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WO1996019563A1 - Compositions detergentes comprenant du copolyol de dimethicone - Google Patents

Compositions detergentes comprenant du copolyol de dimethicone Download PDF

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Publication number
WO1996019563A1
WO1996019563A1 PCT/US1995/016673 US9516673W WO9619563A1 WO 1996019563 A1 WO1996019563 A1 WO 1996019563A1 US 9516673 W US9516673 W US 9516673W WO 9619563 A1 WO9619563 A1 WO 9619563A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
composition according
acid
dimethicone copolyol
alkoxy
Prior art date
Application number
PCT/US1995/016673
Other languages
English (en)
Inventor
Iain Allan Hughes
Elizabeth Mary Ryan
Christopher David White
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to PL95320862A priority Critical patent/PL320862A1/xx
Priority to CZ971904A priority patent/CZ190497A3/cs
Priority to AU46871/96A priority patent/AU700174B2/en
Priority to JP8519992A priority patent/JPH11500471A/ja
Priority to US08/849,984 priority patent/US5759523A/en
Priority to KR1019970704209A priority patent/KR100209998B1/ko
Priority to SK826-97A priority patent/SK82697A3/sk
Priority to BR9510470A priority patent/BR9510470A/pt
Priority to MXPA/A/1997/004665A priority patent/MXPA97004665A/xx
Priority to CA002206489A priority patent/CA2206489C/fr
Priority to EP95944509A priority patent/EP0799301A4/fr
Publication of WO1996019563A1 publication Critical patent/WO1996019563A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
    • C11D3/3738—Alkoxylated silicones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0052—Gas evolving or heat producing compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/10—Carbonates ; Bicarbonates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3942—Inorganic per-compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent

Definitions

  • the present invention relates to cleansing compositions and especially to compositions for use in cleansing dentures and the like.
  • the invention relates to denture cleansing compositions having enhanced antiplaque activity together with excellent denture cleansing performance, appearance, physical and dissolution characteristics, anti-bacterial efficacy and in-use performance characteristics.
  • Effervescent tablets and powders for cleansing dentures and the like are well known in the art.
  • the aim of a denture cleanser product is to clean the denture as fully and as quickly as possible and especially to remove the accumulation of plaque, mucilaginous and bacterial deposits which collect while the denture is being worn.
  • To wear a denture which has not been completely cleaned of plaque and bacterial deposits is not only unhygenic but can also within a short space of time result in a detrimental effect on the mucous membrane.
  • bacterial deposits can lead to so-called bacterial corrosion of the plastics material used to produce the denture with consequent color- change and mal odor-format ion.
  • GB-A- 689,679 discloses a mouthwash containing an organopolysiloxane for preventing adhesion of, or for removing tars, stains, tartar and food particles from the teeth.
  • US-A-2,806,814 discloses dental preparations including, in combination, a higher aliphatic acyl amide of an amino carboxylic acid compound as an active and a silicone compound.
  • silicone compounds have been proposed for prevention of adhesion or to facilitate the removal of tars, stains, tartar and the like from teeth.
  • the silicone compound is said to act as a synergist in improving the antibacterial and acid inhibiting activity of the active ingredient.
  • Dimethyl polysiloxanes are said to be particularly effective.
  • US-A-3624120 discloses quaternary ammonium salts of cyclic siloxane polymers for use as cationic surfactants, bactericides and as anticariogenic agents.
  • Dentures of course are generally made of a plastics material such as acrylic and the problem of preventing plaque accumulation or of removing plaque from dentures is therefore fundamentally different from the problem of plaque prevention and removal from dental enamal.
  • the present invention provides a denture cleanser having improved efficacy on plaque, mucilaginous and bacterial deposits and which at the same time provides excellent denture cleansing performance, appearance, physical characteristics, dissolution and in- use performance characteristics.
  • a denture cleansing composition comprising an inorganic persalt bleaching agent, an effervescence generator and a dimethicone copolyol selected from alkyl- and alkoxy-dimethicone copolyols having the formula (I):
  • X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms
  • Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms
  • n is from about 0 to about 200
  • m is from about 1 to about 40
  • q is from about 1 to about 100
  • the molecular weight of the residue (C2H4 ⁇ -) x (C3H6 ⁇ -) y X is from about 50 to about 2000, preferably from about 250 to about 1000 and x and y are such that the weight ratio of oxyethylene.oxypropylene is from about 100:0 to about 0:100, preferably from about 100:0 to about 20:80.
  • the present invention also relates to the use of the defined dimethicone copolyol as antiplaque agent in denture cleansing compositions
  • the cleansing compositions of the invention thus comprise three essential components, a bleaching agent, a dimethicone copolyol and an effervescent base composition. Each of these will be discussed in turn.
  • the bleaching agent takes the form of an inorganic persalt and can be selected from any of the well-known bleaching agents known for use in denture cleansers such as the alkali metal and ammonium persulfates, perborates, percarbonates and perphosphates and the alkali metal and alkaline earth metal peroxides.
  • suitable bleaching agents include potassium, ammonium, sodium and lithium persulfates and perborate mono- and tetrahydrates, sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides.
  • the alkali metal persulfates, perborates and mixtures thereof are prefered for use herein, highly preferred being the alkali metal perborates.
  • the tablet compositions herein will provide excellent antimicrobial activity even in the absence of alkali metal persulfates.
  • the amount of bleaching agent in the total composition is generally from about 5 to about 70% preferably from about 10% to about 50%.
  • the overall persulfate:perborate ratio is suitably from about 5:1 to about 1:5, more especially from about 2:1 to about 1:2.
  • compositions herein also contain a dimethicone copolyol antiplaque agent.
  • the dimethicone copolyol is selected from alkyl- and alkoxy-dimethicone copolyols having the formula (I):
  • X is selected from hydrogen, alkyl, alkoxy and acyl groups having from about 1 to about 16 carbon atoms
  • Y is selected from alkyl and alkoxy groups having from about 8 to about 22 carbon atoms
  • n is from about 0 to about 200
  • m is from about 1 to about 40
  • q is from about 1 to about 100
  • the molecular weight of the residue (C2H4 ⁇ -) x (C3H6 ⁇ -) y X is from about 50 to about 2000, preferably from about 250 to about 1000 and x and y are such that the weight ratio of oxyethylene:oxypropylene is from about 100:0 to about 0:100, preferably from about 100:0 to about 20:80.
  • the dimethicone copolyol is selected from Cj2 to C20 alkyl dimethicone copolyols and mixtures thereof. Highly preferred is cetyl dimethicone copolyol marketed under the Trade Name Abil EM90.
  • the dimethicone copolyol is generally present in a level of from about 0.01 % to about 25%, preferably from about 0.1 % to about 5%, more preferably from about 0.5% to about 1.5% by weight.
  • the denture cleansing compositions also incorporate an effervescence generator which in preferred embodiments takes the form of a solid base material which in the presence of water releases carbon dioxide or oxygen with effervescence.
  • the effervescence generator utilized in the compositions herein can be selected from generators which are effective under acid, neutral or alkaline pH conditions, but preferably it consists of a combination of a generator which is effective or most effective under acid or neutral pH conditions and a generator which is effective or most effective under alkaline pH conditions.
  • Effervescence generators which are effective under acid or neutral pH conditions include a combination of at least one alkali metal carbonate or bicarbonate, such as sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, potassium carbonate, potassium bicarbonate, or mixtures thereof, in admixture with at least one non-toxic, physiologically-acceptable organic acid, such as tartaric, rumaric, citric, malic, maleic, gluconic, succinic, salicylic, adipic or sulphamic acid, sodium fumarate, sodium or potassium acid phosphates, betaine hydrochloride or mixtures thereof.
  • malic acid is preferred.
  • Effervescence generators which are effective under alkaline pH conditions include persalts such as alkali and alkaline earth metal peroxoborates as well as perborates, persulphates, per carbonates, perphosphates and mixtures thereof as previously described, for example, a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) with a monopersulphate such as Caroat R marketed by E I du Point de Nemours Co. and which is a 2:1:1 mixture of monopersulphate, potassium sulphate and potassium bisulphate and which has an active oxygen content of about 4.5%.
  • persalts such as alkali and alkaline earth metal peroxoborates as well as perborates, persulphates, per carbonates, perphosphates and mixtures thereof as previously described, for example, a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) with a monopersulphate such as Caroat R marketed by E I
  • the solid base material incorporates a (bi)carbonate/acid effervescent couple optionally in combination with a perborate/persulphate oxygen effervescence generator.
  • the combination of generators is valuable for achieving optimum dissolution characteristics and pH conditions for achieving optimum cleaning and antimicrobial activity.
  • the (bi)carbonate components generally comprise from about 5% to about 65%, preferably from about 25% to 55% of the total composition; the acid components generally comprise from about 5% to about 50%, preferably from about 10% to about 30% of the total composition.
  • compositions of the invention can be supplemented by other known components of denture cleansing formulations.
  • An especially preferred additional component is an organic peroxyacid precursor, which in general terms can be defined as a compound having a titre of at least 1.5ml of 0.1 N sodium thiosulfate in the following peracid formation test.
  • test solution is prepared by dissolving the following materials in 1000 mis distilled water:
  • the mixture obtained by addition of the activator is vigorously stirred and maintained at 60 °C. After 5 minutes from addition, a 100 ml portion of the solution is withdrawn and immediately pipetted onto a mixture of 250 g cracked ice and 15 ml glacial acetic acid. Potassium iodide (0.4 g) is then added and the liberated iodine is immediately titrated with 0.1 N sodium thiosulphate with starch as indicator until the first disappearance of the blue colour. The amount of sodium thiosulphate solution used in ml is the titre of the bleach activator.
  • the organic peracid precursors are typically compounds containing one or more acyl groups, which are susceptible to perhydrolysis.
  • the preferred activators are those of the N-acyl or O-acyl compound type containing a acyl radical R-CO wherein R is a hydrocarbon or substituted hydrocarbon group having preferably from about 1 to about 20 carbon atoms.
  • suitable peracid precursors include:
  • N,N - diacetylaniline and N-acetylphthalimide a) N,N - diacetylaniline and N-acetylphthalimide; b) N-acylhydantoins, such as
  • N,N' -diacetyl-5,5-dimethylhydantoin c) Polyacylated alkylene di amines, such as N,N,N'N' -tetraacetylethylenediamine (TAED) and the corresponding hexamethylenediamine (TAHD) derivatives, as disclosed in GB-A-907,356, GB-A-907,357 and GB-A- 907,358; d) Acylated glycolurils, such as tetraacetylglycoluril, as disclosed in GB-A-1, 246,338, GB-A-1, 246,339 and GB-A- 1,247,429.
  • TAED N,N,N'N' -tetraacetylethylenediamine
  • TAHD hexamethylenediamine
  • Examples of compounds of this type include phenyl acetate, sodium acetoxy benzene sulphonate, trichloroethylacetate, sorbitol hexaacetate, fructose pentaacetate, p-nitrobenzaldehyde diacetate, isopropeneyl acetate, acetyl aceto hydroxamic acid, and acetyl salicylic acid.
  • esters of a phenol or substituted phenol with an alpha-chlorinated lower aliphatic carboxylic acid such as chloroacetylphenol and chloroacetylsalicylic acid, as disclosed in US-A-3,130,165.
  • Preferred compounds of this type are those wherein: a) Ac is R3-CO and R3 is a linear or branched alkyl group containing from 6 to 20, preferably 6 to 12, more preferably 7 to 9 carbon atoms and wherein the longest linear alkyl chain extending from and including the carbonyl carbon contains from 5 to 18, preferably 5 to 10 carbon atoms, R3 optionally being substituted (preferably alpha to the carbonyl moiety) by Cl, Br, OCH3 or OC2H5.
  • Examples of this class of material include sodium 3,5,5- trimethylhexanoyloxybenzene sulfonate, sodium 3,5,5- trimethylhexanoyloxybenzoate, sodium 2-ethylhexanoyl oxybenzenesulfonate, sodium nonanoyl oxy benzene sulfonate and sodium octanoyl oxybenezenesulfonate, the acyloxy group in each instance preferably being p- substituted;
  • R3(AO) m XA wherein R3 is a linear or branched alkyl or alkylaryl group containing from 6 to 20, preferably from 6 to 15 carbon atoms in the alkyl moiety, R5 being optionally substituted by Cl, Br, OCH3, or OC2H5, AO is oxyethylene or oxypropylene, m is from 0 to 100, X is O, NR4 or CO-NR4, and A is CO, CO-CO, R6-CO, CO-R6-CO, or CO-NR4-R6-CO wherein R4 is Ci- C4 alkyl and R$ is alkylene, alkenylene, arylene or alkarylene containing from 1 to 8 carbon atoms in the alkylene or alkenylene moiety.
  • m is preferably from 0 to 10
  • R3 is preferably C6-C12, more preferably C ⁇ -Cio alkyl when m is zero and C9-C15 when m is non-zero.
  • the leaving group L is as defined above.
  • Optionally substituted anhydrides of benzoic or phthalic acid for example, benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride.
  • the level of peroxyacid bleach precursor by weight of the total composition is preferably from about 0.1 % to about 10%, more preferably from about 0.5% to about 5% and is generally added in the form of a bleach precursor agglomerate.
  • the bleach precursor agglomerates preferred for use herein generally comprise a binder or agglomerating agent in a level of from about 5 % to about 40%, more especially from about 10% to about 30% by weight thereof.
  • Suitable agglomerating agents include polyvinylpyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 500,000, polyethyleneglycols of molecular weight of from about 1000 to about 50,000, Carbowax having a molecular weight of from 4000 to 20,000, nonionic surfactants, fatty acids, sodium carboxymethyl cellulose, gelatin, fatty alcohols, phosphates and polyphosphates, clays, aluminosilicates and polymeric polycarboxylates.
  • polyethyleneglycols are highly preferred, especially those having molecular weight of from about 1 ,000 to about 30,000, preferably 2000 to about 10,000.
  • bleach precursor agglomerates which comprise from about 10% to about 75%, preferably from about 20% to about 60% by weight thereof of peroxyacid bleach precursor, from about 5% to about 60% preferably from about 5% to about 50%, more preferably from about 10% to about 40% of a (bi) carbonate/acid effervescent couple, from about 0% to about 20% of a peroxoboroate, and from about 5% to about 40%, preferably from about 10% to about 30% of an agglomerating agent.
  • the final bleach precursor granules desirably have an average particle size of from about 500 to about 1500, preferably from about 500 to about 1 ,000 urn, this being valuable from the viewpoint of optimum dissolution performance and aesthetics.
  • the level of bleach precursor agglomerates is preferably from about 1 % to about 20%, more preferably from about 5% to about 15% by weight of composition.
  • compositions of the invention can be in paste, liquid, tablet, granular or powder form, although tablet-form compositions are highly preferred herein.
  • Compositions in tablet form can be single or multiple layered tablets.
  • compositions of the invention can be supplemented by other usual components of denture cleansing formulations, especially surfactants, chelating agents, enzymes, flavorants, physiological cooling agents, antimicrobial compounds, dyestuffs, sweeteners, tablet binders and fillers, foam depressants such as dimethylpolysiloxanes, foam stabilizers such as the fatty acid sugar esters, preservatives, lubricants such as talc, magnesium s tear ate, finely divided amorphous pyrogenic silicas, etc.
  • the free moisture content of the final composition is desirably less than about 1 % and especially less than about 0.5%.
  • Tablet binders and fillers suitable for use herein include polyvinylpyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 500,000, polyethyleneglycols of molecular weight of from about 1000 to about 50,000, Carbowax having a molecular weight of from 4000 to 20,000, nonionic surfactants, fatty acids, sodium carboxymethyl cellulose, gelatin, fatty alcohols, clays, polymeric polycarboxylates, sodium carbonate, calcium carbonate, calcium hydroxide, magnesium oxide, magnesium hydroxide carbonate, sodium sulfate, proteins, cellulose ethers, cellulose esters, poly vinyl alcohol, alginic acid esters, vegetable fatty materials of a pseudocolloidal character.
  • polyethyleneglycols are highly preferred, especially those having molecular weight of from about 1 ,000 to about 30,000, preferably from about 12,000 to about 30,000.
  • the surface active agent used in the compositions of the invention can be selected from the many available that are compatible with the other ingredients of the denture cleanser, both in the dry state and in solution. Such materials are believed to improve the effectiveness of the other ingredients of the composition by aiding their penetration into the interdental surfaces. Also, these materials aid in the removal of food debris attached to the teeth.
  • a dry powder or granular anionic surface active agent such as sodium lauryl sulfate, sodium N- lauroylsarcosinate, sodium lauryl sulfoacetate or dioctyl sodium sulfosuccinate or ricinoleyl sodium sulfosuccinate, may, for example, be included in the composition and preferably the surface active agent comprises between 0.5 and 4 percent of the composition.
  • Suitable cationic, non-ionic and ampholytic surface active agents include, for example, quaternary ammonium compounds such as cetyltrimethylammonium bromide, condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amines or fatty acid alkanol amides, the fatty acid alkanolamides themselves, esters of long-chained (Cg-C22) fa ty acids with polyalcohols or sugars, for example glycerylmonostearate or saccharosemonolaurate or sorbitolpolyoxyethylenemono-or di-stearate, betaines, sulphobetaines or long-chain alkylaminocarboxylic acids.
  • quaternary ammonium compounds such as cetyltrimethylammonium bromide
  • condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amine
  • Chelating agents beneficially aid cleaning and bleach stability by keeping metal ions, such as calcium, magnesium, and heavy metal cations in solution.
  • suitable chelating agents include sodium tripoly phosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, aminopolycarboxylates such as nitrilotriacetic acid and ethylenediamine tetracetic acid and salts thereof, and polyphosphonates and aminopolyphosphonates such as hydroxyethanediphosphonic acid, ethylenediamine tetramethylenephosphonic acid, diethylenetriaminepentamethylenephosphonic acid and salts thereof.
  • the chelating agent selected is not critical except that it must be compatible with the other ingredients of the denture cleanser when in the dry state and in aqueous solution.
  • the chelating agent comprises between 0.1 and 60 percent by weight of the composition and preferably between 0.5 and 30 percent.
  • Phosphonic acid chelating agents preferably comprise from about 0.1 to about 1 percent, preferably from about 0.1% to about 0.5% by weight of composition.
  • Enzymes suitable for use herein are exemplified by proteases, alkalases, amylases, lipases, dextranases, mutanases, glucanases etc.
  • Flavorants suitable for use in the compositions of the invention include wintergreen oil, oregano oil, bay leaf oil, peppermint oil, spearmint oil, clove oil, sage oil, sassafras oil, lemon oil, orange oil, anise oil, benzaldehyde, bitter almond oil, camphor, cedar leaf oil, marjoram oil, citronella oil, lavendar oil, mustard oil, pine oil, pine needle oil, rosemary oil, thyme oil, cinnamon leaf oil, and mixtures thereof.
  • Suitable antimicrobial compounds include thymol, menthol, triclosan, 4-hexylresorcinol, phenol, eucalyptol, benzoic acid, benzoyl peroxide, butyl paraben, methyl paraben, propyl paraben, salicylamides, and mixtures thereof.
  • the following are representative denture cleansing tablets according to the invention.
  • the percentages are by weight of the total tablet.
  • the tablets are made by compressing a mixture of the granulated components in a punch and dye tabletting press at a pressure of about 10*5 kPa.
  • the overall tablet weight is 3 g; diameter 25 mm.
  • the denture cleansing tablets of Examples I to V display improved antiplaque efficacy together with excellent cleansing and anti-bacterial activity, cohesion and other physical and in-use performance characteristics.

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Abstract

Composition pour le nettoyage des appareils dentaires contenant un agent de blanchiment à base de persel inorganique, un effervescent et un copolyol de diméthicone choisi parmi des copolyols d'alkyl- et d'alcoxy-diméthicone de formule (I): (I) X étant choisi parmi hydrogène et des groupes alkyle, alcoxy et acyle à 1 à 16 atomes de carbone environ; Y étant choisi parmi des groupes alkyle et alcoxy à 8 à 22 atomes de carbone environ; n étant compris entre 0 et 200 environ, m entre 1 et 40 environ et q entre 1 et 100 environ; la masse moléculaire du résidu (C2H4O-)x(C3H6O-)yX se situant entre 50 et 2 000 environ; et x et y étant tels que le rapport pondéral oxyéthylène/oxypropylène soit compris entre 100 à 0 et 0 à 100 environ. La composition possède des propriétés antitartre, nettoyantes et bactéricides améliorées, de très bonnes caractéristiques physiques et d'excellentes performances d'utilisation.
PCT/US1995/016673 1994-12-22 1995-12-13 Compositions detergentes comprenant du copolyol de dimethicone WO1996019563A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PL95320862A PL320862A1 (en) 1994-12-22 1995-12-13 Detergent composition containing dimeticone copolyol
CZ971904A CZ190497A3 (en) 1994-12-22 1995-12-13 Detergents containing dimethicones with polyether chains
AU46871/96A AU700174B2 (en) 1994-12-22 1995-12-13 Detergent composition comprising a dimethicone copolyol
JP8519992A JPH11500471A (ja) 1995-12-13 1995-12-13 ジメチコーンコポリオールを含む洗浄組成物
US08/849,984 US5759523A (en) 1994-12-22 1995-12-13 Detergent compositions comprising a dimethicone copolyol
KR1019970704209A KR100209998B1 (ko) 1994-12-22 1995-12-13 디메티콘 코폴리올을 함유하는 세정제 조성물
SK826-97A SK82697A3 (en) 1994-12-22 1995-12-13 Detergent compositions comprising dimethicones with polyether chains
BR9510470A BR9510470A (pt) 1994-12-22 1995-12-13 Composição detergente contendo um copoliol de dimeticone
MXPA/A/1997/004665A MXPA97004665A (en) 1994-12-22 1995-12-13 Detergent composition comprising a dimetic copoliolde
CA002206489A CA2206489C (fr) 1994-12-22 1995-12-13 Compositions detergentes comprenant du copolyol de dimethicone
EP95944509A EP0799301A4 (fr) 1994-12-22 1995-12-13 Compositions detergentes comprenant du copolyol de dimethicone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9425931.4A GB9425931D0 (en) 1994-12-22 1994-12-22 Cleansing compositions
GB9425931.4 1994-12-22

Publications (1)

Publication Number Publication Date
WO1996019563A1 true WO1996019563A1 (fr) 1996-06-27

Family

ID=10766386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/016673 WO1996019563A1 (fr) 1994-12-22 1995-12-13 Compositions detergentes comprenant du copolyol de dimethicone

Country Status (13)

Country Link
EP (1) EP0799301A4 (fr)
CN (1) CN1170432A (fr)
AU (1) AU700174B2 (fr)
BR (1) BR9510470A (fr)
CA (1) CA2206489C (fr)
CZ (1) CZ190497A3 (fr)
GB (1) GB9425931D0 (fr)
HU (1) HUT77707A (fr)
PL (1) PL320862A1 (fr)
RU (1) RU2163479C2 (fr)
SK (1) SK82697A3 (fr)
TR (1) TR199501665A2 (fr)
WO (1) WO1996019563A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031298A1 (fr) 1997-01-16 1998-07-23 The Procter & Gamble Company Procede pour le traitement des protheses dentaires
EP0948590A1 (fr) * 1996-11-01 1999-10-13 The Procter & Gamble Company Compositions de nettoyage
EP0970173A1 (fr) * 1996-11-01 2000-01-12 The Procter & Gamble Company Compositions de blanchiment effervescentes
WO2000074590A1 (fr) 1999-06-07 2000-12-14 The Procter & Gamble Company Appareil pour nettoyage de prothese dentaire
US6294154B1 (en) 1994-12-22 2001-09-25 Procter And Gamble Company Oral compositions containing dimethicone copolyols
US6685921B2 (en) 2000-10-25 2004-02-03 The Procter & Gamble Company Dental care compositions
WO2004073661A1 (fr) * 2003-02-20 2004-09-02 The Procter & Gamble Company Compositions antiplaque adherant a la prothese dentaire
EP2762868A1 (fr) 2013-01-31 2014-08-06 Sensirion Holding AG Détecteur de gaz à oxyde métallique basé sur la diffusion
EP2762882A1 (fr) 2013-01-31 2014-08-06 Sensirion Holding AG Dispositif électronique portable avec capteur de cétone
EP2762864A1 (fr) 2013-01-31 2014-08-06 Sensirion AG Dispositif de capteur à membrane et son procédé de fabrication
EP2801819A1 (fr) 2013-05-08 2014-11-12 Sensirion AG Capteur chimique d'oxyde métallique pour dispositif portable
EP2808675A1 (fr) 2013-05-31 2014-12-03 Sensirion AG Capteur chimique d'oxyde métallique intégré

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607759A (en) * 1969-04-17 1971-09-21 Colgate Palmolive Co Denture soak tablet
US4155868A (en) * 1975-12-22 1979-05-22 Johnson & Johnson Enzyme and active oxygen containing denture cleanser tablet
US5055305A (en) * 1988-12-02 1991-10-08 Richardson-Vicks, Inc. Cleansing compositions
US5310563A (en) * 1991-10-25 1994-05-10 Colgate-Palmolive Company Dental material and method for applying preventative and therapeutic agents
US5403578A (en) * 1994-02-08 1995-04-04 Gordon; Norman Stable tooth and gum dentifrice with microencapsulation and method for making same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2158943A1 (de) * 1970-12-03 1972-06-29 Scherico Ltd., Luzern (Schweiz) Moussierende Zubereitungen
US4115293A (en) * 1975-10-06 1978-09-19 E. I. Du Pont De Nemours And Company Denture cleanser
JPS5756434A (en) * 1980-09-22 1982-04-05 Kao Corp Stabilized foamable composition
US4409118A (en) * 1981-04-03 1983-10-11 Warner-Lambert Company Tablet forming cleanser composition and method of preparation
US4518520A (en) * 1983-04-22 1985-05-21 Warner-Lambert Company Cleaner having improved dissolution time and clarity and improved of preparation
US5290555A (en) * 1989-09-14 1994-03-01 Revlon Consumer Products Corporation Cosmetic compositions with structural color

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607759A (en) * 1969-04-17 1971-09-21 Colgate Palmolive Co Denture soak tablet
US4155868A (en) * 1975-12-22 1979-05-22 Johnson & Johnson Enzyme and active oxygen containing denture cleanser tablet
US5055305A (en) * 1988-12-02 1991-10-08 Richardson-Vicks, Inc. Cleansing compositions
US5310563A (en) * 1991-10-25 1994-05-10 Colgate-Palmolive Company Dental material and method for applying preventative and therapeutic agents
US5403578A (en) * 1994-02-08 1995-04-04 Gordon; Norman Stable tooth and gum dentifrice with microencapsulation and method for making same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0799301A4 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294154B1 (en) 1994-12-22 2001-09-25 Procter And Gamble Company Oral compositions containing dimethicone copolyols
EP0948590A1 (fr) * 1996-11-01 1999-10-13 The Procter & Gamble Company Compositions de nettoyage
EP0970173A1 (fr) * 1996-11-01 2000-01-12 The Procter & Gamble Company Compositions de blanchiment effervescentes
EP0970173A4 (fr) * 1996-11-01 2000-07-12 Procter & Gamble Compositions de blanchiment effervescentes
EP0948590A4 (fr) * 1996-11-01 2000-07-26 Procter & Gamble Compositions de nettoyage
EP0991371A4 (fr) * 1997-01-16 2004-12-01 Procter & Gamble Procede pour le traitement des protheses dentaires
EP0991371A1 (fr) * 1997-01-16 2000-04-12 The Procter & Gamble Company Procede pour le traitement des protheses dentaires
WO1998031298A1 (fr) 1997-01-16 1998-07-23 The Procter & Gamble Company Procede pour le traitement des protheses dentaires
WO2000074590A1 (fr) 1999-06-07 2000-12-14 The Procter & Gamble Company Appareil pour nettoyage de prothese dentaire
US6685921B2 (en) 2000-10-25 2004-02-03 The Procter & Gamble Company Dental care compositions
WO2004073661A1 (fr) * 2003-02-20 2004-09-02 The Procter & Gamble Company Compositions antiplaque adherant a la prothese dentaire
EP2762868A1 (fr) 2013-01-31 2014-08-06 Sensirion Holding AG Détecteur de gaz à oxyde métallique basé sur la diffusion
EP2762882A1 (fr) 2013-01-31 2014-08-06 Sensirion Holding AG Dispositif électronique portable avec capteur de cétone
EP2762864A1 (fr) 2013-01-31 2014-08-06 Sensirion AG Dispositif de capteur à membrane et son procédé de fabrication
EP2801819A1 (fr) 2013-05-08 2014-11-12 Sensirion AG Capteur chimique d'oxyde métallique pour dispositif portable
EP2808675A1 (fr) 2013-05-31 2014-12-03 Sensirion AG Capteur chimique d'oxyde métallique intégré

Also Published As

Publication number Publication date
SK82697A3 (en) 1998-02-04
HUT77707A (hu) 1998-07-28
AU700174B2 (en) 1998-12-24
TR199501665A3 (fr) 1996-07-21
AU4687196A (en) 1996-07-10
BR9510470A (pt) 1998-05-26
CN1170432A (zh) 1998-01-14
EP0799301A4 (fr) 1999-08-18
TR199501665A2 (tr) 1996-07-21
EP0799301A1 (fr) 1997-10-08
PL320862A1 (en) 1997-11-10
CA2206489A1 (fr) 1996-06-27
GB9425931D0 (en) 1995-02-22
MX9704665A (es) 1997-09-30
CA2206489C (fr) 2001-03-27
RU2163479C2 (ru) 2001-02-27
CZ190497A3 (en) 1997-11-12

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