tnfr
US6297367B1 (en) * 1997-12-30 2001-10-02 Chiron Corporation Polynucleotide encoding TNFL1
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
GB9828628D0 (en) 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
CA2360062A1 (fr) 1999-01-25 2000-07-27 Biogen, Inc. Baff, agents bloquants associes et utilisation de ceux-ci pour stimuler et inhiber la reponse immunitaire des lymphocytes b et des immunoglobulines
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
US6475986B1 (en) * 1999-02-02 2002-11-05 Research Development Foundation Uses of THANK, a TNF homologue that activates apoptosis
AU777536B2 (en) * 1999-02-23 2004-10-21 Human Genome Sciences, Inc. Neutrokine-alpha and neutrokine-alpha splice variant
CA2367378A1 (fr) * 1999-04-05 2000-10-12 Incyte Pharmaceuticals, Inc. Molecules du systeme immunitaire
AU4331200A (en) * 1999-04-09 2000-11-14 Human Genome Sciences, Inc. 49 human secreted proteins
US20030022233A1 (en) 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
US6475987B1 (en) 1999-05-06 2002-11-05 National Jewish Medical And Research Center Tall-1 receptor homologues
EP1806143B1 (fr) 1999-08-17 2016-06-15 Biogen MA Inc. Récepteur Baff (BCMA), agent immunorégulateur
UA74798C2 (uk) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
CA2399387C (fr) 2000-02-11 2015-11-03 Biogen, Inc. Polypeptide heterologue de la famille tnf
CA2396793A1 (fr) 2000-02-16 2001-08-23 Genentech, Inc. Utilisation d'agonistes ou d'antagonistes pour moduler l'activite de molecules associees au tnf
US20020086018A1 (en) 2000-05-12 2002-07-04 Theill Lars Eyde Methods and compositions of matter concerning APRIL/G70, BCMA, BLYS/AGP-3, and TACI
DE60143798D1 (de) 2000-06-16 2011-02-17 Cambridge Antibody Tech Immunspezifisch bindende antikörper gegen blys
US7220840B2 (en) 2000-06-16 2007-05-22 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator protein
CA2419661A1 (fr) * 2000-08-15 2002-03-07 Guo-Liang Yu Neutrokine-alpha et variant d'epissage de neutrokine-alpha
US20030091565A1 (en) 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
PL210546B1 (pl) 2001-05-11 2012-01-31 Amgen Peptydy oraz pokrewne cząsteczki wiążące TALL-1
PT2116259E (pt) 2001-05-24 2012-04-09 Zymogenetics Inc Proteínas de fusão de taci-imunoglobulina
AR035119A1 (es) 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
US7700317B2 (en) 2003-03-28 2010-04-20 Biogen Idec Ma Inc. Truncated baff receptors
AU2004256042A1 (en) 2003-06-05 2005-01-20 Genentech, Inc. BlyS antagonists and uses thereof
US20070249530A1 (en) * 2004-01-29 2007-10-25 Genentech, Inc. Bcma Polypeptides and Uses Thereof
CA2580271A1 (fr) 2004-10-05 2006-04-20 Genentech, Inc. Methode de traitement de l'angeite
AU2005295713B2 (en) 2004-10-13 2011-06-16 The Washington University Use of BAFF to treat sepsis
AU2005318086B2 (en) 2004-12-23 2011-07-07 Merck Serono Sa BCMA polypeptides and uses thereof
EP1922079A2 (fr) 2005-08-09 2008-05-21 ZymoGenetics, Inc. Procedes pour le traitement et la prevention de proliferation cellulaire anormale par le biais de molecules de fusion taci
WO2007019575A2 (fr) 2005-08-09 2007-02-15 Zymogenetics, Inc. Procedes destines au traitement des malignites des lymphocytes b au moyen d'une molecule de fusion taci-ig
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
EP1952150B1 (fr) 2005-11-23 2016-12-14 Genentech, Inc. Procedes et compositions lies a des analyses de lymphocytes b
WO2007123765A2 (fr) 2006-03-31 2007-11-01 Human Genome Sciences Inc. NEUTROKINE-ALPHA et variant d'epissage de la neutrokine-alpha
KR20090016707A (ko) 2006-05-15 2009-02-17 아레스 트레이딩 에스.에이. Ｔａｃｉ­ｉｇ 융합 분자를 사용하여 자가면역 질병을 치료하는 방법
WO2010075249A2 (fr) 2008-12-22 2010-07-01 Genentech, Inc. Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b
EP2473637B1 (fr) 2009-09-03 2017-03-29 F. Hoffmann-La Roche AG Procédés pour traiter, diagnostiquer, et surveiller la polyarthrite rhumatoïde
RU2013140975A (ru) 2011-02-28 2015-04-10 Дженентек, Инк. Биологические маркеры и способы прогнозирования восприимчивости к антагонистам в-клеток
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
PH12022550138A1 (en) 2013-03-13 2023-03-06 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018921A1 (fr) * 1996-10-25 1998-05-07 Human Genome Sciences, Inc. Neutrokine alpha

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EMBL DATABASE; EMEST6:HS307C08B; ACCESSION-NO.: D79690, 7 February 1996 (1996-02-07), XP002073749 *
EMBL DATABASE; EMEST8:HS88288; ACCESSION-NO.: R16882, 22 April 1995 (1995-04-22), XP002073748 *

Also Published As

Publication number Publication date
WO1998027114A2 (fr) 1998-06-25
AU5705898A (en) 1998-07-15

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