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WO1994026246A1 - Comprime de nettoyage d'appareils dentaires contenant des particules de precurseurs de blanchiment agglomerees discretes - Google Patents

Comprime de nettoyage d'appareils dentaires contenant des particules de precurseurs de blanchiment agglomerees discretes Download PDF

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Publication number
WO1994026246A1
WO1994026246A1 PCT/US1994/005129 US9405129W WO9426246A1 WO 1994026246 A1 WO1994026246 A1 WO 1994026246A1 US 9405129 W US9405129 W US 9405129W WO 9426246 A1 WO9426246 A1 WO 9426246A1
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WO
WIPO (PCT)
Prior art keywords
cleansing tablet
acid
bleach precursor
tablet according
alkali metal
Prior art date
Application number
PCT/US1994/005129
Other languages
English (en)
Inventor
Saruhan Yurdakul
Nicholas Cummins
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to CA002162667A priority Critical patent/CA2162667C/fr
Priority to JP6525618A priority patent/JPH08510248A/ja
Priority to EP94917938A priority patent/EP0707470A4/fr
Publication of WO1994026246A1 publication Critical patent/WO1994026246A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets
    • C11D17/0065—Solid detergents containing builders
    • C11D17/0073—Tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent

Definitions

  • the present invention relates to cleansing compositions in tablet form, and especially to compositions for use in cleansing dentures and the like.
  • the invention relates to tablet-form compositions having more rapid and useful denture cleansing performance and anti-bacterial activity and improved appearance, physical characteristics, dissolution and in-use performance characteristics.
  • Effervescent tablets for cleansing dentures and the like are well known in the art.
  • the aim of a denture cleanser product is to clean the denture as fully and as quickly as possible and especially to remove the accumulation of plaque, mucilaginous and bacterial deposits which collect while the denture is being worn.
  • To wear a denture which has not been completely cleaned of plaque and bacterial deposits is not only unhygenic but can also within a short space of time result in a detrimental effect on the mucous membrane.
  • bacterial deposits can lead to so-called bacterial corrosion of the plastics material used to produce the denture with consequent color-change and malodor-formation.
  • Denture cleanser tablets containing peroxyacid bleach precursors as a separate tablet layer are also known; however such formulations are difficult to manufacture and suffer from poor coherency and other physical characteristics due, at least in part, to the inherent incompressibility of the bleach activator particles.
  • the present invention provides a denture cleanser which cleanses more rapidly and which is more efficacious on plaque, mucilaginous and bacterial deposits and has greater stain-removal performance than those tablet preparations which are presently known and available on the market.
  • the tablet compositions display excellent cohesion and other physical characteristics as well as improved dissolution and in-use performance characteristics.
  • a cleansing tablet for dentures and the like comprising visually discrete agglomerated particles of an organic peroxyacid bleach precursor dispersed in a water-soluble or water- dispersible matrix comprising an inorganic persalt bleaching agent and a solid base material which in the presence of water releases carbon dioxide or oxygen with effervescence
  • the cleansing tablets of the invention thus comprise three essential components, a bleaching agent, a peroxyacid bleach precursor and an effervescent base composition. Each of these will be discussed in turn.
  • the bleaching agent takes the form of an inorganic persalt and can be selected from any of the well-known bleaching agents known for use in denture cleansers such as the alkali metal and ammonium persulfates, perborates, percarbonates and perphosphates and the alkali metal and alkaline earth metal peroxides.
  • suitable bleaching agents include potassium, ammonium, sodium and lithium persulfates and perborate mono- and tetrahydrates, sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides.
  • the alkali metal persulfates, perborates and mixtures thereof are prefered for use herein, highly preferred being the alkali metal perborates. Indeed, it is a feature of the invention that the tablet compositions herein will provide excellent antimicrobial activity even in the absence of alkali metal persulfates.
  • the amount of bleaching agent in the total composition is generally from about 5 to about 70% preferably from about 10% to about 50%.
  • the overall persulfate:perborate ratio is suitably from about 5: 1 to about 1 :5, more especially from about 2: 1 to about 1 :2.
  • compositions herein also contain an organic peroxyacid precursor, which in general terms can be defined as a compound having a titre of at least 1.5ml of 0. IN sodium thiosulfate in the following peracid formation test
  • test solution is prepared by dissolving the following materials in 1000 mis distilled water: sodium pyrophosphate
  • the mixture obtained by addition of the activator is vigorously stirred and maintained at 60°C. After 5 minutes from addition, a 100 ml portion of the solution is withdrawn and immediately pipetted onto a mixture of 250 g cracked ice and 15 ml glacial acetic acid. Potassium iodide (0.4 g) is then added and the liberated iodine is immediately titrated with 0.1 N sodium thiosulphate with starch as indicator until the first disappearance of the blue colour. The amount of sodium thiosulphate solution used in ml is the titre of the bleach activator.
  • the organic peracid precursors are typically compounds containing one or more acyl groups, which are susceptible to perhydrolysis.
  • the preferred activators are those of the N-acyl or O-acyl compound type containing a acyl radical R-CO wherein R is a hydrocarbon or substituted hydrocarbon group having preferably from about 1 to about 20 carbon atoms.
  • suitable peracid precursors include: 1) Acyl organoamides of the formula RCONR1R2, where RCO is carboxylic acyl radical, R] is an acyl radical and R2 is an organic radical, as disclosed in US-A-3,117,148. Examples of compounds falling under this group include:
  • N,N - diacetylaniline and N-acetylphthalimide a) N,N - diacetylaniline and N-acetylphthalimide; b) N-acylhydantoins, such as
  • Examples of compounds of this type include phenyl acetate, sodium acetoxy benzene sulphonate, trichloroethylacetate, sorbitol hexaacetate, fructose pentaacetate, p-nitrobenzaldehyde diacetate, isopropeneyl acetate, acetyl aceto hydroxamic acid, and acetyl salicylic acid
  • esters of a phenol or substituted phenol with an alpha-chlorinated lower aliphatic carboxylic acid such as chloroacetylphenol and chloroacetylsalicylic acid, as disclosed in US-A- 3,130,165
  • a) Ac is R3-CO and R3 is a linear or branched alkyl group containing from 6 to 20, preferably 6 to 12, more preferably 7 to 9 carbon atoms and wherein the longest linear alkyl chain extending from and including the carbonyl carbon contains from 5 to 18, preferably 5 to 10 carbon atoms, R3 optionally being substituted (preferably alpha to * the carbonyl moiety) by Cl, Br, OCH3 or OC2H5
  • this class of material include sodium 3,5,5-trimethylhexanoyloxybenzene sulfonate, sodium 3,5,5-trimethylhexanoyloxybenzoate, sodium 2- ethylhexanoyl oxybenzenesulfonate, sodium nonanoyl oxybenzene sulfonate and sodium octanoyl oxybenezenesulfonate, the acyloxy group in each instance preferably being p-substituted.
  • R3(AO) m XA wherein R3 is a linear or branched alkyl or alkylaryl group containing from 6 to 20, preferably from 6 to 15 carbon atoms in the alkyl moiety, R5 being optionally substituted by Cl, Br, OCH3, or OC2H5, AO is oxyethylene or oxypropylene, m is from 0 to 100, X is O, NR4 or CO-NR4, and A is CO, CO-CO, Rg-CO, CO-R ⁇ -CO, or CO-NR ⁇ R ⁇ -CO wherein R4 is C j -C alkyl and R_6 is alkylene, alkenylene, arylene or alkarylene containing from 1 to 8 carbon atoms in the alkylene or alkenylene moiety Bleach activator compounds of this type include carbonic acid derivatives of the formula R3(AO) m OCOL, succinic acid derivatives of the formula R3OCO(CH2)2COL, glycollicorone
  • m is preferably from 0 to 10
  • R3 is preferably Cg-C ⁇ , more preferably Cg-Cjo alkyl when m is zero and C9-C15 when m is non ⁇ zero.
  • the leaving group L is as defined above.
  • Optionally substituted anhydrides of benzoic or phthalic acid for example, benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride
  • organic peracid precursors of types 1 (c) and 4(a) are preferred.
  • the level of peroxyacid bleach precursor by weight of the total composition is preferably from about 0.1% to about 10%, more preferably from about 0.5% to about 5%.
  • the solid base material and, in preferred embodiments, the bleach precursor agglomerates also incorporate an effervescence generator
  • the effervescence generator utilized in the compositions herein can be selected from generators which are effective under acid, neutral or alkaline pH conditions, but preferably it consists of a combination of a generator which is effective or most effective under acid or neutral pH conditions and a generator which is effective or most effective under alkaline pH conditions.
  • Effervescence generators which are effective under acid or neutral pH conditions include a combination of at least one alkali metal carbonate or bicarbonate, such as sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, potassium carbonate, potassium bicarbonate, or mixtures thereof, in admixture with at least one non-toxic, physiologically- acceptable organic acid, such as tartaric, fumaric, citric, malic, maleic, gluconic, succinic, salicylic, adipic or sulphamic acid, sodium fumarate, sodium or potassium acid phosphates, betaine hydrochloride or mixtures thereof Of these, malic acid is preferred.
  • alkali metal carbonate or bicarbonate such as sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, potassium carbonate, potassium bicarbonate, or mixtures thereof
  • at least one non-toxic, physiologically- acceptable organic acid such as tartaric, fumaric, citric, malic, maleic, gluconic, succinic, salicylic, adip
  • Effervescence generators which are effective under alkaline pH conditions include persalts such as alkali and alkaline earth metal peroxoborates as well as perborates, persulphates, percarbonates, perphosphates and mixtures thereof as previously described, for example, a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) with a monopersulphate such as Caroat R marketed by E I du Point de Nemours Co. and which is a 2 1 1 mixture of monopersulphate, potassium sulphate and potassium bisulphate and which has an active oxygen content of about 4.5%.
  • persalts such as alkali and alkaline earth metal peroxoborates as well as perborates, persulphates, percarbonates, perphosphates and mixtures thereof as previously described, for example, a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) with a monopersulphate such as Caroat R marketed by E I
  • the solid base material incorporates both a (bi) carbonate/acid effervescent couple and a perborate/persulphate oxygen effervescence generator while the bleach precursor agglomerates incorporates a (bi) carbonate/acid and optionally a peroxoborate oxygen effervescence generator
  • the combination of generators is important for achieving optimum dissolution characteristics and pH conditions for generation of the peroxyacid bleach and for achieving optimum cleaning and antimicrobial activity
  • the (bi) carbonate components generally comprise from about 5% to about 65%, preferably from about 25% to 55% of the total tablet; the acid components generally comprise from about 5% to about 50%, preferably from about 10% to about 30% of the total tablet
  • the inorganic bleaching agent comprises an alkali metal perborate and the solid base material comprises at least one component phase having an acid or neutral pH in aqueous medium, said at least one phase having incorporated therein at least a portion of the alkali metal perborate.
  • the cleansing composition of this embodiment is preferably designed in such a way that the bleach precursor agglomerates dissolve or disperse in water more slowly or later than the acid or neutral phase in order to provide, on placing the cleaning composition in water, an initial pH in the acid or neutral range, preferably from about 2 to about 7.5 and especially from about 5 to about 7 Moreover, it is preferred that the bleach precursor agglomerates have an alkaline pH in aqueous medium and be present in sufficient amount in order to shift, upon completion of effervescence, the pH of the aqueious medium into the alkaline range, preferably to a pH of from about 8 to about 10, this pH being preferred for reasons of cleaning performance and solution clarity.
  • the initial acid or neutral pH should be maintained for a time from about 30 seconds to about 5 minutes, preferably from about 1 minute to about 3 minutes. Effervescence is preferably completed in from about 30 seconds to about 4 minutes, preferably from about 1 to about 3 minutes of the pH being shifted into the alkaline range.
  • the slower dissolution rate of the bleach precursor agglomerates compared with the tablet matrix base material can be achieved in various ways, for example by the use of alkaline salts or compounds which are inherently sparingly or slowly soluble such as anhydrous sodium carbonate, calcium carbonate, calcium hydroxide, magnesium oxide, or magnesium hydroxide carbonate or by mixing or compressing the bleach precursor agglomerate components with a filler which has a slow dissolution rate such as anhydrous sodium sulfate and slowly water-soluble polymers, for example, proteins, cellulose ethers, cellulose esters, polyvinyl alcohol, alginic acid esters, vegetable fatty materials of a pseudocolloidal character.
  • the relative rate of dissolution of the bleach precursor agglomerates and tablet matrix can be additionally controlled by appropriate formulation- and distribution of the binding/agglomerating and effervescent components of the solid base material and bleach precursor agglomerates.
  • the inorganic bleaching agent comprises an alkali metal perborate and the solid base material comprising at least one component phase having an alkaline pH in aqueous medium, said at least one phase having incorporated therein at least a portion of the alkali metal perborate
  • the bleach precursor agglomerates in this embodiment preferably have an acidic or neutral pH in aqueous medium and additionally incorporate an agglomerating agent and a effervescence generator.
  • the bleach precursor agglomerates and the solid base material preferably have a pH difference in aqueous medium of from about 0.5 to about 2 pH units.
  • the level of bleach precursor agglomerates is preferably from about 1% to about 20%, more preferably from about 5% to about 15% by weight of the cleansing tablet
  • the bleach precursor agglomerates preferred for use herein generally comprise a binder or agglomerating agent in a level of from about 5% to about 40%, more especially from about 10% to about 30% by weight thereof
  • Suitable agglomerating agents include polyvinylpyrrolidone, poly (oxyethylene) of molecular weight 20,000 to 500,000, polyethyleneglycols of molecular weight of from about 1000 to about 50,000, Carbowax having a molecular weight of from 4000 to 20,000, nonionic surfactants, fatty acids, sodium carboxymethyl cellulose, gelatin, fatty alcohols, phosphates and polyphosphates, clays, aluminosilicates and polymeric polycarboxylates.
  • polyethyleneglycols are highly preferred, especially those having molecular weight of from about 1,000 to about 30,000, preferably 2000 to about 10,000.
  • bleach precursor agglomerates which comprise from about 10% to about 75%, preferably from about 20% to about 60% by weight thereof of peroxyacid bleach precursor, from about 5% to about 60% preferably from about 5% to about 50%, more preferably from about 10% to about 40% of a (bi) carbonate/acid effervescent couple, from about 0% to about 20% of a peroxoboroate, and from about 5% to about 40%, preferably from about 10% to about 30% of an agglomerating agent.
  • the final bleach precursor granules desirably have an average particle size of from about 500 to about 1500, preferably from about 500 to about 1,000 um, this being valuable from the viewpoint of optimum dissolution performance and aesthetics.
  • compositions of the invention can be supplemented by other usual components of cleansing table formulations, especially surfactants, chelating agents, enzymes, flavor oils such as oils of spearmint, peppermint and wintergreen.
  • dyestuffs, sweeteners, tablet binders such as the above specified bleach precursor agglomerating agents, especially polyethyleneglycols having a molecular weight of from about 12,000 to about 30,000, foam depressants such as dimethylpolysiloxanes, foam stabilizers such as the fatty acid sugar esters, preservatives, lubricants such as talc, magnesium stearate, finely divided amorphous pyrogenic silicas, etc.
  • the free moisture content of the final composition is desirably less than about 1% and especially less than about 0.5%.
  • the surface active agent used in the compositions of the invention can be selected from the many available that are compatible with the other ingredients of the denture cleanser, both in the dry state and in solution. Such materials are believed to improve the effectiveness of the other ingredients of the composition by aiding their penetration into the interdental surfaces. Also, these materials aid in the removal of food debris attached to the teeth.
  • a dry powder or granular anionic surface active agent such as sodium lauryl sulfate, sodium N-lauroylsarcosinate, sodium lauryl sulfoacetate or dioctyl sodium sulfosuccinate or ricinoleyl sodium sulfosuccinate, may, for example, be included in the composition and preferably the surface active agent comprises between 0.5 and 4 percent of the composition.
  • Suitable cationic, non-ionic and ampholytic surface active agents include, for example, quaternary ammonium compounds such as cetyltrimethylammonium bromide, condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amines or fatty acid alkanolamides, the fatty acid alkanolamides themselves, esters of long-chained (C -C22) fatty acids with polyalcohols or sugars, for example glycerylmonostearate or saccharosemonolaurate or sorbitolpolyoxyethylenemono-or di-stearate, betaines, sulphobetaines or long-chain alkylaminocarboxylic acids.
  • quaternary ammonium compounds such as cetyltrimethylammonium bromide
  • condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amines or fatty acid
  • Chelating agents beneficially aid cleaning and bleach stability by keeping metal ions, such as calcium, magnesium, and heavy metal cations in solution.
  • suitable chelating agents include sodium tripolyphosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, aminopolycarboxylates such as nitrilotriacetic acid and ethylenediamine tetracetic acid and salts thereof, and polyphosphonates and aminopolyphosphonates such as hydroxyethanediphosphonic acid, ethylenediamine tetramethylenephosphonic acid, diethylenetriaminepentamethylenephosphonic acid and salts thereof.
  • the chelating 10 includes sodium tripolyphosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, aminopolycarboxylates such as nitrilotriacetic acid and ethylenediamine tetracetic acid and salts thereof, and polyphosphonates and aminopolyphosphonates such as hydroxyethaned
  • the chelating agent selected is not critical except that it must be compatible with the other ingredients of the denture cleanser when in the dry state and in aqueous solution.
  • the chelating agent comprises between 0.1 and 60 percent by weight of the composition and preferably between 0.5 and 30 percent.
  • Phosphonic acid chelating agents preferably comprise from about 0. 1 to about 1 percent, preferably from about 0.1% to about 0.5% by weight of composition.
  • Enzymes suitable for use herein are exemplified by proteases, alkalases, amylases, lipases, dextranases, mutanases, glucanases etc.
  • the following are representative denture cleansing tablets according to the invention.
  • the percentages are by weight of the total tablet.
  • the tablets are made by compressing a mixture of the granulated components in a punch and dye tabletting press at a pressure of about 10* kPa.

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Abstract

L'invention concerne des comprimés de nettoyage d'appareils dentaires contenant des particules agglomérées apparamment discrètes, de précurseur de blanchiment au peroxyacide organique dispersées dans une matrice soluble ou dispersable dans l'eau contenant un agent de blanchiment au persel inorganique et une matière de base solide dégageant au contact de l'eau, par effervescence, de l'oxyde de carbone ou de l'oxygène. Ladite composition présente une activité nettoyante et antibactérienne ainsi que d'excellentes caractéristiques physiques et de performance d'utilisation.
PCT/US1994/005129 1993-05-15 1994-05-09 Comprime de nettoyage d'appareils dentaires contenant des particules de precurseurs de blanchiment agglomerees discretes WO1994026246A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002162667A CA2162667C (fr) 1993-05-15 1994-05-09 Comprime de nettoyage de prothese dentaire contenant des particules grenues et agglomerees de precurseur de blanchiment
JP6525618A JPH08510248A (ja) 1993-05-15 1994-05-09 個別的凝集状ブリーチ前駆物質粒子を含有した義歯クレンジング錠剤
EP94917938A EP0707470A4 (fr) 1993-05-15 1994-05-09 Comprime de nettoyage d'appareils dentaires contenant des particules de precurseurs de blanchiment agglomerees discretes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939310054A GB9310054D0 (en) 1993-05-15 1993-05-15 Cleansing compositions
GB9310054.3 1993-05-15

Publications (1)

Publication Number Publication Date
WO1994026246A1 true WO1994026246A1 (fr) 1994-11-24

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EP (1) EP0707470A4 (fr)
JP (1) JPH08510248A (fr)
CA (1) CA2162667C (fr)
GB (1) GB9310054D0 (fr)
WO (1) WO1994026246A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2309705A (en) * 1996-01-30 1997-08-06 Kukident Gmbh Denture cleansing tablets containing percarbonate and organic peroxyacid bleach precursor
EP0787481A1 (fr) * 1996-01-30 1997-08-06 Kukident GmbH Composition et comprimés pour le nettoyage des dentiers
DE19705930A1 (de) * 1997-02-17 1998-08-20 Kukident Gmbh Gebißreinigungszusammensetzung
EP1009799A4 (fr) * 1997-08-05 2001-04-25 Coltene Whaledent Inc Comprime pour le nettoyage des dents par ultrasons
JP3332752B2 (ja) 1996-10-08 2002-10-07 花王株式会社 義歯洗浄剤組成物
JP3332833B2 (ja) 1997-12-15 2002-10-07 花王株式会社 義歯洗浄剤組成物
WO2009017748A1 (fr) * 2007-07-30 2009-02-05 Milliken & Company Composition solide de nettoyage et procédé d'utilisation

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
JP2003113057A (ja) * 2001-10-05 2003-04-18 Shiseido Co Ltd 脱色用固形組成物
JP2021104964A (ja) * 2019-12-26 2021-07-26 ライオン株式会社 義歯洗浄剤組成物及び義歯洗浄方法
WO2024204221A1 (fr) * 2023-03-27 2024-10-03 株式会社大阪製薬 Préparation de nettoyage solide

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252664A (en) * 1978-10-30 1981-02-24 Colgate-Palmolive Company Effervescent granules
US4422950A (en) * 1980-12-09 1983-12-27 Lever Brothers Company Bleach activator granules and preparation thereof
EP0400858A2 (fr) * 1989-05-27 1990-12-05 The Procter & Gamble Company Composition de nettoyage
US5055305A (en) * 1988-12-02 1991-10-08 Richardson-Vicks, Inc. Cleansing compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7538387A (en) * 1986-07-15 1988-01-21 Warner-Lambert Company Bleach activator compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252664A (en) * 1978-10-30 1981-02-24 Colgate-Palmolive Company Effervescent granules
US4422950A (en) * 1980-12-09 1983-12-27 Lever Brothers Company Bleach activator granules and preparation thereof
US5055305A (en) * 1988-12-02 1991-10-08 Richardson-Vicks, Inc. Cleansing compositions
EP0400858A2 (fr) * 1989-05-27 1990-12-05 The Procter & Gamble Company Composition de nettoyage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0707470A4 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2309705B (en) * 1996-01-30 1999-09-08 Kukident Gmbh Denture cleansing
GB2309705A (en) * 1996-01-30 1997-08-06 Kukident Gmbh Denture cleansing tablets containing percarbonate and organic peroxyacid bleach precursor
EP0787481A1 (fr) * 1996-01-30 1997-08-06 Kukident GmbH Composition et comprimés pour le nettoyage des dentiers
GB2309704A (en) * 1996-01-30 1997-08-06 Kukident Gmbh Denture cleansing tablets containing particulate enzyme and inorganic persalt bleaching agent
AU714214B2 (en) * 1996-01-30 1999-12-23 Kukident Gmbh Denture cleaning
AU706126B2 (en) * 1996-01-30 1999-06-10 Kukident Gmbh Denture cleansing
GB2309704B (en) * 1996-01-30 2000-03-15 Kukident Gmbh Denture cleansing
EP0787482A1 (fr) * 1996-01-30 1997-08-06 Kukident GmbH Compositions pour le nettoyage des dentiers contenant des composés per
JP3332752B2 (ja) 1996-10-08 2002-10-07 花王株式会社 義歯洗浄剤組成物
US6300295B1 (en) 1997-02-17 2001-10-09 Kukident Gmbh Denture cleansing composition
DE19705930A1 (de) * 1997-02-17 1998-08-20 Kukident Gmbh Gebißreinigungszusammensetzung
EP1009799A4 (fr) * 1997-08-05 2001-04-25 Coltene Whaledent Inc Comprime pour le nettoyage des dents par ultrasons
JP3332833B2 (ja) 1997-12-15 2002-10-07 花王株式会社 義歯洗浄剤組成物
WO2009017748A1 (fr) * 2007-07-30 2009-02-05 Milliken & Company Composition solide de nettoyage et procédé d'utilisation

Also Published As

Publication number Publication date
EP0707470A4 (fr) 1998-04-22
GB9310054D0 (en) 1993-06-30
EP0707470A1 (fr) 1996-04-24
CA2162667C (fr) 1999-08-24
JPH08510248A (ja) 1996-10-29
CA2162667A1 (fr) 1994-11-24

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